The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS respons... See more...
Aliases for HSBP1 Gene
Aliases for HSBP1 Gene
External Ids for HSBP1 Gene
- HGNC: 5203
- Entrez Gene: 3281
- Ensembl: ENSG00000230989
- OMIM: 604553
- UniProtKB: O75506
Previous GeneCards Identifiers for HSBP1 Gene
- GC16P074690
- GC16P084806
- GC16P083580
- GC16P083621
- GC16P082400
- GC16P083841
- GC16P069593
Summaries for HSBP1 Gene
-
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSBP1 Gene
HSBP1 (Heat Shock Factor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is HSBP1L1.
UniProtKB/Swiss-Prot Summary for HSBP1 Gene
-
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Additional gene information for HSBP1 Gene
- Monarch Initiative
- Search for HSBP1 at DataMed
- Search for HSBP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSBP1 Gene
Genomics for HSBP1 Gene
GeneHancer (GH) Regulatory Elements for HSBP1 Gene
Promoters and enhancers for HSBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HSBP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HSBP1 gene promoter:
-
- AREB6
- Bach1
- COMP1
- GATA-1
- HSF2
- IRF-7A
- LCR-F1
- p53
- Pax-6
- STAT3
Genomic Locations for HSBP1 Gene
Genomic Locations for HSBP1 Gene
- chr16:83,807,843-83,819,737
- (GRCh38/hg38)
- Size:
- 11,895 bases
- Orientation:
- Plus strand
- chr16:83,841,448-83,853,342
- (GRCh37/hg19)
- Size:
- 11,895 bases
- Orientation:
- Plus strand
Genomic View for HSBP1 Gene
Genes around HSBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q23.3 by HGNC
- 16q23.3 by Entrez Gene
- 16q23.3 by Ensembl
HSBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSBP1 Gene
Proteins for HSBP1 Gene
-
Protein details for HSBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75506-HSBP1_HUMAN
- Recommended name:
- Heat shock factor-binding protein 1
- Protein Accession:
- O75506
- Q53XA8
- Q7Z5Z3
Protein attributes for HSBP1 Gene
- Size:
- 76 amino acids
- Molecular mass:
- 8544 Da
- Quaternary structure:
-
- Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.
Protein Expression for HSBP1 Gene
Post-translational modifications for HSBP1 Gene
Other Protein References for HSBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HSBP1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for HSBP1
- Novus Biologicals Antibodies for HSBP1
-
Abcam antibodies for HSBP1
- Invitrogen Antibodies for HSBP1 (AFLGC-HSBP1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSBP1
Protein Products
-
OriGene Purified Proteins for HSBP1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSBP1
- Origene Custom Protein Services for HSBP1
- Novus Biologicals proteins for HSBP1
- ProSpec Recombinant Proteins for HSBP1
-
Abcam proteins for HSBP1
Assay Products
- antibodies-online: Show 7 available HSBP1 Elisa Kits ranked by validation data
- Compare Top HSBP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for HSBP1 Gene
Domains & Families for HSBP1 Gene
Gene Families for HSBP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for HSBP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Nasopharyngeal carcinoma-associated antigen 13 (HSBP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75506- Family:
-
- Belongs to the HSBP1 family.
Function for HSBP1 Gene
Molecular function for HSBP1 Gene
- UniProtKB/Swiss-Prot Function:
- Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Phenotypes From GWAS Catalog for HSBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003714 | transcription corepressor activity | IEA,TAS | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0042802 | identical protein binding | IPI | 25416956 |
Phenotypes for HSBP1 Gene
- MGI mutant phenotypes for HSBP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HSBP1:
Animal Models for HSBP1 Gene
- MGI Knock Outs for HSBP1:
-
- Hsbp1 Hsbp1<tm1Miv>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSBP1 - Select products 50% OFF >
- * HSBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HSBP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for HSBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSBP1
- genomics-online: gRNA clones - Search for available HSBP1 gRNA products
- Overview of 153 available HSBP1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSBP1
miRNA for HSBP1 Gene
- miRTarBase miRNAs that target HSBP1
-
- hsa-mir-8081 (MIRT444632)
- hsa-mir-627-5p (MIRT444633)
- hsa-mir-937-5p (MIRT444634)
- hsa-mir-924 (MIRT444635)
- hsa-mir-142-3p (MIRT444636)
- hsa-mir-4255 (MIRT444637)
- hsa-mir-5582-3p (MIRT444638)
- hsa-mir-548x-3p (MIRT444639)
- hsa-mir-548j-3p (MIRT444640)
- hsa-mir-548aq-3p (MIRT444641)
- hsa-mir-548am-3p (MIRT444642)
- hsa-mir-548aj-3p (MIRT444643)
- hsa-mir-548ah-3p (MIRT444644)
- hsa-mir-548ae-3p (MIRT444645)
- hsa-mir-548z (MIRT444646)
- hsa-mir-548h-3p (MIRT444647)
- hsa-mir-548d-3p (MIRT444648)
- hsa-mir-548bb-3p (MIRT444649)
- hsa-mir-548ac (MIRT444650)
- hsa-mir-466 (MIRT542897)
- hsa-mir-934 (MIRT542898)
- hsa-mir-3618 (MIRT542899)
- hsa-mir-5699-3p (MIRT542900)
- hsa-mir-5689 (MIRT542901)
- hsa-mir-4421 (MIRT542902)
- hsa-mir-1-5p (MIRT542903)
- hsa-mir-5692c (MIRT542904)
- hsa-mir-5692b (MIRT542905)
- hsa-mir-369-3p (MIRT542906)
- hsa-mir-3163 (MIRT542907)
- hsa-mir-1244 (MIRT542908)
- hsa-mir-4789-3p (MIRT542909)
- hsa-mir-4643 (MIRT542910)
- hsa-mir-1277-5p (MIRT542911)
- hsa-mir-649 (MIRT542912)
- hsa-mir-548ay-3p (MIRT542913)
- hsa-mir-548at-3p (MIRT542914)
- hsa-mir-548as-3p (MIRT542915)
- hsa-mir-548t-3p (MIRT542916)
- hsa-mir-548ap-3p (MIRT542917)
- hsa-mir-548aa (MIRT542918)
- hsa-mir-374b-5p (MIRT542919)
- hsa-mir-374a-5p (MIRT542920)
- hsa-mir-4678 (MIRT709015)
- hsa-mir-452-3p (MIRT709016)
- hsa-mir-3157-5p (MIRT709017)
- hsa-mir-4742-3p (MIRT709018)
- hsa-mir-5685 (MIRT709019)
- hsa-mir-4690-3p (MIRT709020)
- hsa-mir-4687-5p (MIRT709021)
- hsa-mir-1227-3p (MIRT783167)
- hsa-mir-1273g-3p (MIRT783332)
- hsa-mir-1285-3p (MIRT783373)
- hsa-mir-196a-3p (MIRT784060)
- hsa-mir-3187-5p (MIRT784760)
- hsa-mir-4252 (MIRT785531)
- hsa-mir-4793-3p (MIRT786793)
- hsa-mir-508-5p (MIRT787055)
- hsa-mir-5189-5p (MIRT787190)
- hsa-mir-612 (MIRT788070)
- hsa-mir-6512-3p (MIRT788295)
- hsa-mir-661 (MIRT788409)
- hsa-mir-6720-5p (MIRT788457)
- hsa-mir-6790-3p (MIRT788741)
- hsa-mir-6849-3p (MIRT789065)
- hsa-mir-6860 (MIRT789108)
- hsa-mir-6889-3p (MIRT789334)
- hsa-mir-766-3p (MIRT789520)
- hsa-mir-769-5p (MIRT789537)
- hsa-mir-7703 (MIRT789543)
- hsa-mir-939-3p (MIRT789986)
- hsa-mir-943 (MIRT790010)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HSBP1
- Browse OriGene Inhibitory RNA Products For HSBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1
- genomics-online: shRNA clones - Search for available HSBP1 shRNA products
- Overview of 153 available HSBP1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HSBP1 - Select products 50% OFF >
- * HSBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HSBP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for HSBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSBP1
- genomics-online: cdna clones - Search for available HSBP1 CDNA products
- Overview of 153 available HSBP1 gene related products
- orf clones - Search for available HSBP1 ORF products
- Overview of 153 available HSBP1 gene related products
Cell Line Products
-
Horizon Cell Lines for HSBP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSBP1 Gene
Localization for HSBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSBP1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 2 |
| extracellular | 0 |
| mitochondrion | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | IBA | 21873635 |
| GO:0005856 | cytoskeleton | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSBP1 Gene
Pathways & Interactions for HSBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HSF1-dependent transactivation | ||
| 2 | Cellular response to heat stress |
.01
|
|
| 3 | Cellular Senescence (REACTOME) | ||
Pathways by source for HSBP1 Gene
5 Reactome pathways for HSBP1 Gene
Interacting Proteins for HSBP1 Gene
Selected Interacting proteins:
O75506-HSBP1_HUMAN
ENSP00000392896
for HSBP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HSBP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 9649501 |
| GO:0006936 | muscle contraction | IEA | -- |
| GO:0035987 | endodermal cell differentiation | IEA | -- |
| GO:0070370 | cellular heat acclimation | IBA | 21873635 |
| GO:1900034 | regulation of cellular response to heat | TAS | -- |
No data available for SIGNOR curated interactions for HSBP1 Gene
Transcripts for HSBP1 Gene
mRNA/cDNA for HSBP1 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (750) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000433866 8784 bps (ENST00000433866.6)
- ENST00000570259 1020 bps (ENST00000570259.1)
- ENST00000567382 889 bps (ENST00000567382.1)
- ENST00000569301 551 bps (ENST00000569301.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HSBP1 - Select products 50% OFF >
- * HSBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HSBP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for HSBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSBP1
- genomics-online: gRNA clones - Search for available HSBP1 gRNA products
- Overview of 153 available HSBP1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSBP1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HSBP1
- Browse OriGene Inhibitory RNA Products For HSBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1
- genomics-online: shRNA clones - Search for available HSBP1 shRNA products
- Overview of 153 available HSBP1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for HSBP1 - Select products 50% OFF >
- * HSBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HSBP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for HSBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSBP1
- genomics-online: cdna clones - Search for available HSBP1 CDNA products
- Overview of 153 available HSBP1 gene related products
- orf clones - Search for available HSBP1 ORF products
- Overview of 153 available HSBP1 gene related products
Expression for HSBP1 Gene
This gene is overexpressed in Nasal epithelium (23.3), Amniocyte (19.4), and Heart (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSBP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HSBP1 Gene:
HSBP1SOURCE GeneReport for Unigene cluster for HSBP1 Gene:
Hs.250899Evidence on tissue expression from TISSUES for HSBP1 Gene
- Nervous system(5)
- Muscle(4.3)
- Lung(3.6)
- Blood(3.1)
- Kidney(2.9)
- Eye(2.7)
- Liver(2.7)
- Heart(2.6)
- Intestine(2.5)
Primer Products
-
OriGene qPCR primer pairs for HSBP1
-
OriGene qPCR primer pairs and template standards for HSBP1
- genomics-online: primer clones - Search for available HSBP1 Primer products
- Overview of 153 available HSBP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSBP1 Gene
Orthologs for HSBP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HSBP1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | HSBP1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HSBP1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hsbp1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hsbp1 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HSBP1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HSBP1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HSBP1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hsbp1 32 |
|
||
| Str.15318 32 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hsbp1a 32 |
|
||
| HSBP1 33 |
|
OneToOne | |||
| zgc73224 32 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4434 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5446 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | hsb-1 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5786 33 |
|
OneToOne |
- Species where no ortholog for HSBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for HSBP1 Gene
- ENSEMBL:
- Gene Tree for HSBP1 (if available)
- TreeFam:
- Gene Tree for HSBP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HSBP1: view image
Paralogs for HSBP1 Gene
(1) SIMAP similar genes for HSBP1 Gene using alignment to 2 proteins:
- HSBP1_HUMAN
- H3BR28_HUMAN
Pseudogenes.org Pseudogenes for HSBP1 Gene
Variants for HSBP1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000119018 | -- | 83,814,234(+) | C/A/T | 3_prime_UTR_variant | |
| rs1000173691 | -- | 83,817,196(+) | T/C/G | 3_prime_UTR_variant | |
| rs1000238678 | -- | 83,814,466(+) | A/G | 3_prime_UTR_variant | |
| rs1000719161 | -- | 83,813,281(+) | C/G | 3_prime_UTR_variant | |
| rs1000739928 | -- | 83,808,322(+) | C/A | intron_variant |
Residual Variation Intolerance Score:
68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.27;
6.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HSBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HSBP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSBP1 Gene
Disorders for HSBP1 Gene
Additional Disease Information for HSBP1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for HSBP1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1 Gene
Publications for HSBP1 Gene
- Crystal structure of the hexamer of human heat shock factor binding protein 1. (PMID: 18767159) Liu X … Rao Z (Proteins 2009) 3 4 23 56
- Negative regulation of the heat shock transcriptional response by HSBP1. (PMID: 9649501) Satyal SH … Morimoto RI (Genes & development 1998) 2 3 4 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
- The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. (PMID: 9493008) Morimoto RI … Cotto JJ (Essays in biochemistry 1997) 2 3 56
- Nucleotide exchange factors Fes1 and HspBP1 mimic substrate to release misfolded proteins from Hsp70. (PMID: 29323280) Gowda NKC … Andréasson C (Nature structural & molecular biology 2018) 3 56
ExternalLinks
Products for HSBP1 Gene
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- Browse OriGene Inhibitory RNA Products For HSBP1
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- antibodies-online: Show 10 available HSBP1 Antibodies ranked by validation data
- Compare Top HSBP1 Antibodies
- antibodies-online: Show 7 available HSBP1 Elisa Kits ranked by validation data
- Compare Top HSBP1 Elisa Kits
- Quality Products:
- antibodies-online: Show 13 available HSBP1 Proteins ranked by validation data
- Compare Top HSBP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for HSBP1
- Search Santa Cruz Biotechnology (SCBT) for HSBP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HSBP1
- Horizon Cell Lines for HSBP1
- genomics-online: cdna clones - Search for available HSBP1 CDNA products
- Overview of 153 available HSBP1 gene related products
- orf clones - Search for available HSBP1 ORF products
- Overview of 153 available HSBP1 gene related products
- genomics-online: gRNA clones - Search for available HSBP1 gRNA products
- Overview of 153 available HSBP1 gene related products
- genomics-online: primer clones - Search for available HSBP1 Primer products
- Overview of 153 available HSBP1 gene related products
- genomics-online: shRNA clones - Search for available HSBP1 shRNA products
- Overview of 153 available HSBP1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HSBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HSBP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HSBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1
Sources for HSBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource