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Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
HSD17B11 (Hydroxysteroid 17-Beta Dehydrogenase 11) is a Protein Coding gene. Diseases associated with HSD17B11 include Cutaneous T Cell Lymphoma and Lymphoma. Among its related pathways are Metabolism of steroid hormones and superpathway of steroid hormone biosynthesis. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and steroid dehydrogenase activity. An important paralog of this gene is HSD17B13.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004303 | estradiol 17-beta-dehydrogenase activity | TAS | -- |
GO:0016229 | steroid dehydrogenase activity | IDA | 12697717 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 12697717 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005811 | lipid droplet | IDA | 14741744 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of steroid hormones | ||
2 | Metabolism |
.40
|
|
3 | superpathway of steroid hormone biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006694 | steroid biosynthetic process | IEA | -- |
GO:0006703 | estrogen biosynthetic process | TAS | -- |
GO:0006710 | androgen catabolic process | IDA | 12697717 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Estradiol | Approved, Investigational, Vet_approved | Pharma | Sex hormone | 1113 | ||
Estrone | Approved | Pharma | Agonist | Estrogenic hormone | 22 | |
Testosterone | Approved, Experimental, Investigational | Pharma | Endogenous androgen receptor agonist | 660 | ||
Etiocholanolone | Experimental | Pharma | Target | 0 | ||
NAD | Experimental | Pharma | Agonist, Full agonist, Activator | 0 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HSD17B11 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HSD17B11 30 |
|
||
Cow (Bos Taurus) |
Mammalia | HSD17B11 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | HSD17B11 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hsd17b11 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hsd17b11 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | HSD17B11 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HSD17B11 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hsd17b11 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sdr16c5a 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15629 31 |
|
ManyToMany | |
CG9265 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | dhs-29 31 |
|
ManyToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
ManyToMany | |
TDA5 31 |
|
ManyToMany | |||
-- 33 |
|
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1410990 | CNV | deletion | 17803354 |
esv2000200 | CNV | deletion | 18987734 |
esv2057903 | CNV | deletion | 18987734 |
esv2559237 | CNV | deletion | 19546169 |
esv2665467 | CNV | deletion | 23128226 |
esv2727938 | CNV | deletion | 23290073 |
esv2727939 | CNV | deletion | 23290073 |
esv3564200 | CNV | deletion | 23714750 |
esv3564201 | CNV | deletion | 23714750 |
esv3601271 | CNV | loss | 21293372 |
esv3601274 | CNV | loss | 21293372 |
nsv1002789 | CNV | loss | 25217958 |
nsv1004518 | CNV | gain | 25217958 |
nsv1114550 | CNV | deletion | 24896259 |
nsv1114551 | CNV | deletion | 24896259 |
nsv293528 | CNV | deletion | 16902084 |
nsv436424 | CNV | deletion | 17901297 |
nsv4412 | CNV | deletion | 18451855 |
nsv499051 | CNV | loss | 21111241 |
nsv513144 | CNV | loss | 21212237 |
nsv951170 | CNV | deletion | 24416366 |
nsv956429 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cutaneous t cell lymphoma |
|
|
lymphoma |
|
|