Aliases for HSF2BP Gene
Aliases for HSF2BP Gene
External Ids for HSF2BP Gene
- HGNC: 5226
- Entrez Gene: 11077
- Ensembl: ENSG00000160207
- OMIM: 604554
- UniProtKB: O75031
Previous GeneCards Identifiers for HSF2BP Gene
- GC21M041458
- GC21M041541
- GC21M043805
- GC21M043775
- GC21M044949
- GC21M030317
Summaries for HSF2BP Gene
-
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSF2BP Gene
HSF2BP (Heat Shock Transcription Factor 2 Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot for HSF2BP Gene
-
May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).
Additional gene information for HSF2BP Gene
- Monarch Initiative
- Search for HSF2BP at DataMed
- Search for HSF2BP at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF2BP Gene
Genomics for HSF2BP Gene
GeneHancer (GH) Regulatory Elements for HSF2BP Gene
Promoters and enhancers for HSF2BP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21I043658 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE | 572.8 | -0.7 | -674 | 2.8 | HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B | RRP1B HSF2BP WDR4 U2AF1 PWP2 ENSG00000233754 ENSG00000184441 PKNOX1 C21orf2 TRAPPC10 | |
| GH21I043657 | Enhancer | 0.6 | Ensembl ENCODE | 564.2 | +1.9 | 1870 | 0.7 | NFIC JUN | HSF2BP RRP1B MIR6070 | |
| GH21I043659 | Promoter | 0.5 | EPDnew | 564.2 | +1.3 | 1335 | 0.1 | HSF2BP RRP1B MIR6070 | ||
| GH21I043660 | Enhancer | 0.4 | ENCODE | 550.8 | +0.9 | 904 | 0.1 | ZFP36 ZBTB33 | HSF2BP RRP1B MIR6070 | |
| GH21I043724 | Promoter/Enhancer | 2.3 | FANTOM5 Ensembl ENCODE dbSUPER | 22.1 | -73.4 | -73400 | 17.4 | CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 | WDR4 RRP1B U2AF1 PWP2 ENSG00000233754 HSF2BP TRPM2 SIK1 PDXK TRAPPC10 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HSF2BP on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HSF2BP Gene
Genomic Locations for HSF2BP Gene
- chr21:43,529,186-43,659,499
- (GRCh38/hg38)
- Size:
- 130,314 bases
- Orientation:
- Minus strand
- chr21:44,949,072-45,079,374
- (GRCh37/hg19)
Genomic View for HSF2BP Gene
Genes around HSF2BP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Ensembl
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
HSF2BP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSF2BP Gene
Proteins for HSF2BP Gene
-
Protein details for HSF2BP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75031-HSF2B_HUMAN
- Recommended name:
- Heat shock factor 2-binding protein
- Protein Accession:
- O75031
- B4DX36
Protein attributes for HSF2BP Gene
- Size:
- 334 amino acids
- Molecular mass:
- 37645 Da
- Quaternary structure:
-
- Associates with HSF2 (PubMed:9651507). The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (PubMed:9651507). Interacts (via C-terminus) with BNC1 (By similarity).
Protein Expression for HSF2BP Gene
Post-translational modifications for HSF2BP Gene
- Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HSF2BP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for HSF2BP
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-
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Protein Products
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-
Quality Products:
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-
Abcam proteins for HSF2BP
Assay Products
No data available for DME Specific Peptides for HSF2BP Gene
Domains & Families for HSF2BP Gene
Gene Families for HSF2BP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for HSF2BP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HSF2BP Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HSF2BP Gene
Function for HSF2BP Gene
Molecular function for HSF2BP Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).
Phenotypes From GWAS Catalog for HSF2BP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21900206 |
Phenotypes for HSF2BP Gene
- MGI mutant phenotypes for HSF2BP:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HSF2BP:
-
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
Animal Models for HSF2BP Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for HSF2BP gene
-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HSF2BP
-
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Cell Line Products
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Horizon Cell Lines for HSF2BP
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HSF2BP Gene
Localization for HSF2BP Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSF2BP Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,HDA | 16780588 |
Pathways & Interactions for HSF2BP Gene
No Data Available
Interacting Proteins for HSF2BP Gene
Selected Interacting proteins:
O75031-HSF2B_HUMAN
ENSP00000291560
for HSF2BP Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006366 | transcription by RNA polymerase II | TAS | 9651507 |
| GO:0007283 | spermatogenesis | TAS | 9651507 |
No data available for Pathways by source and SIGNOR curated interactions for HSF2BP Gene
Transcripts for HSF2BP Gene
mRNA/cDNA for HSF2BP Gene
- (11) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HSF2BP Gene
CRISPR Products
-
OriGene CRISPR knockouts for HSF2BP
- genomics-online: gRNA clones - Search results for 72 available HSF2BP gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSF2BP
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for HSF2BP
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- genomics-online: shRNA clones - Search results for 72 available HSF2BP gene related products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HSF2BP gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for HSF2BP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HSF2BP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for HSF2BP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HSF2BP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
- XX Germ Cells Ovigerous Cord
-
Gonad
- Secondary Oocyte Antral Follicle
- XX Germ Cells Ovigerous Cord
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HSF2BP Gene
This gene is overexpressed in Testis (x25.1).
This gene is overexpressed in Testis (41.4), Fetal ovary (15.5), and Brain (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSF2BP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HSF2BP Gene:
HSF2BPSOURCE GeneReport for Unigene cluster for HSF2BP Gene:
Hs.406157mRNA Expression by UniProt/SwissProt for HSF2BP Gene:
O75031-HSF2B_HUMAN
Tissue specificity:
Testis specific.
Primer Products
-
OriGene qPCR primer pairs for HSF2BP
-
OriGene qPCR primer pairs and template standards for HSF2BP
- genomics-online: primer clones - Search results for 72 available HSF2BP gene related products
- Overview of 72 available HSF2BP gene related products
Gene Expression Assay Products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2BP Gene
Orthologs for HSF2BP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HSF2BP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HSF2BP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HSF2BP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hsf2bp 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hsf2bp 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HSF2BP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HSF2BP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HSF2BP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HSF2BP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hsf2bp 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hsf2bp 33 34 |
|
- Species where no ortholog for HSF2BP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HSF2BP Gene
Pseudogenes.org Pseudogenes for HSF2BP Gene
No data available for Paralogs for HSF2BP Gene
Variants for HSF2BP Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000012777 | -- | 43,563,103(-) | C/T | intron_variant | |
| rs1000018100 | -- | 43,545,494(-) | C/G/T | intron_variant | |
| rs1000026015 | -- | 43,644,569(-) | C/G | intron_variant | |
| rs1000067629 | -- | 43,618,688(-) | G/A | intron_variant | |
| rs1000075163 | -- | 43,585,124(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.29;
25.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSF2BP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HSF2BP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2BP Gene
Disorders for HSF2BP Gene
Additional Disease Information for HSF2BP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for HSF2BP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSF2BP Gene
Publications for HSF2BP Gene
- Novel testis-specific protein that interacts with heat shock factor 2. (PMID: 9651507) Yoshima T … Yanagi H (Gene 1998) 2 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PMID: 17709345) Jakobs A … Niedenthal R (Nucleic acids research 2007) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
Products for HSF2BP Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HSF2BP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 23 available HSF2BP Antibodies ranked by validation data
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- antibodies-online: Search results for available HSF2BP related products ranked by validation data
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- Overview of 72 available HSF2BP gene related products
Sources for HSF2BP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
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