HSF5 Gene (Protein Coding)

Heat Shock Transcription Factor 5

GC17M058420
GIFtS:
32
See more...

Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor 5 2 3 4 5
  • Heat Shock Transcription Factor Family Member 5 2 3
  • Heat Shock Factor Protein 5 3 4
  • HSTF 5 3 4
  • HSF 5 3 4
  • FLJ40311 2
  • HSTF5 4
  • HSF5 5

External Ids for HSF5 Gene

Previous GeneCards Identifiers for HSF5 Gene

  • GC17M053853
  • GC17M056497
  • GC17M051858

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor 5) is a Protein Coding gene. Diseases associated with HSF5 include Fanconi Anemia, Complementation Group C. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot Summary for HSF5 Gene

Additional gene information for HSF5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HSF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J058487 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.5 527 1.2 CTCF HNRNPL RBFOX2 POLR2A EBF1 MAX ZBTB33 EZH2 HSF5 SETP3 RNF43
GH17J058489 Enhancer 0.2 ENCODE 600.7 -1.6 -1647 0.2 HSF5 piR-36948 MTMR4
GH17J058511 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -27.8 -27808 8.9 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 YBX1 PRDM10 ZNF629 TFE3 MTMR4 TRIM37 RAD51C VEZF1 HSF5 SEPTIN4 SMG8 SRSF1 MKS1 SUPT4H1
GH17J058387 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +98.3 98308 5.8 ZNF221 ARHGAP35 CREB1 GATAD2A ARID3A PRDM10 ZNF629 TFE3 ZNF512 LEF1 lnc-HSF5-2 SRSF1 MKS1 RNF43 TRIM37 SMG8 ENSG00000264112 SUPT4H1 TSPOAP1 SKA2
GH17J058362 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +121.5 121458 8 HNRNPL GATAD2A ATF7 TFE3 LEF1 SOX13 IKZF1 RCOR2 JUND MTA2 TSPOAP1 SRSF1 RAD51C MKS1 RNF43 HSF5 SUPT4H1 TRIM37 lnc-SUPT4H1-1 lnc-HSF5-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSF5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSF5

Top Transcription factor binding sites by QIAGEN in the HSF5 gene promoter:
  • CP2
  • CUTL1
  • Evi-1
  • FOXF2
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • GATA-2
  • RREB-1
  • S8

Genomic Locations for HSF5 Gene

Genomic Locations for HSF5 Gene
chr17:58,420,167-58,488,408
(GRCh38/hg38)
Size:
68,242 bases
Orientation:
Minus strand
chr17:56,497,528-56,565,759
(GRCh37/hg19)
Size:
68,232 bases
Orientation:
Minus strand

Genomic View for HSF5 Gene

Genes around HSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSF5 Gene

Proteins for HSF5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G112-HSF5_HUMAN
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Q4G112
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    Size:
    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF5 Gene

Protein Expression for HSF5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains & Families for HSF5 Gene

Gene Families for HSF5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HSF5 Gene

InterPro:
Blocks:
  • Heat shock factor (HSF)-type DNA-binding domain
ProtoNet:

Suggested Antigen Peptide Sequences for HSF5 Gene

GenScript: Design optimal peptide antigens:
  • HSF5 protein (A0AUM3_HUMAN)
  • Heat shock transcription factor 5 (HSF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4G112

UniProtKB/Swiss-Prot:

HSF5_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF5: view

Function for HSF5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional factor.

Phenotypes From GWAS Catalog for HSF5 Gene

Gene Ontology (GO) - Molecular Function for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with HSF5: view
genes like me logo Genes that share phenotypes with HSF5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with HSF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSF5 Gene

Pathways & Interactions for HSF5 Gene

PathCards logo

SuperPathways for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0034605 cellular response to heat IBA 21873635
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress IBA 21873635
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress IBA 21873635
genes like me logo Genes that share ontologies with HSF5: view

No data available for Pathways by source and SIGNOR curated interactions for HSF5 Gene

Drugs & Compounds for HSF5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HSF5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HSF5 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF5

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
HSF5

Expression for HSF5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSF5 Gene

mRNA expression in normal human tissues for HSF5 Gene
mRNA expression by GTEx for HSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for HSF5 Gene

This gene is overexpressed in Testis (53.4) and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSF5 Gene



Protein tissue co-expression partners for HSF5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSF5

SOURCE GeneReport for Unigene cluster for HSF5 Gene:

Hs.380061

Evidence on tissue expression from TISSUES for HSF5 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with HSF5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF5 Gene

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia HSF5 30 31
  • 99.5 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia HSF5 30 31
  • 91.32 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia HSF5 30 31
  • 89.19 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Hsf5 30 17 31
  • 88.78 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Hsf5 30
  • 88.52 (n)
Oppossum
(Monodelphis domestica)
 Mammalia HSF5 31
  • 87 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia HSF5 31
  • 69 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves LOC100858064 30
  • 70.78 (n)
HSF5 31
  • 57 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia HSF5 31
  • 62 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii hsf5 31
  • 32 (a)
 OneToOne
Species where no ortholog for HSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

ENSEMBL:
Gene Tree for HSF5 (if available)
TreeFam:
Gene Tree for HSF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSF5: view image

Paralogs for HSF5 Gene

Paralogs for HSF5 Gene

genes like me logo Genes that share paralogs with HSF5: view

Variants for HSF5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSF5 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1017089 - p.Asn329Thr
rs3803752 - p.Ser473Asn

Additional dbSNP identifiers (rs#s) for HSF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
esv2666333 CNV deletion 23128226
nsv575800 CNV gain 21841781
nsv960509 CNV duplication 23825009

Variation tolerance for HSF5 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF5 Gene

Disorders for HSF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi anemia, complementation group c
  • fancc
- elite association - COSMIC cancer census association via MalaCards
Search HSF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSF5

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF5 Gene

Publications for HSF5 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3
  2. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. (PMID: 25208829) Anderson D … Blackwell JM (Genes and immunity 2014) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4

ExternalLinks

View latest publications for HSF5 gene in Mastermind

Products for HSF5 Gene

Sources for HSF5 Gene