Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release... See more...

Aliases for HRH3 Gene

Aliases for HRH3 Gene

  • Histamine Receptor H3 2 3 5
  • GPCR97 2 3 4
  • Histamine H3 Receptor 3 4
  • HH3R 3 4
  • H3R 3 4
  • G Protein-Coupled Receptor 97 3
  • G-Protein Coupled Receptor 97 4
  • HRH3 5

External Ids for HRH3 Gene

Previous GeneCards Identifiers for HRH3 Gene

  • GC20M060553
  • GC20M061428
  • GC20M061475
  • GC20M060223
  • GC20M060790
  • GC20M057566

Summaries for HRH3 Gene

Entrez Gene Summary for HRH3 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]

GeneCards Summary for HRH3 Gene

HRH3 (Histamine Receptor H3) is a Protein Coding gene. Diseases associated with HRH3 include Hepatic Coma and Kleine-Levin Hibernation Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and histamine receptor activity. An important paralog of this gene is HRH4.

UniProtKB/Swiss-Prot Summary for HRH3 Gene

  • The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Tocris Summary for HRH3 Gene

  • Histamine H3 receptors are Galphai/o-protein-coupled receptors expressed at high levels on histaminergic neurons in the CNS, particularly in the basal ganglia, cortex and hippocampus. H3 receptors are thought to function as presynaptic autoreceptors.

Gene Wiki entry for HRH3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HRH3 Gene

Genomics for HRH3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HRH3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J062220 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.7 +0.1 77 1.2 ZNF600 NFIC ZIC2 ZBTB10 MXD4 REST SIN3A THAP11 SMAD4 ZNF511 HRH3 HSALNG0131496 MTG2
GH20J062245 Enhancer 1 Ensembl ENCODE dbSUPER 12.7 -26.4 -26442 1.8 ZFP64 SMAD4 SAP130 RARA GABPB1 TEAD3 MBD1 SOX5 BHLHE40 NR2F6 HRH3 LAMA5-AS1 MTG2 ENSG00000226332 HSALNG0131499 OSBPL2 HSALNG0131500 ADRM1
GH20J062243 Enhancer 0.8 Ensembl ENCODE 12.7 -24.2 -24242 1.9 RXRA SMAD4 SAP130 RARA GATAD1 TFAP4 NFIA ARID4B NR2F6 NR2F1 HRH3 MTG2 OSBPL2 LAMA5-AS1 HSALNG0131499 HSALNG0131500 ADRM1
GH20J062010 Enhancer 0.7 ENCODE 10.6 +209.2 209248 0.2 ZNF654 MYC CTCF REST SIN3A TRIM22 BHLHE40 MNT SAP130 RAD21 lnc-PSMA7-5 PSMA7 SS18L1 HRH3 CDH4 LOC105372704 lnc-PSMA7-4 TAF4
GH20J062291 Enhancer 0.6 Ensembl ENCODE 11.2 -72.9 -72854 3.5 EBF1 ZNF18 PKNOX1 KLF1 RAD51 lnc-LAMA5-4 LAMA5 RPS21 HRH3 LAMA5-AS1 OSBPL2 ENSG00000226332 NONHSAG032220.2 ADRM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HRH3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HRH3

Top Transcription factor binding sites by QIAGEN in the HRH3 gene promoter:
  • Arnt
  • C/EBPalpha
  • CBF(2)
  • CBF-A
  • ER-alpha
  • HTF
  • Olf-1
  • Spz1
  • USF-1
  • USF1

Genomic Locations for HRH3 Gene

Latest Assembly
chr20:62,213,845-62,220,278
(GRCh38/hg38)
Size:
6,434 bases
Orientation:
Minus strand

Previous Assembly
chr20:60,790,016-60,795,334
(GRCh37/hg19 by Entrez Gene)
Size:
5,319 bases
Orientation:
Minus strand

chr20:60,790,026-60,795,323
(GRCh37/hg19 by Ensembl)
Size:
5,298 bases
Orientation:
Minus strand

Genomic View for HRH3 Gene

Genes around HRH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH3 Gene

Proteins for HRH3 Gene

  • Protein details for HRH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5N1-HRH3_HUMAN
    Recommended name:
    Histamine H3 receptor
    Protein Accession:
    Q9Y5N1
    Secondary Accessions:
    • Q4QRI7
    • Q9GZX2
    • Q9H4K8

    Protein attributes for HRH3 Gene

    Size:
    445 amino acids
    Molecular mass:
    48671 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Does not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R(-)-alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.

    Alternative splice isoforms for HRH3 Gene

neXtProt entry for HRH3 Gene

Post-translational modifications for HRH3 Gene

  • Glycosylation at Asn11
  • Modification sites at PhosphoSitePlus

Other Protein References for HRH3 Gene

Antibodies for research

No data available for DME Specific Peptides for HRH3 Gene

Domains & Families for HRH3 Gene

Gene Families for HRH3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for HRH3 Gene

InterPro:
Blocks:
  • Histamine H3 receptor signature

Suggested Antigen Peptide Sequences for HRH3 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 97 (HRH3_HUMAN)
  • Histamine H3 receptor isoform 1 (Q548M6_HUMAN)
  • Histamine H3 receptor isoform 6 (Q8NI49_HUMAN)
  • Histamine H3 receptor isoform 5 (Q8NI50_HUMAN)
  • Histamine H3 receptor isoform 4 (Q8WXZ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5N1

UniProtKB/Swiss-Prot:

HRH3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH3: view

Function for HRH3 Gene

Molecular function for HRH3 Gene

UniProtKB/Swiss-Prot Function:
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Phenotypes From GWAS Catalog for HRH3 Gene

Gene Ontology (GO) - Molecular Function for HRH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004969 histamine receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0016907 G protein-coupled acetylcholine receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with HRH3: view
genes like me logo Genes that share phenotypes with HRH3: view

Animal Models for HRH3 Gene

MGI Knock Outs for HRH3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HRH3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HRH3 Gene

Localization for HRH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRH3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HRH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with HRH3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HRH3 Gene

Pathways & Interactions for HRH3 Gene

genes like me logo Genes that share pathways with HRH3: view

SIGNOR curated interactions for HRH3 Gene

Activates:

Gene Ontology (GO) - Biological Process for HRH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001505 regulation of neurotransmitter levels IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS,IBA 21873635
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with HRH3: view

Drugs & Compounds for HRH3 Gene

(102) Drugs for HRH3 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma Agonist, Full agonist, Target 1228
Betahistine Approved, Investigational Pharma Target, antagonist 18
Chlorpheniramine Approved Pharma 75
Cimetidine Approved, Investigational Pharma H2 receptor antagonist 113
Aripiprazole Approved, Investigational Pharma Target, ligand Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 403

(13) Additional Compounds for HRH3 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-[4-(3-piperidin-1-ylpropoxy)benzyl]piperidine
Antagonist
4-(3-piperdin-1-yl-propoxy)benzonitrile
Antagonist
Perceptin®
Agonist, Full agonist
(R)-(-)-alpha-Methylhistamine dihydrobromide
868698-49-1
(S)-(+)-alpha-Methylhistamine dihydrobromide
75614-93-6

(5) Tocris Compounds for HRH3 Gene

Compound Action Cas Number
(R)-(-)-alpha-Methylhistamine dihydrobromide Potent, standard H3 agonist 868698-49-1
(S)-(+)-alpha-Methylhistamine dihydrobromide H3 agonist, less active enantiomer 75614-93-6
Imetit dihydrobromide Standard H3 and H4 agonist (H3 > H4) 32385-58-3
Immepip dihydrobromide Standard H3 agonist. Also H4 agonist 164391-47-3
Nalpha-Methylhistamine dihydrochloride Non-selective H3 agonist 16503-22-3

(41) ApexBio Compounds for HRH3 Gene

Compound Action Cas Number
A 331440 dihydrochloride H3 receptor antagonist,non-imidazole,high affinity 1049740-32-0
Astemizole 68844-77-9
Azatadine dimaleate 3978-86-7
Azelastine HCl 79307-93-0
Benztropine mesylate 132-17-2
Bepotastine Besilate 190786-44-8
Betahistine 2HCl 5579-84-0
Brompheniramine hydrogen maleate 980-71-2
Buclizine HCl 129-74-8
Cetirizine Antihistamine 83881-51-0
Cetirizine DiHCl H1 receptor inverse agonist 83881-52-1
Chlorpheniramine Maleate 113-92-8
Cimetidine H2 receptor antagonist 51481-61-9
Ciproxifan Histamine H3-receptor antagonist 184025-18-1
Clemastine Fumarate 14976-57-9
Clemizole hydrochloride H1 histamine receptor antagonist 1163-36-6
Cyclizine 2HCl 5897-18-7
Cyproheptadine hydrochloride 969-33-5
Desloratadine 100643-71-8
Epinastine HCl 108929-04-0
Famotidine Histamine H2-receptor antagonist 76824-35-6
Fexofenadine HCl 153439-40-8
Histamine 2HCl 56-92-8
Histamine Phosphate 51-74-1
Hydroxyzine 2HCl 2192-20-3
JNJ-7777120 Histamine H4 receptor antagonist 459168-41-3
Ketotifen Fumarate 34580-14-8
Lafutidine 118288-08-7
Levodropropizine Histamine receptor inhibitor,cough suppressant 99291-25-5
Lidocaine Anasthetic and class Ib antiarrhythmic agent 137-58-6
Loratadine Peripheral HH1R antagonist 79794-75-5
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
Mizolastine 108612-45-9
Nizatidine 76963-41-2
Olopatadine HCl Histamine blocker 140462-76-6
Pemirolast potassium 100299-08-9
Ranitidine Histamine H2-receptor antagonist 66357-59-3
Roxatidine Acetate HCl 93793-83-0
Rupatadine Fumarate 182349-12-8
Serotonin HCl 153-98-0
Tripelennamine HCl H1-receptor antagonist 154-69-8
genes like me logo Genes that share compounds with HRH3: view

Drug products for research

Transcripts for HRH3 Gene

mRNA/cDNA for HRH3 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HRH3

Alternative Splicing Database (ASD) splice patterns (SP) for HRH3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for HRH3 Gene

GeneLoc Exon Structure for
HRH3

Expression for HRH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HRH3 Gene

mRNA differential expression in normal tissues according to GTEx for HRH3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x9.2), Brain - Nucleus accumbens (basal ganglia) (x8.4), Brain - Caudate (basal ganglia) (x6.4), Brain - Hypothalamus (x4.9), and Brain - Cerebellum (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HRH3

SOURCE GeneReport for Unigene cluster for HRH3 Gene:

Hs.251399

mRNA Expression by UniProt/SwissProt for HRH3 Gene:

Q9Y5N1-HRH3_HUMAN
Tissue specificity: Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.

Evidence on tissue expression from TISSUES for HRH3 Gene

  • Nervous system(4.6)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with HRH3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRH3 Gene

Orthologs for HRH3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HRH3 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia HRH3 29 30
  • 90.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HRH3 29 30
  • 88.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hrh3 29 16 30
  • 87.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hrh3 29
  • 87.34 (n)
Oppossum
(Monodelphis domestica)
Mammalia HRH3 30
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HRH3 30
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HRH3 29 30
  • 69.88 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HRH3 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hrh3 29
  • 67.16 (n)
Str.4253 29
Zebrafish
(Danio rerio)
Actinopterygii LOC100334962 29
  • 69.4 (n)
hrh3 30
  • 48 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG7918 30
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea gar-2 30
  • 15 (a)
ManyToMany
gar-1 30
  • 13 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 20 (a)
ManyToMany
-- 30
  • 18 (a)
ManyToMany
Species where no ortholog for HRH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HRH3 Gene

ENSEMBL:
Gene Tree for HRH3 (if available)
TreeFam:
Gene Tree for HRH3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HRH3: view image
Alliance of Genome Resources:
Additional Orthologs for HRH3

Paralogs for HRH3 Gene

(17) SIMAP similar genes for HRH3 Gene using alignment to 7 proteins:

  • HRH3_HUMAN
  • Q548M6_HUMAN
  • Q8NI49_HUMAN
  • Q8NI50_HUMAN
  • Q8WXZ9_HUMAN
  • Q8WY00_HUMAN
  • Q8WY01_HUMAN

Pseudogenes.org Pseudogenes for HRH3 Gene

genes like me logo Genes that share paralogs with HRH3: view

Variants for HRH3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HRH3 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs114303636 Benign: not provided 62,219,725(-) G/A
NM_007232.3(HRH3):c.246C>T (p.Leu82=)
SYNONYMOUS
rs141729367 Benign: not provided 62,216,312(-) G/A
NM_007232.3(HRH3):c.1032C>T (p.Phe344=)
SYNONYMOUS
rs2067476 Benign: not provided 62,216,129(-) C/T
NM_007232.3(HRH3):c.1215G>A (p.Ser405=)
SYNONYMOUS
rs752380770 -- p.Ala280Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HRH3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HRH3 Gene

Variant ID Type Subtype PubMed ID
esv2422398 CNV duplication 17116639
nsv1160689 CNV deletion 26073780
nsv470556 CNV loss 18288195
nsv518296 CNV loss 19592680
nsv955149 CNV deletion 24416366

Variation tolerance for HRH3 Gene

Residual Variation Intolerance Score: 33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HRH3 Gene

Human Gene Mutation Database (HGMD)
HRH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRH3
Leiden Open Variation Database (LOVD)
HRH3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH3 Gene

Disorders for HRH3 Gene

MalaCards: The human disease database

(12) MalaCards diseases for HRH3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatic coma
  • hepatocerebral intoxication
kleine-levin hibernation syndrome
  • kleine-levin syndrome
recurrent hypersomnia
  • primary recurrent hypersomnia
central nervous system disease
  • cns
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search HRH3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HRH3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HRH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRH3 Gene

Publications for HRH3 Gene

  1. Cloning and functional expression of the human histamine H3 receptor. (PMID: 10347254) Lovenberg TW … Erlander MG (Molecular pharmacology 1999) 2 3 4 22
  2. Structure of the human histamine H3 receptor gene (HRH3) and identification of naturally occurring variations. (PMID: 11956964) Wiedemann P … Brüss M (Journal of neural transmission (Vienna, Austria : 1996) 2002) 3 4 22
  3. Molecular cloning and characterization of a new human histamine receptor, HH4R. (PMID: 11118334) Nakamura T … Tanaka K (Biochemical and biophysical research communications 2000) 3 4 22
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 40
  5. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) 3 40

Products for HRH3 Gene

  • Addgene plasmids for HRH3

Sources for HRH3 Gene