HSP90AA1 Gene (Protein Coding)

Heat Shock Protein 90 Alpha Family Class A Member 1

GC14M102080
GIFtS:
49
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] See more...

Aliases for HSP90AA1 Gene

Aliases for HSP90AA1 Gene

  • Heat Shock Protein 90 Alpha Family Class A Member 1 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
  • Lipopolysaccharide-Associated Protein 2 3 4
  • Heat Shock 90kDa Protein 1, Alpha 2 3
  • Renal Carcinoma Antigen NY-REN-38 3 4
  • Heat Shock 90kD Protein 1, Alpha 2 3
  • Heat Shock Protein HSP 90-Alpha 3 4
  • LPS-Associated Protein 2 3 4
  • Heat Shock 86 KDa 3 4
  • HSP90A 3 4
  • HSP90N 2 3
  • HSP 86 3 4
  • HSP86 3 4
  • HSPC1 3 4
  • HSPCA 3 4
  • Hsp89 2 3
  • Hsp90 2 3
  • LAP-2 3 4
  • Heat Shock Protein 90kDa Alpha Family Class A Member 1 3
  • Epididymis Secretory Sperm Binding Protein Li 65p 3
  • Epididymis Luminal Secretory Protein 52 3
  • Heat Shock 90kD Protein 1, Alpha-Like 4 3
  • Heat Shock 90kD Protein, Alpha-Like 4 3
  • EC 3.6.4.10 4
  • HEL-S-65p 3
  • HSP90AA1 5
  • FLJ31884 2
  • HSPCAL1 3
  • HSPCAL4 3
  • HSP89A 3
  • Hsp103 3
  • EL52 3
  • HSPN 3
  • LAP2 3

External Ids for HSP90AA1 Gene

Previous HGNC Symbols for HSP90AA1 Gene

  • HSPC1
  • HSPCA

Previous GeneCards Identifiers for HSP90AA1 Gene

  • GC14M101619
  • GC14M102547

Summaries for HSP90AA1 Gene

Entrez Gene Summary for HSP90AA1 Gene

  • The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSP90AA1 Gene

HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Candidiasis and Epidermolysis Bullosa Acquisita. Among its related pathways are HSF1-dependent transactivation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot Summary for HSP90AA1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812).

Tocris Summary for HSP90AA1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Gene Wiki entry for HSP90AA1 Gene

Additional gene information for HSP90AA1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSP90AA1 Gene

Genomics for HSP90AA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HSP90AA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSP90AA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSP90AA1

Top Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:
  • LCR-F1
  • MyoD
  • p53
  • STAT1

Genomic Locations for HSP90AA1 Gene

Latest Assembly
chr14:102,080,742-102,139,749
(GRCh38/hg38)
Size:
59,008 bases
Orientation:
Minus strand

Previous Assembly
chr14:102,547,079-102,606,086
(GRCh37/hg19 by Entrez Gene)
Size:
59,008 bases
Orientation:
Minus strand

chr14:102,547,075-102,606,036
(GRCh37/hg19 by Ensembl)
Size:
58,962 bases
Orientation:
Minus strand

Genomic View for HSP90AA1 Gene

Genes around HSP90AA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSP90AA1 Gene

Proteins for HSP90AA1 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07900-HS90A_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha
    Protein Accession:
    P07900
    Secondary Accessions:
    • A8K500
    • B3KPJ9
    • Q2PP14
    • Q5CAQ6
    • Q5CAQ7
    • Q9BVQ5

    Protein attributes for HSP90AA1 Gene

    Size:
    732 amino acids
    Molecular mass:
    84660 Da
    Quaternary structure:
    • Homodimer (PubMed:7588731, PubMed:8289821, PubMed:18400751, PubMed:29127155). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (PubMed:29127155). The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus) (PubMed:29127155). Interacts with TOM34 (PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917, PubMed:27353360). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226, PubMed:27353360). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (PubMed:23569206, PubMed:27353360). May interact with NWD1 (PubMed:24681825). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (PubMed:17028174, PubMed:27353360). Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1 (PubMed:12604615, PubMed:27353360, PubMed:29127155). Interacts with FLCN in the presence of FNIP1 (PubMed:27353360). Interacts with HSP70, STIP1 and PTGES3 (PubMed:27353360). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:15235609, PubMed:25738358). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with HSF1 in an ATP-dependent manner (PubMed:11583998. PubMed:26517842). Interacts with MET; the interaction suppresses MET kinase activity (PubMed:26517842). Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with HSP90AB1; interaction is constitutive (PubMed:20353823). Interacts with HECTD1 (via N-terminus) (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with NLPR12 (PubMed:30559449, PubMed:17947705). Interacts with PDCL3 (By similarity). Interacts with TOMM70; the interaction is required for preprotein mitochondrial import (PubMed:12526792). Interacts with TOMM70, IRF3 and TBK1; the interactions are direct and mediate the association of TOMM70 with IRF3 and TBK1 (PubMed:20628368).
    • (Microbial infection) Interacts with herpes simplex virus 1 protein US11; this interaction inhibits TBK1-induced interferon production.

    Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene

    Alternative splice isoforms for HSP90AA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSP90AA1 Gene

Protein Expression for HSP90AA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSP90AA1 Gene

  • ISGylated.
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
  • Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.
  • Glycosylation at Asn397
  • Ubiquitination at Lys58, Lys84, Lys224, Lys314, Lys419, Lys436, Lys443, Lys446, Lys478, Lys489, Lys499, Lys513, and Lys632
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HS90A_HUMAN (1301)

Other Protein References for HSP90AA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for HSP90AA1 Gene

Domains & Families for HSP90AA1 Gene

Gene Families for HSP90AA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSP90AA1 Gene

InterPro:
Blocks:
  • ATP-binding region, ATPase-like
  • Heat shock protein Hsp90
ProtoNet:

Suggested Antigen Peptide Sequences for HSP90AA1 Gene

GenScript: Design optimal peptide antigens:
  • Renal carcinoma antigen NY-REN-38 (HS90A_HUMAN)
  • HSP90AA1 protein (Q2VPJ6_HUMAN)
  • HSP90AA1 protein (Q8TBA7_HUMAN)
  • HSP90AA1 protein (Q96HX7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07900

UniProtKB/Swiss-Prot:

HS90A_HUMAN :
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
  • Belongs to the heat shock protein 90 family.
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA1: view

Function for HSP90AA1 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for HSP90AA1 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochodria outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.10; Evidence={ECO:0000269|PubMed:12526792};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for ATP {ECO:0000269|PubMed:18400751};
UniProtKB/Swiss-Prot EnzymeRegulation:
In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation (PubMed:18400751). Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation (PubMed:18400751). After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state (PubMed:18400751). Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity (PubMed:29127155). Inhibited by geldanamycin, Ganetespib (STA-9090) and SNX-2112 (PubMed:29127155, PubMed:12526792).

Enzyme Numbers (IUBMB) for HSP90AA1 Gene

Phenotypes From GWAS Catalog for HSP90AA1 Gene

Gene Ontology (GO) - Molecular Function for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 9660753
GO:0005524 ATP binding IEA,IDA 27353360
GO:0016887 ATPase activity IDA 15937123
genes like me logo Genes that share ontologies with HSP90AA1: view
genes like me logo Genes that share phenotypes with HSP90AA1: view

Animal Models for HSP90AA1 Gene

MGI Knock Outs for HSP90AA1:

Animal Models for research

miRNA for HSP90AA1 Gene

miRTarBase miRNAs that target HSP90AA1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSP90AA1

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene

Localization for HSP90AA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Nucleus. Cytoplasm. Melanosome. Cell membrane. Mitochondrion. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSP90AA1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
lysosome 5
plasma membrane 4
mitochondrion 4
cytoskeleton 3
endoplasmic reticulum 3
endosome 3
golgi apparatus 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,ISS --
GO:0005739 mitochondrion IDA 25609812
genes like me logo Genes that share ontologies with HSP90AA1: view

Pathways & Interactions for HSP90AA1 Gene

genes like me logo Genes that share pathways with HSP90AA1: view

Pathways by source for HSP90AA1 Gene

2 Sino Biological pathways for HSP90AA1 Gene
6 GeneGo (Thomson Reuters) pathways for HSP90AA1 Gene
  • CFTR folding and maturation (norm and CF)
  • Development VEGF signaling via VEGFR2 - generic cascades
  • Development_Glucocorticoid receptor signaling
  • Immune response Antigen presentation by MHC class I
  • Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
1 R&D Systems pathway for HSP90AA1 Gene
1 Tocris pathway for HSP90AA1 Gene
11 Qiagen pathways for HSP90AA1 Gene
  • AHR Pathway
  • Akt Signaling
  • Aldosterone Signaling in Epithelial Cells
  • Androgen Signaling
  • eNOS Signaling
2 GeneTex pathways for HSP90AA1 Gene

SIGNOR curated interactions for HSP90AA1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001934 positive regulation of protein phosphorylation IDA 19363271
GO:0002218 activation of innate immune response IDA 20628368
GO:0002230 positive regulation of defense response to virus by host IDA 20628368
GO:0006457 protein folding IEA,IBA 21873635
genes like me logo Genes that share ontologies with HSP90AA1: view

Drugs & Compounds for HSP90AA1 Gene

Products:

  1. Drug products for research

(145) Drugs for HSP90AA1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifabutin Approved, Investigational Pharma Target, other/unknown 73
Nedocromil Approved, Investigational Pharma Target 5
Copper Approved, Investigational Pharma Target 271
Geldanamycin Experimental, Investigational Pharma Target Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 10
Radicicol Experimental Pharma ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic 0

(49) Additional Compounds for HSP90AA1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7
KRIBB11
342639-96-7

(4) Tocris Compounds for HSP90AA1 Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor 75747-14-7
Geldanamycin Selective Hsp90 inhibitor 30562-34-6
KRIBB11 HSF1 inhibitor 342639-96-7
Radicicol Hsp90 inhibitor. Antifungal antibiotic 12772-57-5

(26) ApexBio Compounds for HSP90AA1 Gene

Compound Action Cas Number
17-AAG (KOS953) Hsp90 inhibitor 75747-14-7
17-DMAG (Alvespimycin) HCl Hsp90 inhibitor 467214-21-7
AT13387 Hsp90 inhibitor 912999-49-6
AUY922 (NVP-AUY922) Potent Hsp90 inhibitor 747412-49-3
BIIB021 Hsp90 inhibitor,selective and competitive 848695-25-0
CH5138303 959763-06-5
EC 144 911397-80-3
Ganetespib (STA-9090) Hsp90 inhibitor,non-geldanamycin 888216-25-9
Gedunin naturally occurring Hsp90 inhibitor 2753-30-2
Geldanamycin Hsp90 inhibitor,potent and specific 30562-34-6
HSP990 (NVP-HSP990) 934343-74-5
IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective 857402-63-2
KNK437 stress-induced HSP synthesis inhibitor 218924-25-5
KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, 819812-04-9
Macbecin I 73341-72-7
MPC-3100 Hsp90 inhibitor 958025-66-6
NMS-E973 Hsp90 inhibitor,potent and selective 1253584-84-7
NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic 847559-80-2
PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective 908115-27-5
PU-WS13 Grp94-specific Hsp90 inhibitor 1454619-14-7
Radicicol ATPase/kinase inhibitor 12772-57-5
Retaspimycin HSP90 inhibitor,antiproliferative and antineoplastic 857402-23-4
SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective 908112-43-6
VER-49009 558640-51-0
VER-50589 747413-08-7
XL-888 Hsp90 inhibitor 1149705-71-4
genes like me logo Genes that share compounds with HSP90AA1: view

Transcripts for HSP90AA1 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for HSP90AA1 Gene

2 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSP90AA1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HSP90AA1 Gene

GeneLoc Exon Structure for
HSP90AA1

Expression for HSP90AA1 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSP90AA1 Gene

mRNA expression in normal human tissues for HSP90AA1 Gene
mRNA expression by GTEx for HSP90AA1 GenemRNA expression by BioGPS for HSP90AA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSP90AA1 Gene

This gene is overexpressed in Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSP90AA1 Gene



Protein tissue co-expression partners for HSP90AA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSP90AA1

SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene:

Hs.525600

Evidence on tissue expression from TISSUES for HSP90AA1 Gene

  • Nervous system(5)
  • Liver(5)
  • Blood(5)
  • Lung(4.9)
  • Heart(4.9)
  • Skin(4.9)
  • Intestine(4.9)
  • Kidney(4.8)
  • Eye(4.7)
  • Pancreas(4.6)
  • Stomach(4.5)
  • Bone(4.3)
  • Muscle(4.2)
  • Spleen(3.7)
  • Adrenal gland(3.4)
  • Lymph node(3.4)
  • Bone marrow(3.4)
  • Thyroid gland(3.1)
  • Gall bladder(2.8)
genes like me logo Genes that share expression patterns with HSP90AA1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AA1 Gene

Orthologs for HSP90AA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia HSP90AA1 30 31
  • 99.18 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia HSP90AA1 31
  • 97 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia HSP90AA1 31
  • 95 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Hsp90aa1 30
  • 90.89 (n)
Mouse
(Mus musculus)
 Mammalia Hsp90aa1 30 17 31
  • 90.12 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia HSP90AA1 30 31
  • 88.62 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia HSP90AA1 30 31
  • 87.47 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves HSP90AA1 30 31
  • 82.01 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia HSP90AA1 31
  • 82 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia hsp90aa1.1 30
  • 79.83 (n)
Zebrafish
(Danio rerio)
 Actinopterygii hsp90aa1.2 30 31
  • 77.44 (n)
 OneToOne
-- 30
Fruit Fly
(Drosophila melanogaster)
 Insecta Hsp83 31
  • 78 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea daf-21 31
  • 77 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HSP82 31 33
  • 61 (a)
 OneToMany
HSC82 33
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons HSP81-2 30
  • 67.96 (n)
Rice
(Oryza sativa)
 Liliopsida Os09g0482100 30
  • 66.43 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11103 31
  • 79 (a)
 OneToMany
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.3846 30
Species where no ortholog for HSP90AA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HSP90AA1 Gene

ENSEMBL:
Gene Tree for HSP90AA1 (if available)
TreeFam:
Gene Tree for HSP90AA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSP90AA1: view image

Paralogs for HSP90AA1 Gene

Paralogs for HSP90AA1 Gene

(14) SIMAP similar genes for HSP90AA1 Gene using alignment to 8 proteins:

  • HS90A_HUMAN
  • G3V2J8_HUMAN
  • G3V592_HUMAN
  • H0YJF5_HUMAN
  • Q2VPJ6_HUMAN
  • Q86U12_HUMAN
  • Q8TBA7_HUMAN
  • Q96HX7_HUMAN

Pseudogenes.org Pseudogenes for HSP90AA1 Gene

genes like me logo Genes that share paralogs with HSP90AA1: view

Variants for HSP90AA1 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSP90AA1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs113261380 Benign: not provided 102,083,847(-) C/T
NM_005348.4(HSP90AA1):c.1284G>A (p.Ala428=) 		SYNONYMOUS
rs11547524 Benign: not provided 102,082,121(-) T/C
NM_005348.4(HSP90AA1):c.2079A>G (p.Lys693=) 		SYNONYMOUS
rs34158504 Benign: not provided 102,083,784(-) T/C
NM_005348.4(HSP90AA1):c.1338+9A>G 		INTRON
rs80020850 Benign: not provided 102,082,104(-) G/T
NM_005348.4(HSP90AA1):c.2089+7C>A 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSP90AA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSP90AA1 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV loss 17160897
esv25342 CNV loss 19812545
esv2670326 CNV deletion 23128226
esv3552074 CNV deletion 23714750
esv3635541 CNV loss 21293372
esv3635542 CNV loss 21293372
esv3635543 CNV loss 21293372
nsv1113674 CNV deletion 24896259
nsv1131163 CNV deletion 24896259
nsv1428 CNV insertion 18451855
nsv565947 CNV gain 21841781
nsv832879 CNV loss 17160897
nsv976371 CNV duplication 23825009
nsv983856 CNV duplication 23825009

Variation tolerance for HSP90AA1 Gene

Residual Variation Intolerance Score: 3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSP90AA1 Gene

Human Gene Mutation Database (HGMD)
HSP90AA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90AA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Disorders for HSP90AA1 Gene

MalaCards: The human disease database

(59) MalaCards diseases for HSP90AA1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
candidiasis
  • disseminated candidiasis
epidermolysis bullosa acquisita
  • acquired epidermolysis bullosa
lobular neoplasia
  • lobular carcinoma in situ
primary hyperoxaluria
  • hyperoxaluria, primary
gastrointestinal stromal tumor
  • gist
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSP90AA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HSP90AA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AA1 Gene

Publications for HSP90AA1 Gene