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Aliases for HS3ST2 Gene

Aliases for HS3ST2 Gene

  • Heparan Sulfate-Glucosamine 3-Sulfotransferase 2 2 3 5
  • Heparan Sulfate D-Glucosaminyl 3-O-Sulfotransferase 2 3 4
  • Heparan Sulfate (Glucosamine) 3-O-Sulfotransferase 2 2 3
  • Heparan Sulfate 3-O-Sulfotransferase 2 3 4
  • H3-OST-2 3 4
  • 3-OST-2 3 4
  • 3OST2 3 4
  • Heparan Sulfate Glucosamine 3-O-Sulfotransferase 2 3
  • Heparin-Glucosamine 3-O-Sulfotransferase 3
  • EC 4
  • EC 2.8.2 56
  • 30ST2 3

External Ids for HS3ST2 Gene

Previous GeneCards Identifiers for HS3ST2 Gene

  • GC16P022226
  • GC16P022834
  • GC16P022792
  • GC16P020915

Summaries for HS3ST2 Gene

Entrez Gene Summary for HS3ST2 Gene

  • Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS3ST2 Gene

HS3ST2 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity. An important paralog of this gene is HS3ST4.

UniProtKB/Swiss-Prot for HS3ST2 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Gene Wiki entry for HS3ST2 Gene

Additional gene information for HS3ST2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS3ST2 Gene

Genomics for HS3ST2 Gene

GeneHancer (GH) Regulatory Elements for HS3ST2 Gene

Promoters and enhancers for HS3ST2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I022813 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 250 1.9 ELF3 MLX ZFP64 KLF17 ZNF2 DNMT3B THRB RAD21 SLC30A9 ZNF335 ENSG00000283213 HS3ST2 GC16M022860
GH16I022814 Enhancer 0.9 ENCODE 550.8 -0.8 -822 0.2 MLX ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF213 ZNF143 NFYC MXD4 ENSG00000283213 HS3ST2 GC16P022677
GH16I022787 Enhancer 0.9 FANTOM5 Ensembl ENCODE 12.8 -25.0 -24962 2.7 JUND POLR2A RCOR1 RUNX3 CHD2 ZNF7 HS3ST2 ENSG00000283213 GC16P022677
GH16I022782 Enhancer 0.8 FANTOM5 12 -31.6 -31603 0.2 HDAC1 JUN TEAD4 TAL1 ZIC2 FOSL1 TCF12 ZNF766 NCOR1 VEZF1 HS3ST2 ENSG00000283213 GC16P022677
GH16I022824 Enhancer 0.2 FANTOM5 3.9 +10.6 10613 0.4 HS3ST2 GC16M022860
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HS3ST2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HS3ST2 gene promoter:

Genomic Locations for HS3ST2 Gene

Genomic Locations for HS3ST2 Gene
102,162 bases
Plus strand

Genomic View for HS3ST2 Gene

Genes around HS3ST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HS3ST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HS3ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS3ST2 Gene

Proteins for HS3ST2 Gene

  • Protein details for HS3ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heparan sulfate glucosamine 3-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q52LZ1

    Protein attributes for HS3ST2 Gene

    367 amino acids
    Molecular mass:
    41501 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HS3ST2 Gene

Selected DME Specific Peptides for HS3ST2 Gene


Post-translational modifications for HS3ST2 Gene

  • Glycosylation at isoforms=102, posLast=193193, posLast=235235, and posLast=306306

Other Protein References for HS3ST2 Gene

Domains & Families for HS3ST2 Gene

Gene Families for HS3ST2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HS3ST2 Gene

Suggested Antigen Peptide Sequences for HS3ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfotransferase 1 family.
  • Belongs to the sulfotransferase 1 family.
genes like me logo Genes that share domains with HS3ST2: view

Function for HS3ST2 Gene

Molecular function for HS3ST2 Gene

GENATLAS Biochemistry:
heparan sulfate D-glucosamine 3-O-sulfotransferase 2,predominantly expressed in brain,putative regulator of heparan sulfate proteoglycan properties
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate.
UniProtKB/Swiss-Prot Function:
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Enzyme Numbers (IUBMB) for HS3ST2 Gene

Phenotypes From GWAS Catalog for HS3ST2 Gene

Gene Ontology (GO) - Molecular Function for HS3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity TAS,IEA 9988767
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS --
GO:0016740 transferase activity IEA --
GO:0033871 [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA --
genes like me logo Genes that share ontologies with HS3ST2: view
genes like me logo Genes that share phenotypes with HS3ST2: view

Animal Model Products

CRISPR Products

miRNA for HS3ST2 Gene

miRTarBase miRNAs that target HS3ST2

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HS3ST2 Gene

Localization for HS3ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HS3ST2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HS3ST2 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for HS3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HS3ST2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HS3ST2 Gene

Pathways & Interactions for HS3ST2 Gene

genes like me logo Genes that share pathways with HS3ST2: view

Interacting Proteins for HS3ST2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: Q9Y278-HS3S2_HUMAN ENSP00000261374 for HS3ST2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for HS3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with HS3ST2: view

No data available for SIGNOR curated interactions for HS3ST2 Gene

Drugs & Compounds for HS3ST2 Gene

(4) Additional Compounds for HS3ST2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Iduronic acid
  • Iduronate
  • L-Iduronate
  • L-Iduronic acid
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with HS3ST2: view

Transcripts for HS3ST2 Gene

mRNA/cDNA for HS3ST2 Gene

Unigene Clusters for HS3ST2 Gene

Heparan sulfate (glucosamine) 3-O-sulfotransferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HS3ST2 Gene

No ASD Table

Relevant External Links for HS3ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HS3ST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HS3ST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HS3ST2 Gene

This gene is overexpressed in Brain - Cortex (x7.3), Brain - Anterior cingulate cortex (BA24) (x7.0), Brain - Frontal Cortex (BA9) (x6.7), and Artery - Aorta (x4.3).

Protein differential expression in normal tissues from HIPED for HS3ST2 Gene

This gene is overexpressed in Cerebrospinal fluid (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HS3ST2 Gene

Protein tissue co-expression partners for HS3ST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HS3ST2 Gene:


SOURCE GeneReport for Unigene cluster for HS3ST2 Gene:


mRNA Expression by UniProt/SwissProt for HS3ST2 Gene:

Tissue specificity: Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for HS3ST2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with HS3ST2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HS3ST2 Gene

Orthologs for HS3ST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HS3ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HS3ST2 33 34
  • 99.09 (n)
(Bos Taurus)
Mammalia HS3ST2 33 34
  • 92.82 (n)
(Canis familiaris)
Mammalia HS3ST2 33 34
  • 91.29 (n)
(Rattus norvegicus)
Mammalia Hs3st2 33
  • 89.83 (n)
(Mus musculus)
Mammalia Hs3st2 33 16 34
  • 89.37 (n)
(Monodelphis domestica)
Mammalia HS3ST2 34
  • 86 (a)
(Gallus gallus)
Aves HS3ST2 33 34
  • 82.76 (n)
(Anolis carolinensis)
Reptilia HS3ST2 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hs3st2 33
  • 64.88 (n)
(Danio rerio)
Actinopterygii hs3st2 33 34
  • 66.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7890 35
  • 58 (a)
(Caenorhabditis elegans)
Secernentea hst-3 35
  • 41 (a)
Species where no ortholog for HS3ST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HS3ST2 Gene

Gene Tree for HS3ST2 (if available)
Gene Tree for HS3ST2 (if available)

Paralogs for HS3ST2 Gene

(6) SIMAP similar genes for HS3ST2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HS3ST2: view

Variants for HS3ST2 Gene

Sequence variations from dbSNP and Humsavar for HS3ST2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000027963 -- 22,860,637(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000057788 -- 22,891,045(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000079076 -- 22,867,134(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000099504 -- 22,834,853(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000128538 -- 22,908,592(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HS3ST2 Gene

Variant ID Type Subtype PubMed ID
nsv958194 CNV deletion 24416366
nsv952953 CNV deletion 24416366
nsv833173 CNV loss 17160897
nsv1070341 CNV deletion 25765185
nsv1064559 CNV loss 25217958
nsv103335 CNV deletion 16902084
esv8326 CNV loss 19470904
esv4772 CNV loss 18987735
esv3638224 CNV loss 21293372
esv3638222 CNV loss 21293372
esv3638221 CNV loss 21293372
esv3553227 CNV deletion 23714750
esv3307071 CNV mobile element insertion 20981092
esv2714081 CNV deletion 23290073
esv2667416 CNV deletion 23128226
esv2666771 CNV deletion 23128226
esv2661611 CNV deletion 23128226
esv2634610 CNV deletion 19546169
esv2548215 CNV deletion 19546169
esv2117994 CNV deletion 18987734
esv1412519 CNV deletion 17803354
dgv1319n106 CNV deletion 24896259

Variation tolerance for HS3ST2 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HS3ST2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST2 Gene

Disorders for HS3ST2 Gene

Additional Disease Information for HS3ST2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HS3ST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HS3ST2 Gene

Publications for HS3ST2 Gene

  1. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. (PMID: 9988767) Shworak NW … Rosenberg RD (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M … Iwata N (Biological psychiatry 2010) 3 44 58
  4. A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. (PMID: 16336986) O'Donnell CD … Shukla D (Virology 2006) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for HS3ST2 Gene

Sources for HS3ST2 Gene

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