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Aliases for HSFY1 Gene

Aliases for HSFY1 Gene

  • Heat Shock Transcription Factor, Y-Linked 1 2 2 3 5
  • Heat Shock Transcription Factor 2-Like Protein 3 4
  • Heat Shock Transcription Factor, Y-Linked 2 3
  • HSF2L 3 4
  • HSFY 3 4
  • HSFY1 HSFY2 4
  • HSF2-Like 4

External Ids for HSFY1 Gene

Previous HGNC Symbols for HSFY1 Gene

  • HSFY

Previous GeneCards Identifiers for HSFY1 Gene

  • GC0YP019604
  • GC0YP019096
  • GC0YP019167
  • GC0YP020708
  • GC0YM014604

Summaries for HSFY1 Gene

Entrez Gene Summary for HSFY1 Gene

  • This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSFY1 Gene

HSFY1 (Heat Shock Transcription Factor, Y-Linked 1) is a Protein Coding gene. Diseases associated with HSFY1 include Spermatogenic Failure, Y-Linked, 2 and Spermatogenic Failure, X-Linked, 1. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSFY2.

Additional gene information for HSFY1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFY1 Gene

Genomics for HSFY1 Gene

GeneHancer (GH) Regulatory Elements for HSFY1 Gene

Promoters and enhancers for HSFY1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI018546 Promoter 0.5 EPDnew 550.8 +0.0 30 0.1 HSFY1 GPM6BP1 ENSG00000251510
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSFY1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSFY1 gene promoter:

Genomic Locations for HSFY1 Gene

Genomic Locations for HSFY1 Gene
42,293 bases
Plus strand

Genomic View for HSFY1 Gene

Genes around HSFY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFY1 Gene

Proteins for HSFY1 Gene

  • Protein details for HSFY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock transcription factor, Y-linked
    Protein Accession:
    Secondary Accessions:
    • Q17RC0
    • Q7Z4L8
    • Q9BZA2
    • Q9BZA3

    Protein attributes for HSFY1 Gene

    401 amino acids
    Molecular mass:
    45107 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSFY1 Gene


neXtProt entry for HSFY1 Gene

Post-translational modifications for HSFY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFY1 Gene

No data available for DME Specific Peptides for HSFY1 Gene

Domains & Families for HSFY1 Gene

Gene Families for HSFY1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFY1: view

No data available for Suggested Antigen Peptide Sequences for HSFY1 Gene

Function for HSFY1 Gene

Gene Ontology (GO) - Molecular Function for HSFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSFY1: view

Phenotypes for HSFY1 Gene

GenomeRNAi human phenotypes for HSFY1:
genes like me logo Genes that share phenotypes with HSFY1: view

Human Phenotype Ontology for HSFY1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSFY1 Gene

Localization for HSFY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFY1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSFY1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HSFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSFY1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSFY1 Gene

Pathways & Interactions for HSFY1 Gene

SuperPathways for HSFY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSFY1: view

No data available for Pathways by source and SIGNOR curated interactions for HSFY1 Gene

Drugs & Compounds for HSFY1 Gene

No Compound Related Data Available

Transcripts for HSFY1 Gene

Unigene Clusters for HSFY1 Gene

Heat shock transcription factor, Y-linked 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSFY1 Gene

No ASD Table

Relevant External Links for HSFY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSFY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSFY1 Gene

mRNA differential expression in normal tissues according to GTEx for HSFY1 Gene

This gene is overexpressed in Brain - Cortex (x6.9), Brain - Hippocampus (x5.8), Testis (x5.3), Brain - Hypothalamus (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSFY1 Gene

Protein tissue co-expression partners for HSFY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSFY1 Gene:


SOURCE GeneReport for Unigene cluster for HSFY1 Gene:


mRNA Expression by UniProt/SwissProt for HSFY1 Gene:

Tissue specificity: Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level).
genes like me logo Genes that share expression patterns with HSFY1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSFY1 Gene

Orthologs for HSFY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSFY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 71 (a)
-- 34
  • 59 (a)
(Bos Taurus)
Mammalia HSFY2 33 34
  • 70.56 (n)
-- 34
  • 45 (a)
-- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 42 (a)
(Mus musculus)
Mammalia Hsfy2 33 34
  • 65.87 (n)
(Rattus norvegicus)
Mammalia Hsfy2 33
  • 65.34 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
-- 34
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Canis familiaris)
Mammalia -- 34
  • 22 (a)
(Gallus gallus)
Aves LOC100859862 33
  • 56.21 (n)
-- 34
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
Species where no ortholog for HSFY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSFY1 Gene

Gene Tree for HSFY1 (if available)
Gene Tree for HSFY1 (if available)

Paralogs for HSFY1 Gene

Paralogs for HSFY1 Gene

genes like me logo Genes that share paralogs with HSFY1: view

Variants for HSFY1 Gene

Sequence variations from dbSNP and Humsavar for HSFY1 Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs111433822 -- 18,539,474(+) A/G genic_upstream_transcript_variant, intron_variant
rs112399323 -- 18,529,173(+) C/T upstream_transcript_variant
rs112948836 -- 18,540,493(+) T/C genic_upstream_transcript_variant, intron_variant
rs113127496 -- 18,562,483(+) C/A genic_downstream_transcript_variant, intron_variant
rs113400567 -- 18,531,739(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSFY1 Gene

Variant ID Type Subtype PubMed ID
esv1670141 OTHER inversion 17803354
esv2758907 CNV loss 17122850
esv3575100 CNV loss 25503493
esv3575101 CNV loss 25503493
esv3577592 CNV gain 25503493
nsv10022 CNV gain 18304495

Additional Variant Information for HSFY1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSFY1 Gene

Disorders for HSFY1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSFY1 Gene - From: HGMD, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure, y-linked, 2
  • spgfy2
spermatogenic failure, x-linked, 1
  • spgfx1
  • spermatogenic failure
- elite association - COSMIC cancer census association via MalaCards
Search HSFY1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSFY1

genes like me logo Genes that share disorders with HSFY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSFY1 Gene

Publications for HSFY1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T … Nakahori Y (Biology of reproduction 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for HSFY1 Gene

Sources for HSFY1 Gene

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