This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its... See more...

Aliases for HRAS Gene

Aliases for HRAS Gene

  • HRas Proto-Oncogene, GTPase 2 3 5
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Transforming Protein P21 3 4
  • GTPase HRas 3 4
  • P21ras 3 4
  • HRAS1 3 4
  • Ras Family Small GTP Binding Protein H-Ras 3
  • Harvey Rat Sarcoma Viral Oncoprotein 3
  • Transformation Gene: Oncogene HAMSV 3
  • GTP- And GDP-Binding Peptide B 3
  • C-Ras-Ki-2 Activated Oncogene 3
  • Ha-Ras1 Proto-Oncoprotein 3
  • C-Has/Bas P21 Protein 3
  • P19 H-RasIDX Protein 3
  • GTPase KRas 3
  • C-BAS/HAS 3
  • C-HA-RAS1 3
  • H-RASIDX 3
  • C-Ki-Ras 3
  • C-H-RAS 3
  • K-Ras 2 3
  • C-K-Ras 3
  • H-Ras-1 4
  • C-H-Ras 4
  • Ki-Ras 3
  • Ha-Ras 4
  • HAMSV 3
  • KRAS2 3
  • RASH1 3
  • RASK2 3
  • CTLO 3
  • KRAS 3

External Ids for HRAS Gene

Previous HGNC Symbols for HRAS Gene

  • HRAS1

Previous GeneCards Identifiers for HRAS Gene

  • GC11P001100
  • GC11P001123
  • GC11P000664
  • GC11M000346

Summaries for HRAS Gene

Entrez Gene Summary for HRAS Gene

  • This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

CIViC Summary for HRAS Gene

GeneCards Summary for HRAS Gene

HRAS (HRas Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with HRAS include Costello Syndrome and Schimmelpenning-Feuerstein-Mims Syndrome. Among its related pathways are Transcription Androgen Receptor nuclear signaling and VEGF Signaling Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is NRAS.

UniProtKB/Swiss-Prot Summary for HRAS Gene

  • Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).

Gene Wiki entry for HRAS Gene

Additional gene information for HRAS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HRAS Gene

Genomics for HRAS Gene

GeneHancer (GH) Regulatory Elements for HRAS Gene

Promoters and enhancers for HRAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HRAS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HRAS gene promoter:
  • NF-1
  • NF-1/L
  • STAT3

Genomic Locations for HRAS Gene

Genomic Locations for HRAS Gene
chr11:532,242-537,287
(GRCh38/hg38)
Size:
5,046 bases
Orientation:
Minus strand
chr11:532,242-537,287
(GRCh37/hg19)
Size:
5,046 bases
Orientation:
Minus strand

Genomic View for HRAS Gene

Genes around HRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HRAS Gene

Proteins for HRAS Gene

  • Protein details for HRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01112-RASH_HUMAN
    Recommended name:
    GTPase HRas
    Protein Accession:
    P01112
    Secondary Accessions:
    • B5BUA0
    • Q14080
    • Q6FHV9
    • Q9BR65
    • Q9UCE2

    Protein attributes for HRAS Gene

    Size:
    189 amino acids
    Molecular mass:
    21298 Da
    Quaternary structure:
    • In its GTP-bound form interacts with PLCE1 (PubMed:11022048). Interacts with TBC1D10C (PubMed:17230191). Interacts with RGL3 (By similarity). Interacts with HSPD1 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ (PubMed:11257115). Interacts with RASSF5 (PubMed:18596699). Interacts with PDE6D (PubMed:11980706). Interacts with IKZF3 (PubMed:10369681). Interacts with RACK1 (PubMed:14500341). Interacts with PIK3CG; the interaction is required for membrane recruitment and beta-gamma G protein dimer-dependent activation of the PI3K gamma complex PIK3CG:PIK3R6 (By similarity). Interacts with RAPGEF2 (PubMed:10608844, PubMed:11598133).

    Three dimensional structures from OCA and Proteopedia for HRAS Gene

    Alternative splice isoforms for HRAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HRAS Gene

Post-translational modifications for HRAS Gene

  • Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
  • S-nitrosylated; critical for redox regulation. Important for stimulating guanine nucleotide exchange. No structural perturbation on nitrosylation.
  • The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation.
  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
  • Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for HRAS Gene

Domains & Families for HRAS Gene

Gene Families for HRAS Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HRAS Gene

GenScript: Design optimal peptide antigens:
  • P21 protein (P78460_HUMAN)
  • P21 protein (Q92468_HUMAN)
  • p21ras (RASH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01112

UniProtKB/Swiss-Prot:

RASH_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with HRAS: view

Function for HRAS Gene

Molecular function for HRAS Gene

UniProtKB/Swiss-Prot Function:
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
GENATLAS Biochemistry:
Harvey rat sarcoma viral (v-Ha-ras1) oncogene homolog

Phenotypes From GWAS Catalog for HRAS Gene

Gene Ontology (GO) - Molecular Function for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA,IMP 9230043
GO:0005515 protein binding IPI 2122974
GO:0005525 GTP binding IMP 9230043
GO:0008022 protein C-terminus binding IPI 9219684
genes like me logo Genes that share ontologies with HRAS: view
genes like me logo Genes that share phenotypes with HRAS: view

Human Phenotype Ontology for HRAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HRAS Gene

MGI Knock Outs for HRAS:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for HRAS

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HRAS Gene

Localization for HRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.
Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HRAS gene
Compartment Confidence
plasma membrane 5
nucleus 5
golgi apparatus 5
cytosol 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 10842192
GO:0005794 Golgi apparatus IEA,IDA 14500341
GO:0005886 plasma membrane TAS,IBA --
genes like me logo Genes that share ontologies with HRAS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HRAS Gene

Pathways & Interactions for HRAS Gene

PathCards logo

SuperPathways for HRAS Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 IL-2 Pathway
.59
.59
.54
.51
.49
.48
.47
.44
.43
.36
.35
.34
4 Regulation of lipid metabolism Insulin signaling-generic cascades
5 Endometrial cancer
genes like me logo Genes that share pathways with HRAS: view

Pathways by source for HRAS Gene

114 Qiagen pathways for HRAS Gene
  • 14-3-3 Induced Intracellular Signaling
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Agrin Interactions at Neuromuscular Junction
  • Akt Signaling
1 Cell Signaling Technology pathway for HRAS Gene
2 GeneTex pathways for HRAS Gene

SIGNOR curated interactions for HRAS Gene

Gene Ontology (GO) - Biological Process for HRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation IDA 22065586
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006897 endocytosis IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with HRAS: view

Drugs & Compounds for HRAS Gene

(83) Drugs for HRAS Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1425,1425
Dabrafenib Approved, Investigational Pharma BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 108
Trametinib Approved Pharma MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 179
Vemurafenib Approved Pharma BRAF kinase inhibitor, B-RAF Inhibitors, Kinase Inhibitors, BRAF inhibitors 130
Aldesleukin Approved Pharma 446

(43) Additional Compounds for HRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for HRAS Gene

Compound Action Cas Number
Kobe0065 Ras inhibitor 436133-68-5
kobe2602 Ras inhibitor 454453-49-7
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with HRAS: view

Transcripts for HRAS Gene

CRISPR Products

Clone Products

  • Addgene plasmids for HRAS

Alternative Splicing Database (ASD) splice patterns (SP) for HRAS Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1:
SP2: -
SP3:
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for HRAS Gene

GeneLoc Exon Structure for
HRAS
ECgene alternative splicing isoforms for
HRAS

Expression for HRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HRAS Gene

This gene is overexpressed in Brain (8.5), Bone (8.0), Peripheral blood mononuclear cells (7.3), Monocytes (6.9), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HRAS Gene



NURSA nuclear receptor signaling pathways regulating expression of HRAS Gene:

HRAS

SOURCE GeneReport for Unigene cluster for HRAS Gene:

Hs.37003

mRNA Expression by UniProt/SwissProt for HRAS Gene:

P01112-RASH_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for HRAS Gene

  • Nervous system(4.6)
  • Intestine(3.7)
  • Lung(3.7)
  • Skin(3.6)
  • Blood(3.1)
  • Pancreas(3.1)
  • Liver(3)
  • Lymph node(3)
  • Thyroid gland(2.9)
  • Kidney(2.8)
  • Bone marrow(2.7)
  • Gall bladder(2.7)
  • Heart(2.7)
  • Muscle(2.7)
  • Stomach(2.5)
  • Adrenal gland(2.4)
  • Spleen(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HRAS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • inner ear
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • thyroid
  • tongue
  • tooth
  • vocal cord
Thorax:
  • aorta
  • bronchus
  • chest wall
  • clavicle
  • diaphragm
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Abdomen:
  • adrenal gland
  • kidney
  • stomach
Pelvis:
  • pelvis
  • placenta
  • testicle
  • urinary bladder
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with HRAS: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for HRAS Gene

Orthologs for HRAS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HRAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRAS 33 32
  • 98.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HRAS 32
  • 89.77 (n)
K-RAS 33
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HRAS 33 32
  • 88.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hras 32
  • 88.36 (n)
mouse
(Mus musculus)
Mammalia Hras 17 33 32
  • 87.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HRAS1 33
  • 98 (a)
OneToOne
HRAS 32
  • 83.42 (n)
lizard
(Anolis carolinensis)
Reptilia HRAS 33
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hras 32
  • 81.31 (n)
Str.6315 32
zebrafish
(Danio rerio)
Actinopterygii hrasa 33
  • 95 (a)
OneToMany
hrasb 33
  • 94 (a)
OneToMany
LOC100151000 32
  • 82.72 (n)
wufa04e08 32
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 33 34
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-60 33
  • 76 (a)
OneToMany
C08F8.7 34
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 33
  • 35 (a)
ManyToMany
RAS2 33
  • 34 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.25522 32
Species where no ortholog for HRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HRAS Gene

ENSEMBL:
Gene Tree for HRAS (if available)
TreeFam:
Gene Tree for HRAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HRAS: view image

Paralogs for HRAS Gene