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Aliases for HS6ST3 Gene

Aliases for HS6ST3 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 3 2 3 5
  • HS6ST-3 3 4
  • Heparan-Sulfate 6-O-Sulfotransferase 3 3
  • EC 2.8.2.- 4
  • EC 2.8.2 56

External Ids for HS6ST3 Gene

Previous GeneCards Identifiers for HS6ST3 Gene

  • GC00U991292
  • GC13P091871
  • GC13P095579
  • GC13P095183
  • GC13P094441
  • GC13P095541
  • GC13P096743

Summaries for HS6ST3 Gene

Entrez Gene Summary for HS6ST3 Gene

  • Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HS6ST3 Gene

HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST2.

UniProtKB/Swiss-Prot for HS6ST3 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Additional gene information for HS6ST3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS6ST3 Gene

Genomics for HS6ST3 Gene

GeneHancer (GH) Regulatory Elements for HS6ST3 Gene

Promoters and enhancers for HS6ST3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I096089 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 0.0 -31 1.4 SIN3A ZNF2 ZNF335 GLIS2 SCRT2 EGR2 SP3 ZBTB11 REST GLIS1 HS6ST3 UGGT2
GH13I095999 Enhancer 0.5 ENCODE 15.1 -90.3 -90303 1.2 SCRT2 MAX POU5F1 ATF2 HS6ST3 UGGT2 GC13P096022 GC13M095889
GH13I096034 Enhancer 0.3 ENCODE 15.2 -55.6 -55602 1.1 ZNF680 HS6ST3 GC13P096022 UGGT2
GH13I096248 Enhancer 0.2 ENCODE 11.2 +158.6 158619 1.2 HS6ST3 GC13M096146 RN7SL164P
GH13I096104 Enhancer 0.6 ENCODE 0.4 +14.2 14166 0.2 SMARCE1 RFX1 NEUROD1 DPF2 ZNF217 CTBP1 GATA3 FOS TCF7L2 UGGT2 HS6ST3 RN7SL164P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HS6ST3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HS6ST3 gene promoter:

Genomic Locations for HS6ST3 Gene

Genomic Locations for HS6ST3 Gene
749,027 bases
Plus strand

Genomic View for HS6ST3 Gene

Genes around HS6ST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS6ST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS6ST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST3 Gene

Proteins for HS6ST3 Gene

  • Protein details for HS6ST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q5W0L0
    • Q68CW6

    Protein attributes for HS6ST3 Gene

    471 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS6ST3 Gene

Selected DME Specific Peptides for HS6ST3 Gene


Post-translational modifications for HS6ST3 Gene

  • Glycosylation at posLast=117117, isoforms=128, isoforms=231, posLast=324324, posLast=329329, and posLast=380380
  • Modification sites at PhosphoSitePlus

Other Protein References for HS6ST3 Gene

Antibody Products

  • R&D Systems Antibodies for HS6ST3 (Heparan Sulfate 6-O-Sulfotransferase 3/HS6ST3)

Domains & Families for HS6ST3 Gene

Gene Families for HS6ST3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for HS6ST3 Gene

Suggested Antigen Peptide Sequences for HS6ST3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 6 family.
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST3: view

Function for HS6ST3 Gene

Molecular function for HS6ST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.
UniProtKB/Swiss-Prot Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Enzyme Numbers (IUBMB) for HS6ST3 Gene

Phenotypes From GWAS Catalog for HS6ST3 Gene

Gene Ontology (GO) - Molecular Function for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0017095 heparan sulfate 6-O-sulfotransferase activity IBA,IEA --
genes like me logo Genes that share ontologies with HS6ST3: view
genes like me logo Genes that share phenotypes with HS6ST3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS6ST3 Gene

Localization for HS6ST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS6ST3 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

Pathways & Interactions for HS6ST3 Gene

genes like me logo Genes that share pathways with HS6ST3: view

Interacting Proteins for HS6ST3 Gene

Gene Ontology (GO) - Biological Process for HS6ST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA,IEA --
genes like me logo Genes that share ontologies with HS6ST3: view

No data available for SIGNOR curated interactions for HS6ST3 Gene

Drugs & Compounds for HS6ST3 Gene

(2) Additional Compounds for HS6ST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with HS6ST3: view

Transcripts for HS6ST3 Gene

mRNA/cDNA for HS6ST3 Gene

Unigene Clusters for HS6ST3 Gene

Heparan sulfate 6-O-sulfotransferase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST3 Gene

No ASD Table

Relevant External Links for HS6ST3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS6ST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HS6ST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.0), and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for HS6ST3 Gene

This gene is overexpressed in Placenta (50.2) and Gallbladder (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HS6ST3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HS6ST3 Gene:


SOURCE GeneReport for Unigene cluster for HS6ST3 Gene:


Evidence on tissue expression from TISSUES for HS6ST3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with HS6ST3: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HS6ST3 Gene

Orthologs for HS6ST3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HS6ST3 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia HS6ST3 33 34
  • 90.02 (n)
(Rattus norvegicus)
Mammalia Hs6st3 33
  • 89.91 (n)
(Mus musculus)
Mammalia Hs6st3 33 16 34
  • 89.15 (n)
(Canis familiaris)
Mammalia HS6ST3 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
(Gallus gallus)
Aves HS6ST3 33 34
  • 78.98 (n)
(Anolis carolinensis)
Reptilia HS6ST3 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st3 33
  • 72.02 (n)
(Danio rerio)
Actinopterygii hs6st3b 33 34
  • 68.61 (n)
hs6st3a 34
  • 62 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea hst-6 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for HS6ST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST3 Gene

Gene Tree for HS6ST3 (if available)
Gene Tree for HS6ST3 (if available)

Paralogs for HS6ST3 Gene

Paralogs for HS6ST3 Gene

(2) SIMAP similar genes for HS6ST3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HS6ST3: view

Variants for HS6ST3 Gene

Sequence variations from dbSNP and Humsavar for HS6ST3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000008237 -- 96,400,755(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000009996 -- 96,456,645(+) G/T genic_downstream_transcript_variant, intron_variant
rs1000010003 -- 96,622,836(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000012370 -- 96,134,694(+) C/G intron_variant
rs1000015041 -- 96,262,692(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HS6ST3 Gene

Variant ID Type Subtype PubMed ID
dgv1017n106 CNV deletion 24896259
dgv3328n54 CNV gain 21841781
dgv3329n54 CNV gain+loss 21841781
dgv3330n54 CNV loss 21841781
dgv376e199 CNV deletion 23128226
dgv576e212 CNV loss 25503493
esv21470 CNV loss 19812545
esv2273382 CNV deletion 18987734
esv2535297 CNV deletion 19546169
esv2659824 CNV deletion 23128226
esv2663826 CNV deletion 23128226
esv2668959 CNV deletion 23128226
esv2673647 CNV deletion 23128226
esv2676311 CNV deletion 23128226
esv2678219 CNV deletion 23128226
esv27253 CNV loss 19812545
esv2747851 CNV deletion 23290073
esv2747853 CNV deletion 23290073
esv2760278 CNV loss 21179565
esv3349216 CNV insertion 20981092
esv3362854 CNV duplication 20981092
esv3401472 CNV insertion 20981092
esv3422946 CNV insertion 20981092
esv3550933 CNV deletion 23714750
esv3580852 CNV loss 25503493
esv3633263 CNV loss 21293372
esv3633264 CNV loss 21293372
esv3633265 CNV loss 21293372
esv3633266 CNV loss 21293372
esv3633268 CNV loss 21293372
esv3633269 CNV loss 21293372
esv3633270 CNV loss 21293372
esv3633271 CNV loss 21293372
esv3633273 CNV loss 21293372
esv3633276 CNV loss 21293372
esv3633277 CNV loss 21293372
esv3633278 CNV loss 21293372
esv3633279 CNV loss 21293372
esv3633281 CNV loss 21293372
esv3892432 CNV gain 25118596
nsv1039781 CNV loss 25217958
nsv1040320 CNV gain 25217958
nsv1041165 CNV loss 25217958
nsv1070189 CNV deletion 25765185
nsv1136 CNV deletion 18451855
nsv474189 CNV novel sequence insertion 20440878
nsv507727 OTHER sequence alteration 20534489
nsv516784 CNV gain+loss 19592680
nsv517907 CNV loss 19592680
nsv519951 CNV loss 19592680
nsv521410 CNV loss 19592680
nsv522493 CNV loss 19592680
nsv562792 CNV gain 21841781
nsv562793 CNV gain 21841781
nsv7246 OTHER inversion 18451855
nsv976262 CNV deletion 23825009

Variation tolerance for HS6ST3 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HS6ST3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS6ST3 Gene

Disorders for HS6ST3 Gene

Additional Disease Information for HS6ST3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HS6ST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS6ST3 Gene

Publications for HS6ST3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  3. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H … Kimata K (The Journal of biological chemistry 2000) 3 22 58
  4. Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1. (PMID: 28017727) Iravani O … Yip GW (Experimental cell research 2017) 3 58
  5. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. (PMID: 24684796) Cox AJ … Bowden DW (Neurobiology of aging 2014) 3 58

Products for HS6ST3 Gene

Sources for HS6ST3 Gene

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