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Aliases for HS3ST3A1 Gene

Aliases for HS3ST3A1 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 3A1 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 3A1 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 3A1 3 4
  • 3-OST-3A 3 4
  • 3OST3A1 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 3A1 3
  • Heparin-Glucosamine 3-O-Sulfotransferase 3
  • EC 2.8.2.30 4
  • H3-OST-3A 4
  • EC 2.8.2 56
  • HS3ST3A 4

External Ids for HS3ST3A1 Gene

Previous GeneCards Identifiers for HS3ST3A1 Gene

  • GC17M013765
  • GC17M014513
  • GC17M013342
  • GC17M013599
  • GC17M013339

Summaries for HS3ST3A1 Gene

Entrez Gene Summary for HS3ST3A1 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]

GeneCards Summary for HS3ST3A1 Gene

HS3ST3A1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity. An important paralog of this gene is HS3ST3B1.

UniProtKB/Swiss-Prot for HS3ST3A1 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Gene Wiki entry for HS3ST3A1 Gene

Additional gene information for HS3ST3A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST3A1 Gene

Genomics for HS3ST3A1 Gene

GeneHancer (GH) Regulatory Elements for HS3ST3A1 Gene

Promoters and enhancers for HS3ST3A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I013597 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 557.1 +1.5 1529 5.4 PKNOX1 SIN3A FEZF1 ZNF2 ZNF213 SP3 REST ZNF610 GLIS1 WT1 HS3ST3A1 GC17P013587
GH17I013575 Enhancer 1 ENCODE dbSUPER 12.2 +26.1 26066 1.6 HDAC1 CTCF PKNOX1 USF1 TEAD4 TAL1 FEZF1 ZIC2 CCNT2 TCF12 HS3ST3A1 GC17P013587 MIR548H3
GH17I013543 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +57.2 57247 2 JUND POLR2A MNT FOS ZBTB40 MIR548H3 HS3ST3A1 GC17P013587
GH17I013538 Enhancer 1.1 ENCODE dbSUPER 6.9 +61.7 61693 3.9 PKNOX1 TAF9B ZBTB40 TCF12 ZNF766 GATA2 RCOR1 FOS CREM CEBPB HS3ST3A1 MIR548H3 GC17P013426
GH17I013556 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 8.4 +44.5 44488 1.6 JUND FOS ZBTB33 HS3ST3A1 MIR548H3 GC17P013587
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HS3ST3A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HS3ST3A1 gene promoter:

Genomic Locations for HS3ST3A1 Gene

Genomic Locations for HS3ST3A1 Gene
chr17:13,494,032-13,601,974
(GRCh38/hg38)
Size:
107,943 bases
Orientation:
Minus strand
chr17:13,399,006-13,505,244
(GRCh37/hg19)

Genomic View for HS3ST3A1 Gene

Genes around HS3ST3A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST3A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST3A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST3A1 Gene

Proteins for HS3ST3A1 Gene

  • Protein details for HS3ST3A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y663-HS3SA_HUMAN
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
    Protein Accession:
    Q9Y663
    Secondary Accessions:
    • A8K7N2

    Protein attributes for HS3ST3A1 Gene

    Size:
    406 amino acids
    Molecular mass:
    44900 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HS3ST3A1 Gene

neXtProt entry for HS3ST3A1 Gene

Selected DME Specific Peptides for HS3ST3A1 Gene

Q9Y663:
  • KGGTRALLE
  • EPHFFDR
  • LREFYRP
  • EKTPSYFVT
  • FYFNKTKGF
  • TKGFPCLKK

Post-translational modifications for HS3ST3A1 Gene

  • Glycosylation at isoforms=273 and posLast=344344

Other Protein References for HS3ST3A1 Gene

Domains & Families for HS3ST3A1 Gene

Gene Families for HS3ST3A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HS3ST3A1 Gene

Suggested Antigen Peptide Sequences for HS3ST3A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y663

UniProtKB/Swiss-Prot:

HS3SA_HUMAN :
  • Belongs to the sulfotransferase 1 family.
Family:
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST3A1: view

Function for HS3ST3A1 Gene

Molecular function for HS3ST3A1 Gene

GENATLAS Biochemistry:
heparan sulfate D-glucosamine 3-O-sulfotransferase 3A1,widely expressed with multiple transcripts active according to the saccharide structures around the GLN residue,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST3A1 Gene

Phenotypes From GWAS Catalog for HS3ST3A1 Gene

Gene Ontology (GO) - Molecular Function for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS,IEA 9988767
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS --
GO:0016740 transferase activity IEA --
GO:0033872 [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity IEA --
genes like me logo Genes that share ontologies with HS3ST3A1: view

Phenotypes for HS3ST3A1 Gene

genes like me logo Genes that share phenotypes with HS3ST3A1: view

Animal Model Products

miRNA for HS3ST3A1 Gene

miRTarBase miRNAs that target HS3ST3A1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST3A1 Gene

Localization for HS3ST3A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST3A1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS3ST3A1 gene
Compartment Confidence
golgi apparatus 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with HS3ST3A1: view

Pathways & Interactions for HS3ST3A1 Gene

genes like me logo Genes that share pathways with HS3ST3A1: view

Gene Ontology (GO) - Biological Process for HS3ST3A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
genes like me logo Genes that share ontologies with HS3ST3A1: view

No data available for SIGNOR curated interactions for HS3ST3A1 Gene

Drugs & Compounds for HS3ST3A1 Gene

(5) Drugs for HS3ST3A1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citric Acid Approved, Vet_approved Nutra Agonist, Activator, Target 1243
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
Adenosine-3'-5'-Diphosphate Experimental Pharma Target 0
N,O6-Disulfo-Glucosamine Experimental Pharma Target 0
O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0

(3) Additional Compounds for HS3ST3A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Iduronic acid
  • Iduronate
  • L-Iduronate
  • L-Iduronic acid
3402-98-0
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with HS3ST3A1: view

Transcripts for HS3ST3A1 Gene

mRNA/cDNA for HS3ST3A1 Gene

Unigene Clusters for HS3ST3A1 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST3A1 Gene

No ASD Table

Relevant External Links for HS3ST3A1 Gene

GeneLoc Exon Structure for
HS3ST3A1
ECgene alternative splicing isoforms for
HS3ST3A1

Expression for HS3ST3A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HS3ST3A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST3A1 Gene

This gene is overexpressed in Ovary (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of HS3ST3A1 Gene:

HS3ST3A1

SOURCE GeneReport for Unigene cluster for HS3ST3A1 Gene:

Hs.462270

mRNA Expression by UniProt/SwissProt for HS3ST3A1 Gene:

Q9Y663-HS3SA_HUMAN
Tissue specificity: Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney.

Evidence on tissue expression from TISSUES for HS3ST3A1 Gene

  • Liver(4.1)
  • Spleen(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HS3ST3A1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HS3ST3A1 Gene

Orthologs for HS3ST3A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST3A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS3ST3A1 33 34
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia HS3ST3A1 33
  • 90.63 (n)
-- 34
  • 90 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia HS3ST3A1 33
  • 88.64 (n)
-- 34
  • 87 (a)
ManyToMany
HS3ST3B1 34
  • 69 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hs3st3a1 33 16 34
  • 85.41 (n)
Hs3st3b1 34
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hs3st3a1 33
  • 84.14 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 81 (a)
ManyToMany
-- 34
  • 79 (a)
ManyToMany
-- 34
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st3a1 33
  • 74.62 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-216b21.2 34
  • 66 (a)
ManyToMany
hs3st3b1b 34
  • 63 (a)
ManyToMany
hs3st3l 34
  • 62 (a)
ManyToMany
hs3st3b1a 34
  • 59 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7890 35
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-3 35
  • 41 (a)
Species where no ortholog for HS3ST3A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST3A1 Gene

ENSEMBL:
Gene Tree for HS3ST3A1 (if available)
TreeFam:
Gene Tree for HS3ST3A1 (if available)

Paralogs for HS3ST3A1 Gene

(7) SIMAP similar genes for HS3ST3A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST3A1: view

Variants for HS3ST3A1 Gene

Sequence variations from dbSNP and Humsavar for HS3ST3A1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000005817 -- 13,561,522(-) G/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000005956 -- 13,542,292(-) G/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000014652 -- 13,506,558(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000052801 -- 13,511,116(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000058307 -- 13,561,263(-) T/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST3A1 Gene

Variant ID Type Subtype PubMed ID
esv2715679 CNV deletion 23290073
esv3373832 CNV insertion 20981092
esv3405281 CNV insertion 20981092
nsv833375 CNV loss 17160897
nsv574377 CNV gain 21841781
nsv471696 CNV gain+loss 15918152
nsv469679 CNV loss 16826518
nsv111994 CNV deletion 16902084
esv3639992 CNV loss 21293372
esv3639991 CNV loss 21293372
esv3572409 CNV gain 25503493
esv34170 CNV loss 18971310

Variation tolerance for HS3ST3A1 Gene

Gene Damage Index Score: 4.15; 61.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HS3ST3A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HS3ST3A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST3A1 Gene

Disorders for HS3ST3A1 Gene

Additional Disease Information for HS3ST3A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HS3ST3A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST3A1 Gene

Publications for HS3ST3A1 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. (PMID: 9988767) Shworak NW … Rosenberg RD (The Journal of biological chemistry 1999) 2 3 4 58
  2. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D … Mitchell GF (BMC medical genetics 2007) 3 44 58
  3. Structural analysis of the sulfotransferase (3-o-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. (PMID: 15304505) Moon AF … Pedersen LC (The Journal of biological chemistry 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for HS3ST3A1 Gene

Sources for HS3ST3A1 Gene

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