Aliases for HS3ST4 Gene
External Ids for HS3ST4 Gene
Previous GeneCards Identifiers for HS3ST4 Gene
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HS3ST4 Gene
HS3ST4 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 4) is a Protein Coding gene. Diseases associated with HS3ST4 include Spherocytosis, Type 3 and Apical Myocardial Infarction. Among its related pathways are Cytochrome P450 - arranged by substrate type and heparan sulfate biosynthesis. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST2.
UniProtKB/Swiss-Prot Summary for HS3ST4 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).