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Aliases for HSD17B8 Gene

Aliases for HSD17B8 Gene

  • Hydroxysteroid 17-Beta Dehydrogenase 8 2 3 5
  • 3-Ketoacyl-[Acyl-Carrier-Protein] Reductase Alpha Subunit 3 4
  • Short Chain Dehydrogenase/Reductase Family 30C Member 1 3 4
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
  • 17-Beta-Hydroxysteroid Dehydrogenase 8 3 4
  • Really Interesting New Gene 2 Protein 3 4
  • Testosterone 17-Beta-Dehydrogenase 8 3 4
  • KAR Alpha Subunit 3 4
  • 17-Beta-HSD 8 3 4
  • Protein Ke6 3 4
  • SDR30C1 3 4
  • FABGL 3 4
  • RING2 3 4
  • Ke-6 3 4
  • HKE6 3 4
  • FabG (Beta-Ketoacyl-[Acyl-Carrier-Protein] Reductase, E Coli) Like (E. Coli) 2
  • Short Chain Dehydrogenase/Reductase Family 30C, Member 1 2
  • Hydroxysteroid (17-Beta) Dehydrogenase 8 2
  • Estradiol 17-Beta-Dehydrogenase 8 3
  • Estrogen 17-Oxidoreductase 3
  • EC 4
  • DJ1033B10.9 3
  • EC 4
  • EC 1.1.1.- 4
  • D6S2245E 3
  • H2-KE6 3
  • FABG 3
  • KE6 3

External Ids for HSD17B8 Gene

Previous HGNC Symbols for HSD17B8 Gene


Previous GeneCards Identifiers for HSD17B8 Gene

  • GC06P033175
  • GC06P033165
  • GC06P033219
  • GC06P033280
  • GC06P033173
  • GC06P032914
  • GC06P033182
  • GC06P033194

Summaries for HSD17B8 Gene

Entrez Gene Summary for HSD17B8 Gene

  • In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSD17B8 Gene

HSD17B8 (Hydroxysteroid 17-Beta Dehydrogenase 8) is a Protein Coding gene. Among its related pathways are Metabolism and Steroid hormone biosynthesis. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and 3-hydroxyacyl-CoA dehydrogenase activity. An important paralog of this gene is CBR4.

UniProtKB/Swiss-Prot for HSD17B8 Gene

  • NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).

Gene Wiki entry for HSD17B8 Gene

Additional gene information for HSD17B8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B8 Gene

Genomics for HSD17B8 Gene

GeneHancer (GH) Regulatory Elements for HSD17B8 Gene

Promoters and enhancers for HSD17B8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J033203 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 666.4 +1.8 1766 5.8 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RING1 HSD17B8 MIR219A1 GC06P033209 BRD2 LEMD2 VPS52 DAXX RXRB WDR46
GH06J033160 Enhancer 1.4 FANTOM5 Ensembl ENCODE 15.3 -43.1 -43103 1.9 ZFP64 ARID4B DMAP1 ZNF2 ZNF48 GLIS2 ZNF143 ATF7 KLF13 SP3 HSD17B8 HCG24 RPS18 HLA-DPB1 HLA-DPB2 COL11A2 GC06M032900
GH06J033287 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 +84.9 84880 3.1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF766 WDR46 PFDN6 MIR6834 TAPBP ZBTB22 KIFC1 PHF1 RPL35AP4 CUTA SYNGAP1
GH06J033198 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7 -3.6 -3636 4 MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 RXRB RNY4P10 GC06P033199 SLC39A7 DAXX BRD2 WDR46 RGL2 LEMD2 RPS18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSD17B8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSD17B8 gene promoter:
  • Sp1

Genomic Locations for HSD17B8 Gene

Genomic Locations for HSD17B8 Gene
2,195 bases
Plus strand
2,190 bases
Plus strand

Genomic View for HSD17B8 Gene

Genes around HSD17B8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD17B8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD17B8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSD17B8 Gene

  • Protein details for HSD17B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Estradiol 17-beta-dehydrogenase 8
    Protein Accession:
    Secondary Accessions:
    • A6NLX7
    • Q5STP7
    • Q9UIQ1

    Protein attributes for HSD17B8 Gene

    261 amino acids
    Molecular mass:
    26974 Da
    Quaternary structure:
    • Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.

    Three dimensional structures from OCA and Proteopedia for HSD17B8 Gene

neXtProt entry for HSD17B8 Gene

Post-translational modifications for HSD17B8 Gene

  • Ubiquitination at isoforms=173
  • Modification sites at PhosphoSitePlus

Other Protein References for HSD17B8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSD17B8 Gene

Domains & Families for HSD17B8 Gene

Gene Families for HSD17B8 Gene

Suggested Antigen Peptide Sequences for HSD17B8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD17B8: view

Function for HSD17B8 Gene

Molecular function for HSD17B8 Gene

UniProtKB/Swiss-Prot Function:
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).
UniProtKB/Swiss-Prot CatalyticActivity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
UniProtKB/Swiss-Prot CatalyticActivity:
Testosterone + NAD(+) = androstenedione + NADH.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estradiol.

Enzyme Numbers (IUBMB) for HSD17B8 Gene

Phenotypes From GWAS Catalog for HSD17B8 Gene

Gene Ontology (GO) - Molecular Function for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IDA 19571038
GO:0004303 estradiol 17-beta-dehydrogenase activity IDA 17978863
GO:0005515 protein binding IPI 19571038
GO:0016491 oxidoreductase activity IEA --
GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity IMP 25203508
genes like me logo Genes that share ontologies with HSD17B8: view
genes like me logo Genes that share phenotypes with HSD17B8: view

Animal Model Products

CRISPR Products

miRNA for HSD17B8 Gene

miRTarBase miRNAs that target HSD17B8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSD17B8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSD17B8 Gene

Localization for HSD17B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B8 Gene

Mitochondrion matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSD17B8 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005740 mitochondrial envelope IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSD17B8 Gene

Pathways & Interactions for HSD17B8 Gene

genes like me logo Genes that share pathways with HSD17B8: view

Pathways by source for HSD17B8 Gene

UniProtKB/Swiss-Prot Q92506-DHB8_HUMAN

  • Pathway: Steroid biosynthesis; estrogen biosynthesis.
  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IMP 25203508
GO:0006694 steroid biosynthetic process IEA --
GO:0006703 estrogen biosynthetic process IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

No data available for SIGNOR curated interactions for HSD17B8 Gene

Drugs & Compounds for HSD17B8 Gene

(8) Drugs for HSD17B8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estriol Approved, Investigational, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 22
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 594

(8) Additional Compounds for HSD17B8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11beta-Hydroxytestosterone
  • 11b-Hydroxytestosterone
  • 11β-hydroxytestosterone
  • 11b,17b-Dihydroxy-4-androsten-3-one
  • 11β,17β-dihydroxy-4-androsten-3-one
  • 11beta-Hydroxy-4-androstene-3,17-dione
  • 4-Androsten-11beta-ol-3,17-dione
  • Androst-4-ene-3,17-dione-11beta-ol
  • 11b-Hydroxy-4-androstene-3,17-dione
  • 11β-hydroxy-4-androstene-3,17-dione
  • 16 alpha OHE
  • 3,16alpha-Dihydroxy-1,3,5(10)-estratrien-17-one
  • 3,16alpha-Dihydroxyestra-1,3,5(10)-trien-17-one
  • Estra-1,3,5(10)-triene-3,16alpha-diol-17-one
  • 16 a OHE
  • (16beta)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
  • 16-Hydroxyestrone
  • 3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
  • 3,16beta-Dihydroxy-estra-1,3,5(10)-trien-17-one
  • (16b)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
Hydrogen Ion
  • H+
  • H(+)
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with HSD17B8: view

Transcripts for HSD17B8 Gene

mRNA/cDNA for HSD17B8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSD17B8 Gene

Hydroxysteroid (17-beta) dehydrogenase 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSD17B8

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B8 Gene

No ASD Table

Relevant External Links for HSD17B8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSD17B8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSD17B8 Gene

mRNA differential expression in normal tissues according to GTEx for HSD17B8 Gene

This gene is overexpressed in Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for HSD17B8 Gene

This gene is overexpressed in Liver (10.1) and Salivary gland (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSD17B8 Gene

Protein tissue co-expression partners for HSD17B8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSD17B8 Gene:


SOURCE GeneReport for Unigene cluster for HSD17B8 Gene:


mRNA Expression by UniProt/SwissProt for HSD17B8 Gene:

Tissue specificity: Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.

Evidence on tissue expression from TISSUES for HSD17B8 Gene

  • Liver(4.5)
  • Nervous system(4.2)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with HSD17B8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSD17B8 Gene

Orthologs for HSD17B8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD17B8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSD17B8 34 33
  • 99.62 (n)
(Canis familiaris)
Mammalia HSD17B8 34 33
  • 89.7 (n)
(Bos Taurus)
Mammalia HSD17B8 34 33
  • 88.93 (n)
(Mus musculus)
Mammalia H2-Ke6 16 34 33
  • 87.13 (n)
(Rattus norvegicus)
Mammalia Hsd17b8 33
  • 86.49 (n)
(Monodelphis domestica)
Mammalia HSD17B8 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b8 33
  • 60.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10316 33
(Danio rerio)
Actinopterygii hsd17b8 34 33
  • 60 (n)
fabgl 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14027 33
fruit fly
(Drosophila melanogaster)
Insecta CG3603 34 35 33
  • 55.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009633 33
  • 54.91 (n)
(Caenorhabditis elegans)
Secernentea dhs-25 34 33
  • 53.28 (n)
dhs-11 34
  • 43 (a)
(Oryza sativa)
Liliopsida Os04g0376300 33
  • 51.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
-- 34
  • 36 (a)
Species where no ortholog for HSD17B8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B8 Gene

Gene Tree for HSD17B8 (if available)
Gene Tree for HSD17B8 (if available)
Evolutionary constrained regions (ECRs) for HSD17B8: view image

Paralogs for HSD17B8 Gene

Paralogs for HSD17B8 Gene

(6) SIMAP similar genes for HSD17B8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSD17B8: view

Variants for HSD17B8 Gene

Sequence variations from dbSNP and Humsavar for HSD17B8 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_035844 A breast cancer sample p.Val158Leu
rs1000076425 -- 33,204,090(+) G/A upstream_transcript_variant
rs1000424042 -- 33,204,059(+) A/G upstream_transcript_variant
rs1002924466 -- 33,206,914(+) C/T downstream_transcript_variant
rs1003134062 -- 33,206,898(+) AA/AAA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSD17B8 Gene

Variant ID Type Subtype PubMed ID
dgv10609n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv522719 CNV loss 19592680
nsv830634 CNV loss 17160897

Variation tolerance for HSD17B8 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSD17B8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD17B8 Gene

Disorders for HSD17B8 Gene

Additional Disease Information for HSD17B8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HSD17B8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSD17B8 Gene

Publications for HSD17B8 Gene

  1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A … Inoko H (Genomics 1996) 2 3 4 22 58
  2. Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. (PMID: 18852215) Rotinen M … Villar J (The Journal of endocrinology 2009) 3 4 22 58
  3. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. (PMID: 17978863) Ohno S … Nakajin S (Molecular and cellular biochemistry 2008) 3 4 22 58
  4. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. (PMID: 25203508) Venkatesan R … Chen Z (Nature communications 2014) 3 4 58
  5. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J … Hall P (Breast cancer research : BCR 2010) 3 44 58

Products for HSD17B8 Gene

Sources for HSD17B8 Gene

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