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Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversio... See more...
Aliases for HS3ST1 Gene
Aliases for HS3ST1 Gene
External Ids for HS3ST1 Gene
- HGNC: 5194
- Entrez Gene: 9957
- Ensembl: ENSG00000002587
- OMIM: 603244
- UniProtKB: O14792
Previous GeneCards Identifiers for HS3ST1 Gene
- GC04M011074
- GC04M011350
- GC04M011151
- GC04M011076
- GC04M011009
- GC04M010732
Summaries for HS3ST1 Gene
-
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for HS3ST1 Gene
HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1) is a Protein Coding gene. Diseases associated with HS3ST1 include Arteriosclerosis and Spherocytosis, Type 3. Among its related pathways are Cytochrome P450 - arranged by substrate type and heparan sulfate biosynthesis. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST5.
UniProtKB/Swiss-Prot Summary for HS3ST1 Gene
-
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
Additional gene information for HS3ST1 Gene
- HGNC(5194)
- Entrez Gene(9957)
- Ensembl(ENSG00000002587)
- OMIM(603244)
- UniProtKB(O14792)
- Open Targets Platform(ENSG00000002587)
- Search for HS3ST1 at DataMed
- Search for HS3ST1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HS3ST1 Gene
Genomics for HS3ST1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HS3ST1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HS3ST1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HS3ST1
- Top Transcription factor binding sites by QIAGEN in the HS3ST1 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- Pbx1a
- POU2F1
- POU2F1a
- POU2F1b
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for HS3ST1 Gene
Genomic Locations for HS3ST1 Gene
- chr4:11,393,150-11,434,398
- (GRCh38/hg38)
- Size:
- 41,249 bases
- Orientation:
- Minus strand
- chr4:11,394,774-11,431,389
- (GRCh37/hg19)
- Size:
- 36,616 bases
- Orientation:
- Minus strand
Genomic View for HS3ST1 Gene
Genes around HS3ST1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.33 by HGNC
- 4p15.33 by Entrez Gene
- 4p15.33 by Ensembl
HS3ST1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HS3ST1 Gene
Proteins for HS3ST1 Gene
-
Protein details for HS3ST1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14792-HS3S1_HUMAN
- Recommended name:
- Heparan sulfate glucosamine 3-O-sulfotransferase 1
- Protein Accession:
- O14792
- B3KUA6
- Q6PEY8
Protein attributes for HS3ST1 Gene
- Size:
- 307 amino acids
- Molecular mass:
- 35773 Da
- Quaternary structure:
- No Data Available
Protein Expression for HS3ST1 Gene
Selected DME Specific Peptides for HS3ST1 Gene
- O14792:
-
- IIIGVRKGGTRALLEML
- KGGTRALLE
- FYFNKTKGF
Post-translational modifications for HS3ST1 Gene
Other Protein References for HS3ST1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HS3ST1
-
Abcam antibodies for HS3ST1
- Invitrogen Antibodies for HS3ST1 (AFLGC-HS3ST1)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HS3ST1
- Origene Custom Protein Services for HS3ST1
- Sino Biological Recombinant Proteins for HS3ST1
- Sino Biological Cell Lysates for HS3ST1
- ProSpec Recombinant Proteins for HS3ST1
-
Abcam proteins for HS3ST1
Assay Products
- RayBiotech Custom Human HS3ST1 ELISA
- antibodies-online: Show 16 available HS3ST1 Elisa Kits ranked by validation data
- Compare Top HS3ST1 Elisa Kits
-
Quality Products:
Domains & Families for HS3ST1 Gene
Gene Families for HS3ST1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for HS3ST1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HS3ST1 Gene
- GenScript: Design optimal peptide antigens:
-
- Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1 (HS3S1_HUMAN)
- HS3ST1 protein (Q05CH3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14792- Family:
-
- Belongs to the sulfotransferase 1 family.
Function for HS3ST1 Gene
Molecular function for HS3ST1 Gene
- UniProtKB/Swiss-Prot Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+); Xref=Rhea:RHEA:15461, Rhea:RHEA-COMP:9830, Rhea:RHEA-COMP:9831, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58388, ChEBI:CHEBI:70975; EC=2.8.2.23;.
Enzyme Numbers (IUBMB) for HS3ST1 Gene
Phenotypes From GWAS Catalog for HS3ST1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008146 | sulfotransferase activity | IEA,TAS | 9988767 |
| GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity | IBA | 21873635 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for HS3ST1 Gene
- MGI mutant phenotypes for HS3ST1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HS3ST1:
Animal Models for HS3ST1 Gene
- MGI Knock Outs for HS3ST1:
-
- Hs3st1 Hs3st1<tm1Nws>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HS3ST1 - Select products 50% OFF >
- * HS3ST1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HS3ST1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HS3ST1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HS3ST1
miRNA for HS3ST1 Gene
- miRTarBase miRNAs that target HS3ST1
-
- hsa-miR-6885-3p (MIRT448217)
- hsa-miR-1273e (MIRT448218)
- hsa-miR-6126 (MIRT448219)
- hsa-miR-6864-5p (MIRT448220)
- hsa-miR-1251-3p (MIRT448221)
- hsa-miR-144-5p (MIRT448222)
- hsa-miR-493-3p (MIRT448223)
- hsa-miR-4635 (MIRT448224)
- hsa-miR-570-5p (MIRT448225)
- hsa-miR-548ba (MIRT448226)
- hsa-miR-548ai (MIRT448227)
- hsa-miR-548ag (MIRT448228)
- hsa-miR-4659b-3p (MIRT448229)
- hsa-miR-6875-3p (MIRT448230)
- hsa-miR-4659a-3p (MIRT448231)
- hsa-miR-573 (MIRT448232)
- hsa-miR-3616-5p (MIRT448233)
- hsa-miR-3182 (MIRT448234)
- hsa-miR-4766-5p (MIRT448235)
- hsa-miR-3662 (MIRT448236)
- hsa-miR-6780a-3p (MIRT545757)
- hsa-miR-6720-5p (MIRT545758)
- hsa-miR-6512-3p (MIRT545759)
- hsa-miR-4680-5p (MIRT545760)
- hsa-miR-4539 (MIRT545761)
- hsa-miR-766-3p (MIRT545762)
- hsa-miR-4691-3p (MIRT545763)
- hsa-miR-6849-3p (MIRT545764)
- hsa-miR-4724-5p (MIRT545765)
- hsa-miR-483-3p (MIRT545766)
- hsa-miR-5582-3p (MIRT545767)
- hsa-miR-508-5p (MIRT545768)
- hsa-miR-548f-3p (MIRT545769)
- hsa-miR-548e-3p (MIRT545770)
- hsa-miR-548az-3p (MIRT545771)
- hsa-miR-548ar-3p (MIRT545772)
- hsa-miR-548a-3p (MIRT545773)
- hsa-miR-7109-3p (MIRT616134)
- hsa-miR-30e-3p (MIRT616135)
- hsa-miR-30d-3p (MIRT616136)
- hsa-miR-30a-3p (MIRT616137)
- hsa-miR-6744-3p (MIRT616138)
- hsa-miR-4757-5p (MIRT616139)
- hsa-miR-4290 (MIRT616140)
- hsa-miR-18a-3p (MIRT616141)
- hsa-miR-6845-3p (MIRT616142)
- hsa-miR-1976 (MIRT616143)
- hsa-miR-3653-5p (MIRT616144)
- hsa-miR-7107-5p (MIRT616145)
- hsa-miR-1234-3p (MIRT616146)
- hsa-miR-6747-3p (MIRT616147)
- hsa-miR-6727-3p (MIRT616148)
- hsa-miR-4722-3p (MIRT616149)
- hsa-miR-335-3p (MIRT623651)
- hsa-miR-4276 (MIRT623652)
- hsa-miR-3925-3p (MIRT623653)
- hsa-miR-5190 (MIRT623654)
- hsa-miR-548c-3p (MIRT623655)
- hsa-miR-5698 (MIRT627132)
- hsa-miR-744-3p (MIRT627133)
- hsa-miR-4642 (MIRT627134)
- hsa-miR-4423-5p (MIRT627135)
- hsa-miR-6501-5p (MIRT627136)
- hsa-miR-143-5p (MIRT627137)
- hsa-miR-4430 (MIRT627138)
- hsa-miR-3652 (MIRT627139)
- hsa-miR-122-5p (MIRT627140)
- hsa-miR-504-3p (MIRT627141)
- hsa-miR-3135b (MIRT627142)
- hsa-miR-6499-3p (MIRT627143)
- hsa-miR-367-5p (MIRT627144)
- hsa-miR-1267 (MIRT627145)
- hsa-miR-4638-5p (MIRT627146)
- hsa-miR-1307-3p (MIRT627147)
- hsa-miR-6075 (MIRT627148)
- hsa-miR-5693 (MIRT627149)
- hsa-miR-6805-3p (MIRT638073)
- hsa-miR-5691 (MIRT638074)
- hsa-miR-3194-3p (MIRT638075)
- hsa-miR-5089-5p (MIRT686141)
- hsa-miR-6878-3p (MIRT686142)
- hsa-miR-6807-5p (MIRT686143)
- hsa-miR-7151-3p (MIRT686144)
- hsa-miR-5095 (MIRT686145)
- hsa-miR-5589-5p (MIRT686146)
- hsa-miR-4731-5p (MIRT686147)
- hsa-miR-6778-3p (MIRT686148)
- hsa-miR-150-5p (MIRT686149)
- hsa-miR-186-3p (MIRT686150)
- hsa-miR-520h (MIRT686151)
- hsa-miR-520g-3p (MIRT686152)
- hsa-miR-6504-3p (MIRT686153)
- hsa-miR-512-3p (MIRT686154)
- hsa-miR-4438 (MIRT686155)
- hsa-miR-520e (MIRT686156)
- hsa-miR-520d-3p (MIRT686157)
- hsa-miR-520c-3p (MIRT686158)
- hsa-miR-520b (MIRT686159)
- hsa-miR-520a-3p (MIRT686160)
- hsa-miR-373-3p (MIRT686161)
- hsa-miR-372-3p (MIRT686162)
- hsa-miR-302e (MIRT686163)
- hsa-miR-302d-3p (MIRT686164)
- hsa-miR-302c-3p (MIRT686165)
- hsa-miR-302b-3p (MIRT686166)
- hsa-miR-302a-3p (MIRT686167)
- hsa-miR-93-5p (MIRT686168)
- hsa-miR-526b-3p (MIRT686169)
- hsa-miR-519d-3p (MIRT686170)
- hsa-miR-20b-5p (MIRT686171)
- hsa-miR-20a-5p (MIRT686172)
- hsa-miR-17-5p (MIRT686173)
- hsa-miR-106b-5p (MIRT686174)
- hsa-miR-106a-5p (MIRT686175)
- hsa-miR-6506-5p (MIRT702800)
- hsa-miR-619-5p (MIRT702801)
- hsa-miR-941 (MIRT702802)
- hsa-miR-4313 (MIRT715336)
- hsa-miR-4772-3p (MIRT715337)
- hsa-miR-6810-3p (MIRT715338)
- hsa-miR-6801-3p (MIRT715339)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HS3ST1
- Browse OriGene Inhibitory RNA Products For HS3ST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HS3ST1
Clone Products
- Applied Biological Materials (abm): Clones for HS3ST1 - Select products 50% OFF >
- * HS3ST1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HS3ST1
- Addgene plasmids for HS3ST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HS3ST1
Cell Line Products
-
Horizon Cell Lines for HS3ST1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HS3ST1 Gene
Localization for HS3ST1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HS3ST1 Gene
- Golgi apparatus lumen.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 4 |
| extracellular | 3 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for HS3ST1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycosaminoglycan metabolism | ||
| 2 | heparan sulfate biosynthesis | ||
| 3 | Articular Cartilage Extracellular Matrix | ||
| 4 | Metabolism |
.40
|
|
| 5 | Cytochrome P450 - arranged by substrate type | ||
Pathways by source for HS3ST1 Gene
3 BioSystems pathways for HS3ST1 Gene
5 Reactome pathways for HS3ST1 Gene
1 KEGG pathway for HS3ST1 Gene
1 R&D Systems pathway for HS3ST1 Gene
Interacting Proteins for HS3ST1 Gene
GPS-Prot Interaction Network for HS3ST1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006024 | glycosaminoglycan biosynthetic process | TAS | -- |
No data available for SIGNOR curated interactions for HS3ST1 Gene
Transcripts for HS3ST1 Gene
mRNA/cDNA for HS3ST1 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000002596 7160 nts (view in UCSC)
- ENST00000510712 496 nts (view in UCSC)
- ENST00000514690 491 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HS3ST1 - Select products 50% OFF >
- * HS3ST1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HS3ST1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HS3ST1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HS3ST1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HS3ST1
- Browse OriGene Inhibitory RNA Products For HS3ST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HS3ST1
Clone Products
- Applied Biological Materials (abm): Clones for HS3ST1 - Select products 50% OFF >
- * HS3ST1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HS3ST1
- Addgene plasmids for HS3ST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HS3ST1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | - | - | - |
Relevant External Links for HS3ST1 Gene
- GeneLoc Exon Structure for
- HS3ST1
Expression for HS3ST1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
mRNA differential expression in normal tissues according to GTEx for HS3ST1 Gene
This gene is overexpressed in Ovary (x9.3), Brain - Cerebellar Hemisphere (x6.1), and Brain - Cerebellum (x5.2).
This gene is overexpressed in Islet of Langerhans (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HS3ST1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HS3ST1
SOURCE GeneReport for Unigene cluster for HS3ST1 Gene:
Hs.507348mRNA Expression by UniProt/SwissProt for HS3ST1 Gene:
O14792-HS3S1_HUMAN
Tissue specificity:
Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta.
Evidence on tissue expression from TISSUES for HS3ST1 Gene
- Nervous system(4.9)
- Eye(3.5)
- Skin(3.2)
- Intestine(3.1)
- Lung(3.1)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for HS3ST1
-
OriGene qPCR primer pairs and template standards for HS3ST1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HS3ST1 Gene
Orthologs for HS3ST1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HS3ST1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HS3ST1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HS3ST1 30 |
|
||
| 3OST1 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Hs3st1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hs3st1 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HS3ST1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HS3ST1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HS3ST1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hs3st1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398971 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hs3st1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Hs3st-A 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | hst-3 32 |
|
|
|
| hst-3.1 31 |
|
OneToMany |
- Species where no ortholog for HS3ST1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for HS3ST1 Gene
- ENSEMBL:
- Gene Tree for HS3ST1 (if available)
- TreeFam:
- Gene Tree for HS3ST1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HS3ST1: view image
Paralogs for HS3ST1 Gene
Paralogs for HS3ST1 Gene
(9) SIMAP similar genes for HS3ST1 Gene using alignment to 3 proteins:
- HS3S1_HUMAN
- E9PDE3_HUMAN
- Q05CH3_HUMAN
Variants for HS3ST1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HS3ST1 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16881446 | Risk Factor: Coronary artery disease; Arteriosclerosis | 11,406,961(-) | T/C | INTRON_VARIANT | |
| rs11559238 | - | p.Pro22Thr | |||
| rs34719057 | - | p.Lys295Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3599645 | CNV | loss | 21293372 |
| nsv1000613 | CNV | loss | 25217958 |
| nsv1010891 | CNV | loss | 25217958 |
| nsv829862 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.62;
56.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HS3ST1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HS3ST1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HS3ST1 Gene
Disorders for HS3ST1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| arteriosclerosis |
|
|
| spherocytosis, type 3 |
|
|
| coronary heart disease 1 |
|
|
| overhydrated hereditary stomatocytosis |
|
|
| acute retinal necrosis syndrome |
|
|
Search HS3ST1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HS3ST1
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for HS3ST1 Gene
Publications for HS3ST1 Gene
- Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. (PMID: 9988767) Shworak NW … Rosenberg RD (The Journal of biological chemistry 1999) 2 3 4 23
- Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. (PMID: 9988768) Liu J … Rosenberg RD (The Journal of biological chemistry 1999) 3 4 23
- Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. (PMID: 9346953) Shworak NW … Rosenberg RD (The Journal of biological chemistry 1997) 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for HS3ST1 Gene
- View all 2 R&D Systems HS3ST1 (Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1) Products
- View all R&D Systems HS3ST1 (Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1) Proteins and Enzymes
- View all R&D Systems HS3ST1 (Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1) Primary Antibodies
- Learn more about R&D Systems custom HS3ST1 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
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- Search Origene for MassSpec and Protein Over-expression Lysates for HS3ST1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for HS3ST1
- Browse OriGene Inhibitory RNA Products For HS3ST1
- OriGene qPCR primer pairs for HS3ST1
- OriGene qPCR primer pairs and template standards for HS3ST1
- OriGene CRISPR knockouts for HS3ST1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HS3ST1
- Sino Biological Human cDNA Clone for HS3ST1
- Sino Biological Recombinant Proteins for HS3ST1
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- Browse Sino Biological Antibodies
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- Novus Biologicals proteins and lysates for HS3ST1
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- VectorBuilder Custom and pre-made DNA vectors for HS3ST1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for HS3ST1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for HS3ST1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for HS3ST1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for HS3ST1
- Addgene plasmids for HS3ST1
- antibodies-online: Show 7 available HS3ST1 Antibodies ranked by validation data
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- antibodies-online: Show 9 available HS3ST1 Proteins ranked by validation data
- Compare Top HS3ST1 Proteins
- Horizon Cell Lines for HS3ST1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HS3ST1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HS3ST1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HS3ST1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HS3ST1
Sources for HS3ST1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (15) ProtoNet
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- (30) HomoloGene
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- (68) GeneGo (Thomson Reuters)
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- (70) SIMAP
- (71) GenomeRNAi
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