The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gen... See more...

Aliases for HSF2 Gene

Aliases for HSF2 Gene

  • Heat Shock Transcription Factor 2 2 3 4 5
  • Heat Shock Factor Protein 2 3 4
  • HSTF 2 3 4
  • HSF 2 3 4
  • HSTF2 4
  • HSF2 5

External Ids for HSF2 Gene

Previous GeneCards Identifiers for HSF2 Gene

  • GC06P122491
  • GC06P122678
  • GC06P122702
  • GC06P122703
  • GC06P122762
  • GC06P120297

Summaries for HSF2 Gene

Entrez Gene Summary for HSF2 Gene

  • The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for HSF2 Gene

HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include Spermatogenic Failure, Y-Linked, 2. Among its related pathways are Proteolysis Putative SUMO-1 pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot Summary for HSF2 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Wiki entry for HSF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSF2 Gene

Genomics for HSF2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSF2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSF2

Top Transcription factor binding sites by QIAGEN in the HSF2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • FOXL1
  • FOXO1
  • FOXO1a
  • HFH-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • Sp1

Genomic Locations for HSF2 Gene

Latest Assembly
chr6:122,399,551-122,433,119
(GRCh38/hg38)
Size:
33,569 bases
Orientation:
Plus strand

Previous Assembly
chr6:122,720,696-122,754,264
(GRCh37/hg19 by Entrez Gene)
Size:
33,569 bases
Orientation:
Plus strand

chr6:122,720,691-122,754,264
(GRCh37/hg19 by Ensembl)
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for HSF2 Gene

Genes around HSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2 Gene

Proteins for HSF2 Gene

  • Protein details for HSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03933-HSF2_HUMAN
    Recommended name:
    Heat shock factor protein 2
    Protein Accession:
    Q03933
    Secondary Accessions:
    • B4DGJ4
    • Q0VAH9
    • Q2M1K4
    • Q9H445

    Protein attributes for HSF2 Gene

    Size:
    536 amino acids
    Molecular mass:
    60348 Da
    Quaternary structure:
    • DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

    Three dimensional structures from OCA and Proteopedia for HSF2 Gene

    Alternative splice isoforms for HSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF2 Gene

Post-translational modifications for HSF2 Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for HSF2 Gene

No data available for DME Specific Peptides for HSF2 Gene

Domains & Families for HSF2 Gene

Gene Families for HSF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HSF2 Gene

InterPro:
Blocks:
  • Heat shock factor (HSF)-type DNA-binding domain
  • Vertebrate heat shock transcription factor

Suggested Antigen Peptide Sequences for HSF2 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock transcription factor 2 (HSF2_HUMAN)
  • HSF2 protein (Q9BS48_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03933

UniProtKB/Swiss-Prot:

HSF2_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF2: view

Function for HSF2 Gene

Molecular function for HSF2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Phenotypes From GWAS Catalog for HSF2 Gene

Gene Ontology (GO) - Molecular Function for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10561509
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 8972228
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 10561509
genes like me logo Genes that share ontologies with HSF2: view
genes like me logo Genes that share phenotypes with HSF2: view

Animal Models for HSF2 Gene

MGI Knock Outs for HSF2:
  • Hsf2 Hsf2<tm1Ijb>
  • Hsf2 Hsf2<tm1Miv>
  • Hsf2 Hsf2<tm1Mmr>
  • Hsf2 Hsf2<tm1b(KOMP)Wtsi>

Transcription Factor Targets for HSF2 Gene

Selected GeneGlobe predicted Target genes for HSF2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HSF2 Gene

Localization for HSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF2 gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with HSF2: view

Pathways & Interactions for HSF2 Gene

PathCards logo

SuperPathways for HSF2 Gene

SuperPathway Contained pathways
1 Proteolysis Putative SUMO-1 pathway
.35
genes like me logo Genes that share pathways with HSF2: view

Pathways by source for HSF2 Gene

1 GeneGo (Thomson Reuters) pathway for HSF2 Gene
  • Proteolysis Putative SUMO-1 pathway

SIGNOR curated interactions for HSF2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007283 spermatogenesis IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 10561509
genes like me logo Genes that share ontologies with HSF2: view

Drugs & Compounds for HSF2 Gene

(4) Drugs for HSF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for HSF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSF2: view

Transcripts for HSF2 Gene

mRNA/cDNA for HSF2 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF2

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:
SP7:

Relevant External Links for HSF2 Gene

GeneLoc Exon Structure for
HSF2

Expression for HSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSF2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for HSF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSF2 Gene



Protein tissue co-expression partners for HSF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSF2

SOURCE GeneReport for Unigene cluster for HSF2 Gene:

Hs.158195

Evidence on tissue expression from TISSUES for HSF2 Gene

  • Nervous system(4.8)
  • Muscle(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with HSF2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2 Gene

Orthologs for HSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSF2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HSF2 29 30
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HSF2 29 30
  • 95.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HSF2 29 30
  • 95.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hsf2 29
  • 90.9 (n)
Mouse
(Mus musculus)
Mammalia Hsf2 29 16 30
  • 90.57 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HSF2 30
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HSF2 30
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HSF2 29 30
  • 76.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HSF2 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hsf2 29
  • 67.82 (n)
Zebrafish
(Danio rerio)
Actinopterygii hsf2 29 30
  • 61.62 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7999 29
Fruit Fly
(Drosophila melanogaster)
Insecta Hsf 30 31
  • 19 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 31
  • 28 (a)
hsf-1 30
  • 18 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 30
  • 14 (a)
OneToMany
SKN7 32
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 28 (a)
OneToMany
Species where no ortholog for HSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HSF2 Gene

ENSEMBL:
Gene Tree for HSF2 (if available)
TreeFam:
Gene Tree for HSF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSF2: view image
Alliance of Genome Resources:
Additional Orthologs for HSF2

Paralogs for HSF2 Gene

Paralogs for HSF2 Gene

(2) SIMAP similar genes for HSF2 Gene using alignment to 4 proteins:

  • HSF2_HUMAN
  • L8E7P1_HUMAN
  • Q9BS48_HUMAN
  • V9GZ44_HUMAN

Pseudogenes.org Pseudogenes for HSF2 Gene

genes like me logo Genes that share paralogs with HSF2: view

Variants for HSF2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSF2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1582613322 Uncertain Significance: not provided 122,416,218(+) TAGTG/T
NC_000006.12:g.122416221_122416224del
rs770437959 Uncertain Significance: Variant of unknown significance 122,432,114(+) G/A
NM_004506.4(HSF2):c.1505G>A (p.Arg502His)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HSF2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HSF2 Gene

Variant ID Type Subtype PubMed ID
esv2759467 CNV loss 17122850
nsv1161448 CNV duplication 26073780

Variation tolerance for HSF2 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSF2 Gene

Human Gene Mutation Database (HGMD)
HSF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF2
Leiden Open Variation Database (LOVD)
HSF2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2 Gene

Disorders for HSF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF2 Gene - From: COP

Disorder Aliases PubMed IDs
spermatogenic failure, y-linked, 2
  • spgfy2
- elite association - COSMIC cancer census association via MalaCards
Search HSF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSF2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HSF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF2 Gene

Publications for HSF2 Gene

  1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PMID: 1871106) Schuetz TJ … Kingston RE (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22
  2. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PMID: 8339932) Sheldon LA … Kingston RE (Genes & development 1993) 3 4 22
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  4. PEST sequences mediate heat shock factor 2 turnover by interacting with the Cul3 subunit of the Cul3-RING ubiquitin ligase. (PMID: 19768582) Xing H … Sarge KD (Cell stress & chaperones 2010) 3 22
  5. Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2. (PMID: 19017645) Tateishi Y … Shirakawa M (The Journal of biological chemistry 2009) 3 22

Products for HSF2 Gene

Sources for HSF2 Gene