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HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008] See more...
Aliases for HSF2BP Gene
Aliases for HSF2BP Gene
External Ids for HSF2BP Gene
- HGNC: 5226
- Entrez Gene: 11077
- Ensembl: ENSG00000160207
- OMIM: 604554
- UniProtKB: O75031
Previous GeneCards Identifiers for HSF2BP Gene
- GC21M041458
- GC21M041541
- GC21M043805
- GC21M043775
- GC21M044949
- GC21M030317
- GC21M043529
Summaries for HSF2BP Gene
-
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSF2BP Gene
HSF2BP (Heat Shock Transcription Factor 2 Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for HSF2BP Gene
-
May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).
Additional gene information for HSF2BP Gene
- HGNC(5226)
- Entrez Gene(11077)
- Ensembl(ENSG00000160207)
- OMIM(604554)
- UniProtKB(O75031)
- Open Targets Platform(ENSG00000160207)
- Monarch Initiative
- Search for HSF2BP at DataMed
- Search for HSF2BP at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSF2BP Gene
Genomics for HSF2BP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HSF2BP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSF2BP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSF2BP
- Top Transcription factor binding sites by QIAGEN in the HSF2BP gene promoter:
-
- AML1a
- AP-4
- ATF
- HEN1
- Hlf
- Ik-1
- NF-1
- NF-1/L
- Nkx5-1
Genomic Locations for HSF2BP Gene
Genomic Locations for HSF2BP Gene
- chr21:43,453,987-43,659,499
- (GRCh38/hg38)
- Size:
- 205,513 bases
- Orientation:
- Minus strand
- chr21:44,949,072-45,079,374
- (GRCh37/hg19)
- Size:
- 130,303 bases
- Orientation:
- Minus strand
Genomic View for HSF2BP Gene
Genes around HSF2BP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by HGNC
- 21q22.3 by Entrez Gene
- 21q22.3 by Ensembl
HSF2BP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSF2BP Gene
Proteins for HSF2BP Gene
-
Protein details for HSF2BP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75031-HSF2B_HUMAN
- Recommended name:
- Heat shock factor 2-binding protein
- Protein Accession:
- O75031
- B4DX36
Protein attributes for HSF2BP Gene
- Size:
- 334 amino acids
- Molecular mass:
- 37645 Da
- Quaternary structure:
-
- Associates with HSF2 (PubMed:9651507). The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (PubMed:9651507). Interacts (via C-terminus) with BNC1 (By similarity).
Protein Expression for HSF2BP Gene
Post-translational modifications for HSF2BP Gene
- Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HSF2BP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-HSF2BP antibody
- Novus Biologicals Antibodies for HSF2BP
-
Abcam antibodies for HSF2BP
- Invitrogen Antibodies for HSF2BP (AFLGC-HSF2BP)
-
Biorbyt antibodies for HSF2BP
-
Boster Bio Antibodies for HSF2BP
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSF2BP
Protein Products
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- ProSpec Recombinant Proteins for HSF2BP
- antibodies-online: Show 6 available HSF2BP Proteins ranked by validation data
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-
Quality Products:
-
Abcam proteins for HSF2BP
No data available for DME Specific Peptides for HSF2BP Gene
Domains & Families for HSF2BP Gene
Gene Families for HSF2BP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HSF2BP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HSF2BP Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50271, highly similar to Heat shock factor 2-binding protein (B4DX36_HUMAN)
- Heat shock factor 2-binding protein (HSF2B_HUMAN)
- cDNA, FLJ94816, Homo sapiens heat shock transcription factor 2 binding protein(HSF2BP), mRNA (Q6IAT7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HSF2BP Gene
Function for HSF2BP Gene
Molecular function for HSF2BP Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).
Phenotypes From GWAS Catalog for HSF2BP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21900206 |
Phenotypes for HSF2BP Gene
- MGI mutant phenotypes for HSF2BP:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HSF2BP:
-
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
Animal Models for HSF2BP Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSF2BP - Select products 50% OFF >
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for HSF2BP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSF2BP
Cell Line Products
-
Horizon Cell Lines for HSF2BP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HSF2BP Gene
Localization for HSF2BP Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSF2BP Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| golgi apparatus | 0 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | HDA | 16780588 |
Pathways & Interactions for HSF2BP Gene
Interacting Proteins for HSF2BP Gene
Selected Interacting proteins:
O75031-HSF2B_HUMAN
ENSP00000291560
for HSF2BP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HSF2BP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006366 | transcription by RNA polymerase II | TAS | 9651507 |
| GO:0007283 | spermatogenesis | TAS | 9651507 |
No data available for Pathways by source and SIGNOR curated interactions for HSF2BP Gene
Transcripts for HSF2BP Gene
mRNA/cDNA for HSF2BP Gene
- 1 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000291560 1900 nts (view in UCSC)
- ENST00000443485 989 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSF2BP - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for HSF2BP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSF2BP
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Clone Products
- Applied Biological Materials (abm): Clones for HSF2BP - Select products 50% OFF >
- * HSF2BP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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- Sino Biological Human cDNA Clone for HSF2BP
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Relevant External Links for HSF2BP Gene
- GeneLoc Exon Structure for
- HSF2BP
Expression for HSF2BP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
- XX Germ Cells Ovigerous Cord
-
Gonad
- Secondary Oocyte Antral Follicle
- XX Germ Cells Ovigerous Cord
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HSF2BP Gene
This gene is overexpressed in Testis (x25.1).
This gene is overexpressed in Testis (41.4), Fetal ovary (15.5), and Brain (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSF2BP Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSF2BP
SOURCE GeneReport for Unigene cluster for HSF2BP Gene:
Hs.406157mRNA Expression by UniProt/SwissProt for HSF2BP Gene:
O75031-HSF2B_HUMAN
Tissue specificity:
Testis specific.
Primer Products
-
OriGene qPCR primer pairs for HSF2BP
-
OriGene qPCR primer pairs and template standards for HSF2BP
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2BP Gene
Orthologs for HSF2BP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HSF2BP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HSF2BP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HSF2BP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hsf2bp 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hsf2bp 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | HSF2BP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HSF2BP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HSF2BP 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HSF2BP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hsf2bp 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hsf2bp 30 31 |
|
OneToOne |
- Species where no ortholog for HSF2BP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HSF2BP Gene
- ENSEMBL:
- Gene Tree for HSF2BP (if available)
- TreeFam:
- Gene Tree for HSF2BP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSF2BP: view image
Paralogs for HSF2BP Gene
Pseudogenes.org Pseudogenes for HSF2BP Gene
No data available for Paralogs for HSF2BP Gene
Variants for HSF2BP Gene
Residual Variation Intolerance Score:
61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSF2BP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HSF2BP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSF2BP Gene
Disorders for HSF2BP Gene
Additional Disease Information for HSF2BP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for HSF2BP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSF2BP Gene
Publications for HSF2BP Gene
- Novel testis-specific protein that interacts with heat shock factor 2. (PMID: 9651507) Yoshima T … Yanagi H (Gene 1998) 2 3 4 23
- A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. (PMID: 30760716) Zhang J … Shibuya H (Nature communications 2019) 2 3
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PMID: 17709345) Jakobs A … Niedenthal R (Nucleic acids research 2007) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for HSF2BP Gene
- Custom Antibody Services
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- antibodies-online: Show 7 available HSF2BP Antibodies ranked by validation data
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- antibodies-online: Show 6 available HSF2BP Proteins ranked by validation data
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- Boster Bio Antibodies for HSF2BP
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Sources for HSF2BP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
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- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB