Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSP90AA2P Gene

Aliases for HSP90AA2P Gene

  • Heat Shock Protein 90 Alpha Family Class A Member 2, Pseudogene 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2, Pseudogene 2 3
  • Heat Shock 90kDa Protein 1, Alpha-Like 3 2 3
  • HSP90AA2 3 4
  • HSPCAL3 3 4
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 Pseudogene 3
  • Heat Shock Protein 90kDa Alpha Family Class A Member 2, Pseudogene 3
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2 2
  • Heat Shock Protein HSP 90-Alpha A2 Pseudogene 4
  • Heat Shock 90 KDa Protein 1 Alpha-Like 3 4
  • Heat Shock 90kD Protein 1, Alpha-Like 3 2
  • Heat Shock 90kD Protein, Alpha-Like 3 3
  • Heat Shock Protein HSP 90-Alpha A2 4
  • Heat Shock Protein 86 3
  • HSP90ALPHA 3
  • HSPCA 3

External Ids for HSP90AA2P Gene

Previous HGNC Symbols for HSP90AA2P Gene

  • HSPCAL3
  • HSP90AA2

Summaries for HSP90AA2P Gene

Entrez Gene Summary for HSP90AA2P Gene

  • HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008]

GeneCards Summary for HSP90AA2P Gene

HSP90AA2P (Heat Shock Protein 90 Alpha Family Class A Member 2, Pseudogene) is a Pseudogene. Among its related pathways are MAPK Pathway. Gene Ontology (GO) annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for HSP90AA2P Gene

  • Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Additional gene information for HSP90AA2P Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA2P Gene

Genomics for HSP90AA2P Gene

GeneHancer (GH) Regulatory Elements for HSP90AA2P Gene

Promoters and enhancers for HSP90AA2P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J027890 Promoter 0.6 Ensembl 600.7 +0.5 491 1.2 ZNF680 HSP90AA2P ENSG00000255496
GH11J027904 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -12.9 -12909 2.8 POLR2A JUN JUND FOSL2 FOS HSP90AA2P GC11P028009
GH11J027932 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -43.3 -43301 3.2 ELF1 POLR2A CEBPB JUN SP1 RCOR1 JUND MAX MAZ USF1 KIF18A BDNF HSP90AA2P GC11P028009
GH11J027881 Enhancer 0.8 Ensembl ENCODE 0.4 +8.7 8745 1.4 SP1 RCOR1 DPF2 EP300 JUNB TCF7L2 GATA3 BATF JUND ETV6 ENSG00000255496 HSP90AA2P
GH11J027910 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.4 -19.4 -19409 1 FOSL2 JUND ENSG00000254862 HSP90AA2P GC11P028009
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSP90AA2P on UCSC Golden Path with GeneCards custom track

Genomic Locations for HSP90AA2P Gene

Genomic Locations for HSP90AA2P Gene
chr11:27,888,171-27,891,092
(GRCh38/hg38)
Size:
2,922 bases
Orientation:
Minus strand
chr11:27,909,718-27,912,639
(GRCh37/hg19)
Size:
2,922 bases
Orientation:
Minus strand

Genomic View for HSP90AA2P Gene

Genes around HSP90AA2P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AA2P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AA2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AA2P Gene

Proteins for HSP90AA2P Gene

  • Protein details for HSP90AA2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14568-HS902_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha A2
    Protein Accession:
    Q14568

    Protein attributes for HSP90AA2P Gene

    Size:
    343 amino acids
    Molecular mass:
    39365 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSP90AA2P Gene

Post-translational modifications for HSP90AA2P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSP90AA2P Gene

Domains & Families for HSP90AA2P Gene

Suggested Antigen Peptide Sequences for HSP90AA2P Gene

GenScript: Design optimal peptide antigens:
  • Heat shock 90 kDa protein 1 alpha-like 3 (HS902_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14568

UniProtKB/Swiss-Prot:

HS902_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA2P: view

No data available for Gene Families for HSP90AA2P Gene

Function for HSP90AA2P Gene

Molecular function for HSP90AA2P Gene

UniProtKB/Swiss-Prot Function:
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Gene Ontology (GO) - Molecular Function for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IBA 21873635
GO:0051082 unfolded protein binding IBA 21873635
GO:0097718 disordered domain specific binding IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA2P: view

Phenotypes for HSP90AA2P Gene

genes like me logo Genes that share phenotypes with HSP90AA2P: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for HSP90AA2P - Now 50% OFF >
  • * HSP90AA2P as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * HSP90AA2P tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSP90AA2P Gene

Localization for HSP90AA2P Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA2P Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0009986 cell surface IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA2P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HSP90AA2P Gene

Pathways & Interactions for HSP90AA2P Gene

PathCards logo

SuperPathways for HSP90AA2P Gene

SuperPathway Contained pathways
1 MAPK Pathway
genes like me logo Genes that share pathways with HSP90AA2P: view

Pathways by source for HSP90AA2P Gene

1 Tocris pathway for HSP90AA2P Gene

Interacting Proteins for HSP90AA2P Gene

Selected Interacting proteins: Q14568-HS902_HUMAN for HSP90AA2P Gene via IID

Gene Ontology (GO) - Biological Process for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0008150 biological_process ND --
GO:0034605 cellular response to heat IBA 21873635
GO:0050821 protein stabilization IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA2P: view

No data available for SIGNOR curated interactions for HSP90AA2P Gene

Drugs & Compounds for HSP90AA2P Gene

(26) Drugs for HSP90AA2P Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Geldanamycin Experimental, Investigational Pharma Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 0
Radicicol Experimental Pharma ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic 0
BIIB021 Investigational Pharma Hsp90 inhibitor,selective and competitive 0
PU-H71 Investigational Pharma Hsp90 inhibitor,potent and selective 0
XL-888 Investigational Pharma Hsp90 inhibitor 0

(2) Additional Compounds for HSP90AA2P Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7
KRIBB11
342639-96-7

(4) Tocris Compounds for HSP90AA2P Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor 75747-14-7
Geldanamycin Selective Hsp90 inhibitor 30562-34-6
KRIBB11 HSF1 inhibitor 342639-96-7
Radicicol Hsp90 inhibitor. Antifungal antibiotic 12772-57-5

(19) ApexBio Compounds for HSP90AA2P Gene

Compound Action Cas Number
17-AAG (KOS953) Hsp90 inhibitor 75747-14-7
17-DMAG (Alvespimycin) HCl Hsp90 inhibitor 467214-21-7
AT13387 Hsp90 inhibitor 912999-49-6
AUY922 (NVP-AUY922) Potent Hsp90 inhibitor 747412-49-3
BIIB021 Hsp90 inhibitor,selective and competitive 848695-25-0
CH5138303 959763-06-5
Ganetespib (STA-9090) Hsp90 inhibitor,non-geldanamycin 888216-25-9
Geldanamycin Hsp90 inhibitor,potent and specific 30562-34-6
HSP990 (NVP-HSP990) 934343-74-5
IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective 857402-63-2
KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, 819812-04-9
NMS-E973 Hsp90 inhibitor,potent and selective 1253584-84-7
NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic 847559-80-2
PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective 908115-27-5
PU-H71 Hsp90 inhibitor,potent and selective 873436-91-0
SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective 908112-43-6
VER-49009 558640-51-0
VER-50589 747413-08-7
XL-888 Hsp90 inhibitor 1149705-71-4
genes like me logo Genes that share compounds with HSP90AA2P: view

Drug Products

Transcripts for HSP90AA2P Gene

mRNA/cDNA for HSP90AA2P Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for HSP90AA2P - Now 50% OFF >
  • * HSP90AA2P as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * HSP90AA2P tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA2P Gene

No ASD Table

Relevant External Links for HSP90AA2P Gene

GeneLoc Exon Structure for
HSP90AA2P
ECgene alternative splicing isoforms for
HSP90AA2P

Expression for HSP90AA2P Gene

Protein differential expression in normal tissues from HIPED for HSP90AA2P Gene

This gene is overexpressed in Cervix (43.0) and Lavage (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSP90AA2P Gene



NURSA nuclear receptor signaling pathways regulating expression of HSP90AA2P Gene:

HSP90AA2P

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AA2P Gene

Orthologs for HSP90AA2P Gene

Evolution for HSP90AA2P Gene

ENSEMBL:
Gene Tree for HSP90AA2P (if available)
TreeFam:
Gene Tree for HSP90AA2P (if available)

No data available for Orthologs for HSP90AA2P Gene

Paralogs for HSP90AA2P Gene

No data available for Paralogs for HSP90AA2P Gene

Variants for HSP90AA2P Gene

Sequence variations from dbSNP and Humsavar for HSP90AA2P Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1826330 - p.Thr235Ala
rs2726836 - p.Cys312Tyr

Additional Variant Information for HSP90AA2P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90AA2P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for HSP90AA2P Gene

Disorders for HSP90AA2P Gene

Additional Disease Information for HSP90AA2P

No disorders were found for HSP90AA2P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSP90AA2P Gene

Publications for HSP90AA2P Gene

  1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B … Monteiro A (Genomics 2005) 2 3 4 58
  2. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PMID: 1740332) Ozawa K … Yokoyama K (Genomics 1992) 2 3 4 58
  3. Single nucleotide polymorphism that accompanies a missense mutation (Gln488His) impedes the dimerization of Hsp90. (PMID: 19130193) Kobayakawa T … Nemoto TK (The protein journal 2009) 3 23 58
  4. The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors. (PMID: 17724475) Ammirante M … Turco MC (Oncogene 2008) 3 23 58
  5. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. (PMID: 18559531) Yang Y … Bhalla K (Cancer research 2008) 3 23 58

Products for HSP90AA2P Gene

Sources for HSP90AA2P Gene

Content
Loading form....