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The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gen... See more...
Aliases for HSF2 Gene
Aliases for HSF2 Gene
External Ids for HSF2 Gene
- HGNC: 5225
- Entrez Gene: 3298
- Ensembl: ENSG00000025156
- OMIM: 140581
- UniProtKB: Q03933
Previous GeneCards Identifiers for HSF2 Gene
- GC06P122491
- GC06P122678
- GC06P122702
- GC06P122703
- GC06P122762
- GC06P120297
Summaries for HSF2 Gene
-
The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for HSF2 Gene
HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include Erythroleukemia, Familial. Among its related pathways are Proteolysis Putative SUMO-1 pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSF1.
UniProtKB/Swiss-Prot Summary for HSF2 Gene
-
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSF2 Gene
Genomics for HSF2 Gene
GeneHancer (GH) Regulatory Elements for HSF2 Gene
Promoters and enhancers for HSF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSF2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HSF2 gene promoter:
-
- C/EBPalpha
- CHOP-10
- FOXL1
- FOXO1
- FOXO1a
- HFH-1
- PPAR-gamma1
- PPAR-gamma2
- RORalpha1
- Sp1
Genomic Locations for HSF2 Gene
Genomic Locations for HSF2 Gene
- chr6:122,399,546-122,433,119
- (GRCh38/hg38)
- Size:
- 33,574 bases
- Orientation:
- Plus strand
- chr6:122,720,691-122,754,264
- (GRCh37/hg19)
- Size:
- 33,574 bases
- Orientation:
- Plus strand
Genomic View for HSF2 Gene
Genes around HSF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.31 by HGNC
- 6q22.31 by Entrez Gene
- 6q22.31 by Ensembl
HSF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSF2 Gene
Proteins for HSF2 Gene
-
Protein details for HSF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03933-HSF2_HUMAN
- Recommended name:
- Heat shock factor protein 2
- Protein Accession:
- Q03933
- B4DGJ4
- Q0VAH9
- Q2M1K4
- Q9H445
Protein attributes for HSF2 Gene
- Size:
- 536 amino acids
- Molecular mass:
- 60348 Da
- Quaternary structure:
-
- DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.
Protein Expression for HSF2 Gene
Post-translational modifications for HSF2 Gene
Other Protein References for HSF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HSF2 Antibody
- NSJ Bioreagents HSF2 Antibody
- Atlas Antibodies Anti-HSF2 Antibody
-
Creative Diagnostics
-
Creative Biolabs
- Rat Anti-HSF2 Recombinant Antibody (CBFYH-2056)
- Rabbit Anti-HSF2 Recombinant Antibody (CBFYH-2055)
- Mouse Anti-HSF2 (AA 74-324) Recombinant Antibody (CBFYH-2044)
- Mouse Anti-HSF2 Recombinant Antibody (CBFYH-2050)
- Mouse Anti-HSF2 Recombinant Antibody (CBFYH-2057)
- Rat Anti-HSF2 Recombinant Antibody (CBFYH-2058)
- Rat Anti-HSF2 Recombinant Antibody (CBFYH-2052)
- Mouse Anti-HSF2 Recombinant Antibody (2C1)
- Mouse Anti-HSF2 (AA 74-324) Recombinant Antibody (CBFYH-2049)
- Rat Anti-HSF2 Recombinant Antibody (CBFYH-2047)
- Rabbit Anti-HSF2 Recombinant Antibody (CBFYH-2045)
- Mouse Anti-HSF2 Recombinant Antibody (CBFYH-2054)
- Mouse Anti-HSF2 Recombinant Antibody (CBFYH-2053)
- Mouse Anti-HSF2 (AA 1-230) Recombinant Antibody (CBFYH-3214)
- Recombinant Mouse Anti-Human HSF2 Antibody (clone 832E2)
- Rat Anti-HSF2 (AA 1-517) Recombinant Antibody (CBFYH-2043)
- Hi-Affi™ Recombinant Rabbit Anti-HSF2 Monoclonal Antibody (DS1686AB)
- Novus Biologicals Antibodies for HSF2
-
Abcam antibodies for HSF2
- Invitrogen Antibodies for HSF2 (AFLGC-HSF2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSF2
Protein Products
- G Biosciences Human HSF2, Lyophilized
-
OriGene Purified Proteins for HSF2
- Search Origene for MassSpec and Protein Over-expression Lysates for HSF2
- Origene Custom Protein Services for HSF2
- antibodies-online: Search results for available HSF2 related products ranked by validation data
-
ProSci Proteins for HSF2
-
Abcam proteins for HSF2
Assay Products
- Aviva Systems Biology HSF2 ELISA Kit (Human) (OKDD00319) and HSF2 ELISA Kit (Human) (OKCD06358)
- Novus Biologicals ELISA Kits for HSF2
- antibodies-online: Search results for available HSF2 related products ranked by validation data
-
Boster Bio ELISA Kits for HSF2
No data available for DME Specific Peptides for HSF2 Gene
Domains & Families for HSF2 Gene
Gene Families for HSF2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HSF2 Gene
Suggested Antigen Peptide Sequences for HSF2 Gene
- GenScript: Design optimal peptide antigens:
-
- Heat shock transcription factor 2 (HSF2_HUMAN)
- HSF2 protein (Q9BS48_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q03933- Family:
-
- Belongs to the HSF family.
Function for HSF2 Gene
Molecular function for HSF2 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Phenotypes From GWAS Catalog for HSF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 10561509 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | IDA | 10561509 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 10561509 |
Phenotypes for HSF2 Gene
- MGI mutant phenotypes for HSF2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for HSF2:
Animal Models for HSF2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for HSF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSF2
- genomics-online: gRNA clones - Search results for available HSF2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for HSF2 - Select products 50% OFF >
- * HSF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HSF2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSF2
miRNA for HSF2 Gene
- miRTarBase miRNAs that target HSF2
-
- hsa-mir-18a-5p (MIRT005361)
- hsa-mir-26b-5p (MIRT029326)
- hsa-mir-24-3p (MIRT030504)
- hsa-let-7b-5p (MIRT052083)
- hsa-let-7a-5p (MIRT052530)
- hsa-mir-1324 (MIRT790104)
- hsa-mir-190a-3p (MIRT790142)
- hsa-mir-2115-3p (MIRT790178)
- hsa-mir-361-5p (MIRT790314)
- hsa-mir-3927-5p (MIRT790372)
- hsa-mir-4487 (MIRT790482)
- hsa-mir-454-5p (MIRT790520)
- hsa-mir-4633-3p (MIRT790525)
- hsa-mir-4802-5p (MIRT790653)
- hsa-mir-5011-5p (MIRT790680)
- hsa-mir-6500-5p (MIRT790851)
- hsa-mir-6514-5p (MIRT790862)
- hsa-mir-652-5p (MIRT790867)
- hsa-mir-6874-5p (MIRT791067)
- hsa-mir-8076 (MIRT791138)
Transcription Factor Targets for HSF2 Gene
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HSF2
- Browse OriGene Inhibitory RNA Products For HSF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF2
- genomics-online: shRNA clones - Search results for available HSF2 gene related products
Clone Products
-
- MG208286
- MR208286
- MR208286L3
- MR208286L3V
- MR208286L4
- MR208286L4V
- RC210751
- RC210751L1
- RC210751L1V
- RC210751L2
- RC210751L2V
- RC210751L3
- RC210751L3V
- RC210751L4
- RC210751L4V
- RC226533
- RC226533L3
- RC226533L3V
- RC226533L4
- RC226533L4V
- RC232215
- RG210751
- RG226533
- RG232215
- RR210514
- RR210514L1
- RR210514L1V
- RR210514L2
- RR210514L2V
- RR210514L3
- RR210514L3V
- RR210514L4
- RR210514L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSF2
- Addgene plasmids for HSF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSF2
- genomics-online: cdna clones - Search results for available HSF2 gene related products
- orf clones - Search results for available HSF2 gene related products
- Applied Biological Materials (abm): Clones for HSF2 - Select products 50% OFF >
- * HSF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HSF2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for HSF2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HSF2 Gene
Localization for HSF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSF2 Gene
- Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for HSF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Proteolysis Putative SUMO-1 pathway | ||
Pathways by source for HSF2 Gene
1 GeneGo (Thomson Reuters) pathway for HSF2 Gene
Interacting Proteins for HSF2 Gene
Selected Interacting proteins:
Q03933-HSF2_HUMAN
ENSP00000357440
for HSF2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HSF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | TAS | 1871106 |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0034605 | cellular response to heat | IBA | 21873635 |
Drugs & Compounds for HSF2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for HSF2 Gene
mRNA/cDNA for HSF2 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (164) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368455 2549 bps (ENST00000368455.8)
- ENST00000465214 642 bps (ENST00000465214.2)
- ENST00000452194 2643 bps (ENST00000452194.5)
CRISPR Products
-
OriGene CRISPR knockouts for HSF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSF2
- genomics-online: gRNA clones - Search results for available HSF2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for HSF2 - Select products 50% OFF >
- * HSF2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HSF2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSF2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HSF2
- Browse OriGene Inhibitory RNA Products For HSF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF2
- genomics-online: shRNA clones - Search results for available HSF2 gene related products
Clone Products
-
- MG208286
- MR208286
- MR208286L3
- MR208286L3V
- MR208286L4
- MR208286L4V
- RC210751
- RC210751L1
- RC210751L1V
- RC210751L2
- RC210751L2V
- RC210751L3
- RC210751L3V
- RC210751L4
- RC210751L4V
- RC226533
- RC226533L3
- RC226533L3V
- RC226533L4
- RC226533L4V
- RC232215
- RG210751
- RG226533
- RG232215
- RR210514
- RR210514L1
- RR210514L1V
- RR210514L2
- RR210514L2V
- RR210514L3
- RR210514L3V
- RR210514L4
- RR210514L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSF2
- Addgene plasmids for HSF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSF2
- genomics-online: cdna clones - Search results for available HSF2 gene related products
- orf clones - Search results for available HSF2 gene related products
- Applied Biological Materials (abm): Clones for HSF2 - Select products 50% OFF >
- * HSF2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HSF2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for HSF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for HSF2 Gene
This gene is overexpressed in Muscle - Skeletal (x4.4).
This gene is overexpressed in Bone marrow mesenchymal stem cell (68.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSF2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HSF2 Gene:
HSF2SOURCE GeneReport for Unigene cluster for HSF2 Gene:
Hs.158195Evidence on tissue expression from TISSUES for HSF2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for HSF2
-
OriGene qPCR primer pairs and template standards for HSF2
- genomics-online: primer clones - Search results for available HSF2 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2 Gene
Orthologs for HSF2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HSF2 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HSF2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HSF2 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hsf2 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Hsf2 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HSF2 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HSF2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HSF2 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HSF2 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hsf2 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hsf2 33 32 32 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7999 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Hsf 33 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | Y53C10A.12 34 |
|
|
|
| hsf-1 33 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSF1 33 |
|
OneToMany | |
| SKN7 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for HSF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HSF2 Gene
- ENSEMBL:
- Gene Tree for HSF2 (if available)
- TreeFam:
- Gene Tree for HSF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSF2: view image
Paralogs for HSF2 Gene
(2) SIMAP similar genes for HSF2 Gene using alignment to 4 proteins:
- HSF2_HUMAN
- L8E7P1_HUMAN
- Q9BS48_HUMAN
- V9GZ44_HUMAN
Pseudogenes.org Pseudogenes for HSF2 Gene
Variants for HSF2 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs770437959 | uncertain-significance, Variant of unknown significance | 122,432,114(+) | G/A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1000001736 | -- | 122,401,317(+) | A/C/G | intron_variant | |
| rs1000101898 | -- | 122,408,492(+) | A/C | intron_variant | |
| rs1000228563 | -- | 122,426,992(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000351585 | -- | 122,401,649(+) | T/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759467 | CNV | loss | 17122850 |
| nsv1161448 | CNV | duplication | 26073780 |
Residual Variation Intolerance Score:
14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.82;
17.14% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSF2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2 Gene
Disorders for HSF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| erythroleukemia, familial |
|
Search HSF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HSF2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HSF2 Gene
Publications for HSF2 Gene
- Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PMID: 1871106) Schuetz TJ … Kingston RE (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23 56
- Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PMID: 8339932) Sheldon LA … Kingston RE (Genes & development 1993) 3 4 23 56
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
- PEST sequences mediate heat shock factor 2 turnover by interacting with the Cul3 subunit of the Cul3-RING ubiquitin ligase. (PMID: 19768582) Xing H … Sarge KD (Cell stress & chaperones 2010) 3 23 56
- Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. (PMID: 19129477) Sandqvist A … Sistonen L (Molecular biology of the cell 2009) 3 23 56
ExternalLinks
Products for HSF2 Gene
- Custom Antibody ServicesOriGene Antibodies for HSF2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HSF2
- Search Origene for MassSpec and Protein Over-expression Lysates for HSF2
- Origene Custom Protein Services for HSF2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HSF2
- Browse OriGene Inhibitory RNA Products For HSF2
- OriGene qPCR primer pairs for HSF2
- OriGene qPCR primer pairs and template standards for HSF2
- OriGene CRISPR knockouts for HSF2
- MG208286
- MR208286
- MR208286L3
- MR208286L3V
- MR208286L4
- MR208286L4V
- RC210751
- RC210751L1
- RC210751L1V
- RC210751L2
- RC210751L2V
- RC210751L3
- RC210751L3V
- RC210751L4
- RC210751L4V
- RC226533
- RC226533L3
- RC226533L3V
- RC226533L4
- RC226533L4V
- RC232215
- RG210751
- RG226533
- RG232215
- RR210514
- RR210514L1
- RR210514L1V
- RR210514L2
- RR210514L2V
- RR210514L3
- RR210514L3V
- RR210514L4
- RR210514L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 90 available HSF2 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for HSF2
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Sources for HSF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
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- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
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- (118) NCBI Bookshelf
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- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
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- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource