Aliases for HS6ST3 Gene
External Ids for HS6ST3 Gene
Previous GeneCards Identifiers for HS6ST3 Gene
Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HS6ST3 Gene
HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3) is a Protein Coding gene. Diseases associated with HS6ST3 include Omodysplasia and Cantu Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST2.
UniProtKB/Swiss-Prot Summary for HS6ST3 Gene
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.