Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSFX1 Gene

Aliases for HSFX1 Gene

  • Heat Shock Transcription Factor Family, X-Linked 1 2 3 5
  • LW-1 3 4
  • Heat Shock Transcription Factor, X-Linked 3
  • Testicular Secretory Protein Li 21 3
  • HSFX1 HSFX2 4

External Ids for HSFX1 Gene

Previous GeneCards Identifiers for HSFX1 Gene

  • GC0XM148481
  • GC0XP148665
  • GC0XP148855

Summaries for HSFX1 Gene

GeneCards Summary for HSFX1 Gene

HSFX1 (Heat Shock Transcription Factor Family, X-Linked 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSFX2.

Additional gene information for HSFX1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFX1 Gene

Genomics for HSFX1 Gene

GeneHancer (GH) Regulatory Elements for HSFX1 Gene

Promoters and enhancers for HSFX1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI149773 Promoter 0.5 EPDnew 550.8 -0.1 -72 0.1 GC0XP149772 HSFX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSFX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSFX1 gene promoter:

Genomic Locations for HSFX1 Gene

Genomic Locations for HSFX1 Gene
2,803 bases
Plus strand

Genomic View for HSFX1 Gene

Genes around HSFX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFX1 Gene

Proteins for HSFX1 Gene

  • Protein details for HSFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock transcription factor, X-linked
    Protein Accession:

    Protein attributes for HSFX1 Gene

    423 amino acids
    Molecular mass:
    46742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSFX1 Gene

Post-translational modifications for HSFX1 Gene

No Post-translational modifications

Other Protein References for HSFX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSFX1 Gene

Domains & Families for HSFX1 Gene

Gene Families for HSFX1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFX1: view

No data available for Suggested Antigen Peptide Sequences for HSFX1 Gene

Function for HSFX1 Gene

Gene Ontology (GO) - Molecular Function for HSFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16713569
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSFX1: view
genes like me logo Genes that share phenotypes with HSFX1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSFX1 Gene

Localization for HSFX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFX1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSFX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HSFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSFX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSFX1 Gene

Pathways & Interactions for HSFX1 Gene

SuperPathways for HSFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSFX1: view

No data available for Pathways by source and SIGNOR curated interactions for HSFX1 Gene

Drugs & Compounds for HSFX1 Gene

No Compound Related Data Available

Transcripts for HSFX1 Gene

mRNA/cDNA for HSFX1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSFX1 Gene

No ASD Table

Relevant External Links for HSFX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSFX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSFX1 Gene

Protein differential expression in normal tissues from HIPED for HSFX1 Gene

This gene is overexpressed in Plasma (37.3) and Monocytes (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSFX1 Gene

Protein tissue co-expression partners for HSFX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSFX1 Gene:


SOURCE GeneReport for Unigene cluster for HSFX1 Gene:


mRNA Expression by UniProt/SwissProt for HSFX1 Gene:

Tissue specificity: Testis-specific.

Evidence on tissue expression from TISSUES for HSFX1 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with HSFX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSFX1 Gene

Orthologs for HSFX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSFX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 35 (a)
-- 34
  • 33 (a)
-- 34
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
-- 34
  • 26 (a)
(Mus musculus)
Mammalia Hsfy2 34
  • 23 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 20 (a)
(Bos Taurus)
Mammalia -- 34
  • 19 (a)
(Gallus gallus)
Aves -- 34
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
Species where no ortholog for HSFX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSFX1 Gene

Gene Tree for HSFX1 (if available)
Gene Tree for HSFX1 (if available)

Paralogs for HSFX1 Gene

Paralogs for HSFX1 Gene

(1) SIMAP similar genes for HSFX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSFX1: view

Variants for HSFX1 Gene

Sequence variations from dbSNP and Humsavar for HSFX1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1269785 -- 149,777,206(+) C/T downstream_transcript_variant
rs146101546 -- 149,773,236(+) T/G upstream_transcript_variant
rs200471336 -- 149,776,278(+) C/T coding_sequence_variant, missense_variant
rs201098724 -- 149,775,127(+) C/T coding_sequence_variant, missense_variant
rs201561571 -- 149,774,735(+) A/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for HSFX1 Gene

Variant ID Type Subtype PubMed ID
esv3577504 CNV gain 25503493
esv3577518 CNV gain 25503493
esv3577519 CNV gain 25503493
nsv1149848 CNV duplication 26484159
nsv508809 CNV insertion 20534489
nsv518742 CNV gain 19592680
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855
nsv818041 CNV gain 17921354

Additional Variant Information for HSFX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSFX1 Gene

Disorders for HSFX1 Gene

Additional Disease Information for HSFX1

No disorders were found for HSFX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSFX1 Gene

Publications for HSFX1 Gene

  1. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T … Nakahori Y (Biology of reproduction 2004) 2 3 4 58
  2. In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. (PMID: 20388717) Blomster HA … Sistonen L (The Journal of biological chemistry 2010) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Skin collagen fluorophore LW-1 versus skin fluorescence as markers for the long-term progression of subclinical macrovascular disease in type 1 diabetes. (PMID: 26864236) Sell DR … Monnier VM (Cardiovascular diabetology 2016) 3 58
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 58

Products for HSFX1 Gene

Sources for HSFX1 Gene

Loading form....