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Aliases for HSFY2 Gene

Aliases for HSFY2 Gene

  • Heat Shock Transcription Factor, Y-Linked 2 2 3 5
  • Heat Shock Transcription Factor 2-Like Protein 3 4
  • HSF2L 3 4
  • HSFY 3 4
  • Heat Shock Transcription Factor, Y-Linked 3
  • HSFY1 HSFY2 4
  • HSF2-Like 4

External Ids for HSFY2 Gene

Previous GeneCards Identifiers for HSFY2 Gene

  • GC0YP019605
  • GC0YM019281
  • GC0YM020893

Summaries for HSFY2 Gene

Entrez Gene Summary for HSFY2 Gene

  • This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSFY2 Gene

HSFY2 (Heat Shock Transcription Factor, Y-Linked 2) is a Protein Coding gene. Diseases associated with HSFY2 include Spermatogenic Failure, X-Linked, 1. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSFY1.

Additional gene information for HSFY2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFY2 Gene

Genomics for HSFY2 Gene

GeneHancer (GH) Regulatory Elements for HSFY2 Gene

Promoters and enhancers for HSFY2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI018773 Promoter 0.5 EPDnew 550.2 +55.0 54956 0.1 HSFY2 USP9YP2 GPM6BP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSFY2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSFY2 gene promoter:

Genomic Locations for HSFY2 Gene

Genomic Locations for HSFY2 Gene
97,223 bases
Minus strand

Genomic View for HSFY2 Gene

Genes around HSFY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFY2 Gene

Proteins for HSFY2 Gene

  • Protein details for HSFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock transcription factor, Y-linked
    Protein Accession:
    Secondary Accessions:
    • Q17RC0
    • Q7Z4L8
    • Q9BZA2
    • Q9BZA3

    Protein attributes for HSFY2 Gene

    401 amino acids
    Molecular mass:
    45107 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSFY2 Gene


neXtProt entry for HSFY2 Gene

Post-translational modifications for HSFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFY2 Gene

No data available for DME Specific Peptides for HSFY2 Gene

Domains & Families for HSFY2 Gene

Gene Families for HSFY2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HSFY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFY2: view

Function for HSFY2 Gene

Gene Ontology (GO) - Molecular Function for HSFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSFY2: view

Phenotypes for HSFY2 Gene

GenomeRNAi human phenotypes for HSFY2:
genes like me logo Genes that share phenotypes with HSFY2: view

Animal Model Products

CRISPR Products

miRNA for HSFY2 Gene

miRTarBase miRNAs that target HSFY2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSFY2 Gene

Localization for HSFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFY2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSFY2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HSFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSFY2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSFY2 Gene

Pathways & Interactions for HSFY2 Gene

SuperPathways for HSFY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSFY2: view

No data available for Pathways by source and SIGNOR curated interactions for HSFY2 Gene

Drugs & Compounds for HSFY2 Gene

No Compound Related Data Available

Transcripts for HSFY2 Gene

Unigene Clusters for HSFY2 Gene

Heat shock transcription factor, Y linked 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSFY2 Gene

No ASD Table

Relevant External Links for HSFY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSFY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSFY2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSFY2 Gene

Protein tissue co-expression partners for HSFY2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSFY2 Gene:


SOURCE GeneReport for Unigene cluster for HSFY2 Gene:


mRNA Expression by UniProt/SwissProt for HSFY2 Gene:

Tissue specificity: Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level).
genes like me logo Genes that share expression patterns with HSFY2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSFY2 Gene

Orthologs for HSFY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSFY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 71 (a)
-- 34
  • 59 (a)
(Bos Taurus)
Mammalia HSFY2 33 34
  • 70.56 (n)
-- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 42 (a)
(Mus musculus)
Mammalia Hsfy2 33 16 34
  • 65.87 (n)
(Rattus norvegicus)
Mammalia Hsfy2 33
  • 65.34 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
-- 34
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Canis familiaris)
Mammalia -- 34
  • 22 (a)
(Gallus gallus)
Aves LOC100859862 33
  • 56.21 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
Species where no ortholog for HSFY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSFY2 Gene

Gene Tree for HSFY2 (if available)
Gene Tree for HSFY2 (if available)

Paralogs for HSFY2 Gene

Paralogs for HSFY2 Gene

genes like me logo Genes that share paralogs with HSFY2: view

Variants for HSFY2 Gene

Sequence variations from dbSNP and Humsavar for HSFY2 Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs111359694 -- 18,788,648(-) G/C genic_upstream_transcript_variant, intron_variant
rs113200071 -- 18,785,109(-) A/C genic_upstream_transcript_variant, intron_variant
rs113420648 -- 18,780,608(-) T/A genic_upstream_transcript_variant, intron_variant
rs113534513 -- 18,783,474(-) A/G genic_upstream_transcript_variant, intron_variant
rs113957233 -- 18,791,384(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSFY2 Gene

Variant ID Type Subtype PubMed ID
esv1670141 OTHER inversion 17803354
esv2758907 CNV loss 17122850
esv3575100 CNV loss 25503493
esv3575101 CNV loss 25503493
esv3577592 CNV gain 25503493
nsv10022 CNV gain 18304495

Additional Variant Information for HSFY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSFY2 Gene

Disorders for HSFY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSFY2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatogenic failure, x-linked, 1
  • spgfx1
- elite association - COSMIC cancer census association via MalaCards
Search HSFY2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSFY2

genes like me logo Genes that share disorders with HSFY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSFY2 Gene

Publications for HSFY2 Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T … Nakahori Y (Biology of reproduction 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for HSFY2 Gene

Sources for HSFY2 Gene

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