Aliases for HS3ST1 Gene
External Ids for HS3ST1 Gene
Previous GeneCards Identifiers for HS3ST1 Gene
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for HS3ST1 Gene
HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1) is a Protein Coding gene. Diseases associated with HS3ST1 include Arteriosclerosis and Coronary Heart Disease 1. Among its related pathways are Glycosaminoglycan metabolism and Articular Cartilage Extracellular Matrix Pathway. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. An important paralog of this gene is HS3ST5.
UniProtKB/Swiss-Prot for HS3ST1 Gene
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.