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The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
HSBP1 (Heat Shock Factor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and HSF1-dependent transactivation. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is HSBP1L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003714 | transcription corepressor activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO:0042802 | identical protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | IBA | 21873635 |
GO:0005856 | cytoskeleton | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HSF1-dependent transactivation | ||
2 | Cellular response to heat stress |
.01
|
|
3 | Cellular Senescence (REACTOME) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | 9649501 |
GO:0006936 | muscle contraction | IEA | -- |
GO:0035987 | endodermal cell differentiation | IEA | -- |
GO:0070370 | cellular heat acclimation | IBA | 21873635 |
GO:1900034 | regulation of cellular response to heat | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HSBP1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | HSBP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HSBP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hsbp1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hsbp1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | HSBP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HSBP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HSBP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hsbp1 30 |
|
||
Str.15318 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | hsbp1a 30 |
|
||
HSBP1 31 |
|
OneToOne | |||
zgc73224 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4434 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5446 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | hsb-1 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5786 31 |
|
OneToOne |
No disorders were found for HSBP1 Gene.