Aliases for HS3ST4 Gene
External Ids for HS3ST4 Gene
Previous GeneCards Identifiers for HS3ST4 Gene
This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HS3ST4 Gene
HS3ST4 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 4) is a Protein Coding gene. Diseases associated with HS3ST4 include Apical Myocardial Infarction and Spherocytosis, Type 3. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST2.
UniProtKB/Swiss-Prot Summary for HS3ST4 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity).