Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009] See more...

Aliases for HSD17B11 Gene

Aliases for HSD17B11 Gene

  • Hydroxysteroid 17-Beta Dehydrogenase 11 2 3 5
  • Retinal Short-Chain Dehydrogenase/Reductase 2 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C Member 2 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-03 3 4
  • Dehydrogenase/Reductase SDR Family Member 8 3 4
  • Estradiol 17-Beta-Dehydrogenase 11 3 4
  • CTCL-Associated Antigen HD-CL-03 3 4
  • EC 1.1.1.62 4 52
  • SDR16C2 3 4
  • DHRS8 3 4
  • PAN1B 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 2 2
  • Dehydrogenase/Reductase (SDR Family) Member 8 2
  • 17-Beta-Hydroxysteroid Dehydrogenase Type XI 3
  • Hydroxysteroid (17-Beta) Dehydrogenase 11 2
  • 17-Beta-Hydroxysteroid Dehydrogenase 11 4
  • 17-Beta-Hydroxysteroid Dehydrogenase XI 4
  • CTCL Tumor Antigen HD-CL-03 3
  • 17-Beta-HSD 11 4
  • 17-Beta-HSD XI 4
  • 17-BETA-HSD11 3
  • 17-BETA-HSDXI 3
  • 17betaHSD11 4
  • 17betaHSDXI 4
  • 17BHSD11 3
  • 17bHSD11 4
  • EC 1.1.1 52
  • RETSDR2 3
  • RetSDR2 4

External Ids for HSD17B11 Gene

Previous HGNC Symbols for HSD17B11 Gene

  • DHRS8

Previous GeneCards Identifiers for HSD17B11 Gene

  • GC04M088477
  • GC04M088257
  • GC04M084003

Summaries for HSD17B11 Gene

Entrez Gene Summary for HSD17B11 Gene

  • Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

GeneCards Summary for HSD17B11 Gene

HSD17B11 (Hydroxysteroid 17-Beta Dehydrogenase 11) is a Protein Coding gene. Diseases associated with HSD17B11 include Cutaneous T Cell Lymphoma and Lymphoma. Among its related pathways are superpathway of steroid hormone biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and steroid dehydrogenase activity. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot Summary for HSD17B11 Gene

  • Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Gene Wiki entry for HSD17B11 Gene

Additional gene information for HSD17B11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSD17B11 Gene

Genomics for HSD17B11 Gene

GeneHancer (GH) Regulatory Elements for HSD17B11 Gene

Promoters and enhancers for HSD17B11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSD17B11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSD17B11

Top Transcription factor binding sites by QIAGEN in the HSD17B11 gene promoter:
  • AML1a
  • CREB
  • deltaCREB
  • FOXO1
  • FOXO1a
  • ISGF-3
  • PPAR-alpha
  • SRF
  • SRF (504 AA)
  • SRY

Genomic Locations for HSD17B11 Gene

Genomic Locations for HSD17B11 Gene
chr4:87,336,515-87,391,303
(GRCh38/hg38)
Size:
54,789 bases
Orientation:
Minus strand
chr4:88,257,691-88,312,538
(GRCh37/hg19)
Size:
54,848 bases
Orientation:
Minus strand

Genomic View for HSD17B11 Gene

Genes around HSD17B11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD17B11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD17B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD17B11 Gene

Proteins for HSD17B11 Gene

  • Protein details for HSD17B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBQ5-DHB11_HUMAN
    Recommended name:
    Estradiol 17-beta-dehydrogenase 11
    Protein Accession:
    Q8NBQ5
    Secondary Accessions:
    • Q96HF6
    • Q9UKU4

    Protein attributes for HSD17B11 Gene

    Size:
    300 amino acids
    Molecular mass:
    32936 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HSD17B11 Gene

neXtProt entry for HSD17B11 Gene

Selected DME Specific Peptides for HSD17B11 Gene

Q8NBQ5:
  • VLITGAG
  • VLITGAGHGIGRLTAYEFAK
  • TTKAFLP
  • VTVASAAGH
  • GDVSILVNNAGVVYT
  • NTGFIKNPST

Post-translational modifications for HSD17B11 Gene

  • Ubiquitination at Lys62
  • Modification sites at PhosphoSitePlus

Other Protein References for HSD17B11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HSD17B11 Gene

Gene Families for HSD17B11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HSD17B11 Gene

Blocks:
  • Short-chain dehydrogenase/reductase SDR
  • Glucose/ribitol dehydrogenase family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSD17B11 Gene

GenScript: Design optimal peptide antigens:
  • Retinal short-chain dehydrogenase/reductase 2 (DHB11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NBQ5

UniProtKB/Swiss-Prot:

DHB11_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
genes like me logo Genes that share domains with HSD17B11: view

Function for HSD17B11 Gene

Molecular function for HSD17B11 Gene

UniProtKB/Swiss-Prot Function:
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence=. ;.

Enzyme Numbers (IUBMB) for HSD17B11 Gene

Phenotypes From GWAS Catalog for HSD17B11 Gene

Gene Ontology (GO) - Molecular Function for HSD17B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004303 estradiol 17-beta-dehydrogenase activity TAS --
GO:0016229 steroid dehydrogenase activity IDA 12697717
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HSD17B11: view
genes like me logo Genes that share phenotypes with HSD17B11: view

Animal Models for HSD17B11 Gene

MGI Knock Outs for HSD17B11:

Animal Model Products

  • Taconic Biosciences Mouse Models for HSD17B11

CRISPR Products

miRNA for HSD17B11 Gene

miRTarBase miRNAs that target HSD17B11

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSD17B11 Gene

Localization for HSD17B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B11 Gene

Endoplasmic reticulum. Lipid droplet. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250 UniProtKB:Q9EQ06}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSD17B11 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSD17B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12697717
GO:0005783 endoplasmic reticulum IEA --
GO:0005811 lipid droplet IDA 14741744
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HSD17B11: view

Pathways & Interactions for HSD17B11 Gene

genes like me logo Genes that share pathways with HSD17B11: view

Pathways by source for HSD17B11 Gene

Gene Ontology (GO) - Biological Process for HSD17B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0006703 estrogen biosynthetic process TAS --
GO:0006710 androgen catabolic process IDA 12697717
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD17B11: view

No data available for SIGNOR curated interactions for HSD17B11 Gene

Drugs & Compounds for HSD17B11 Gene

(5) Drugs for HSD17B11 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1393
Estrone Approved Pharma Agonist Estrogenic hormone 23
Testosterone Approved, Experimental, Investigational Pharma Endogenous androgen receptor agonist 674
Etiocholanolone Experimental Pharma Target 0
NAD Experimental Pharma Full agonist, Agonist, Activator 0
genes like me logo Genes that share compounds with HSD17B11: view

Transcripts for HSD17B11 Gene

mRNA/cDNA for HSD17B11 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B11 Gene

No ASD Table

Relevant External Links for HSD17B11 Gene

GeneLoc Exon Structure for
HSD17B11

Expression for HSD17B11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSD17B11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSD17B11 Gene

This gene is overexpressed in Whole Blood (x7.8).

Protein differential expression in normal tissues from HIPED for HSD17B11 Gene

This gene is overexpressed in Fetal Liver (10.3), Nasal epithelium (8.5), and Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSD17B11 Gene



Protein tissue co-expression partners for HSD17B11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSD17B11

SOURCE GeneReport for Unigene cluster for HSD17B11 Gene:

Hs.594923

mRNA Expression by UniProt/SwissProt for HSD17B11 Gene:

Q8NBQ5-DHB11_HUMAN
Tissue specificity: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.

Evidence on tissue expression from TISSUES for HSD17B11 Gene

  • Liver(4.6)
  • Intestine(4.5)
  • Kidney(4.4)
  • Bone marrow(4.3)
  • Eye(4.2)
  • Nervous system(3.1)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with HSD17B11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HSD17B11 Gene

Orthologs for HSD17B11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSD17B11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSD17B11 31 30
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HSD17B11 30
  • 88.22 (n)
cow
(Bos Taurus)
Mammalia HSD17B11 31 30
  • 87.44 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSD17B11 31
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsd17b11 17 31 30
  • 78.97 (n)
rat
(Rattus norvegicus)
Mammalia Hsd17b11 30
  • 77.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HSD17B11 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSD17B11 30
  • 65.82 (n)
-- 31
  • 64 (a)
OneToMany
-- 31
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b11 30
  • 66.3 (n)
zebrafish
(Danio rerio)
Actinopterygii sdr16c5a 31
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15629 31
  • 32 (a)
ManyToMany
CG9265 31
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-29 31
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 31
  • 19 (a)
ManyToMany
TDA5 31
  • 17 (a)
ManyToMany
-- 33
Species where no ortholog for HSD17B11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B11 Gene

ENSEMBL:
Gene Tree for HSD17B11 (if available)
TreeFam:
Gene Tree for HSD17B11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSD17B11: view image

Paralogs for HSD17B11 Gene

(4) SIMAP similar genes for HSD17B11 Gene using alignment to 2 proteins:

  • DHB11_HUMAN
  • D6RCD0_HUMAN
genes like me logo Genes that share paralogs with HSD17B11: view

Variants for HSD17B11 Gene

Additional dbSNP identifiers (rs#s) for HSD17B11 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSD17B11 Gene

Variant ID Type Subtype PubMed ID
esv1410990 CNV deletion 17803354
esv2000200 CNV deletion 18987734
esv2057903 CNV deletion 18987734
esv2559237 CNV deletion 19546169
esv2665467 CNV deletion 23128226
esv2727938 CNV deletion 23290073
esv2727939 CNV deletion 23290073
esv3564200 CNV deletion 23714750
esv3564201 CNV deletion 23714750
esv3601271 CNV loss 21293372
esv3601274 CNV loss 21293372
nsv1002789 CNV loss 25217958
nsv1004518 CNV gain 25217958
nsv1114550 CNV deletion 24896259
nsv1114551 CNV deletion 24896259
nsv293528 CNV deletion 16902084
nsv436424 CNV deletion 17901297
nsv4412 CNV deletion 18451855
nsv499051 CNV loss 21111241
nsv513144 CNV loss 21212237
nsv951170 CNV deletion 24416366
nsv956429 CNV deletion 24416366

Variation tolerance for HSD17B11 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSD17B11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSD17B11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSD17B11 Gene

Disorders for HSD17B11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSD17B11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSD17B11

genes like me logo Genes that share disorders with HSD17B11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSD17B11 Gene

Publications for HSD17B11 Gene

  1. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. (PMID: 12697717) Chai Z … Krozowski Z (Endocrinology 2003) 2 3 4 23 54
  2. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. (PMID: 11165019) Brereton P … Krozowski Z (Molecular and cellular endocrinology 2001) 2 3 4 54
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 54
  4. 17beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer. (PMID: 19469652) Nakamura Y … Sasano H (Neoplasma 2009) 3 23 54
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54

Products for HSD17B11 Gene

Sources for HSD17B11 Gene