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Aliases for HRH2 Gene

Aliases for HRH2 Gene

  • Histamine Receptor H2 2 3 5
  • Gastric Receptor I 3 4
  • HH2R 3 4
  • H2R 3 4
  • Histamine H2 Receptor 3
  • Gastric Receptor 1 3

External Ids for HRH2 Gene

Previous GeneCards Identifiers for HRH2 Gene

  • GC05P175424
  • GC05P175931
  • GC05P175045
  • GC05P175090
  • GC05P175042
  • GC05P175085
  • GC05P170183

Summaries for HRH2 Gene

Entrez Gene Summary for HRH2 Gene

  • Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HRH2 Gene

HRH2 (Histamine Receptor H2) is a Protein Coding gene. Diseases associated with HRH2 include Duodenal Ulcer and Peptic Ulcer Disease. Among its related pathways are Salivary secretion and Monoamine GPCRs. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is ADRB1.

UniProtKB/Swiss-Prot for HRH2 Gene

  • The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Tocris Summary for HRH2 Gene

  • Histamine H2 receptors are Galphas-protein-coupled receptors involved in the suppressive activities of histamine. H2 receptors exhibit a widespread distribution and are found in the gastrointestinal tract, the central nervous system, smooth muscle cells and endothelial cells.

Gene Wiki entry for HRH2 Gene

Additional gene information for HRH2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRH2 Gene

Genomics for HRH2 Gene

GeneHancer (GH) Regulatory Elements for HRH2 Gene

Promoters and enhancers for HRH2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I175657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 415 1.2 ZNF133 SIN3A GLI4 ZBTB7B ZNF335 GLIS2 ZNF366 KLF7 EGR2 SP3 HRH2 LOC105377743
GH05I175658 Enhancer 0.7 ENCODE dbSUPER 550.8 +1.1 1137 0.2 CTCF SIN3A CTBP2 EZH2 HRH2 LOC105377743
GH05I175686 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +31.3 31349 4.9 CTCF L3MBTL2 NRF1 MAX ZIC2 POLR2A GLIS1 GABPB1 ZNF512 MYC HRH2 LOC105377743
GH05I175670 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 14.3 +13.4 13405 1.2 POLR2A REST HRH2 LOC105377743
GH05I175693 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +37.4 37428 4 PKNOX1 RB1 ZBTB40 ZNF2 RAD21 ETS1 E2F8 ZNF143 ETV6 RUNX3 LOC105377743 HRH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HRH2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HRH2 gene promoter:

Genomic Locations for HRH2 Gene

Genomic Locations for HRH2 Gene
52,961 bases
Plus strand

Genomic View for HRH2 Gene

Genes around HRH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRH2 Gene

Proteins for HRH2 Gene

  • Protein details for HRH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histamine H2 receptor
    Protein Accession:
    Secondary Accessions:
    • B5BUP7
    • Q14464
    • Q7Z5R9

    Protein attributes for HRH2 Gene

    359 amino acids
    Molecular mass:
    40098 Da
    Quaternary structure:
    No Data Available
    • Antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. Certain antagonists are used in the treatment of neuropsychiatric and neurological diseases such as schizophrenia, Alzheimer disease and Parkinson disease.

    Alternative splice isoforms for HRH2 Gene


neXtProt entry for HRH2 Gene

Post-translational modifications for HRH2 Gene

  • Glycosylation at posLast=44
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HRH2 Gene

Domains & Families for HRH2 Gene

Gene Families for HRH2 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for HRH2 Gene

Suggested Antigen Peptide Sequences for HRH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HRH2: view

Function for HRH2 Gene

Molecular function for HRH2 Gene

GENATLAS Biochemistry:
histamine H2 receptor,G protein coupled receptor superfamily,activating adenylate cyclase,stimulating gastric acid secretion,increasing contraction of cardiac muscle
UniProtKB/Swiss-Prot Function:
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

Phenotypes From GWAS Catalog for HRH2 Gene

Gene Ontology (GO) - Molecular Function for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004969 histamine receptor activity TAS,IBA --
genes like me logo Genes that share ontologies with HRH2: view
genes like me logo Genes that share phenotypes with HRH2: view

Animal Models for HRH2 Gene

MGI Knock Outs for HRH2:

Clone Products

  • Addgene plasmids for HRH2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HRH2 Gene

Localization for HRH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRH2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRH2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1714721
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HRH2 Gene

Pathways & Interactions for HRH2 Gene

genes like me logo Genes that share pathways with HRH2: view

Gene Ontology (GO) - Biological Process for HRH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001697 histamine-induced gastric acid secretion IBA --
GO:0001698 gastrin-induced gastric acid secretion IEA --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006955 immune response TAS 9725260
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with HRH2: view

No data available for SIGNOR curated interactions for HRH2 Gene

Drugs & Compounds for HRH2 Gene

(169) Drugs for HRH2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ranitidine Approved Pharma Antagonist, Target, antagonist Histamine H2-receptor antagonist 86
Cimetidine Approved, Investigational Pharma Inhibition, Inhibitor, Target, antagonist H2 receptor antagonist 81
Famotidine Approved Pharma Target, antagonist Histamine H2-receptor antagonist 64
Nizatidine Approved Pharma Target, antagonist 9
Histamine Approved, Investigational Pharma Full agonist, Agonist, Target, agonist 1105

(27) Additional Compounds for HRH2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for HRH2 Gene

Compound Action Cas Number
Aminopotentidine H2 antagonist 140873-26-3
Amthamine dihydrobromide Highly selective standard H2 agonist 142457-00-9
Dimaprit dihydrochloride Standard H2 selective agonist 23256-33-9
ICI 162,846 Potent H2 antagonist, active in vivo 84545-30-2
Tiotidine Potent, selective H2 antagonist 69014-14-8

(88) ApexBio Compounds for HRH2 Gene

Compound Action Cas Number
(R)-(-)-α-Methylhistamine dihydrobromide 868698-49-1
(S)-(+)-α-Methylhistamine dihydrobromide 75614-93-6
2-Pyridylethylamine dihydrochloride 3343-39-3
Alcaftadine 147084-10-4
Aminopotentidine 140873-26-3
Amthamine dihydrobromide 142457-00-9
Astemizole 68844-77-9
Azatadine 3964-81-6
Azatadine dimaleate 3978-86-7
Azelastine HCl 79307-93-0
Benztropine mesylate 132-17-2
Bepotastine Besilate 190786-44-8
Betahistine 2HCl 5579-84-0
Bilastine 202189-78-4
Brompheniramine hydrogen maleate 980-71-2
Buclizine HCl 129-74-8
Carcinine ditrifluoroacetate 56897-53-1
Cetirizine Antihistamine 83881-51-0
Cetirizine DiHCl H1 receptor inverse agonist 83881-52-1
Chlorpheniramine Maleate 113-92-8
Cimetidine H2 receptor antagonist 51481-61-9
Ciproxifan Histamine H3-receptor antagonist 184025-18-1
Ciproxifan maleate 184025-19-2
Clemastine Fumarate 14976-57-9
Clemizole hydrochloride H1 histamine receptor antagonist 1163-36-6
Clobenpropit dihydrobromide 145231-35-2
Conessine 546-06-5
Cyclizine 2HCl 5897-18-7
Cyproheptadine hydrochloride 969-33-5
Decloxizine 3733-63-9
Decloxizine dihydrochloride 13073-96-6
Desloratadine 100643-71-8
Dimaprit dihydrochloride 23256-33-9
DPPE fumarate 1185241-83-1
Ebrotidine H2-receptor antagonist,competitive 100981-43-9
Epinastine HCl 108929-04-0
Famotidine Histamine H2-receptor antagonist 76824-35-6
Fexofenadine HCl 153439-40-8
GT 2016 152241-24-2
Histamine 2HCl 56-92-8
Histamine Phosphate 51-74-1
HTMT dimaleate 195867-54-0
Hydroxyzine 68-88-2
Hydroxyzine 2HCl 2192-20-3
ICI 162,846 84545-30-2
Imetit dihydrobromide 32385-58-3
Immepip dihydrobromide 164391-47-3
Immethridine dihydrobromide 699020-93-4
Impentamine dihydrobromide 149629-70-9
Iodophenpropit dihydrobromide 145196-87-8
JNJ 10181457 dihydrochloride 544707-20-2
JNJ 10191584 maleate 869497-75-6
JNJ 5207852 dihydrochloride 398473-34-2
JNJ-7777120 Histamine H4 receptor antagonist 459168-41-3
Ketotifen Fumarate 34580-14-8
Lafutidine 118288-08-7
LED209 Highly selective for histidine sensor kinase QseC 245342-14-7
Levodropropizine Histamine receptor inhibitor,cough suppressant 99291-25-5
Lidocaine Anasthetic and class Ib antiarrhythmic agent 137-58-6
Loratadine Peripheral HH1R antagonist 79794-75-5
Mepyramine maleate 59-33-6
Methimepip dihydrobromide 817636-54-7
Metiamide Histamine H2-receptor antagonist 34839-70-8
Mianserin 24219-97-4
Mianserin HCl 5-HT2 receptor antagonist 21535-47-7
Mizolastine 108612-45-9
Nizatidine 76963-41-2
Nα-Methylhistamine dihydrochloride 16503-22-3
Olopatadine HCl Histamine blocker 140462-76-6
Pemirolast potassium 100299-08-9
Pitolisant Nonimidazole inverse agonist 362665-56-3
Pitolisant hydrochloride Nonimidazole inverse agonist 903576-44-3
Pitolisant oxalate Nonimidazole inverse agonist 362665-57-4
Proxyfan oxalate 177708-09-7
Ranitidine Histamine H2-receptor antagonist 66357-59-3
ROS 234 dioxalate 184576-87-2
Roxatidine Acetate HCl 93793-83-0
Rupatadine Fumarate 182349-12-8
Serotonin HCl 153-98-0
Thioperamide 106243-16-7
Tiotidine 69014-14-8
trans-Triprolidine hydrochloride 550-70-9
Tripelennamine HCl H1-receptor antagonist 154-69-8
VUF 10460 1028327-66-3
VUF 5681 dihydrobromide 639089-06-8
VUF 8430 dihydrobromide 100130-32-3
Zaltidine H2-receptor antagonist 85604-00-8
Zolantidine dimaleate 104076-39-3
genes like me logo Genes that share compounds with HRH2: view

Drug Products

Transcripts for HRH2 Gene

mRNA/cDNA for HRH2 Gene

Unigene Clusters for HRH2 Gene

Histamine receptor H2:
Representative Sequences:

Clone Products

  • Addgene plasmids for HRH2

Alternative Splicing Database (ASD) splice patterns (SP) for HRH2 Gene

No ASD Table

Relevant External Links for HRH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HRH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRH2 Gene

mRNA differential expression in normal tissues according to GTEx for HRH2 Gene

This gene is overexpressed in Whole Blood (x30.6).

NURSA nuclear receptor signaling pathways regulating expression of HRH2 Gene:


SOURCE GeneReport for Unigene cluster for HRH2 Gene:


Evidence on tissue expression from TISSUES for HRH2 Gene

  • Stomach(4.6)
  • Nervous system(4.4)
  • Liver(4.3)
  • Skin(4.2)
  • Intestine(2.5)
  • Heart(2.3)
  • Blood(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with HRH2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRH2 Gene

Orthologs for HRH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HRH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HRH2 33 34
  • 99.81 (n)
(Canis familiaris)
Mammalia HRH2 33 34
  • 87.47 (n)
(Rattus norvegicus)
Mammalia Hrh2 33
  • 85.01 (n)
(Mus musculus)
Mammalia Hrh2 33 16 34
  • 83.99 (n)
(Bos Taurus)
Mammalia LOC521257 33
  • 83.57 (n)
HRH2 34
  • 80 (a)
(Monodelphis domestica)
Mammalia HRH2 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia HRH2 34
  • 55 (a)
(Gallus gallus)
Aves HRH2 33 34
  • 67.18 (n)
(Anolis carolinensis)
Reptilia HRH2 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hrh2 33
  • 61.64 (n)
(Danio rerio)
Actinopterygii hrh2 33
  • 59.86 (n)
HRH2 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Octbeta3R 33
  • 52.23 (n)
CG6919 35
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRNNA3 33
  • 51.52 (n)
(Caenorhabditis elegans)
Secernentea M03F4.3 35
  • 39 (a)
ser-6 34
  • 26 (a)
ser-5 34
  • 20 (a)
Species where no ortholog for HRH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRH2 Gene

Gene Tree for HRH2 (if available)
Gene Tree for HRH2 (if available)

Paralogs for HRH2 Gene

(25) SIMAP similar genes for HRH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HRH2: view

Variants for HRH2 Gene

Sequence variations from dbSNP and Humsavar for HRH2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000044005 -- 175,676,118(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000142021 -- 175,686,391(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000146634 -- 175,708,112(+) GGGG/GGG 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000230301 -- 175,665,840(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000237198 -- 175,691,886(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HRH2 Gene

Variant ID Type Subtype PubMed ID
nsv469707 CNV loss 16826518
nsv600335 CNV loss 21841781
nsv600336 CNV loss 21841781

Variation tolerance for HRH2 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HRH2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRH2 Gene

Disorders for HRH2 Gene

MalaCards: The human disease database

(24) MalaCards diseases for HRH2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenal ulcer
  • curling ulcer
peptic ulcer disease
  • acute peptic ulcer with hemorrhage
gastric ulcer
  • acute gastric ulcer with haemorrhage and perforation
zollinger-ellison syndrome
  • gastrinoma
gastroesophageal reflux
  • ger
- elite association - COSMIC cancer census association via MalaCards
Search HRH2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HRH2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HRH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRH2 Gene

Publications for HRH2 Gene

  1. Molecular cloning of the human histamine H2 receptor. (PMID: 1714721) Gantz I … Yamada T (Biochemical and biophysical research communications 1991) 2 3 4 22 58
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 44 58
  5. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. (PMID: 19026982) Toubanaki DK … Flordellis CS (Analytical biochemistry 2009) 3 44 58

Products for HRH2 Gene

  • Addgene plasmids for HRH2

Sources for HRH2 Gene

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