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Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor 5 2 3 4 5
  • Heat Shock Transcription Factor Family Member 5 2
  • HSTF 5 4
  • HSTF5 4
  • HSF 5 4

External Ids for HSF5 Gene

Previous GeneCards Identifiers for HSF5 Gene

  • GC17M053853
  • GC17M056497
  • GC17M051858

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for HSF5 Gene

  • May act as a transcriptional factor.

Additional gene information for HSF5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

GeneHancer (GH) Regulatory Elements for HSF5 Gene

Promoters and enhancers for HSF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I058487 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.8 +0.5 472 1.5 CTCF FOXA2 POLR2A MAX EBF1 ZBTB33 FOXA1 EZH2 HSF5 SETP3
GH17I058489 Enhancer 0.2 ENCODE 550.8 -1.7 -1654 0.2 HSF5 PIR59993 MTMR4
GH17I058511 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 -27.8 -27815 8.9 ZFP64 YBX1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 MTMR4 TRIM37 RAD51C SRSF1 MKS1 HSF5 VEZF1 SEPT4 C17orf47 SMG8
GH17I058389 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +97.3 97312 2.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A RNF43 TRIM37 ENSG00000264112 SUPT4H1 HSF5 SRSF1 TSPOAP1-AS1
GH17I058374 Enhancer 1.4 Ensembl ENCODE dbSUPER 11 +108.4 108444 10.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B TRIM37 RAD51C RNF43 SRSF1 SUPT4H1 MKS1 HSF5 LPO EPX MSX2P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSF5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSF5 gene promoter:

Genomic Locations for HSF5 Gene

Genomic Locations for HSF5 Gene
chr17:58,420,167-58,488,401
(GRCh38/hg38)
Size:
68,235 bases
Orientation:
Minus strand
chr17:56,497,528-56,565,759
(GRCh37/hg19)

Genomic View for HSF5 Gene

Genes around HSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF5 Gene

Proteins for HSF5 Gene

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G112-HSF5_HUMAN
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Q4G112
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    Size:
    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF5 Gene

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains & Families for HSF5 Gene

Gene Families for HSF5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q4G112

UniProtKB/Swiss-Prot:

HSF5_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF5: view

Function for HSF5 Gene

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional factor.

Phenotypes From GWAS Catalog for HSF5 Gene

Gene Ontology (GO) - Molecular Function for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSF5: view
genes like me logo Genes that share phenotypes with HSF5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HSF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSF5 Gene

Pathways & Interactions for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSF5: view

No data available for Pathways by source and SIGNOR curated interactions for HSF5 Gene

Drugs & Compounds for HSF5 Gene

No Compound Related Data Available

Transcripts for HSF5 Gene

mRNA/cDNA for HSF5 Gene

Unigene Clusters for HSF5 Gene

Heat shock transcription factor family member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
HSF5
ECgene alternative splicing isoforms for
HSF5

Expression for HSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF5 Gene

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for HSF5 Gene

This gene is overexpressed in Testis (53.4) and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSF5 Gene



Protein tissue co-expression partners for HSF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF5 Gene:

HSF5

SOURCE GeneReport for Unigene cluster for HSF5 Gene:

Hs.380061
genes like me logo Genes that share expression patterns with HSF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF5 Gene

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF5 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia HSF5 33 34
  • 91.32 (n)
cow
(Bos Taurus)
Mammalia HSF5 33 34
  • 89.19 (n)
mouse
(Mus musculus)
Mammalia Hsf5 33 16 34
  • 88.78 (n)
rat
(Rattus norvegicus)
Mammalia Hsf5 33
  • 88.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF5 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF5 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858064 33
  • 70.78 (n)
HSF5 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF5 34
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hsf5 34
  • 32 (a)
OneToOne
Species where no ortholog for HSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

ENSEMBL:
Gene Tree for HSF5 (if available)
TreeFam:
Gene Tree for HSF5 (if available)

Paralogs for HSF5 Gene

No data available for Paralogs for HSF5 Gene

Variants for HSF5 Gene

Sequence variations from dbSNP and Humsavar for HSF5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000020417 -- 58,463,544(-) A/C intron_variant
rs1000050063 -- 58,463,919(-) A/T intron_variant
rs1000073788 -- 58,459,921(-) C/A intron_variant
rs1000077964 -- 58,467,643(-) T/C intron_variant
rs1000129261 -- 58,452,671(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
esv2666333 CNV deletion 23128226
nsv575800 CNV gain 21841781
nsv960509 CNV duplication 23825009

Variation tolerance for HSF5 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF5 Gene

Disorders for HSF5 Gene

Additional Disease Information for HSF5

No disorders were found for HSF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSF5 Gene

Publications for HSF5 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 58
  2. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. (PMID: 25208829) Anderson D … Blackwell JM (Genes and immunity 2014) 3 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for HSF5 Gene

Sources for HSF5 Gene

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