Aliases for HSP90AA4P Gene

Aliases for HSP90AA4P Gene

  • Heat Shock Protein 90 Alpha Family Class A Member 4, Pseudogene 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 4, Pseudogene 2 3
  • Heat Shock 90kDa Protein 1, Alpha-Like 2 2 3
  • Heat Shock 90kD Protein 1, Alpha-Like 2 2 3
  • Heat Shock Protein 90Ad 3 4
  • HSPCAL2 3 4
  • Heat Shock Protein 90kDa Alpha Family Class A Member 4, Pseudogene 3
  • Putative Heat Shock Protein HSP 90-Alpha A4 4
  • Heat Shock 90 KDa Protein 1 Alpha-Like 2 4
  • Heat Shock Protein 90-Alpha D 4
  • HSP90Ad 3
  • HSP90AD 4

External Ids for HSP90AA4P Gene

Previous HGNC Symbols for HSP90AA4P Gene

  • HSPCAL2

Previous GeneCards Identifiers for HSP90AA4P Gene

  • GC04P190631
  • GC04P190394
  • GC04P186110

Summaries for HSP90AA4P Gene

GeneCards Summary for HSP90AA4P Gene

HSP90AA4P (Heat Shock Protein 90 Alpha Family Class A Member 4, Pseudogene) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot Summary for HSP90AA4P Gene

  • Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Additional gene information for HSP90AA4P Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSP90AA4P Gene

Genomics for HSP90AA4P Gene

GeneHancer (GH) Regulatory Elements for HSP90AA4P Gene

Promoters and enhancers for HSP90AA4P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J189504 Enhancer 0.3 Ensembl 0.3 +31.5 31495 0.8 SPI1 HSP90AA4P lnc-FRG1-11
GH04J189530 Enhancer 0.3 Ensembl 0.2 +58.0 57995 1 NFIC NFIB lnc-FRG1-11 HSP90AA4P
GH04J189493 Enhancer 0.2 Ensembl 0.4 +21.0 20995 1 HSP90AA4P lnc-FRG1-11
GH04J189498 Enhancer 0.2 Ensembl 0.3 +25.2 25195 0.2 HSP90AA4P lnc-FRG1-11
GH04J189517 Enhancer 0.2 Ensembl 0.3 +44.4 44395 0.2 lnc-FRG1-11 HSP90AA4P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSP90AA4P on UCSC Golden Path with GeneCards custom track

Genomic Locations for HSP90AA4P Gene

Genomic Locations for HSP90AA4P Gene
chr4:189,472,906-189,475,853
(GRCh38/hg38)
Size:
2,948 bases
Orientation:
Plus strand
chr4:190,394,119-190,396,346
(GRCh37/hg19)
Size:
2,228 bases
Orientation:
Plus strand

Genomic View for HSP90AA4P Gene

Genes around HSP90AA4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AA4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AA4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AA4P Gene

Proteins for HSP90AA4P Gene

  • Protein details for HSP90AA4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58FG1-HS904_HUMAN
    Recommended name:
    Putative heat shock protein HSP 90-alpha A4
    Protein Accession:
    Q58FG1

    Protein attributes for HSP90AA4P Gene

    Size:
    418 amino acids
    Molecular mass:
    47712 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSP90AA4P Gene

Post-translational modifications for HSP90AA4P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSP90AA4P Gene

Domains & Families for HSP90AA4P Gene

Protein Domains for HSP90AA4P Gene

Suggested Antigen Peptide Sequences for HSP90AA4P Gene

GenScript: Design optimal peptide antigens:
  • Heat shock protein 90-alpha D (HS904_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q58FG1

UniProtKB/Swiss-Prot:

HS904_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA4P: view

No data available for Gene Families for HSP90AA4P Gene

Function for HSP90AA4P Gene

Molecular function for HSP90AA4P Gene

UniProtKB/Swiss-Prot Function:
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Phenotypes From GWAS Catalog for HSP90AA4P Gene

Gene Ontology (GO) - Molecular Function for HSP90AA4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IBA 21873635
GO:0051082 unfolded protein binding IBA 21873635
GO:0097718 disordered domain specific binding IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA4P: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSP90AA4P Gene

Localization for HSP90AA4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA4P Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for HSP90AA4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA4P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HSP90AA4P Gene

Pathways & Interactions for HSP90AA4P Gene

PathCards logo

SuperPathways for HSP90AA4P Gene

No Data Available

Interacting Proteins for HSP90AA4P Gene

Selected Interacting proteins: Q58FG1-HS904_HUMAN for HSP90AA4P Gene via IID

;

Gene Ontology (GO) - Biological Process for HSP90AA4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0008150 biological_process ND --
GO:0034605 cellular response to heat IBA 21873635
GO:0050821 protein stabilization IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA4P: view

No data available for Pathways by source and SIGNOR curated interactions for HSP90AA4P Gene

Drugs & Compounds for HSP90AA4P Gene

No Compound Related Data Available

Transcripts for HSP90AA4P Gene

mRNA/cDNA for HSP90AA4P Gene

1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA4P Gene

No ASD Table

Relevant External Links for HSP90AA4P Gene

GeneLoc Exon Structure for
HSP90AA4P

Expression for HSP90AA4P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSP90AA4P Gene

mRNA differential expression in normal tissues according to GTEx for HSP90AA4P Gene

This gene is overexpressed in Testis (x30.7), Kidney - Cortex (x4.8), Brain - Hypothalamus (x4.8), Bladder (x4.7), and Brain - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for HSP90AA4P Gene

This gene is overexpressed in Brain (19.9), Heart (18.8), and Lung (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSP90AA4P Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSP90AA4P

SOURCE GeneReport for Unigene cluster for HSP90AA4P Gene:

Hs.553481
genes like me logo Genes that share expression patterns with HSP90AA4P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AA4P Gene

Orthologs for HSP90AA4P Gene

Evolution for HSP90AA4P Gene

ENSEMBL:
Gene Tree for HSP90AA4P (if available)
TreeFam:
Gene Tree for HSP90AA4P (if available)

No data available for Orthologs for HSP90AA4P Gene

Paralogs for HSP90AA4P Gene

(6) SIMAP similar genes for HSP90AA4P Gene using alignment to 1 proteins:

  • HS904_HUMAN
genes like me logo Genes that share paralogs with HSP90AA4P: view

No data available for Paralogs for HSP90AA4P Gene

Variants for HSP90AA4P Gene

Additional Variant Information for HSP90AA4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90AA4P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for HSP90AA4P Gene

Disorders for HSP90AA4P Gene

Additional Disease Information for HSP90AA4P

No disorders were found for HSP90AA4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSP90AA4P Gene

Publications for HSP90AA4P Gene

  1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B … Monteiro A (Genomics 2005) 2 3 4 54
  2. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PMID: 1740332) Ozawa K … Yokoyama K (Genomics 1992) 2 3 54
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 54

Products for HSP90AA4P Gene

Sources for HSP90AA4P Gene