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Aliases for HS6ST2 Gene

Aliases for HS6ST2 Gene

  • Heparan Sulfate 6-O-Sulfotransferase 2 2 3 5
  • HS6ST-2 3 4
  • Heparan-Sulfate 6-O-Sulfotransferase 2 3
  • EC 2.8.2.- 4

External Ids for HS6ST2 Gene

Previous GeneCards Identifiers for HS6ST2 Gene

  • GC0XM126407
  • GC0XM128605
  • GC0XM129705
  • GC0XM130465
  • GC0XM131485
  • GC0XM131587
  • GC0XM131760
  • GC0XM121164

Summaries for HS6ST2 Gene

Entrez Gene Summary for HS6ST2 Gene

  • Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS6ST2 Gene

HS6ST2 (Heparan Sulfate 6-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type and heparan sulfate biosynthesis. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and heparan sulfate 6-O-sulfotransferase activity. An important paralog of this gene is HS6ST3.

UniProtKB/Swiss-Prot for HS6ST2 Gene

  • 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Additional gene information for HS6ST2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS6ST2 Gene

Genomics for HS6ST2 Gene

GeneHancer (GH) Regulatory Elements for HS6ST2 Gene

Promoters and enhancers for HS6ST2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ132956 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 658.4 +3.5 3520 2.1 ZNF473 ZFP64 ZSCAN4 ZNF2 ZNF335 GLIS2 ZNF213 EGR2 SP3 ZBTB11 HS6ST2 ENSG00000227064
GH0XJ132960 Enhancer 0.4 ENCODE 650.7 +0.6 628 0.1 PRDM10 PRDM1 HS6ST2 ENSG00000227064
GH0XJ133189 Enhancer 0.2 FANTOM5 26.1 -228.0 -228023 0.2 HS6ST2 USP26 GPC4 TFDP3 ENSG00000207100
GH0XJ132831 Enhancer 0.4 ENCODE 8.8 +129.8 129761 1.1 SCRT1 SCRT2 HS6ST2 ENSG00000227064 HS6ST2-AS1
GH0XJ133150 Enhancer 0.4 ENCODE 7.7 -190.0 -190049 1.4 HNF1A GABPA ENSG00000207100 GC0XP133154 HS6ST2 LOC100533716
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HS6ST2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HS6ST2 gene promoter:
  • Nkx2-5
  • CUTL1
  • GATA-3
  • NF-kappaB
  • NF-kappaB1
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for HS6ST2 Gene

Genomic Locations for HS6ST2 Gene
335,386 bases
Minus strand
335,386 bases
Minus strand

Genomic View for HS6ST2 Gene

Genes around HS6ST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS6ST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS6ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS6ST2 Gene

Proteins for HS6ST2 Gene

  • Protein details for HS6ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan-sulfate 6-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • B9WRT4
    • B9WRT5
    • E9PDY5
    • Q2TB13
    • Q4VC07
    • Q6PIC4
    • Q86SM9
    • Q8N3T4
    • Q8NBN4
    • Q96SJ4

    Protein attributes for HS6ST2 Gene

    605 amino acids
    Molecular mass:
    69130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HS6ST2 Gene


neXtProt entry for HS6ST2 Gene

Post-translational modifications for HS6ST2 Gene

  • Glycosylation at isoforms=2, 3, 4592, isoforms=2, 3, 4589, Asn564, isoforms=2, 3, 4556, isoforms=2, 3, 4544, Thr528, isoforms=2, 3, 4460, isoforms=2, 3, 4404, and Asn209
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HS6ST2 Gene

Domains & Families for HS6ST2 Gene

Gene Families for HS6ST2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for HS6ST2 Gene

Suggested Antigen Peptide Sequences for HS6ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 6 family.
  • Belongs to the sulfotransferase 6 family.
genes like me logo Genes that share domains with HS6ST2: view

Function for HS6ST2 Gene

Molecular function for HS6ST2 Gene

UniProtKB/Swiss-Prot Function:
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3-phosphoadenosine 5-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.

Enzyme Numbers (IUBMB) for HS6ST2 Gene

Phenotypes From GWAS Catalog for HS6ST2 Gene

Gene Ontology (GO) - Molecular Function for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0017095 heparan sulfate 6-O-sulfotransferase activity TAS --
genes like me logo Genes that share ontologies with HS6ST2: view
genes like me logo Genes that share phenotypes with HS6ST2: view

Animal Models for HS6ST2 Gene

MGI Knock Outs for HS6ST2:

Animal Model Products

  • Taconic Biosciences Mouse Models for HS6ST2

miRNA for HS6ST2 Gene

miRTarBase miRNAs that target HS6ST2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HS6ST2 Gene

Localization for HS6ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS6ST2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS6ST2 gene
Compartment Confidence
extracellular 5
nucleus 5
golgi apparatus 5
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with HS6ST2: view

Pathways & Interactions for HS6ST2 Gene

genes like me logo Genes that share pathways with HS6ST2: view

Gene Ontology (GO) - Biological Process for HS6ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA --
genes like me logo Genes that share ontologies with HS6ST2: view

No data available for SIGNOR curated interactions for HS6ST2 Gene

Drugs & Compounds for HS6ST2 Gene

(2) Additional Compounds for HS6ST2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoadenylate
  • Adenosine 3',5'-bisphosphate
  • PAP
  • Phosphoadenosine phosphate
  • 3'-Phosphoadenylic acid
Phosphoadenosine phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenylyl sulfate
  • PAPS
  • 3'-Phosphoadenosine 5'-phosphosulfuric acid
  • 3'-Phosphoadenosine 5'-phosphosulphate
genes like me logo Genes that share compounds with HS6ST2: view

Transcripts for HS6ST2 Gene

Unigene Clusters for HS6ST2 Gene

Heparan sulfate 6-O-sulfotransferase 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS6ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -

Relevant External Links for HS6ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS6ST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HS6ST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS6ST2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.6), Ovary (x4.8), and Brain - Hypothalamus (x4.6).

Protein differential expression in normal tissues from HIPED for HS6ST2 Gene

This gene is overexpressed in Testis (37.3) and Ovary (31.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS6ST2 Gene

Protein tissue co-expression partners for HS6ST2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HS6ST2 Gene:


SOURCE GeneReport for Unigene cluster for HS6ST2 Gene:


Evidence on tissue expression from TISSUES for HS6ST2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with HS6ST2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HS6ST2 Gene

Orthologs for HS6ST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS6ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HS6ST2 34 33
  • 94.21 (n)
(Pan troglodytes)
Mammalia HS6ST2 34 33
  • 94.01 (n)
(Bos Taurus)
Mammalia HS6ST2 33
  • 92.18 (n)
HS6ST3 34
  • 41 (a)
(Mus musculus)
Mammalia Hs6st2 16 34 33
  • 91.37 (n)
(Rattus norvegicus)
Mammalia Hs6st2 33
  • 90.49 (n)
(Ornithorhynchus anatinus)
Mammalia HS6ST2 34
  • 85 (a)
(Monodelphis domestica)
Mammalia HS6ST2 34
  • 79 (a)
(Gallus gallus)
Aves HS6ST2 34 33
  • 79.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs6st2 33
  • 77.54 (n)
(Danio rerio)
Actinopterygii CU929314.1 34
  • 74 (a)
hs6st2 34 33
  • 65.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hs6st 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea hst-6 34 33
  • 51.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
Species where no ortholog for HS6ST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS6ST2 Gene

Gene Tree for HS6ST2 (if available)
Gene Tree for HS6ST2 (if available)
Evolutionary constrained regions (ECRs) for HS6ST2: view image

Paralogs for HS6ST2 Gene

Paralogs for HS6ST2 Gene

(2) SIMAP similar genes for HS6ST2 Gene using alignment to 3 proteins:

  • B7Z5H6_HUMAN
  • J3KP99_HUMAN
genes like me logo Genes that share paralogs with HS6ST2: view

Variants for HS6ST2 Gene

Sequence variations from dbSNP and Humsavar for HS6ST2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000013089 -- 132,780,340(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000024263 -- 132,879,453(-) T/G intron_variant
rs1000037374 -- 132,668,198(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000046375 -- 132,946,632(-) C/T intron_variant
rs1000046849 -- 132,798,084(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HS6ST2 Gene

Variant ID Type Subtype PubMed ID
dgv2428e212 CNV loss 25503493
esv21961 CNV loss 19812545
esv2657460 CNV deletion 23128226
esv2670884 CNV deletion 23128226
esv2740485 CNV deletion 23290073
esv33324 CNV loss 17666407
esv3352524 CNV insertion 20981092
esv3559342 CNV deletion 23714750
esv3559346 CNV deletion 23714750
esv3574579 CNV loss 25503493
esv3574583 CNV loss 25503493
nsv1115290 CNV deletion 24896259
nsv1118404 CNV deletion 24896259
nsv474556 CNV novel sequence insertion 20440878
nsv7093 CNV insertion 18451855
nsv7094 CNV insertion 18451855
nsv7095 CNV insertion 18451855
nsv7096 CNV insertion 18451855

Variation tolerance for HS6ST2 Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HS6ST2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS6ST2 Gene

Disorders for HS6ST2 Gene

Additional Disease Information for HS6ST2

No disorders were found for HS6ST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS6ST2 Gene

Publications for HS6ST2 Gene

  1. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. (PMID: 10644753) Habuchi H … Kimata K (The Journal of biological chemistry 2000) 2 3 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for HS6ST2 Gene

Sources for HS6ST2 Gene

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