The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS respons... See more...

Aliases for HSBP1 Gene

Aliases for HSBP1 Gene

  • Heat Shock Factor Binding Protein 1 2 3 5
  • Nasopharyngeal Carcinoma-Associated Antigen 13 3 4
  • Heat Shock Factor-Binding Protein 1 3 4
  • NPC-A-13 3 4
  • HSF1BP 4
  • HSBP1 5

External Ids for HSBP1 Gene

Previous GeneCards Identifiers for HSBP1 Gene

  • GC16P074690
  • GC16P084806
  • GC16P083580
  • GC16P083621
  • GC16P082400
  • GC16P083841
  • GC16P069593

Summaries for HSBP1 Gene

Entrez Gene Summary for HSBP1 Gene

  • The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSBP1 Gene

HSBP1 (Heat Shock Factor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and HSF1-dependent transactivation. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is HSBP1L1.

UniProtKB/Swiss-Prot Summary for HSBP1 Gene

  • Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HSBP1 Gene

Genomics for HSBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HSBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J083803 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -1.2 -1150 5.9 BRCA1 ARHGAP35 CREB1 GATAD2A PRDM10 TFE3 SIX5 IKZF1 NFKBIZ POLR2A ENSG00000260228 HSBP1 lnc-HSBP1-1 piR-47675-051 lnc-CDH13-1 LOC102724163
GH16J084498 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.9 +695.0 694965 8.4 SP1 HNRNPL CREB1 CTCF PRDM10 RFX1 ZNF692 FOS TARDBP JUND MEAK7 lnc-COTL1-1 ATP2C2-AS1 HSBP1 HSALNG0113141 ENSG00000261243 ATP2C2
GH16J083778 Enhancer 0.6 Ensembl 11.7 -28.2 -28177 2.8 FOXA1 ZXDB FOXA2 OSR2 GATA3 RCOR1 NFIB FEZF1 NFIA ZNF398 RF00004-051 piR-43107-113 HSBP1 ENSG00000260228 ENSG00000260788 piR-38351-207
GH16J083838 Enhancer 1 Ensembl ENCODE dbSUPER 6 +37.1 37084 12.5 RNF2 TEAD4 ZBTB20 ZNF316 MAFF USF1 MAFK YY1 POLR2A CEBPG LOC102724163 MLYCD OSGIN1 HSBP1 ENSG00000260228 lnc-SLC38A8-10 lnc-HSBP1-1
GH16J083773 Enhancer 0.3 Ensembl 11.7 -34.1 -34077 2.2 ZNF48 ENSG00000260788 HSBP1 ENSG00000260228 RF00004-051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HSBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HSBP1

Top Transcription factor binding sites by QIAGEN in the HSBP1 gene promoter:
  • AREB6
  • Bach1
  • COMP1
  • GATA-1
  • HSF2
  • IRF-7A
  • LCR-F1
  • p53
  • Pax-6
  • STAT3

Genomic Locations for HSBP1 Gene

Genomic Locations for HSBP1 Gene
chr16:83,807,978-83,819,737
(GRCh38/hg38)
Size:
11,760 bases
Orientation:
Plus strand
chr16:83,841,448-83,853,342
(GRCh37/hg19)
Size:
11,895 bases
Orientation:
Plus strand

Genomic View for HSBP1 Gene

Genes around HSBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSBP1 Gene

Proteins for HSBP1 Gene

  • Protein details for HSBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75506-HSBP1_HUMAN
    Recommended name:
    Heat shock factor-binding protein 1
    Protein Accession:
    O75506
    Secondary Accessions:
    • Q53XA8
    • Q7Z5Z3

    Protein attributes for HSBP1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8544 Da
    Quaternary structure:
    • Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.

    Three dimensional structures from OCA and Proteopedia for HSBP1 Gene

neXtProt entry for HSBP1 Gene

Post-translational modifications for HSBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HSBP1
  • Santa Cruz Biotechnology (SCBT) Antibodies for HSBP1

No data available for DME Specific Peptides for HSBP1 Gene

Domains & Families for HSBP1 Gene

Gene Families for HSBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSBP1 Gene

GenScript: Design optimal peptide antigens:
  • Nasopharyngeal carcinoma-associated antigen 13 (HSBP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75506

UniProtKB/Swiss-Prot:

HSBP1_HUMAN :
  • Belongs to the HSBP1 family.
Family:
  • Belongs to the HSBP1 family.
genes like me logo Genes that share domains with HSBP1: view

Function for HSBP1 Gene

Molecular function for HSBP1 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Phenotypes From GWAS Catalog for HSBP1 Gene

Gene Ontology (GO) - Molecular Function for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with HSBP1: view
genes like me logo Genes that share phenotypes with HSBP1: view

Animal Models for HSBP1 Gene

MGI Knock Outs for HSBP1:

Animal Model Products

CRISPR Products

miRNA for HSBP1 Gene

miRTarBase miRNAs that target HSBP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSBP1 Gene

Localization for HSBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSBP1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with HSBP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSBP1 Gene

Pathways & Interactions for HSBP1 Gene

genes like me logo Genes that share pathways with HSBP1: view

SIGNOR curated interactions for HSBP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 9649501
GO:0006936 muscle contraction IEA --
GO:0035987 endodermal cell differentiation IEA --
GO:0070370 cellular heat acclimation IBA 21873635
GO:1900034 regulation of cellular response to heat TAS --
genes like me logo Genes that share ontologies with HSBP1: view

Drugs & Compounds for HSBP1 Gene

No Compound Related Data Available

Transcripts for HSBP1 Gene

mRNA/cDNA for HSBP1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HSBP1

Alternative Splicing Database (ASD) splice patterns (SP) for HSBP1 Gene

No ASD Table

Relevant External Links for HSBP1 Gene

GeneLoc Exon Structure for
HSBP1

Expression for HSBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSBP1 Gene

Protein differential expression in normal tissues from HIPED for HSBP1 Gene

This gene is overexpressed in Nasal epithelium (23.3), Amniocyte (19.4), and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HSBP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HSBP1

SOURCE GeneReport for Unigene cluster for HSBP1 Gene:

Hs.250899

Evidence on tissue expression from TISSUES for HSBP1 Gene

  • Nervous system(5)
  • Blood(4.7)
  • Muscle(4.4)
  • Lung(3.6)
  • Kidney(3.2)
  • Heart(2.9)
  • Liver(2.9)
  • Intestine(2.8)
  • Eye(2.7)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with HSBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSBP1 Gene

Orthologs for HSBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HSBP1 30 31
  • 99.56 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
-- 31
  • 88 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
-- 31
  • 82 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia HSBP1 30 31
  • 90.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HSBP1 30 31
  • 89.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hsbp1 30 17 31
  • 85.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hsbp1 30
  • 82.46 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia HSBP1 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HSBP1 30 31
  • 80.37 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HSBP1 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hsbp1 30
  • 82.13 (n)
Str.15318 30
Zebrafish
(Danio rerio)
Actinopterygii hsbp1a 30
  • 75.85 (n)
HSBP1 31
  • 30 (a)
OneToOne
zgc73224 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4434 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5446 31
  • 52 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea hsb-1 31
  • 46 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5786 31
  • 66 (a)
OneToOne
Species where no ortholog for HSBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HSBP1 Gene

ENSEMBL:
Gene Tree for HSBP1 (if available)
TreeFam:
Gene Tree for HSBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HSBP1: view image

Paralogs for HSBP1 Gene

Paralogs for HSBP1 Gene

(1) SIMAP similar genes for HSBP1 Gene using alignment to 2 proteins:

  • HSBP1_HUMAN
  • H3BR28_HUMAN

Pseudogenes.org Pseudogenes for HSBP1 Gene

genes like me logo Genes that share paralogs with HSBP1: view

Variants for HSBP1 Gene

Additional dbSNP identifiers (rs#s) for HSBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSBP1 Gene

Variant ID Type Subtype PubMed ID
dgv3054n100 CNV gain 25217958
nsv1064977 CNV loss 25217958
nsv1907 CNV insertion 18451855
nsv573398 CNV gain 21841781
nsv573401 CNV gain 21841781
nsv573405 CNV gain 21841781
nsv833308 CNV loss 17160897

Variation tolerance for HSBP1 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSBP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HSBP1 Gene

Disorders for HSBP1 Gene

Additional Disease Information for HSBP1

No disorders were found for HSBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSBP1 Gene

Publications for HSBP1 Gene

  1. Crystal structure of the hexamer of human heat shock factor binding protein 1. (PMID: 18767159) Liu X … Rao Z (Proteins 2009) 3 4 23
  2. Negative regulation of the heat shock transcriptional response by HSBP1. (PMID: 9649501) Satyal SH … Morimoto RI (Genes & development 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. (PMID: 9493008) Morimoto RI … Cotto JJ (Essays in biochemistry 1997) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for HSBP1 Gene

  • Signalway Proteins for HSBP1

Sources for HSBP1 Gene