Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008] See more...

Aliases for HS6ST3 Gene

Aliases for HS6ST3 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 3 2 3 5
  • Heparan-Sulfate 6-O-Sulfotransferase 3 3 4
  • HS6ST-3 3 4
  • EC 2.8.2.- 4
  • EC 2.8.2 52

External Ids for HS6ST3 Gene

Previous GeneCards Identifiers for HS6ST3 Gene

  • GC00U991292
  • GC13P091871
  • GC13P095579
  • GC13P095183
  • GC13P094441
  • GC13P095541
  • GC13P096743

Summaries for HS6ST3 Gene

Entrez Gene Summary for HS6ST3 Gene

  • Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HS6ST3 Gene

HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3) is a Protein Coding gene. Diseases associated with HS6ST3 include Omodysplasia and Cantu Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST2.

UniProtKB/Swiss-Prot Summary for HS6ST3 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Additional gene information for HS6ST3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HS6ST3 Gene

Genomics for HS6ST3 Gene

GeneHancer (GH) Regulatory Elements for HS6ST3 Gene

Promoters and enhancers for HS6ST3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J096089 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 364 2.2 ZIC2 ZBTB26 EZH2 ZNF341 KLF9 WT1 SMC3 SP2 ZBTB17 ZNF263 HS6ST3 HSALNG0098757 UGGT2 piR-43105-148
GH13J095999 Enhancer 0.6 Ensembl ENCODE 15.1 -90.3 -90303 1.2 ATF2 POU5F1 NANOG MAX SCRT2 HS6ST3 UGGT2 piR-38351-141 lnc-DZIP1-9
GH13J096002 Enhancer 0.4 Ensembl 16.5 -87.7 -87735 2 CTCF SMC3 RAD21 ZNF577 HS6ST3 UGGT2 piR-38351-141 lnc-DZIP1-9
GH13J096034 Enhancer 0.4 Ensembl ENCODE 15.2 -55.6 -55602 1.1 ZNF680 piR-38351-142 HS6ST3 lnc-HS6ST3-1 UGGT2
GH13J096024 Enhancer 0.4 Ensembl 16.7 -64.9 -64935 1.6 FOS GATA2 JUN HS6ST3 lnc-HS6ST3-1 piR-38351-142 UGGT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HS6ST3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HS6ST3

Top Transcription factor binding sites by QIAGEN in the HS6ST3 gene promoter:
  • AML1a
  • AP-1
  • AP-4
  • AREB6
  • Cdc5
  • Evi-1
  • Gfi-1
  • IRF-1

Genomic Locations for HS6ST3 Gene

Genomic Locations for HS6ST3 Gene
chr13:96,090,536-96,839,562
(GRCh38/hg38)
Size:
749,027 bases
Orientation:
Plus strand
chr13:96,743,093-97,491,812
(GRCh37/hg19)
Size:
748,720 bases
Orientation:
Plus strand

Genomic View for HS6ST3 Gene

Genes around HS6ST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS6ST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS6ST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST3 Gene

Proteins for HS6ST3 Gene

  • Protein details for HS6ST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZP7-H6ST3_HUMAN
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 3
    Protein Accession:
    Q8IZP7
    Secondary Accessions:
    • Q5W0L0
    • Q68CW6

    Protein attributes for HS6ST3 Gene

    Size:
    471 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS6ST3 Gene

Selected DME Specific Peptides for HS6ST3 Gene

Q8IZP7:
  • CDGRSPT
  • LFERTFNLKFI
  • HVQRGATWKTSLHMCDGR
  • WLFSRFSTGWSCGLHADWTELTNCVP
  • FISPFTQ
  • GQKKCTC
  • LRDPVSRYLSEW
  • IVFLHIQKTGGTTFGRHLV
  • MAFFGLTE
  • DLFQQRY

Post-translational modifications for HS6ST3 Gene

  • Glycosylation at Asn117, Asn128, Asn231, Asn324, Asn329, and Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for HS6ST3 Gene

Domains & Families for HS6ST3 Gene

Gene Families for HS6ST3 Gene

Protein Domains for HS6ST3 Gene

Suggested Antigen Peptide Sequences for HS6ST3 Gene

GenScript: Design optimal peptide antigens:
  • Heparan-sulfate 6-O-sulfotransferase 3 (H6ST3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZP7

UniProtKB/Swiss-Prot:

H6ST3_HUMAN :
  • Belongs to the sulfotransferase 6 family.
Family:
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST3: view

Function for HS6ST3 Gene

Molecular function for HS6ST3 Gene

UniProtKB/Swiss-Prot Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:56604, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:14621, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:140604;.

Enzyme Numbers (IUBMB) for HS6ST3 Gene

Phenotypes From GWAS Catalog for HS6ST3 Gene

Gene Ontology (GO) - Molecular Function for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0017095 heparan sulfate 6-O-sulfotransferase activity IBA,IEA 21873635
genes like me logo Genes that share ontologies with HS6ST3: view
genes like me logo Genes that share phenotypes with HS6ST3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HS6ST3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS6ST3 Gene

Localization for HS6ST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS6ST3 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

Pathways & Interactions for HS6ST3 Gene

genes like me logo Genes that share pathways with HS6ST3: view

Interacting Proteins for HS6ST3 Gene

;

Gene Ontology (GO) - Biological Process for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IEA,IBA 21873635
genes like me logo Genes that share ontologies with HS6ST3: view

No data available for SIGNOR curated interactions for HS6ST3 Gene

Drugs & Compounds for HS6ST3 Gene

(2) Additional Compounds for HS6ST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoadenylate
  • Adenosine 3',5'-bisphosphate
  • PAP
  • Phosphoadenosine phosphate
  • 3'-Phosphoadenylic acid
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenylyl sulfate
  • PAPS
  • 3'-Phosphoadenosine 5'-phosphosulfuric acid
  • 3'-Phosphoadenosine 5'-phosphosulphate
482-67-7
genes like me logo Genes that share compounds with HS6ST3: view

Transcripts for HS6ST3 Gene

mRNA/cDNA for HS6ST3 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HS6ST3

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST3 Gene

No ASD Table

Relevant External Links for HS6ST3 Gene

GeneLoc Exon Structure for
HS6ST3

Expression for HS6ST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HS6ST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.0), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for HS6ST3 Gene

This gene is overexpressed in Placenta (50.2) and Gallbladder (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS6ST3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HS6ST3

SOURCE GeneReport for Unigene cluster for HS6ST3 Gene:

Hs.171001

Evidence on tissue expression from TISSUES for HS6ST3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with HS6ST3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HS6ST3 Gene

Orthologs for HS6ST3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS6ST3 31 30
  • 99.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HS6ST3 31 30
  • 90.02 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs6st3 30
  • 89.91 (n)
mouse
(Mus musculus)
Mammalia Hs6st3 17 31 30
  • 89.15 (n)
dog
(Canis familiaris)
Mammalia HS6ST3 31
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HS6ST3 31 30
  • 78.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HS6ST3 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st3 30
  • 72.02 (n)
zebrafish
(Danio rerio)
Actinopterygii hs6st3b 31 30
  • 68.61 (n)
OneToMany
hs6st3a 31
  • 62 (a)
OneToMany
-- 30
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 31
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hst-6 31
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for HS6ST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST3 Gene

ENSEMBL:
Gene Tree for HS6ST3 (if available)
TreeFam:
Gene Tree for HS6ST3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HS6ST3: view image

Paralogs for HS6ST3 Gene

Paralogs for HS6ST3 Gene

(2) SIMAP similar genes for HS6ST3 Gene using alignment to 1 proteins:

  • H6ST3_HUMAN
genes like me logo Genes that share paralogs with HS6ST3: view

Variants for HS6ST3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HS6ST3 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs9516771 - p.Lys265Arg

Additional dbSNP identifiers (rs#s) for HS6ST3 Gene

Structural Variations from Database of Genomic Variants (DGV) for HS6ST3 Gene

Variant ID Type Subtype PubMed ID
dgv1017n106 CNV deletion 24896259
dgv3328n54 CNV gain 21841781
dgv3329n54 CNV gain+loss 21841781
dgv3330n54 CNV loss 21841781
dgv376e199 CNV deletion 23128226
dgv576e212 CNV loss 25503493
esv21470 CNV loss 19812545
esv2273382 CNV deletion 18987734
esv2535297 CNV deletion 19546169
esv2659824 CNV deletion 23128226
esv2663826 CNV deletion 23128226
esv2668959 CNV deletion 23128226
esv2673647 CNV deletion 23128226
esv2676311 CNV deletion 23128226
esv2678219 CNV deletion 23128226
esv27253 CNV loss 19812545
esv2747851 CNV deletion 23290073
esv2747853 CNV deletion 23290073
esv2760278 CNV loss 21179565
esv3349216 CNV insertion 20981092
esv3362854 CNV duplication 20981092
esv3401472 CNV insertion 20981092
esv3422946 CNV insertion 20981092
esv3550933 CNV deletion 23714750
esv3580852 CNV loss 25503493
esv3633263 CNV loss 21293372
esv3633264 CNV loss 21293372
esv3633265 CNV loss 21293372
esv3633266 CNV loss 21293372
esv3633268 CNV loss 21293372
esv3633269 CNV loss 21293372
esv3633270 CNV loss 21293372
esv3633271 CNV loss 21293372
esv3633273 CNV loss 21293372
esv3633276 CNV loss 21293372
esv3633277 CNV loss 21293372
esv3633278 CNV loss 21293372
esv3633279 CNV loss 21293372
esv3633281 CNV loss 21293372
esv3892432 CNV gain 25118596
nsv1039781 CNV loss 25217958
nsv1040320 CNV gain 25217958
nsv1041165 CNV loss 25217958
nsv1070189 CNV deletion 25765185
nsv1136 CNV deletion 18451855
nsv474189 CNV novel sequence insertion 20440878
nsv507727 OTHER sequence alteration 20534489
nsv516784 CNV gain+loss 19592680
nsv517907 CNV loss 19592680
nsv519951 CNV loss 19592680
nsv521410 CNV loss 19592680
nsv522493 CNV loss 19592680
nsv562792 CNV gain 21841781
nsv562793 CNV gain 21841781
nsv7246 OTHER inversion 18451855
nsv976262 CNV deletion 23825009

Variation tolerance for HS6ST3 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HS6ST3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HS6ST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS6ST3 Gene

Disorders for HS6ST3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HS6ST3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
omodysplasia
  • omodysplasia 2
cantu syndrome
  • hypertrichotic osteochondrodysplasia
generalized epilepsy with febrile seizures plus
  • gefs+
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HS6ST3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HS6ST3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HS6ST3 Gene

Publications for HS6ST3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 54
  3. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H … Kimata K (The Journal of biological chemistry 2000) 3 23 54
  4. Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1. (PMID: 28017727) Iravani O … Yip GW (Experimental cell research 2017) 3 54
  5. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. (PMID: 24684796) Cox AJ … Bowden DW (Neurobiology of aging 2014) 3 54

Products for HS6ST3 Gene

Sources for HS6ST3 Gene