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The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include Erythroleukemia, Familial and Spermatogenic Failure, Y-Linked, 2. Among its related pathways are Proteolysis Putative SUMO-1 pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 10561509 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | IDA | 10561509 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 10561509 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0042025 | host cell nucleus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Proteolysis Putative SUMO-1 pathway |
Proteolysis Putative SUMO-1 pathway
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | TAS | 1871106 |
GO:0007283 | spermatogenesis | IEA | -- |
GO:0034605 | cellular response to heat | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HSF2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HSF2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HSF2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hsf2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hsf2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HSF2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HSF2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HSF2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HSF2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hsf2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hsf2 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7999 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Hsf 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | Y53C10A.12 32 |
|
|
|
hsf-1 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSF1 31 |
|
OneToMany | |
SKN7 33 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
666264 | Uncertain Significance: not provided | 122,416,218(+) | TAGTG/T | ||
rs770437959 | Uncertain Significance: Variant of unknown significance | 122,432,114(+) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759467 | CNV | loss | 17122850 |
nsv1161448 | CNV | duplication | 26073780 |
Disorder | Aliases | PubMed IDs |
---|---|---|
erythroleukemia, familial |
|
|
spermatogenic failure, y-linked, 2 |
|
|