The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gen... See more...

Aliases for HSF2 Gene

Aliases for HSF2 Gene

  • Heat Shock Transcription Factor 2 2 3 4 5
  • Heat Shock Factor Protein 2 3 4
  • HSTF 2 3 4
  • HSF 2 3 4
  • HSTF2 4

External Ids for HSF2 Gene

Previous GeneCards Identifiers for HSF2 Gene

  • GC06P122491
  • GC06P122678
  • GC06P122702
  • GC06P122703
  • GC06P122762
  • GC06P120297

Summaries for HSF2 Gene

Entrez Gene Summary for HSF2 Gene

  • The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for HSF2 Gene

HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include Erythroleukemia, Familial. Among its related pathways are Proteolysis Putative SUMO-1 pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot Summary for HSF2 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Wiki entry for HSF2 Gene

Additional gene information for HSF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSF2 Gene

Genomics for HSF2 Gene

GeneHancer (GH) Regulatory Elements for HSF2 Gene

Promoters and enhancers for HSF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J122398 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 769.6 +0.6 649 3.2 SP1 CTCF RBPJ POLR2A USF2 FOS MIXL1 ZNF362 CC2D1A NFYC HSF2 PKIB ENSG00000279453 lnc-SERINC1-3
GH06J122470 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18 +71.8 71755 3 SP1 ZBTB40 RBPJ SMARCE1 POLR2A ATF1 CREB1 HCFC1 MIXL1 ELF1 PKIB ENSG00000279114 SERINC1 HSF2 ENSG00000275339
GH06J122481 Promoter 0.9 Ensembl 15.4 +83.9 83855 3.2 SMARCE1 CC2D1A L3MBTL2 MAX SMARCA4 TRIM24 ATF1 PKNOX1 HDAC1 NFE2 HSF2 PKIB ENSG00000279114 ENSG00000277408
GH06J122609 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 6.2 +211.3 211349 3 CTCF ZBTB6 TCF7L2 ZNF362 MNT SP7 ZSCAN21 PRDM1 POLR2A SP5 PKIB SERINC1 HSF2 SMPDL3A ENSG00000287258 piR-53030-002
GH06J122455 Enhancer 0.6 dbSUPER 18.1 +60.9 60915 9.9 CTBP1 ZNF316 SOX13 RFX1 POLR2A DPF2 ZNF217 CUX1 PLRG1 FOXA1 HSF2 PKIB ENSG00000275339 SERINC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSF2 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • FOXL1
  • FOXO1
  • FOXO1a
  • HFH-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha1
  • Sp1

Genomic Locations for HSF2 Gene

Genomic Locations for HSF2 Gene
chr6:122,399,546-122,433,119
(GRCh38/hg38)
Size:
33,574 bases
Orientation:
Plus strand
chr6:122,720,691-122,754,264
(GRCh37/hg19)
Size:
33,574 bases
Orientation:
Plus strand

Genomic View for HSF2 Gene

Genes around HSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2 Gene

Proteins for HSF2 Gene

  • Protein details for HSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03933-HSF2_HUMAN
    Recommended name:
    Heat shock factor protein 2
    Protein Accession:
    Q03933
    Secondary Accessions:
    • B4DGJ4
    • Q0VAH9
    • Q2M1K4
    • Q9H445

    Protein attributes for HSF2 Gene

    Size:
    536 amino acids
    Molecular mass:
    60348 Da
    Quaternary structure:
    • DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

    Three dimensional structures from OCA and Proteopedia for HSF2 Gene

    Alternative splice isoforms for HSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF2 Gene

Post-translational modifications for HSF2 Gene

  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for HSF2 Gene

Antibody Products

  • Abcam antibodies for HSF2

No data available for DME Specific Peptides for HSF2 Gene

Domains & Families for HSF2 Gene

Gene Families for HSF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HSF2 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock transcription factor 2 (HSF2_HUMAN)
  • HSF2 protein (Q9BS48_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q03933

UniProtKB/Swiss-Prot:

HSF2_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF2: view

Function for HSF2 Gene

Molecular function for HSF2 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Phenotypes From GWAS Catalog for HSF2 Gene

Gene Ontology (GO) - Molecular Function for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10561509
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 10561509
genes like me logo Genes that share ontologies with HSF2: view
genes like me logo Genes that share phenotypes with HSF2: view

Animal Models for HSF2 Gene

MGI Knock Outs for HSF2:
  • Hsf2 Hsf2<tm1Mmr>
  • Hsf2 Hsf2<tm1Miv>
  • Hsf2 Hsf2<tm1b(KOMP)Wtsi>
  • Hsf2 Hsf2<tm1Ijb>

Animal Model Products

CRISPR Products

Transcription Factor Targets for HSF2 Gene

Selected GeneGlobe predicted Target genes for HSF2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF2

Clone Products

  • Addgene plasmids for HSF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HSF2 Gene

Localization for HSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF2 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSF2: view

Pathways & Interactions for HSF2 Gene

PathCards logo

SuperPathways for HSF2 Gene

genes like me logo Genes that share pathways with HSF2: view

Pathways by source for HSF2 Gene

1 GeneGo (Thomson Reuters) pathway for HSF2 Gene

SIGNOR curated interactions for HSF2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006366 transcription by RNA polymerase II TAS 1871106
GO:0007283 spermatogenesis IEA --
GO:0034605 cellular response to heat IBA 21873635
genes like me logo Genes that share ontologies with HSF2: view

Drugs & Compounds for HSF2 Gene

(4) Drugs for HSF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for HSF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSF2: view

Transcripts for HSF2 Gene

mRNA/cDNA for HSF2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSF2

Clone Products

  • Addgene plasmids for HSF2

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - -
SP6:
SP7:

Relevant External Links for HSF2 Gene

GeneLoc Exon Structure for
HSF2
ECgene alternative splicing isoforms for
HSF2

Expression for HSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSF2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for HSF2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSF2 Gene



Protein tissue co-expression partners for HSF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSF2 Gene:

HSF2

SOURCE GeneReport for Unigene cluster for HSF2 Gene:

Hs.158195

Evidence on tissue expression from TISSUES for HSF2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with HSF2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF2 Gene

Orthologs for HSF2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF2 33 32
  • 99.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HSF2 33 32
  • 95.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HSF2 33 32
  • 95.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsf2 32
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Hsf2 17 33 32
  • 90.57 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF2 33
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF2 33
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSF2 33 32
  • 76.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF2 33
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsf2 32
  • 67.82 (n)
zebrafish
(Danio rerio)
Actinopterygii hsf2 33 32 32
  • 61.62 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7999 32
fruit fly
(Drosophila melanogaster)
Insecta Hsf 33 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 34
  • 28 (a)
hsf-1 33
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 33
  • 14 (a)
OneToMany
SKN7 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 28 (a)
OneToMany
Species where no ortholog for HSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF2 Gene

ENSEMBL:
Gene Tree for HSF2 (if available)
TreeFam:
Gene Tree for HSF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSF2: view image

Paralogs for HSF2 Gene

Paralogs for HSF2 Gene

(2) SIMAP similar genes for HSF2 Gene using alignment to 4 proteins:

  • HSF2_HUMAN
  • L8E7P1_HUMAN
  • Q9BS48_HUMAN
  • V9GZ44_HUMAN

Pseudogenes.org Pseudogenes for HSF2 Gene

genes like me logo Genes that share paralogs with HSF2: view

Variants for HSF2 Gene

Sequence variations from dbSNP and Humsavar for HSF2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs770437959 uncertain-significance, Variant of unknown significance 122,432,114(+) G/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000001736 -- 122,401,317(+) A/C/G intron_variant
rs1000101898 -- 122,408,492(+) A/C intron_variant
rs1000228563 -- 122,426,992(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000351585 -- 122,401,649(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSF2 Gene

Variant ID Type Subtype PubMed ID
esv2759467 CNV loss 17122850
nsv1161448 CNV duplication 26073780

Variation tolerance for HSF2 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSF2 Gene

Human Gene Mutation Database (HGMD)
HSF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF2 Gene

Disorders for HSF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF2 Gene - From: HGMD and Novoseek

Disorder Aliases PubMed IDs
erythroleukemia, familial
  • erythroleukemia, familial, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search HSF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HSF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF2 Gene

Publications for HSF2 Gene

  1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PMID: 1871106) Schuetz TJ … Kingston RE (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 23 56
  2. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PMID: 8339932) Sheldon LA … Kingston RE (Genes & development 1993) 3 4 23 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. PEST sequences mediate heat shock factor 2 turnover by interacting with the Cul3 subunit of the Cul3-RING ubiquitin ligase. (PMID: 19768582) Xing H … Sarge KD (Cell stress & chaperones 2010) 3 23 56
  5. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. (PMID: 19129477) Sandqvist A … Sistonen L (Molecular biology of the cell 2009) 3 23 56

Products for HSF2 Gene

Sources for HSF2 Gene