Aliases for HPX Gene
External Ids for HPX Gene
Previous GeneCards Identifiers for HPX Gene
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
GeneCards Summary for HPX Gene
HPX (Hemopexin) is a Protein Coding gene. Diseases associated with HPX include Hepatitis E and Blackwater Fever. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include heme transporter activity. An important paralog of this gene is MMP13.
UniProtKB/Swiss-Prot Summary for HPX Gene
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.