Aliases for HSFX2 Gene

Aliases for HSFX2 Gene

  • Heat Shock Transcription Factor Family, X-Linked 2 2 3 5
  • Heat Shock Transcription Factor, X-Linked 3 4
  • HSFX2 5
  • LW-1 4

External Ids for HSFX2 Gene

Previous GeneCards Identifiers for HSFX2 Gene

  • GC0XU900657
  • GC0XP148663
  • GC0XM148483
  • GC0XM148674

Summaries for HSFX2 Gene

GeneCards Summary for HSFX2 Gene

HSFX2 (Heat Shock Transcription Factor Family, X-Linked 2) is a Protein Coding gene. Diseases associated with HSFX2 include Microsporidiosis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSFX1.

Additional gene information for HSFX2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSFX2 Gene

Genomics for HSFX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSFX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ149594 Promoter 0.3 EPDnew 600.7 +0.6 572 0.1 HSFX2 MAGEA9B
GH0XJ149630 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 -36.0 -35986 2.6 POLR2A LARP7 YY1 ZFX NRF1 TAF1 DPF2 EGR1 OSR2 ZBTB26 TMEM185A EOLA1 IDS HSFX2
GH0XJ149627 Enhancer 0.6 ENCODE 0.3 -33.1 -33137 1 FOXA1 RXRB RFX1 FOXA2 TEAD1 SMAD4 RARA TEAD3 NR2F6 ARID3A TMEM185A HSFX2
GH0XJ149624 Enhancer 0.3 Ensembl 0.3 -29.3 -29287 0.8 PRDM1 TMEM185A HSFX2
GH0XJ149603 Enhancer 0.2 FANTOM5 0.4 -7.9 -7942 0.4 HSFX2 TMEM185A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSFX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSFX2

Top Transcription factor binding sites by QIAGEN in the HSFX2 gene promoter:
  • CUTL1
  • GR
  • GR-alpha
  • GR-beta
  • HFH-1
  • HNF-3beta
  • LCR-F1
  • SREBP-1a
  • TGIF
  • YY1

Genomic Locations for HSFX2 Gene

Genomic Locations for HSFX2 Gene
chrX:149,592,512-149,595,314
(GRCh38/hg38)
Size:
2,803 bases
Orientation:
Minus strand
chrX:148,674,172-148,676,974
(GRCh37/hg19)
Size:
2,803 bases
Orientation:
Minus strand

Genomic View for HSFX2 Gene

Genes around HSFX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFX2 Gene

Proteins for HSFX2 Gene

  • Protein details for HSFX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD0-HSFX1_HUMAN
    Recommended name:
    Heat shock transcription factor, X-linked
    Protein Accession:
    Q9UBD0

    Protein attributes for HSFX2 Gene

    Size:
    423 amino acids
    Molecular mass:
    46742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSFX2 Gene

Post-translational modifications for HSFX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSFX2 Gene

Domains & Families for HSFX2 Gene

Gene Families for HSFX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HSFX2 Gene

InterPro:
Blocks:
  • Heat shock factor (HSF)-type DNA-binding domain
ProtoNet:

Suggested Antigen Peptide Sequences for HSFX2 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock transcription factor, X-linked (HSFX1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBD0

UniProtKB/Swiss-Prot:

HSFX1_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFX2: view

Function for HSFX2 Gene

Gene Ontology (GO) - Molecular Function for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with HSFX2: view

Phenotypes for HSFX2 Gene

genes like me logo Genes that share phenotypes with HSFX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSFX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSFX2 Gene

Localization for HSFX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFX2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSFX2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with HSFX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSFX2 Gene

Pathways & Interactions for HSFX2 Gene

PathCards logo

SuperPathways for HSFX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0034605 cellular response to heat IBA 21873635
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress IBA 21873635
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress IBA 21873635
genes like me logo Genes that share ontologies with HSFX2: view

No data available for Pathways by source and SIGNOR curated interactions for HSFX2 Gene

Drugs & Compounds for HSFX2 Gene

No Compound Related Data Available

Transcripts for HSFX2 Gene

mRNA/cDNA for HSFX2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSFX2

Alternative Splicing Database (ASD) splice patterns (SP) for HSFX2 Gene

No ASD Table

Relevant External Links for HSFX2 Gene

GeneLoc Exon Structure for
HSFX2

Expression for HSFX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSFX2 Gene

Protein differential expression in normal tissues from HIPED for HSFX2 Gene

This gene is overexpressed in Plasma (37.3) and Monocytes (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSFX2 Gene



Protein tissue co-expression partners for HSFX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSFX2

mRNA Expression by UniProt/SwissProt for HSFX2 Gene:

Q9UBD0-HSFX1_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with HSFX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSFX2 Gene

Orthologs for HSFX2 Gene

Evolution for HSFX2 Gene

ENSEMBL:
Gene Tree for HSFX2 (if available)
TreeFam:
Gene Tree for HSFX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSFX2: view image

No data available for Orthologs for HSFX2 Gene

Paralogs for HSFX2 Gene

Paralogs for HSFX2 Gene

(1) SIMAP similar genes for HSFX2 Gene using alignment to 2 proteins:

  • HSFX1_HUMAN
  • E5RG41_HUMAN
genes like me logo Genes that share paralogs with HSFX2: view

Variants for HSFX2 Gene

Additional dbSNP identifiers (rs#s) for HSFX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSFX2 Gene

Variant ID Type Subtype PubMed ID
esv3577504 CNV gain 25503493
esv3577518 CNV gain 25503493
esv3577519 CNV gain 25503493
nsv1149848 CNV duplication 26484159
nsv508809 CNV insertion 20534489
nsv518742 CNV gain 19592680
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855
nsv818041 CNV gain 17921354

Additional Variant Information for HSFX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSFX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for HSFX2 Gene

Disorders for HSFX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSFX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
microsporidiosis
  • infection by microspora
- elite association - COSMIC cancer census association via MalaCards
Search HSFX2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with HSFX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSFX2 Gene

Publications for HSFX2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T … Nakahori Y (Biology of reproduction 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3
  5. No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes. (PMID: 23094017) Katsura Y … Satta Y (PloS one 2012) 3

Products for HSFX2 Gene

Sources for HSFX2 Gene