Aliases for HSP90AA1 Gene
Aliases for HSP90AA1 Gene
- Heat Shock Protein 90 Alpha Family Class A Member 1 2 3 5
- Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
- Lipopolysaccharide-Associated Protein 2 3 4
- Renal Carcinoma Antigen NY-REN-38 3 4
- Heat Shock 90kDa Protein 1, Alpha 2 3
- Heat Shock 90kD Protein 1, Alpha 2 3
- LPS-Associated Protein 2 3 4
- Heat Shock 86 KDa 3 4
- HSP 86 3 4
- HSP90A 3 4
- HSPC1 3 4
- HSPCA 3 4
- HSP86 3 4
- LAP-2 3 4
- Heat Shock Protein 90kDa Alpha Family Class A Member 1 3
- Epididymis Secretory Sperm Binding Protein Li 65p 3
External Ids for HSP90AA1 Gene
- HGNC: 5253
- Entrez Gene: 3320
- Ensembl: ENSG00000080824
- OMIM: 140571
- UniProtKB: P07900
Previous HGNC Symbols for HSP90AA1 Gene
- HSPC1
- HSPCA
Previous GeneCards Identifiers for HSP90AA1 Gene
- GC14M101619
- GC14M102547
Summaries for HSP90AA1 Gene
-
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for HSP90AA1 Gene
HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Hypersensitivity Vasculitis and Hypersensitivity Reaction Type Iii Disease. Among its related pathways are Akt Signaling and LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HSP90AB1.
UniProtKB/Swiss-Prot for HSP90AA1 Gene
-
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
-
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
Additional gene information for HSP90AA1 Gene
- Monarch Initiative
- Search for HSP90AA1 at DataMed
- Search for HSP90AA1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA1 Gene
Genomics for HSP90AA1 Gene
GeneHancer (GH) Regulatory Elements for HSP90AA1 Gene
Promoters and enhancers for HSP90AA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSP90AA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:
-
- MyoD
- STAT1
- p53
- LCR-F1
Regulatory Element Products
Genomic Locations for HSP90AA1 Gene
Genomic Locations for HSP90AA1 Gene
- chr14:102,080,738-102,139,759
- (GRCh38/hg38)
- Size:
- 59,022 bases
- Orientation:
- Minus strand
- chr14:102,547,075-102,606,086
- (GRCh37/hg19)
- Size:
- 59,012 bases
- Orientation:
- Minus strand
Genomic View for HSP90AA1 Gene
Genes around HSP90AA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.31 by Entrez Gene
- 14q32.31 by HGNC
- 14q32.31 by Ensembl
HSP90AA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSP90AA1 Gene
Proteins for HSP90AA1 Gene
-
Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07900-HS90A_HUMAN
- Recommended name:
- Heat shock protein HSP 90-alpha
- Protein Accession:
- P07900
- A8K500
- B3KPJ9
- Q2PP14
- Q5CAQ6
- Q5CAQ7
- Q9BVQ5
Protein attributes for HSP90AA1 Gene
- Size:
- 732 amino acids
- Molecular mass:
- 84660 Da
- Quaternary structure:
-
- Homodimer (PubMed:7588731, PubMed:8289821, PubMed:18400751, PubMed:29127155). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (PubMed:29127155). The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus) (PubMed:29127155). Interacts with TOM34 (PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917, PubMed:27353360). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226, PubMed:27353360). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (PubMed:23569206, PubMed:27353360). May interact with NWD1 (PubMed:24681825). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (PubMed:17028174, PubMed:27353360). Interacts with co-chaperone AHSA1 (phosphorylated on Tyr-223); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1 (PubMed:12604615, PubMed:27353360, PubMed:29127155). Interacts with FLCN in the presence of FNIP1 (PubMed:27353360). Interacts with HSP70, STIP1 and PTGES3 (PubMed:27353360). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:15235609, PubMed:25738358). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with HSF1 in an ATP-dependent manner (PubMed:11583998. PubMed:26517842). Interacts with MET; the interaction suppresses MET kinase activity (PubMed:26517842). Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with HSP90AB1; interaction is constitutive (PubMed:20353823). Interacts with HECTD1 (via N-terminus) (By similarity).
Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene
Protein Expression for HSP90AA1 Gene
Post-translational modifications for HSP90AA1 Gene
- ISGylated.
- S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
- Ubiquitinated via Lys-63-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.
- Ubiquitination at isoforms=2513, Lys478, isoforms=2446, Lys436, Lys419, Lys314, isoforms=2294, and Lys84
- Modification sites at PhosphoSitePlus
Other Protein References for HSP90AA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
- Novus Biologicals Antibodies for HSP90AA1
-
Abcam antibodies for HSP90AA1
- Invitrogen Antibodies for HSP90AA1 (AFLGC-HSP90AA1)
- antibodies-online: Search results for 86 available HSP90AA1 Antibodies ranked by validation data
- Compare Top HSP90AA1 Antibodies
-
Recommended
- 49 WB Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 41 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 78 WB Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 49 WB Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 41 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 78 WB Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- GeneTex HSP90AA1 Antibody for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSP90AA1
- Sino Biological Antibodies for HSP90AA1
Protein Products
- R&D Systems Proteins and Enzymes for HSP90AA1 (HSP90 alpha)
-
OriGene Purified Proteins for HSP90AA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSP90AA1
- Origene Custom Protein Services for HSP90AA1
- Sino Biological Recombinant Proteins for HSP90AA1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HSP90AA1
- GeneTex Proteins for HSP90AA1
-
Abcam proteins for HSP90AA1
Assay Products
- Novus Biologicals ELISA Kits for HSP90AA1
- antibodies-online: Search results for 18 available HSP90AA1 Elisa Kits ranked by validation data
- Compare Top HSP90AA1 Elisa Kits
-
Recommended
-
Boster Bio ELISA Kits for HSP90AA1
No data available for DME Specific Peptides for HSP90AA1 Gene
Domains & Families for HSP90AA1 Gene
Gene Families for HSP90AA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for HSP90AA1 Gene
Suggested Antigen Peptide Sequences for HSP90AA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07900UniProtKB/Swiss-Prot:
HS90A_HUMAN :- The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
- Belongs to the heat shock protein 90 family.
- Domain:
-
- The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
- Family:
-
- Belongs to the heat shock protein 90 family.
Function for HSP90AA1 Gene
Molecular function for HSP90AA1 Gene
- UniProtKB/Swiss-Prot Function:
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation (PubMed:18400751). Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation (PubMed:18400751). After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state (PubMed:18400751). Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity (PubMed:29127155). Inhibited by Ganetespib (STA-9090) and SNX-2112 (PubMed:29127155).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=300 uM for ATP {ECO:0000269 PubMed:18400751};
Phenotypes From GWAS Catalog for HSP90AA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | TAS | 11470816 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004713 | protein tyrosine kinase activity | EXP | 17349580 |
| GO:0005515 | protein binding | IPI | 9660753 |
| GO:0005524 | ATP binding | TAS,IEA | 11470816 |
Phenotypes for HSP90AA1 Gene
- MGI mutant phenotypes for HSP90AA1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HSP90AA1:
Animal Models for HSP90AA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HSP90AA1
-
CRISPR Products
-
OriGene CRISPR knockouts for HSP90AA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSP90AA1
- genomics-online: gRNA clones - Search results for 26 available HSP90AA1 gene related products
- Overview of 26 available HSP90AA1 gene related products
- Applied Biological Materials CRISPR for HSP90AA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
miRNA for HSP90AA1 Gene
- miRTarBase miRNAs that target HSP90AA1
-
- hsa-mir-375 (MIRT020063)
- hsa-mir-16-5p (MIRT031959)
- hsa-mir-1226-3p (MIRT036428)
- hsa-mir-760 (MIRT036729)
- hsa-mir-425-5p (MIRT039331)
- hsa-mir-421 (MIRT039416)
- hsa-mir-501-5p (MIRT041140)
- hsa-mir-484 (MIRT041642)
- hsa-mir-324-3p (MIRT042829)
- hsa-mir-378a-3p (MIRT043944)
- hsa-mir-30e-5p (MIRT044155)
- hsa-mir-186-5p (MIRT045178)
- hsa-mir-185-5p (MIRT045325)
- hsa-mir-222-3p (MIRT046648)
- hsa-mir-204-5p (MIRT047015)
- hsa-mir-183-5p (MIRT047124)
- hsa-mir-10a-5p (MIRT047507)
- hsa-mir-30c-5p (MIRT047953)
- hsa-mir-25-3p (MIRT050304)
- hsa-mir-17-5p (MIRT050979)
- hsa-let-7b-5p (MIRT052238)
- hsa-mir-3943 (MIRT052896)
- hsa-mir-1277-5p (MIRT069282)
- hsa-mir-4703-3p (MIRT190328)
- hsa-mir-4677-3p (MIRT277530)
- hsa-mir-4679 (MIRT277531)
- hsa-mir-889-3p (MIRT277538)
- hsa-mir-1323 (MIRT438030)
- hsa-mir-34c-5p (MIRT438031)
- hsa-mir-371a-5p (MIRT438032)
- hsa-mir-3674 (MIRT493566)
- hsa-mir-374a-3p (MIRT493567)
- hsa-mir-4732-5p (MIRT493568)
- hsa-mir-6832-5p (MIRT493569)
- hsa-mir-219a-2-3p (MIRT493570)
- hsa-mir-4257 (MIRT493571)
- hsa-mir-6847-5p (MIRT493572)
- hsa-mir-2115-3p (MIRT493573)
- hsa-mir-1278 (MIRT493574)
- hsa-mir-6859-5p (MIRT493575)
- hsa-mir-3916 (MIRT493576)
- hsa-mir-3125 (MIRT493577)
- hsa-mir-4724-5p (MIRT493578)
- hsa-mir-361-5p (MIRT493579)
- hsa-mir-499b-5p (MIRT511420)
- hsa-mir-500b-5p (MIRT511421)
- hsa-mir-362-5p (MIRT511422)
- hsa-mir-656-3p (MIRT511423)
- hsa-mir-224-5p (MIRT511424)
- hsa-mir-7-2-3p (MIRT511425)
- hsa-mir-7-1-3p (MIRT511426)
- hsa-mir-3133 (MIRT511427)
- hsa-mir-495-3p (MIRT511428)
- hsa-mir-5688 (MIRT511429)
- hsa-mir-139-5p (MIRT541190)
- hsa-mir-6798-3p (MIRT541191)
- hsa-mir-582-5p (MIRT541192)
- hsa-mir-101-3p (MIRT541193)
- hsa-mir-550a-3p (MIRT541194)
- hsa-mir-200c-5p (MIRT541195)
- hsa-mir-600 (MIRT541196)
- hsa-mir-152-3p (MIRT541197)
- hsa-mir-148b-3p (MIRT541198)
- hsa-mir-148a-3p (MIRT541199)
- hsa-mir-497-3p (MIRT541200)
- hsa-mir-5590-5p (MIRT567246)
- hsa-mir-6826-3p (MIRT567247)
- hsa-mir-6755-3p (MIRT567248)
- hsa-mir-6756-3p (MIRT567249)
- hsa-mir-3127-3p (MIRT567250)
- hsa-mir-141-5p (MIRT567251)
- hsa-mir-1244 (MIRT567252)
- hsa-mir-548l (MIRT567253)
- hsa-mir-8054 (MIRT567254)
- hsa-mir-548k (MIRT567255)
- hsa-mir-548av-5p (MIRT567256)
- hsa-mir-559 (MIRT567257)
- hsa-mir-548y (MIRT567258)
- hsa-mir-548w (MIRT567259)
- hsa-mir-548o-5p (MIRT567260)
- hsa-mir-548j-5p (MIRT567261)
- hsa-mir-548i (MIRT567262)
- hsa-mir-548h-5p (MIRT567263)
- hsa-mir-548d-5p (MIRT567264)
- hsa-mir-548c-5p (MIRT567265)
- hsa-mir-548bb-5p (MIRT567266)
- hsa-mir-548b-5p (MIRT567267)
- hsa-mir-548ay-5p (MIRT567268)
- hsa-mir-548au-5p (MIRT567269)
- hsa-mir-548as-5p (MIRT567270)
- hsa-mir-548ar-5p (MIRT567271)
- hsa-mir-548aq-5p (MIRT567272)
- hsa-mir-548ap-5p (MIRT567273)
- hsa-mir-548am-5p (MIRT567274)
- hsa-mir-548ak (MIRT567275)
- hsa-mir-548ae-5p (MIRT567276)
- hsa-mir-548ad-5p (MIRT567277)
- hsa-mir-548ab (MIRT567278)
- hsa-mir-548a-5p (MIRT567279)
- hsa-mir-23a-3p (MIRT732475)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSP90AA1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSP90AA1
- genomics-online: shRNA clones - Search results for 26 available HSP90AA1 gene related products
- Overview of 26 available HSP90AA1 gene related products
Clone Products
-
OriGene ORF clones in human for HSP90AA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSP90AA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSP90AA1
- Applied Biological Materials Clones for HSP90AA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HSP90AA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene
Localization for HSP90AA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene
- Nucleus. Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| mitochondrion | 3 |
| endoplasmic reticulum | 3 |
| cytoskeleton | 2 |
| golgi apparatus | 2 |
| endosome | 2 |
| peroxisome | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA,ISS | -- |
Pathways & Interactions for HSP90AA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Signaling by EGFR in Cancer | ||
| 3 | eNOS activation and regulation |
.01
|
|
| 4 | Influenza Viral RNA Transcription and Replication |
.01
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for HSP90AA1 Gene
2 Sino Biological pathways for HSP90AA1 Gene
2 GeneTex pathways for HSP90AA1 Gene
23 BioSystems pathways for HSP90AA1 Gene
64 Reactome pathways for HSP90AA1 Gene
1 PharmGKB pathway for HSP90AA1 Gene
12 KEGG pathways for HSP90AA1 Gene
6 GeneGo (Thomson Reuters) pathways for HSP90AA1 Gene
1 R&D Systems pathway for HSP90AA1 Gene
1 Tocris pathway for HSP90AA1 Gene
11 Qiagen pathways for HSP90AA1 Gene
Interacting Proteins for HSP90AA1 Gene
Selected Interacting proteins:
P07900-HS90A_HUMAN
ENSP00000335153
for HSP90AA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HSP90AA1
SIGNOR curated interactions for HSP90AA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | 19363271 |
| GO:0006457 | protein folding | IEA | -- |
| GO:0006839 | mitochondrial transport | TAS | 12526792 |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
Drugs & Compounds for HSP90AA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Rifabutin | Approved, Investigational | Pharma | Target, other/unknown | 58 | ||
| Nedocromil | Approved, Investigational | Pharma | Target | 5 | ||
| Copper | Approved, Investigational | Pharma | Target | 202 | ||
| Polaprezinc | Approved, Investigational | Pharma | Target, agonist | 2 | ||
| Geldanamycin | Experimental, Investigational | Pharma | Target | Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 17-AAG |
|
75747-14-7 |
|
|
||
| KRIBB11 |
|
342639-96-7 |
|
|
(4) Tocris Compounds for HSP90AA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 17-AAG | Selective Hsp90 inhibitor | 75747-14-7 |
| Geldanamycin | Selective Hsp90 inhibitor | 30562-34-6 |
| KRIBB11 | HSF1 inhibitor | 342639-96-7 |
| Radicicol | Hsp90 inhibitor. Antifungal antibiotic | 12772-57-5 |
Transcripts for HSP90AA1 Gene
mRNA/cDNA for HSP90AA1 Gene
- (3) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (2627) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000216281 3379 bps (uc001yku.5)
- ENST00000334701 3510 bps (uc001ykv.5)
- ENST00000554401 1710 bps (uc059fkh.1)
- ENST00000557089 694 bps (uc059fki.1)
- ENST00000560130 488 bps (uc059fkj.1)
Unigene Clusters for HSP90AA1 Gene
- Heat shock protein 90kDa alpha (cytosolic), class A member 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HSP90AA1
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- Overview of 26 available HSP90AA1 gene related products
- Applied Biological Materials CRISPR for HSP90AA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
miRNA Products
Inhibitory RNA Products
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- Overview of 26 available HSP90AA1 gene related products
Clone Products
-
OriGene ORF clones in human for HSP90AA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Applied Biological Materials Clones for HSP90AA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 16a | · | 16b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: |
Expression for HSP90AA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Neural Tube (Nervous System)
- Tooth (Integumentary System)
- Liver (Hepatobiliary System)
- Endoderm (Gastrulation Derivatives)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Lymph node (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSP90AA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HSP90AA1 Gene:
HSP90AA1SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene:
Hs.525600Evidence on tissue expression from TISSUES for HSP90AA1 Gene
- Liver(5)
- Nervous system(5)
- Blood(4.9)
- Heart(4.9)
- Lung(4.9)
- Skin(4.9)
- Intestine(4.8)
- Kidney(4.8)
- Eye(4.6)
- Pancreas(4.5)
- Stomach(4.3)
- Bone(4.2)
- Muscle(4.1)
- Spleen(3.5)
- Adrenal gland(3.1)
- Bone marrow(3)
- Lymph node(3)
- Thyroid gland(2.6)
- Gall bladder(2.3)
Primer Products
-
OriGene qPCR primer pairs for HSP90AA1
- genomics-online: primer clones - Search results for 26 available HSP90AA1 gene related products
- Overview of 26 available HSP90AA1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AA1 Gene
Orthologs for HSP90AA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HSP90AA1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HSP90AA1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HSP90AA1 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hsp90aa1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hsp90aa1 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | HSP90AA1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HSP90AA1 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HSP90AA1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HSP90AA1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hsp90aa1.1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hsp90aa1.2 34 33 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Hsp83 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | daf-21 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSP82 36 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HSP81-2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0482100 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11103 34 |
|
OneToMany | |
| Cin.3846 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3846 33 |
|
- Species where no ortholog for HSP90AA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HSP90AA1 Gene
- ENSEMBL:
- Gene Tree for HSP90AA1 (if available)
- TreeFam:
- Gene Tree for HSP90AA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSP90AA1: view image
Paralogs for HSP90AA1 Gene
(14) SIMAP similar genes for HSP90AA1 Gene using alignment to 8 proteins:
- HS90A_HUMAN
- G3V2J8_HUMAN
- G3V592_HUMAN
- H0YJF5_HUMAN
- Q2VPJ6_HUMAN
- Q86U12_HUMAN
- Q8TBA7_HUMAN
- Q96HX7_HUMAN
Pseudogenes.org Pseudogenes for HSP90AA1 Gene
Variants for HSP90AA1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055689 | -- | 102,139,847(-) | G/A | upstream_transcript_variant | |
| rs1000062529 | -- | 102,110,873(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000100990 | -- | 102,116,518(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000151696 | -- | 102,096,101(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000176361 | -- | 102,108,647(-) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv25n68 | CNV | loss | 17160897 |
| esv25342 | CNV | loss | 19812545 |
| esv2670326 | CNV | deletion | 23128226 |
| esv3552074 | CNV | deletion | 23714750 |
| esv3635541 | CNV | loss | 21293372 |
| esv3635542 | CNV | loss | 21293372 |
| esv3635543 | CNV | loss | 21293372 |
| nsv1113674 | CNV | deletion | 24896259 |
| nsv1131163 | CNV | deletion | 24896259 |
| nsv1428 | CNV | insertion | 18451855 |
| nsv565947 | CNV | gain | 21841781 |
| nsv832879 | CNV | loss | 17160897 |
| nsv976371 | CNV | duplication | 23825009 |
| nsv983856 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.05;
37.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSP90AA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene
Disorders for HSP90AA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypersensitivity vasculitis |
|
|
| hypersensitivity reaction type iii disease |
|
|
| hand-foot-genital syndrome |
|
|
| epidermolysis bullosa acquisita |
|
|
| lobular neoplasia |
|
|
Search HSP90AA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HSP90AA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AA1 Gene
Publications for HSP90AA1 Gene
- A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PMID: 19875381) Gano JJ … Simon JA (Molecular & cellular proteomics : MCP 2010) 3 4 22 58
- Hsp90 is regulated by a switch point in the C-terminal domain. (PMID: 19696785) Retzlaff M … Buchner J (EMBO reports 2009) 3 4 22 58
- Conserved conformational changes in the ATPase cycle of human Hsp90. (PMID: 18400751) Richter K … Buchner J (The Journal of biological chemistry 2008) 3 4 22 58
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B … Monteiro A (Genomics 2005) 2 3 4 58
- S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PMID: 15937123) Martínez-Ruiz A … Lamas S (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58
Products for HSP90AA1 Gene
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