Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor 5 2 3 4 5
  • Heat Shock Transcription Factor Family Member 5 2 3
  • Heat Shock Factor Protein 5 3 4
  • HSTF 5 3 4
  • HSF 5 3 4
  • HSTF5 4

External Ids for HSF5 Gene

Previous GeneCards Identifiers for HSF5 Gene

  • GC17M053853
  • GC17M056497
  • GC17M051858

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor 5) is a Protein Coding gene. Diseases associated with HSF5 include Prediabetes Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot Summary for HSF5 Gene

Additional gene information for HSF5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

GeneHancer (GH) Regulatory Elements for HSF5 Gene

Promoters and enhancers for HSF5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J058487 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.5 520 1.2 POLR2A CTCF MAX EBF1 ZBTB33 HSF5 SETP3
GH17J058489 Enhancer 0.2 ENCODE 750.6 -1.7 -1654 0.2 HSF5 piR-36948 MTMR4
GH17J058511 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.6 -27.8 -27815 8.9 E2F8 SIN3A SP1 ZBTB40 CTCF SIX5 ZBTB6 FOXA1 RBPJ POLR2A MTMR4 MKS1 SRSF1 TRIM37 RAD51C SMG8 VEZF1 ENSG00000108387 GDPD1 ENSG00000224738
GH17J058362 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +121.5 121451 8 ZBTB40 RBPJ SMARCE1 NR2F1 NR2F6 ATF1 CREB1 MIXL1 ZNF362 CC2D1A TSPOAP1 RAD51C MKS1 SMG8 SRSF1 RNF43 HSF5 SUPT4H1 TRIM37 lnc-SUPT4H1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSF5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSF5 gene promoter:
  • CP2
  • CUTL1
  • Evi-1
  • FOXF2
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • GATA-2
  • RREB-1
  • S8

Genomic Locations for HSF5 Gene

Genomic Locations for HSF5 Gene
68,235 bases
Minus strand
68,232 bases
Minus strand

Genomic View for HSF5 Gene

Genes around HSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF5 Gene

Proteins for HSF5 Gene

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene


neXtProt entry for HSF5 Gene

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains & Families for HSF5 Gene

Gene Families for HSF5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HSF5 Gene

GenScript: Design optimal peptide antigens:
  • HSF5 protein (A0AUM3_HUMAN)
  • Heat shock transcription factor 5 (HSF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF5: view

Function for HSF5 Gene

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional factor.

Phenotypes From GWAS Catalog for HSF5 Gene

Gene Ontology (GO) - Molecular Function for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with HSF5: view
genes like me logo Genes that share phenotypes with HSF5: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with HSF5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSF5 Gene

Pathways & Interactions for HSF5 Gene

PathCards logo

SuperPathways for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0034605 cellular response to heat IBA 21873635
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress IBA 21873635
genes like me logo Genes that share ontologies with HSF5: view

No data available for Pathways by source and SIGNOR curated interactions for HSF5 Gene

Drugs & Compounds for HSF5 Gene

No Compound Related Data Available

Transcripts for HSF5 Gene

mRNA/cDNA for HSF5 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF5 Gene

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for HSF5 Gene

This gene is overexpressed in Testis (53.4) and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSF5 Gene

Protein tissue co-expression partners for HSF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF5 Gene:


SOURCE GeneReport for Unigene cluster for HSF5 Gene:

genes like me logo Genes that share expression patterns with HSF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF5 Gene

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSF5 33 32
  • 99.5 (n)
(Canis familiaris)
Mammalia HSF5 33 32
  • 91.32 (n)
(Bos Taurus)
Mammalia HSF5 33 32
  • 89.19 (n)
(Mus musculus)
Mammalia Hsf5 17 33 32
  • 88.78 (n)
(Rattus norvegicus)
Mammalia Hsf5 32
  • 88.52 (n)
(Monodelphis domestica)
Mammalia HSF5 33
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia HSF5 33
  • 69 (a)
(Gallus gallus)
Aves LOC100858064 32
  • 70.78 (n)
HSF5 33
  • 57 (a)
(Anolis carolinensis)
Reptilia HSF5 33
  • 62 (a)
(Danio rerio)
Actinopterygii hsf5 33
  • 32 (a)
Species where no ortholog for HSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

Gene Tree for HSF5 (if available)
Gene Tree for HSF5 (if available)
Evolutionary constrained regions (ECRs) for HSF5: view image

Paralogs for HSF5 Gene

Paralogs for HSF5 Gene

genes like me logo Genes that share paralogs with HSF5: view

Variants for HSF5 Gene

Sequence variations from dbSNP and Humsavar for HSF5 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000020417 -- 58,463,544(-) A/C intron_variant
rs1000050063 -- 58,463,919(-) A/T intron_variant
rs1000073788 -- 58,459,921(-) C/A intron_variant
rs1000077964 -- 58,467,643(-) T/C intron_variant
rs1000129261 -- 58,452,671(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
esv2666333 CNV deletion 23128226
nsv575800 CNV gain 21841781
nsv960509 CNV duplication 23825009

Variation tolerance for HSF5 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF5 Gene

Disorders for HSF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prediabetes syndrome
  • prediabetes
- elite association - COSMIC cancer census association via MalaCards
Search HSF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSF5

genes like me logo Genes that share disorders with HSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF5 Gene

Publications for HSF5 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 56
  2. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. (PMID: 25208829) Anderson D … Blackwell JM (Genes and immunity 2014) 3 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 56
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 56

Products for HSF5 Gene

Sources for HSF5 Gene