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Aliases for HSBP1L1 Gene
Aliases for HSBP1L1 Gene
External Ids for HSBP1L1 Gene
- HGNC: 37243
- Entrez Gene: 440498
- Ensembl: ENSG00000226742
- UniProtKB: C9JCN9
Previous GeneCards Identifiers for HSBP1L1 Gene
- GC18P077724
- GC18P074346
Summaries for HSBP1L1 Gene
GeneCards Summary for HSBP1L1 Gene
HSBP1L1 (Heat Shock Factor Binding Protein 1 Like 1) is a Protein Coding gene. An important paralog of this gene is HSBP1.
Additional gene information for HSBP1L1 Gene
- HGNC(37243)
- Entrez Gene(440498)
- Ensembl(ENSG00000226742)
- UniProtKB(C9JCN9)
- Open Targets Platform(ENSG00000226742)
- Search for HSBP1L1 at DataMed
- Search for HSBP1L1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSBP1L1 Gene
Genomics for HSBP1L1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HSBP1L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSBP1L1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSBP1L1
Genomic Locations for HSBP1L1 Gene
Genomic Locations for HSBP1L1 Gene
- chr18:79,964,582-79,970,822
- (GRCh38/hg38)
- Size:
- 6,241 bases
- Orientation:
- Plus strand
- chr18:77,724,561-77,730,822
- (GRCh37/hg19)
- Size:
- 6,262 bases
- Orientation:
- Plus strand
Genomic View for HSBP1L1 Gene
Genes around HSBP1L1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q23 by HGNC
- 18q23 by Entrez Gene
- 18q23 by Ensembl
HSBP1L1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSBP1L1 Gene
Proteins for HSBP1L1 Gene
-
Protein details for HSBP1L1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- C9JCN9-HSBPL_HUMAN
- Recommended name:
- Heat shock factor-binding protein 1-like protein 1
- Protein Accession:
- C9JCN9
- B2RXG9
Protein attributes for HSBP1L1 Gene
- Size:
- 74 amino acids
- Molecular mass:
- 8384 Da
- Quaternary structure:
- No Data Available
Protein Expression for HSBP1L1 Gene
Post-translational modifications for HSBP1L1 Gene
Other Protein References for HSBP1L1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HSBP1L1
- Invitrogen Antibodies for HSBP1L1 (AFLGC-HSBP1L1)
- antibodies-online: Show 10 available HSBP1L1 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for HSBP1L1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSBP1L1
- Origene Custom Protein Services for HSBP1L1
- Novus Biologicals proteins for HSBP1L1
- ProSpec Recombinant Proteins for HSBP1L1
No data available for DME Specific Peptides for HSBP1L1 Gene
Domains & Families for HSBP1L1 Gene
Gene Families for HSBP1L1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for HSBP1L1 Gene
- GenScript: Design optimal peptide antigens:
-
- Heat shock factor-binding protein 1-like protein 1 (HSBPL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
C9JCN9- Family:
-
- Belongs to the HSBP1 family.
Function for HSBP1L1 Gene
Phenotypes From GWAS Catalog for HSBP1L1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | IEA | -- |
Phenotypes for HSBP1L1 Gene
- MGI mutant phenotypes for HSBP1L1:
- inferred from 1 alleles
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSBP1L1 - Select products 50% OFF >
- * HSBP1L1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HSBP1L1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSBP1L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSBP1L1
miRNA for HSBP1L1 Gene
- miRTarBase miRNAs that target HSBP1L1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSBP1L1
- Browse OriGene Inhibitory RNA Products For HSBP1L1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1L1
Clone Products
- Applied Biological Materials (abm): Clones for HSBP1L1 - Select products 50% OFF >
- * HSBP1L1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HSBP1L1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSBP1L1
Cell Line Products
-
Horizon Cell Lines for HSBP1L1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSBP1L1 Gene
Localization for HSBP1L1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytosol | 3 |
| extracellular | 2 |
| plasma membrane | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSBP1L1 Gene
Pathways & Interactions for HSBP1L1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070370 | cellular heat acclimation | IBA | 21873635 |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HSBP1L1 Gene
Transcripts for HSBP1L1 Gene
mRNA/cDNA for HSBP1L1 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000451882 689 nts (view in UCSC)
- ENST00000587347 1057 nts (view in UCSC)
- ENST00000589516 800 nts (view in UCSC)
- ENST00000590571 775 nts (view in UCSC)
- ENST00000592352 564 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSBP1L1 - Select products 50% OFF >
- * HSBP1L1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HSBP1L1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSBP1L1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSBP1L1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSBP1L1
- Browse OriGene Inhibitory RNA Products For HSBP1L1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1L1
Clone Products
- Applied Biological Materials (abm): Clones for HSBP1L1 - Select products 50% OFF >
- * HSBP1L1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HSBP1L1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSBP1L1
Relevant External Links for HSBP1L1 Gene
- GeneLoc Exon Structure for
- HSBP1L1
Expression for HSBP1L1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
This gene is overexpressed in Cerebrospinal fluid (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSBP1L1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSBP1L1
SOURCE GeneReport for Unigene cluster for HSBP1L1 Gene:
Hs.191582Evidence on tissue expression from TISSUES for HSBP1L1 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for HSBP1L1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSBP1L1 Gene
Orthologs for HSBP1L1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | HSBP1L1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HSBP1L1 30 |
|
||
| Chimpanzee (Pan troglodytes) |
Mammalia | HSBP1L1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hsbp1l1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hsbp1l1 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HSBP1L1 31 |
|
OneToOne |
- Species where no ortholog for HSBP1L1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for HSBP1L1 Gene
- ENSEMBL:
- Gene Tree for HSBP1L1 (if available)
- TreeFam:
- Gene Tree for HSBP1L1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSBP1L1: view image
Paralogs for HSBP1L1 Gene
Variants for HSBP1L1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3412n100 | CNV | gain | 25217958 |
| esv3643326 | CNV | loss | 21293372 |
| esv3643327 | CNV | loss | 21293372 |
| nsv1061450 | CNV | gain | 25217958 |
| nsv1065902 | CNV | gain | 25217958 |
| nsv428359 | CNV | gain | 18775914 |
| nsv469607 | CNV | loss | 16826518 |
| nsv470437 | CNV | loss | 18288195 |
| nsv577953 | CNV | loss | 21841781 |
| nsv577958 | CNV | gain | 21841781 |
Gene Damage Index Score:
0.20;
4.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSBP1L1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HSBP1L1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSBP1L1 Gene
Disorders for HSBP1L1 Gene
Additional Disease Information for HSBP1L1
No disorders were found for HSBP1L1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1L1 Gene
Publications for HSBP1L1 Gene
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
- DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4
ExternalLinks
Products for HSBP1L1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HSBP1L1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSBP1L1
- Origene Custom Protein Services for HSBP1L1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HSBP1L1
- Browse OriGene Inhibitory RNA Products For HSBP1L1
- OriGene qPCR primer pairs for HSBP1L1
- OriGene CRISPR knockouts for HSBP1L1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HSBP1L1
- Sino Biological Human cDNA Clone for HSBP1L1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HSBP1L1
- Novus Biologicals proteins for HSBP1L1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder Custom and pre-made DNA vectors for HSBP1L1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HSBP1L1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HSBP1L1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HSBP1L1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HSBP1L1
- antibodies-online: Show 10 available HSBP1L1 Antibodies ranked by validation data
- antibodies-online: Search results for available HSBP1L1 related products ranked by validation data
- antibodies-online: Search results for available HSBP1L1 related products ranked by validation data
- Horizon Cell Lines for HSBP1L1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSBP1L1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSBP1L1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HSBP1L1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1L1
Sources for HSBP1L1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB