HSP90AA1 Gene (Protein Coding)

Heat Shock Protein 90 Alpha Family Class A Member 1

GCID:: GC14M102080

GIFtS:: 50

Genes Participants

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] See more...

Aliases for HSP90AA1 Gene

Heat Shock Protein 90 Alpha Family Class A Member 1 ² ³ ⁵
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 ² ³
Lipopolysaccharide-Associated Protein 2 ³ ⁴
Renal Carcinoma Antigen NY-REN-38 ³ ⁴
Heat Shock 90kDa Protein 1, Alpha ² ³
Heat Shock 90kD Protein 1, Alpha ² ³
Heat Shock Protein HSP 90-Alpha ³ ⁴
LPS-Associated Protein 2 ³ ⁴
Heat Shock 86 KDa ³ ⁴
HSP 86 ³ ⁴
HSP90A ³ ⁴
HSPC1 ³ ⁴
HSPCA ³ ⁴
HSP86 ³ ⁴
LAP-2 ³ ⁴

Heat Shock Protein 90kDa Alpha Family Class A Member 1 ³
Epididymis Secretory Sperm Binding Protein Li 65p ³
Epididymis Luminal Secretory Protein 52 ³
Heat Shock 90kD Protein 1, Alpha-Like 4 ³
Heat Shock 90kD Protein, Alpha-Like 4 ³
HEL-S-65p ³
HSPCAL1 ³
HSPCAL4 ³
HSP89A ³
HSP90N ³
Hsp103 ³
Hsp89 ³
Hsp90 ³
EL52 ³
HSPN ³
LAP2 ³

External Ids for HSP90AA1 Gene

HGNC: 5253
Entrez Gene: 3320
Ensembl: ENSG00000080824
OMIM: 140571
UniProtKB: P07900

Previous HGNC Symbols for HSP90AA1 Gene

HSPC1
HSPCA

Previous GeneCards Identifiers for HSP90AA1 Gene

GC14M101619
GC14M102547

Search aliases for HSP90AA1 gene in PubMed and other databases

Summaries for HSP90AA1 Gene

Entrez Gene Summary for HSP90AA1 Gene

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSP90AA1 Gene

HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Candidiasis and Epidermolysis Bullosa Acquisita. Among its related pathways are Oocyte meiosis and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot Summary for HSP90AA1 Gene

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
- HS90A_HUMAN,P07900

Tocris Summary for HSP90AA1 Gene

Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Gene Wiki entry for HSP90AA1 Gene

Additional gene information for HSP90AA1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSP90AA1 Gene

Genomics for HSP90AA1 Gene

GeneHancer (GH) Regulatory Elements for HSP90AA1 Gene

Promoters and enhancers for HSP90AA1 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH14J102083	Promoter/Enhancer	2.6	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	512.6	+53.5	53528	6.1	HNRNPK EP300 CTCF NRF1 MYC USF1 POLR2G SP1 PHF8 ZFX	HSP90AA1 lnc-DYNC1H1-6 lnc-MOK-6 lnc-MOK-7 WDR20 ZNF839 ENSG00000258959 MOK piR-48765-002 lnc-HSP90AA1-5
GH14J102138	Promoter/Enhancer	2	EPDnew Ensembl ENCODE CraniofacialAtlas	500.7	-0.5	-542	4.2	FOXK2 HNRNPK ZNF217 SIN3A NRF1 TCF12 MYC POLR2G PHF8 ZFX	HSP90AA1 WDR20 lnc-HSP90AA1-5 CDC42BPB MOK ZNF839 ENSG00000271780 RF00017-1681 lnc-HSP90AA1-2
GH14J102191	Enhancer	1.4	FANTOM5 Ensembl ENCODE dbSUPER	26.7	-53.5	-53508	6.9	EP300 NCOR1 KDM6A TCF7 RFX1 SKI TEAD1 TBX3 MXI1 ZNF316	lnc-MOK-2 HSP90AA1 MOK WDR20 TECPR2 CINP ZNF839 LOC105370677 lnc-HSP90AA1-2
GH14J101962	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	14.7	+174.9	174870	6	EP300 ZNF217 ZSCAN5C SIN3A NRF1 USF1 POLR2G SP1 PHF8 SIX5	DYNC1H1 HSP90AA1 PPP2R5C WDR20 ZNF839 ENSG00000259013 lnc-HSP90AA1-12
GH14J102303	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	10.4	-164.9	-164895	2.9	EP300 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 POLR2G SP1 NCOR1 PHF8	MOK lnc-CINP-2 WDR20 HSP90AA1 RCOR1 ZNF839 piR-50129-078

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSP90AA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSP90AA1

Top Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:

LCR-F1
MyoD
p53
STAT1

Genomic Locations for HSP90AA1 Gene

chr14:102,080,738-102,139,759: (GRCh38/hg38)

Size:: 59,022 bases
Orientation:: Minus strand

chr14:102,547,075-102,606,086: (GRCh37/hg19)

Size:: 59,012 bases
Orientation:: Minus strand

Genomic View for HSP90AA1 Gene

Genes around HSP90AA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

14q32.31 by HGNC
14q32.31 by Entrez Gene
14q32.31 by Ensembl

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for HSP90AA1 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSP90AA1 Gene

NC_000014.9

Proteins for HSP90AA1 Gene

Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P07900-HS90A_HUMAN

Recommended name:

Heat shock protein HSP 90-alpha

Protein Accession:

P07900

Secondary Accessions:
- A8K500
- B3KPJ9
- Q2PP14
- Q5CAQ6
- Q5CAQ7
- Q9BVQ5
Protein attributes for HSP90AA1 Gene
Size:

732 amino acids

Molecular mass:

84660 Da
Quaternary structure:
Homodimer (PubMed:7588731, PubMed:8289821, PubMed:18400751, PubMed:29127155). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (PubMed:29127155). The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus) (PubMed:29127155). Interacts with TOM34 (PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917, PubMed:27353360). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226, PubMed:27353360). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (PubMed:23569206, PubMed:27353360). May interact with NWD1 (PubMed:24681825). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (PubMed:17028174, PubMed:27353360). Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1 (PubMed:12604615, PubMed:27353360, PubMed:29127155). Interacts with FLCN in the presence of FNIP1 (PubMed:27353360). Interacts with HSP70, STIP1 and PTGES3 (PubMed:27353360). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:15235609, PubMed:25738358). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with HSF1 in an ATP-dependent manner (PubMed:11583998. PubMed:26517842). Interacts with MET; the interaction suppresses MET kinase activity (PubMed:26517842). Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (PubMed:26517842). Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with HSP90AB1; interaction is constitutive (PubMed:20353823). Interacts with HECTD1 (via N-terminus) (By similarity). Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity). Interacts with NLPR12 (PubMed:30559449, PubMed:17947705). Interacts with PDCL3 (By similarity).

(Microbial infection) Interacts with herpes simplex virus 1 protein US11; this interaction inhibits TBK1-induced interferon production.
Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene
- 1BYQ (3D)
- 1OSF (3D)
- 1UY6 (3D)
- 1UY7 (3D)
- 1UY8 (3D)
- 1UY9 (3D)
Alternative splice isoforms for HSP90AA1 Gene
UniProtKB/Swiss-Prot:
P07900-1

P07900-2

neXtProt entry for HSP90AA1 Gene

Protein Expression for HSP90AA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSP90AA1 Gene

ISGylated.
- P07900-HS90A_HUMAN
S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
- P07900-HS90A_HUMAN
Ubiquitinated via 'Lys-63'-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.
- P07900-HS90A_HUMAN
Glycosylation at Asn397
- NX_P07900 (NX_P07900-1)
Ubiquitination at Lys58, Lys84, Lys224, Lys314, Lys419, Lys436, Lys443, Lys446, Lys478, Lys489, Lys499, Lys513, and Lys632
- NX_P07900 (NX_P07900-1)
Modification sites at PhosphoSitePlus
- P07900
Glycosylation from GlyConnect
- HS90A_HUMAN (1301)

Other Protein References for HSP90AA1 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

LifeSpan BioSciences HSP90AA1 / Hsp90 Alpha A1 Antibody and HSP90AA1 / Hsp90 Alpha A1 Monoclonal Antibody

RayBiotech Rabbit anti-Hsp90alpha (147-166aa), Rabbit anti-Hsp90alpha (711-732aa), and Rabbit anti-Human HSP90A (541-560aa)

NSJ Bioreagents HSP90 alpha Antibody / HSP90AA1 (Rabbit Monoclonal)

Creative Diagnostics Anti-HSP90AA1 monoclonal antibody, clone 6H6

Creative Biolabs

BioLegend Hsp90alpha Antibody

GeneTex Anti-Hsp90 alpha antibody

OriGene Antibodies for HSP90AA1
- AM06760PU-N
- AM26034PU-N
- AP22747PU-N
- AP23429PU-N
- CF500883
- TA307631
- TA309402
- TA319143
- TA319144
- TA326367
- TA326368
- TA326369
- TA326447
- TA332385
- TA336841
- TA336843
- TA347782
- TA349210
- TA354342
- TA500883
- TA500883S
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Novus Biologicals Antibodies for HSP90AA1

Abcam antibodies for HSP90AA1
- Hsp90
- Hsp90 alpha

Invitrogen Antibodies for HSP90AA1 (AFLGC-HSP90AA1)

Biorbyt antibodies for HSP90AA1
- orb214065
- orb228236
- orb323174
- orb5489
- orb97461

Boster Bio Antibodies for HSP90AA1
- M01103
- M01103-1
- M01103-2
- M01103-3
- PB9089
- PB9635

Santa Cruz Biotechnology (SCBT) Antibodies for HSP90AA1

Sino Biological Antibodies for HSP90AA1

Protein Products

RayBiotech Recombinant Human HSP 90-alpha, transfected HEK293 cell lysate, Recombinant Human HSP 90-alpha, transfected HEK293 cell culture supernatant, and Recombinant Human HSP 90-alpha

Creative Biomart Recombinant Human Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1

Recombinant Human HSP90 alpha Protein, CF (AP-160)

OriGene Purified Proteins for HSP90AA1
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Novus Biologicals proteins and lysates for HSP90AA1

Sino Biological Recombinant Proteins for HSP90AA1
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ProSpec Recombinant Proteins for HSP90AA1

antibodies-online: Show 13 available HSP90AA1 Proteins ranked by validation data
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Signalway Proteins for HSP90AA1
- AP73685
- AP73717
- AP78701
- GP10006

ProSci Proteins for HSP90AA1
- heat shock protein 90kDa alpha (cytosolic), class A member 1

Abcam proteins for HSP90AA1
- Hsp90
- Hsp90 alpha

Assay Products

Creative Diagnostics Human Hsp90 alpha ELISA KIT

Aviva Systems Biology HSP90AA1 ELISA Kit (Human) (OKEH00641)

Novus Biologicals ELISA Kits for HSP90AA1

antibodies-online: Show 17 available HSP90AA1 Elisa Kits ranked by validation data
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Quality Products:

Boster Bio ELISA Kits for HSP90AA1
- EK7108

Signalway ELISA kits for HSP90AA1
- EK2369
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No data available for DME Specific Peptides for HSP90AA1 Gene

Domains & Families for HSP90AA1 Gene

Gene Families for HSP90AA1 Gene

HGNC:

Heat shock 90kDa proteins

Human Protein Atlas (HPA):

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Protein Domains for HSP90AA1 Gene

Blocks:

ATP-binding region, ATPase-like
Heat shock protein Hsp90

InterPro:

ProtoNet:

P07900

Suggested Antigen Peptide Sequences for HSP90AA1 Gene

GenScript: Design optimal peptide antigens:

Renal carcinoma antigen NY-REN-38 (HS90A_HUMAN)
HSP90AA1 protein (Q2VPJ6_HUMAN)
HSP90AA1 protein (Q8TBA7_HUMAN)
HSP90AA1 protein (Q96HX7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07900

UniProtKB/Swiss-Prot:

HS90A_HUMAN :

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
Belongs to the heat shock protein 90 family.

Domain:

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.

Family:

Belongs to the heat shock protein 90 family.

Function for HSP90AA1 Gene

Molecular function for HSP90AA1 Gene

UniProtKB/Swiss-Prot Function:

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).

HS90A_HUMAN,P07900

UniProtKB/Swiss-Prot EnzymeRegulation:

In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation (PubMed:18400751). Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation (PubMed:18400751). After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state (PubMed:18400751). Co-chaperone TSC1 promotes ATP binding and inhibits HSP90AA1 ATPase activity (PubMed:29127155). Binding to phosphorylated AHSA1 promotes HSP90AA1 ATPase activity (PubMed:29127155). Inhibited by Ganetespib (STA-9090) and SNX-2112 (PubMed:29127155).

HS90A_HUMAN,P07900

UniProtKB/Swiss-Prot BiophysicochemicalProperties:

Kinetic parameters: KM=300 uM for ATP {ECO:0000269 PubMed:18400751};

HS90A_HUMAN,P07900

Phenotypes From GWAS Catalog for HSP90AA1 Gene

Gene Ontology (GO) - Molecular Function for HSP90AA1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	TAS	11470816
GO:0003723	RNA binding	HDA	22658674
GO:0005515	protein binding	IPI	9660753
GO:0005524	ATP binding	IEA,TAS	11470816
GO:0016887	ATPase activity	IDA	15937123

Phenotypes for HSP90AA1 Gene

MGI mutant phenotypes for HSP90AA1:

inferred from 6 alleles

GenomeRNAi human phenotypes for HSP90AA1:

Animal Models for HSP90AA1 Gene

MGI Knock Outs for HSP90AA1:

Hsp90aa1 ^{Hsp90aa1<tm1(KOMP)Wtsi>}
Hsp90aa1 ^{Hsp90aa1<tm1.1Udon>}

Animal Model Products

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CRISPR Products

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OriGene CRISPR knockouts for HSP90AA1
- GA102267
- KN212496
- KN212496BN
- KN212496LP
- KN212496RB
- KN412496
- KN507993

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Overview of 22 available HSP90AA1 gene related products
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miRNA for HSP90AA1 Gene

miRTarBase miRNAs that target HSP90AA1

miRNA Products

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Inhibitory RNA Products

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OriGene clones in human,mouse,rat for HSP90AA1
- SC211516
- SC211517
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- SC112678
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OriGene ORF clones in human,mouse,rat for HSP90AA1
- MG210348
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- RC212496
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- RC218420
- RC218420L1
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- RR215336L3
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- MR210352L4V
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- RC212496L3V
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- RC218420L1V
- RC218420L2V
- RC218420L3V
- RC218420L4V
- RR215336L3V
- RR215336L4V
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Sino Biological Human cDNA Clone for HSP90AA1

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Horizon Cell Lines for HSP90AA1
- HSP90AA1 knockout cell line
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene

Localization for HSP90AA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Nucleus. Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

P07900-HS90A_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
extracellular	5
nucleus	5
cytosol	5
lysosome	5
plasma membrane	4
cytoskeleton	3
mitochondrion	3
endoplasmic reticulum	3
golgi apparatus	3
peroxisome	2
endosome	2

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (4)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSP90AA1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005634	nucleus	IBA,ISS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA,ISS	--
GO:0005829	cytosol	TAS,IEA	--

Pathways & Interactions for HSP90AA1 Gene

SuperPathways for HSP90AA1 Gene

	SuperPathway	Contained pathways
1	Regulation of PLK1 Activity at G2/M Transition	Centrosome maturation .88 Loss of Nlp from mitotic centrosomes .88 Loss of proteins required for interphase microtubule organization from the centrosome .88 Recruitment of mitotic centrosome proteins and complexes .88 AURKA Activation by TPX2 .85	Regulation of PLK1 Activity at G2/M Transition .80 Anchoring of the basal body to the plasma membrane .72 G2/M Transition .49 Mitotic G2-G2/M phases .49
2	Signaling by Ligand-Responsive EGFR Variants in Cancer	Signaling by EGFRvIII in Cancer .80 Signaling by Ligand-Responsive EGFR Variants in Cancer .80 Constitutive Signaling by EGFRvIII .01	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants .01 Signaling by EGFR in Cancer .01
3	Metabolism of nitric oxide	eNOS activation and regulation 1.00 Metabolism of nitric oxide 1.00	eNOS activation .01 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation .01
4	Influenza Viral RNA Transcription and Replication	Influenza Life Cycle .94 Influenza Viral RNA Transcription and Replication .94	Influenza Infection .93 vRNP Assembly .01
5	HIV Life Cycle	Infectious disease .61 Disease .45	Diseases of signal transduction .43

Pathways by source for HSP90AA1 Gene

2 Sino Biological pathways for HSP90AA1 Gene

23 BioSystems pathways for HSP90AA1 Gene

64 Reactome pathways for HSP90AA1 Gene

1 PharmGKB pathway for HSP90AA1 Gene

Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

12 KEGG pathways for HSP90AA1 Gene

6 GeneGo (Thomson Reuters) pathways for HSP90AA1 Gene

CFTR folding and maturation (norm and CF)
Development VEGF signaling via VEGFR2 - generic cascades
Development_Glucocorticoid receptor signaling
Immune response Antigen presentation by MHC class I
Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

1 R&D Systems pathway for HSP90AA1 Gene

Apoptosis Signaling Pathways

1 Tocris pathway for HSP90AA1 Gene

MAPK Pathway

11 Qiagen pathways for HSP90AA1 Gene

AHR Pathway
Akt Signaling
Aldosterone Signaling in Epithelial Cells
Androgen Signaling
eNOS Signaling

2 GeneTex pathways for HSP90AA1 Gene

Interacting Proteins for HSP90AA1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P07900-HS90A_HUMAN ENSP00000335153 for HSP90AA1 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
FKBP4	Q02790 ⁴ ²⁰ ¹²⁷ ENSP00000001008 ²¹	EBI-296047, EBI-1047444 MINT-7710488 STRING: ENSP00000001008 IID: # exp=11 # pred=3
FKBP8	Q14318 ⁴ ²⁰ ¹²⁷ ENSP00000476767 ²¹	EBI-296047, EBI-724839 MINT-3378966 STRING: ENSP00000476767 IID: # exp=3 # pred=2
AHSA1	O95433 ⁴ ¹²⁷ ENSP00000216479 ²¹	EBI-296047, EBI-448610 STRING: ENSP00000216479 IID: # exp=14 # pred=3
AICDA	Q9GZX7 ²⁰ ¹²⁷ ENSP00000229335 ²¹	MINT-8380842 STRING: ENSP00000229335 IID: # exp=1
CCDC117	Q8IWD4 ⁴ ¹²⁷ ENSP00000249064 ²¹	EBI-296047, EBI-3387963 STRING: ENSP00000249064 IID: # exp=3

GPS-Prot Interaction Network for HSP90AA1

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SIGNOR curated interactions for HSP90AA1 Gene

Activates:

Inactivates:

NR3C1

Is activated by:

AHSA1

Is inactivated by:

PRKCG

Other effect:

Gene Ontology (GO) - Biological Process for HSP90AA1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0001934	positive regulation of protein phosphorylation	IDA	19363271
GO:0006457	protein folding	IBA,IEA	21873635
GO:0006839	mitochondrial transport	TAS	12526792
GO:0006898	receptor-mediated endocytosis	TAS	--

Drugs & Compounds for HSP90AA1 Gene

(147) Drugs for HSP90AA1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Rifabutin	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, other/unknown		64
Nedocromil	Approved, Investigational	MalaCards Medline Plus	Pharma	Target		5
Copper	Approved, Investigational	MalaCards Medline Plus	Pharma	Target		236
Geldanamycin	Experimental, Investigational	MalaCards Medline Plus	Pharma	Target	Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor	10
Radicicol	Experimental	MalaCards Medline Plus	Pharma		ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic	0

(49) Additional Compounds for HSP90AA1 Gene - From: Novoseek and Tocris

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
17-AAG			MalaCards Medline Plus	75747-14-7
KRIBB11			MalaCards Medline Plus	342639-96-7

(4) Tocris Compounds for HSP90AA1 Gene

Compound	Action	Cas Number
17-AAG	Selective Hsp90 inhibitor	75747-14-7
Geldanamycin	Selective Hsp90 inhibitor	30562-34-6
KRIBB11	HSF1 inhibitor	342639-96-7
Radicicol	Hsp90 inhibitor. Antifungal antibiotic	12772-57-5

(29) ApexBio Compounds for HSP90AA1 Gene

Compound	Action	Cas Number
17-AAG (KOS953)	Hsp90 inhibitor	75747-14-7
17-AAG Hydrochloride	Hsp90 inhibitor,geldanamycin analogue	911710-03-7
17-DMAG (Alvespimycin) HCl	Hsp90 inhibitor	467214-21-7
Alvespimycin	Hsp90 inhibitor,potent and selective	467214-20-6
AT13387	Hsp90 inhibitor	912999-49-6
AUY922 (NVP-AUY922)	Potent Hsp90 inhibitor	747412-49-3
BIIB021	Hsp90 inhibitor,selective and competitive	848695-25-0
CH5138303		959763-06-5
EC 144		911397-80-3
Ganetespib (STA-9090)	Hsp90 inhibitor,non-geldanamycin	888216-25-9
Gedunin	naturally occurring Hsp90 inhibitor	2753-30-2
Geldanamycin	Hsp90 inhibitor,potent and specific	30562-34-6
HSP990 (NVP-HSP990)		934343-74-5
IPI-504 (Retaspimycin hydrochloride)	Hsp90 inhibitor,novel, potent,selective	857402-63-2
KNK437	stress-induced HSP synthesis inhibitor	218924-25-5
KW-2478	Potent Hsp90 inhibitor, novel, non-ansamycin,	819812-04-9
Macbecin I		73341-72-7
MPC-3100	Hsp90 inhibitor	958025-66-6
NMS-E973	Hsp90 inhibitor,potent and selective	1253584-84-7
NVP-BEP800	Oral Hsp90β inhibitor, novel, fully synthetic	847559-80-2
PF-04929113 (SNX-5422)	Hsp90 inhibitor,potent and selective	908115-27-5
PU-H71	Hsp90 inhibitor,potent and selective	873436-91-0
PU-WS13	Grp94-specific Hsp90 inhibitor	1454619-14-7
Radicicol	ATPase/kinase inhibitor	12772-57-5
Retaspimycin	HSP90 inhibitor,antiproliferative and antineoplastic	857402-23-4
SNX-2112	Hsp90 inhibitor,ATP-competitve,potent and selective	908112-43-6
VER-49009		558640-51-0
VER-50589		747413-08-7
XL-888	Hsp90 inhibitor	1149705-71-4

Drug Products

RayBiotech Recombinant Human HSP 90-alpha, transfected HEK293 cell lysate, Recombinant Human HSP 90-alpha, transfected HEK293 cell culture supernatant, and Recombinant Human HSP 90-alpha

Creative Biomart Recombinant Human Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1

Tocris compounds for HSP90AA1

ApexBio compounds for HSP90AA1

Transcripts for HSP90AA1 Gene