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Aliases for HSF2BP Gene

Aliases for HSF2BP Gene

  • Heat Shock Transcription Factor 2 Binding Protein 2 3 5
  • Heat Shock Factor 2 Binding Protein 2

External Ids for HSF2BP Gene

Previous GeneCards Identifiers for HSF2BP Gene

  • GC21M041458
  • GC21M041541
  • GC21M043805
  • GC21M043775
  • GC21M044949
  • GC21M030317

Summaries for HSF2BP Gene

Entrez Gene Summary for HSF2BP Gene

  • HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSF2BP Gene

HSF2BP (Heat Shock Transcription Factor 2 Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for HSF2BP Gene

  • May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).

Additional gene information for HSF2BP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF2BP Gene

Genomics for HSF2BP Gene

GeneHancer (GH) Regulatory Elements for HSF2BP Gene

Promoters and enhancers for HSF2BP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I043658 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 572.8 -0.7 -674 2.8 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B RRP1B HSF2BP WDR4 U2AF1 PWP2 ENSG00000233754 ENSG00000184441 PKNOX1 C21orf2 TRAPPC10
GH21I043657 Enhancer 0.6 Ensembl ENCODE 564.2 +1.9 1870 0.7 NFIC JUN HSF2BP RRP1B MIR6070
GH21I043659 Promoter 0.5 EPDnew 564.2 +1.3 1335 0.1 HSF2BP RRP1B MIR6070
GH21I043660 Enhancer 0.4 ENCODE 550.8 +0.9 904 0.1 ZFP36 ZBTB33 HSF2BP RRP1B MIR6070
GH21I043724 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 22.1 -73.4 -73400 17.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WDR4 RRP1B U2AF1 PWP2 ENSG00000233754 HSF2BP TRPM2 SIK1 PDXK TRAPPC10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSF2BP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSF2BP gene promoter:

Genomic Locations for HSF2BP Gene

Genomic Locations for HSF2BP Gene
130,314 bases
Minus strand

Genomic View for HSF2BP Gene

Genes around HSF2BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF2BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2BP Gene

Proteins for HSF2BP Gene

  • Protein details for HSF2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock factor 2-binding protein
    Protein Accession:
    Secondary Accessions:
    • B4DX36

    Protein attributes for HSF2BP Gene

    334 amino acids
    Molecular mass:
    37645 Da
    Quaternary structure:
    • Associates with HSF2 (PubMed:9651507). The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (PubMed:9651507). Interacts (via C-terminus) with BNC1 (By similarity).

    Alternative splice isoforms for HSF2BP Gene


neXtProt entry for HSF2BP Gene

Post-translational modifications for HSF2BP Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSF2BP Gene

Domains & Families for HSF2BP Gene

Gene Families for HSF2BP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSF2BP Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSF2BP: view

No data available for UniProtKB/Swiss-Prot for HSF2BP Gene

Function for HSF2BP Gene

Molecular function for HSF2BP Gene

UniProtKB/Swiss-Prot Function:
May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).

Phenotypes From GWAS Catalog for HSF2BP Gene

Gene Ontology (GO) - Molecular Function for HSF2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21900206
genes like me logo Genes that share ontologies with HSF2BP: view
genes like me logo Genes that share phenotypes with HSF2BP: view

Animal Models for HSF2BP Gene

MGI Knock Outs for HSF2BP:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HSF2BP Gene

Localization for HSF2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF2BP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF2BP gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSF2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,HDA 16780588
genes like me logo Genes that share ontologies with HSF2BP: view

Pathways & Interactions for HSF2BP Gene

SuperPathways for HSF2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS 9651507
GO:0007283 spermatogenesis TAS 9651507
genes like me logo Genes that share ontologies with HSF2BP: view

No data available for Pathways by source and SIGNOR curated interactions for HSF2BP Gene

Drugs & Compounds for HSF2BP Gene

No Compound Related Data Available

Transcripts for HSF2BP Gene

Unigene Clusters for HSF2BP Gene

Heat shock transcription factor 2 binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2BP Gene

No ASD Table

Relevant External Links for HSF2BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSF2BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF2BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSF2BP Gene

This gene is overexpressed in Testis (x25.1).

Protein differential expression in normal tissues from HIPED for HSF2BP Gene

This gene is overexpressed in Testis (41.4), Fetal ovary (15.5), and Brain (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSF2BP Gene

Protein tissue co-expression partners for HSF2BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF2BP Gene:


SOURCE GeneReport for Unigene cluster for HSF2BP Gene:


mRNA Expression by UniProt/SwissProt for HSF2BP Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with HSF2BP: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2BP Gene

Orthologs for HSF2BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF2BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSF2BP 33 34
  • 99.4 (n)
(Canis familiaris)
Mammalia HSF2BP 33 34
  • 88.82 (n)
(Bos Taurus)
Mammalia HSF2BP 33 34
  • 86.63 (n)
(Mus musculus)
Mammalia Hsf2bp 33 16 34
  • 85.43 (n)
(Rattus norvegicus)
Mammalia Hsf2bp 33
  • 85.23 (n)
(Monodelphis domestica)
Mammalia HSF2BP 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia HSF2BP 34
  • 74 (a)
(Gallus gallus)
Aves HSF2BP 33 34
  • 75.05 (n)
(Anolis carolinensis)
Reptilia HSF2BP 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hsf2bp 33
  • 59.54 (n)
(Danio rerio)
Actinopterygii hsf2bp 33 34
  • 60.64 (n)
Species where no ortholog for HSF2BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF2BP Gene

Gene Tree for HSF2BP (if available)
Gene Tree for HSF2BP (if available)

Paralogs for HSF2BP Gene Pseudogenes for HSF2BP Gene

genes like me logo Genes that share paralogs with HSF2BP: view

No data available for Paralogs for HSF2BP Gene

Variants for HSF2BP Gene

Sequence variations from dbSNP and Humsavar for HSF2BP Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000012777 -- 43,563,103(-) C/T intron_variant
rs1000018100 -- 43,545,494(-) C/G/T intron_variant
rs1000026015 -- 43,644,569(-) C/G intron_variant
rs1000067629 -- 43,618,688(-) G/A intron_variant
rs1000075163 -- 43,585,124(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSF2BP Gene

Variant ID Type Subtype PubMed ID
dgv109n6 CNV deletion 16902084
dgv1275e212 CNV loss 25503493
dgv2399n106 CNV deletion 24896259
dgv2503e59 CNV duplication 20981092
dgv7873n54 CNV loss 21841781
esv1010827 CNV gain 20482838
esv1180297 CNV deletion 17803354
esv2108372 CNV deletion 18987734
esv2421821 CNV deletion 20811451
esv2474541 CNV loss 19546169
esv2627317 CNV deletion 19546169
esv2659710 CNV deletion 23128226
esv2723610 CNV deletion 23290073
esv2723611 CNV deletion 23290073
esv2723612 CNV deletion 23290073
esv2723613 CNV deletion 23290073
esv27911 CNV loss 19812545
esv2807 CNV loss 18987735
esv29530 CNV gain 19812545
esv3449507 CNV duplication 20981092
esv3557786 CNV deletion 23714750
esv3557787 CNV deletion 23714750
esv3568214 CNV loss 25503493
esv3575396 CNV gain 25503493
esv3647106 CNV loss 21293372
esv3647107 CNV loss 21293372
esv3647108 CNV loss 21293372
esv3647109 CNV gain 21293372
esv3647110 CNV gain 21293372
esv7883 CNV loss 19470904
nsv1061539 CNV loss 25217958
nsv1065359 CNV gain 25217958
nsv1070865 CNV deletion 25765185
nsv1135909 CNV deletion 24896259
nsv1136645 CNV deletion 24896259
nsv1144953 CNV deletion 24896259
nsv1147937 CNV duplication 26484159
nsv1148607 CNV deletion 26484159
nsv1160718 OTHER complex 26073780
nsv187429 CNV deletion 16902084
nsv3537 CNV deletion 18451855
nsv436338 CNV deletion 17901297
nsv442789 CNV loss 18776908
nsv459289 CNV loss 19166990
nsv470903 CNV loss 18288195
nsv511632 CNV loss 21212237
nsv512641 CNV loss 21212237
nsv514957 CNV loss 21397061
nsv521700 CNV loss 19592680
nsv587689 CNV loss 21841781
nsv587690 CNV loss 21841781
nsv587691 CNV gain 21841781
nsv587692 CNV gain+loss 21841781
nsv587693 CNV gain 21841781
nsv587694 CNV loss 21841781
nsv587695 CNV gain 21841781
nsv587696 CNV gain+loss 21841781
nsv587697 CNV loss 21841781
nsv587700 CNV loss 21841781
nsv820925 CNV deletion 20802225
nsv828905 CNV gain+loss 20364138
nsv828906 CNV loss 20364138
nsv834106 CNV loss 17160897
nsv953641 CNV deletion 24416366
nsv965983 CNV duplication 23825009
nsv965984 CNV duplication 23825009

Variation tolerance for HSF2BP Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSF2BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2BP Gene

Disorders for HSF2BP Gene

Additional Disease Information for HSF2BP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HSF2BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSF2BP Gene

Publications for HSF2BP Gene

  1. Novel testis-specific protein that interacts with heat shock factor 2. (PMID: 9651507) Yoshima T … Yanagi H (Gene 1998) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PMID: 17709345) Jakobs A … Niedenthal R (Nucleic acids research 2007) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58

Products for HSF2BP Gene

Sources for HSF2BP Gene

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