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The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Candidiasis and Epidermolysis Bullosa Acquisita. Among its related pathways are HSF1-dependent transactivation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HSP90AB1.
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 9660753 |
GO:0005524 | ATP binding | IEA,IDA | 27353360 |
GO:0016887 | ATPase activity | IDA | 15937123 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005634 | nucleus | IBA,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IDA,ISS | -- |
GO:0005739 | mitochondrion | IDA | 25609812 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
2 | Signaling by EGFR in Cancer | ||
3 | eNOS activation and regulation |
.01
|
|
4 | Influenza Viral RNA Transcription and Replication |
.01
|
|
5 | HIV Life Cycle |
.45
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0001934 | positive regulation of protein phosphorylation | IDA | 19363271 |
GO:0002218 | activation of innate immune response | IDA | 20628368 |
GO:0002230 | positive regulation of defense response to virus by host | IDA | 20628368 |
GO:0006457 | protein folding | IEA,IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Rifabutin | Approved, Investigational | Pharma | Target, other/unknown | 73 | ||
Nedocromil | Approved, Investigational | Pharma | Target | 5 | ||
Copper | Approved, Investigational | Pharma | Target | 271 | ||
Geldanamycin | Experimental, Investigational | Pharma | Target | Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor | 10 | |
Radicicol | Experimental | Pharma | ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
17-AAG |
|
75747-14-7 |
|
|
||
KRIBB11 |
|
342639-96-7 |
|
|
Compound | Action | Cas Number |
---|---|---|
17-AAG | Selective Hsp90 inhibitor | 75747-14-7 |
Geldanamycin | Selective Hsp90 inhibitor | 30562-34-6 |
KRIBB11 | HSF1 inhibitor | 342639-96-7 |
Radicicol | Hsp90 inhibitor. Antifungal antibiotic | 12772-57-5 |
Compound | Action | Cas Number |
---|---|---|
17-AAG (KOS953) | Hsp90 inhibitor | 75747-14-7 |
17-DMAG (Alvespimycin) HCl | Hsp90 inhibitor | 467214-21-7 |
AT13387 | Hsp90 inhibitor | 912999-49-6 |
AUY922 (NVP-AUY922) | Potent Hsp90 inhibitor | 747412-49-3 |
BIIB021 | Hsp90 inhibitor,selective and competitive | 848695-25-0 |
CH5138303 | 959763-06-5 | |
EC 144 | 911397-80-3 | |
Ganetespib (STA-9090) | Hsp90 inhibitor,non-geldanamycin | 888216-25-9 |
Gedunin | naturally occurring Hsp90 inhibitor | 2753-30-2 |
Geldanamycin | Hsp90 inhibitor,potent and specific | 30562-34-6 |
HSP990 (NVP-HSP990) | 934343-74-5 | |
IPI-504 (Retaspimycin hydrochloride) | Hsp90 inhibitor,novel, potent,selective | 857402-63-2 |
KNK437 | stress-induced HSP synthesis inhibitor | 218924-25-5 |
KW-2478 | Potent Hsp90 inhibitor, novel, non-ansamycin, | 819812-04-9 |
Macbecin I | 73341-72-7 | |
MPC-3100 | Hsp90 inhibitor | 958025-66-6 |
NMS-E973 | Hsp90 inhibitor,potent and selective | 1253584-84-7 |
NVP-BEP800 | Oral Hsp90β inhibitor, novel, fully synthetic | 847559-80-2 |
PF-04929113 (SNX-5422) | Hsp90 inhibitor,potent and selective | 908115-27-5 |
PU-WS13 | Grp94-specific Hsp90 inhibitor | 1454619-14-7 |
Radicicol | ATPase/kinase inhibitor | 12772-57-5 |
Retaspimycin | HSP90 inhibitor,antiproliferative and antineoplastic | 857402-23-4 |
SNX-2112 | Hsp90 inhibitor,ATP-competitve,potent and selective | 908112-43-6 |
VER-49009 | 558640-51-0 | |
VER-50589 | 747413-08-7 | |
XL-888 | Hsp90 inhibitor | 1149705-71-4 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 16a | · | 16b |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: | |||
SP12: | |||
SP13: | |||
SP14: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HSP90AA1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HSP90AA1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HSP90AA1 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hsp90aa1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hsp90aa1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HSP90AA1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HSP90AA1 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HSP90AA1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HSP90AA1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hsp90aa1.1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hsp90aa1.2 30 31 |
|
OneToOne | |
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Hsp83 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | daf-21 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSP82 31 33 |
|
OneToMany | |
HSC82 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | HSP81-2 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0482100 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11103 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3846 30 |
|
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs113261380 | Benign: not provided | 102,083,847(-) |
C/T NM_005348.4(HSP90AA1):c.1284G>A (p.Ala428=) |
SYNONYMOUS | |
rs11547524 | Benign: not provided | 102,082,121(-) |
T/C NM_005348.4(HSP90AA1):c.2079A>G (p.Lys693=) |
SYNONYMOUS | |
rs34158504 | Benign: not provided | 102,083,784(-) |
T/C NM_005348.4(HSP90AA1):c.1338+9A>G |
INTRON | |
rs80020850 | Benign: not provided | 102,082,104(-) |
G/T NM_005348.4(HSP90AA1):c.2089+7C>A |
INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv25n68 | CNV | loss | 17160897 |
esv25342 | CNV | loss | 19812545 |
esv2670326 | CNV | deletion | 23128226 |
esv3552074 | CNV | deletion | 23714750 |
esv3635541 | CNV | loss | 21293372 |
esv3635542 | CNV | loss | 21293372 |
esv3635543 | CNV | loss | 21293372 |
nsv1113674 | CNV | deletion | 24896259 |
nsv1131163 | CNV | deletion | 24896259 |
nsv1428 | CNV | insertion | 18451855 |
nsv565947 | CNV | gain | 21841781 |
nsv832879 | CNV | loss | 17160897 |
nsv976371 | CNV | duplication | 23825009 |
nsv983856 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
candidiasis |
|
|
epidermolysis bullosa acquisita |
|
|
lobular neoplasia |
|
|
primary hyperoxaluria |
|
|
gastrointestinal stromal tumor |
|
|