Aliases for HRH4 Gene
External Ids for HRH4 Gene
Previous GeneCards Identifiers for HRH4 Gene
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for HRH4 Gene
HRH4 (Histamine Receptor H4) is a Protein Coding gene. Diseases associated with HRH4 include Paraneoplastic Cerebellar Degeneration and Allergic Hypersensitivity Disease. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and histamine binding. An important paralog of this gene is HRH3.
UniProtKB/Swiss-Prot for HRH4 Gene
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Histamine H4 receptors are Galphai/o-protein-coupled receptors, first cloned in 2000. H4 receptors are expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral hematopoietic cells, including eosinophils and T lymphocytes.