Aliases for HRCT1 Gene

Aliases for HRCT1 Gene

  • Histidine Rich Carboxyl Terminus 1 2 3 5
  • Histidine-Rich Carboxyl Terminus Protein 1 3 4
  • LGLL338 3
  • PRO537 3
  • UNQ338 3

External Ids for HRCT1 Gene

Summaries for HRCT1 Gene

GeneCards Summary for HRCT1 Gene

HRCT1 (Histidine Rich Carboxyl Terminus 1) is a Protein Coding gene. Diseases associated with HRCT1 include Lipoid Proteinosis Of Urbach And Wiethe.

Additional gene information for HRCT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HRCT1 Gene

Genomics for HRCT1 Gene

GeneHancer (GH) Regulatory Elements for HRCT1 Gene

Promoters and enhancers for HRCT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HRCT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HRCT1

Top Transcription factor binding sites by QIAGEN in the HRCT1 gene promoter:
  • AML1a
  • C/EBPalpha
  • Pbx1a
  • Sox5
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for HRCT1 Gene

Genomic Locations for HRCT1 Gene
chr9:35,906,192-35,907,141
(GRCh38/hg38)
Size:
950 bases
Orientation:
Plus strand
chr9:35,906,189-35,907,138
(GRCh37/hg19)
Size:
950 bases
Orientation:
Plus strand

Genomic View for HRCT1 Gene

Genes around HRCT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRCT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRCT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRCT1 Gene

Proteins for HRCT1 Gene

  • Protein details for HRCT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXD1-HRCT1_HUMAN
    Recommended name:
    Histidine-rich carboxyl terminus protein 1
    Protein Accession:
    Q6UXD1
    Secondary Accessions:
    • B7ZBJ1

    Protein attributes for HRCT1 Gene

    Size:
    115 amino acids
    Molecular mass:
    13183 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HRCT1 Gene

Post-translational modifications for HRCT1 Gene

No Post-translational modifications

Other Protein References for HRCT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HRCT1 Gene

Domains & Families for HRCT1 Gene

Gene Families for HRCT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HRCT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HRCT1 Gene

GenScript: Design optimal peptide antigens:
  • Histidine-rich carboxyl terminus protein 1 (HRCT1_HUMAN)
genes like me logo Genes that share domains with HRCT1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for HRCT1 Gene

Function for HRCT1 Gene

Phenotypes From GWAS Catalog for HRCT1 Gene

Phenotypes for HRCT1 Gene

genes like me logo Genes that share phenotypes with HRCT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HRCT1

CRISPR Products

miRNA for HRCT1 Gene

miRTarBase miRNAs that target HRCT1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HRCT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HRCT1 Gene

Localization for HRCT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRCT1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRCT1 gene
Compartment Confidence
extracellular 3
plasma membrane 1
peroxisome 0
endoplasmic reticulum 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HRCT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HRCT1: view

Pathways & Interactions for HRCT1 Gene

PathCards logo

SuperPathways for HRCT1 Gene

No Data Available

Interacting Proteins for HRCT1 Gene

;

Gene Ontology (GO) - Biological Process for HRCT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HRCT1 Gene

Drugs & Compounds for HRCT1 Gene

No Compound Related Data Available

Transcripts for HRCT1 Gene

mRNA/cDNA for HRCT1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HRCT1

Alternative Splicing Database (ASD) splice patterns (SP) for HRCT1 Gene

No ASD Table

Relevant External Links for HRCT1 Gene

GeneLoc Exon Structure for
HRCT1

Expression for HRCT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HRCT1 Gene

mRNA differential expression in normal tissues according to GTEx for HRCT1 Gene

This gene is overexpressed in Artery - Tibial (x5.7), Artery - Aorta (x5.3), and Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for HRCT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HRCT1 Gene



Protein tissue co-expression partners for HRCT1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HRCT1

SOURCE GeneReport for Unigene cluster for HRCT1 Gene:

Hs.208081
genes like me logo Genes that share expression patterns with HRCT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRCT1 Gene

Orthologs for HRCT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HRCT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRCT1 31 30
  • 96.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HRCT1 31
  • 63 (a)
OneToOne
Species where no ortholog for HRCT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HRCT1 Gene

ENSEMBL:
Gene Tree for HRCT1 (if available)
TreeFam:
Gene Tree for HRCT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HRCT1: view image

Paralogs for HRCT1 Gene

No data available for Paralogs for HRCT1 Gene

Variants for HRCT1 Gene

Additional dbSNP identifiers (rs#s) for HRCT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HRCT1 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Variation tolerance for HRCT1 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.12; 92.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HRCT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HRCT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HRCT1 Gene

Disorders for HRCT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HRCT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lipoid proteinosis of urbach and wiethe
  • lipoid proteinosis
- elite association - COSMIC cancer census association via MalaCards
Search HRCT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HRCT1

genes like me logo Genes that share disorders with HRCT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRCT1 Gene

Publications for HRCT1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 54

Products for HRCT1 Gene

Sources for HRCT1 Gene