Aliases for HSH2D Gene
External Ids for HSH2D Gene
Previous GeneCards Identifiers for HSH2D Gene
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HSH2D Gene
HSH2D (Hematopoietic SH2 Domain Containing) is a Protein Coding gene. Diseases associated with HSH2D include Parietal Foramina. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SH2D7.
UniProtKB/Swiss-Prot Summary for HSH2D Gene
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.