Aliases for HSBP1L1 Gene

Aliases for HSBP1L1 Gene

  • Heat Shock Factor Binding Protein 1 Like 1 2 3 5
  • Heat Shock Factor-Binding Protein 1-Like Protein 1 3 4
  • MGC189743 2
  • FLJ10967 2
  • HSBP1L1 5

External Ids for HSBP1L1 Gene

Previous GeneCards Identifiers for HSBP1L1 Gene

  • GC18P077724
  • GC18P074346

Summaries for HSBP1L1 Gene

GeneCards Summary for HSBP1L1 Gene

HSBP1L1 (Heat Shock Factor Binding Protein 1 Like 1) is a Protein Coding gene. An important paralog of this gene is HSBP1.

Additional gene information for HSBP1L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSBP1L1 Gene

Genomics for HSBP1L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSBP1L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSBP1L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSBP1L1

Genomic Locations for HSBP1L1 Gene

Genomic Locations for HSBP1L1 Gene
chr18:79,964,582-79,970,822
(GRCh38/hg38)
Size:
6,241 bases
Orientation:
Plus strand
chr18:77,724,561-77,730,822
(GRCh37/hg19)
Size:
6,262 bases
Orientation:
Plus strand

Genomic View for HSBP1L1 Gene

Genes around HSBP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSBP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSBP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSBP1L1 Gene

Proteins for HSBP1L1 Gene

  • Protein details for HSBP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JCN9-HSBPL_HUMAN
    Recommended name:
    Heat shock factor-binding protein 1-like protein 1
    Protein Accession:
    C9JCN9
    Secondary Accessions:
    • B2RXG9

    Protein attributes for HSBP1L1 Gene

    Size:
    74 amino acids
    Molecular mass:
    8384 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSBP1L1 Gene

Post-translational modifications for HSBP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSBP1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSBP1L1 Gene

Domains & Families for HSBP1L1 Gene

Gene Families for HSBP1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSBP1L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSBP1L1 Gene

GenScript: Design optimal peptide antigens:
  • Heat shock factor-binding protein 1-like protein 1 (HSBPL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

C9JCN9

UniProtKB/Swiss-Prot:

HSBPL_HUMAN :
  • Belongs to the HSBP1 family.
Family:
  • Belongs to the HSBP1 family.
genes like me logo Genes that share domains with HSBP1L1: view

Function for HSBP1L1 Gene

Phenotypes From GWAS Catalog for HSBP1L1 Gene

Gene Ontology (GO) - Molecular Function for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

Phenotypes for HSBP1L1 Gene

genes like me logo Genes that share phenotypes with HSBP1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1L1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSBP1L1 Gene

Localization for HSBP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSBP1L1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with HSBP1L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSBP1L1 Gene

Pathways & Interactions for HSBP1L1 Gene

PathCards logo

SuperPathways for HSBP1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSBP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070370 cellular heat acclimation IBA 21873635
GO:1903507 negative regulation of nucleic acid-templated transcription IEA --
genes like me logo Genes that share ontologies with HSBP1L1: view

No data available for Pathways by source and SIGNOR curated interactions for HSBP1L1 Gene

Drugs & Compounds for HSBP1L1 Gene

No Compound Related Data Available

Transcripts for HSBP1L1 Gene

mRNA/cDNA for HSBP1L1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1L1

Alternative Splicing Database (ASD) splice patterns (SP) for HSBP1L1 Gene

No ASD Table

Relevant External Links for HSBP1L1 Gene

GeneLoc Exon Structure for
HSBP1L1

Expression for HSBP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSBP1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSBP1L1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSBP1L1 Gene



Protein tissue co-expression partners for HSBP1L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSBP1L1

SOURCE GeneReport for Unigene cluster for HSBP1L1 Gene:

Hs.191582

Evidence on tissue expression from TISSUES for HSBP1L1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HSBP1L1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSBP1L1 Gene

Orthologs for HSBP1L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSBP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia HSBP1L1 30 31
  • 84.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HSBP1L1 30
  • 84.02 (n)
Chimpanzee
(Pan troglodytes)
Mammalia HSBP1L1 31
  • 84 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hsbp1l1 30
  • 82.13 (n)
Mouse
(Mus musculus)
Mammalia Hsbp1l1 30 17 31
  • 76.33 (n)
OneToOne
Chicken
(Gallus gallus)
Aves HSBP1L1 31
  • 51 (a)
OneToOne
Species where no ortholog for HSBP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for HSBP1L1 Gene

ENSEMBL:
Gene Tree for HSBP1L1 (if available)
TreeFam:
Gene Tree for HSBP1L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSBP1L1: view image

Paralogs for HSBP1L1 Gene

Paralogs for HSBP1L1 Gene

(1) SIMAP similar genes for HSBP1L1 Gene using alignment to 2 proteins:

  • HSBPL_HUMAN
  • K7ENV5_HUMAN
genes like me logo Genes that share paralogs with HSBP1L1: view

Variants for HSBP1L1 Gene

Additional dbSNP identifiers (rs#s) for HSBP1L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSBP1L1 Gene

Variant ID Type Subtype PubMed ID
dgv3412n100 CNV gain 25217958
esv3643326 CNV loss 21293372
esv3643327 CNV loss 21293372
nsv1061450 CNV gain 25217958
nsv1065902 CNV gain 25217958
nsv428359 CNV gain 18775914
nsv469607 CNV loss 16826518
nsv470437 CNV loss 18288195
nsv577953 CNV loss 21841781
nsv577958 CNV gain 21841781

Variation tolerance for HSBP1L1 Gene

Gene Damage Index Score: 0.20; 4.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSBP1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSBP1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSBP1L1 Gene

Disorders for HSBP1L1 Gene

No disorders were found for HSBP1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1L1 Gene

Publications for HSBP1L1 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4

Products for HSBP1L1 Gene

Sources for HSBP1L1 Gene