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Aliases for HRASLS5 Gene

Aliases for HRASLS5 Gene

  • HRAS Like Suppressor Family Member 5 2 3 5
  • H-Rev107-Like Protein 5 3 4
  • HRAS-Like Suppressor 5 3 4
  • HRLP5 3 4
  • HRSL5 3 4
  • INAT 3 4
  • Calcium-Independent Phosphatidylethanolamine N-Acyltransferase 3
  • Lecithin-Retinol Acyltransferase (LRAT)-Like Protein-1 3
  • HRAS-Like Suppressor Family, Member 5 2
  • Ca(2+)-Independent N-Acyltransferase 3
  • Testicular Tissue Protein Li 90 3
  • EC 2.3.1.- 4
  • RLP1 3

External Ids for HRASLS5 Gene

Previous GeneCards Identifiers for HRASLS5 Gene

  • GC11M062988
  • GC11M063230
  • GC11M059557

Summaries for HRASLS5 Gene

GeneCards Summary for HRASLS5 Gene

HRASLS5 (HRAS Like Suppressor Family Member 5) is a Protein Coding gene. Diseases associated with HRASLS5 include Poland Syndrome and Myasthenic Syndrome, Congenital, 5. Among its related pathways are Metabolism and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is PLA2G16.

UniProtKB/Swiss-Prot for HRASLS5 Gene

  • catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide.

Additional gene information for HRASLS5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HRASLS5 Gene

Genomics for HRASLS5 Gene

GeneHancer (GH) Regulatory Elements for HRASLS5 Gene

Promoters and enhancers for HRASLS5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I063489 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.4 358 3.7 ATF1 FOXA2 TCF12 ZNF766 GATA2 ATF7 SP5 NCOA1 NFIL3 SMARCA4 HRASLS5 PLA2G16 ENSG00000203520 ENSG00000256789 BSCL2 ATL3 LOC100533643
GH11I063608 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -118.6 -118582 3.2 ELF3 SIN3A RAD21 RARA YY1 ZNF335 GLIS2 EGR1 RUNX3 EGR2 LGALS12 PLA2G16 HRASLS5 ENSG00000203520 LOC105369335 GC11M063550
GH11I063494 Enhancer 0.7 ENCODE dbSUPER 0.8 -4.2 -4233 1.2 MEIS2 FOXA2 PKNOX1 HNF4A FOXA1 RARRES3 PLA2G16 ENSG00000203520 ENSG00000256789 ATL3 LGALS12 HRASLS5
GH11I063478 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +12.2 12153 0.3 HDGF RB1 ARNT RAD21 YY1 RFX5 E2F8 ARID2 ZNF143 BCLAF1 NXF1 CSKMT GANAB SNHG1 EML3 INTS5 STX5 MTA2 ENSG00000256789 TUT1
GH11I063502 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 -12.0 -11988 2.3 L3MBTL2 NR4A1 BACH1 CBFA2T3 GABPA MITF POLR2A IKZF1 CUX1 MYC RARRES3 PLA2G16 ENSG00000203520 ENSG00000256789 ATL3 MARK2 RTN3 LGALS12 HRASLS5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HRASLS5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HRASLS5 gene promoter:

Genomic Locations for HRASLS5 Gene

Genomic Locations for HRASLS5 Gene
29,805 bases
Minus strand

Genomic View for HRASLS5 Gene

Genes around HRASLS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRASLS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRASLS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRASLS5 Gene

Proteins for HRASLS5 Gene

  • Protein details for HRASLS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ca(2+)-independent N-acyltransferase
    Protein Accession:
    Secondary Accessions:
    • B7X6T1
    • F5GZ87
    • F5H4Y9

    Protein attributes for HRASLS5 Gene

    279 amino acids
    Molecular mass:
    30312 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HRASLS5 Gene


neXtProt entry for HRASLS5 Gene

Post-translational modifications for HRASLS5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HRASLS5 Gene

Domains & Families for HRASLS5 Gene

Gene Families for HRASLS5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HRASLS5 Gene


Suggested Antigen Peptide Sequences for HRASLS5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the H-rev107 family.
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with HRASLS5: view

Function for HRASLS5 Gene

Molecular function for HRASLS5 Gene

UniProtKB/Swiss-Prot Function:
catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide.

Enzyme Numbers (IUBMB) for HRASLS5 Gene

Gene Ontology (GO) - Molecular Function for HRASLS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016410 N-acyltransferase activity IDA 19000777
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with HRASLS5: view
genes like me logo Genes that share phenotypes with HRASLS5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HRASLS5 Gene

Localization for HRASLS5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRASLS5 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for HRASLS5 Gene

Pathways & Interactions for HRASLS5 Gene

genes like me logo Genes that share pathways with HRASLS5: view

Pathways by source for HRASLS5 Gene

Gene Ontology (GO) - Biological Process for HRASLS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070292 N-acylphosphatidylethanolamine metabolic process IDA,IEA 19000777
genes like me logo Genes that share ontologies with HRASLS5: view

No data available for SIGNOR curated interactions for HRASLS5 Gene

Drugs & Compounds for HRASLS5 Gene

No Compound Related Data Available

Transcripts for HRASLS5 Gene

Unigene Clusters for HRASLS5 Gene

HRAS-like suppressor family, member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HRASLS5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - -
SP6: -

Relevant External Links for HRASLS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HRASLS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRASLS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HRASLS5 Gene

This gene is overexpressed in Testis (x13.0), Adipose - Visceral (Omentum) (x5.0), and Adipose - Subcutaneous (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HRASLS5 Gene

Protein tissue co-expression partners for HRASLS5 Gene

NURSA nuclear receptor signaling pathways regulating expression of HRASLS5 Gene:


SOURCE GeneReport for Unigene cluster for HRASLS5 Gene:


mRNA Expression by UniProt/SwissProt for HRASLS5 Gene:

Tissue specificity: Highest expression level in testis and pancreas.
genes like me logo Genes that share expression patterns with HRASLS5: view

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HRASLS5 Gene

Orthologs for HRASLS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HRASLS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HRASLS5 33 34
  • 98.92 (n)
(Bos Taurus)
Mammalia HRASLS5 33 34
  • 86.21 (n)
(Canis familiaris)
Mammalia HRASLS5 33 34
  • 84.27 (n)
(Mus musculus)
Mammalia Hrasls5 33 16 34
  • 76.99 (n)
(Rattus norvegicus)
Mammalia Hrasls5 33
  • 75.42 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
(Danio rerio)
Actinopterygii CR383676.3 34
  • 40 (a)
CU138503.3 34
  • 36 (a)
zgc:92249 34
  • 36 (a)
zgc:154040 34
  • 34 (a)
Species where no ortholog for HRASLS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HRASLS5 Gene

Gene Tree for HRASLS5 (if available)
Gene Tree for HRASLS5 (if available)

Paralogs for HRASLS5 Gene

Paralogs for HRASLS5 Gene

(4) SIMAP similar genes for HRASLS5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HRASLS5: view

Variants for HRASLS5 Gene

Sequence variations from dbSNP and Humsavar for HRASLS5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000062038 -- 63,465,647(-) G/C intron_variant
rs1000142795 -- 63,473,578(-) C/G intron_variant
rs1000263319 -- 63,492,187(-) AGTTAG/AG upstream_transcript_variant
rs1000371253 -- 63,467,451(-) G/T intron_variant
rs1000413915 -- 63,461,261(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HRASLS5 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV loss 19166990
nsv509417 CNV insertion 20534489
nsv555179 CNV loss 21841781

Variation tolerance for HRASLS5 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HRASLS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HRASLS5 Gene

Disorders for HRASLS5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HRASLS5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
myasthenic syndrome, congenital, 5
  • cms5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HRASLS5

genes like me logo Genes that share disorders with HRASLS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HRASLS5 Gene

Publications for HRASLS5 Gene

  1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. (PMID: 19000777) Jin XH … Ueda N (Biochimica et biophysica acta 2009) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for HRASLS5 Gene

Sources for HRASLS5 Gene

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