This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009] See more...

Aliases for HPX Gene

Aliases for HPX Gene

  • Hemopexin 2 3 4 5
  • Beta-1B-Glycoprotein 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • HPX 5
  • HX 3

External Ids for HPX Gene

Previous GeneCards Identifiers for HPX Gene

  • GC11M007195
  • GC11M006912
  • GC11M006411
  • GC11M006416
  • GC11M006408
  • GC11M006452
  • GC11M006112

Summaries for HPX Gene

Entrez Gene Summary for HPX Gene

  • This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

GeneCards Summary for HPX Gene

HPX (Hemopexin) is a Protein Coding gene. Diseases associated with HPX include Hepatitis E and Blackwater Fever. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include heme transporter activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot Summary for HPX Gene

  • Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Gene Wiki entry for HPX Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPX Gene

Genomics for HPX Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HPX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006438 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 250.7 +3.4 3416 4 ZNF654 IKZF1 CEBPA ATF3 YY1 MXD4 REST FOXA1 TRIM22 CTCF HPX lnc-TRIM3-2 SMPD1 CAVIN3 APBB1 HSALNG0082421
GH11J006443 Enhancer 0.8 Ensembl ENCODE 250.7 -0.9 -926 0.7 YY1 CTCF REST TRIM22 ZFP64 SMAD4 RXRA RAD21 SMC3 JUND HPX RRP8 APBB1 DNHD1 ARFIP2 TIMM10B SMPD1 HSALNG0082427 TRIM3
GH11J006400 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 10.9 +39.2 39247 5.5 BCLAF1 SP1 SIN3A RAD51 GABPA IRF4 EBF1 CBFB MBD1 BHLHE40 SMPD1 HPX TIMM10B ARFIP2 CAVIN3 APBB1 MK280144-064 lnc-HPX-2
GH11J006432 Enhancer 0.4 Ensembl 6.8 +10.5 10517 0.6 JUND FOS EP300 HSALNG0082421 APBB1 HPX lnc-TRIM3-2
GH11J006468 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 0.3 -26.8 -26754 1.5 ZNF10 NFIC POLR2A MBD2 KLF9 SP2 ELF1 ZFP91 ZBTB48 SUPT5H OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPX on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HPX

Top Transcription factor binding sites by QIAGEN in the HPX gene promoter:
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CHOP-10
  • E2F
  • E2F-1
  • GATA-2
  • p300

Genomic Locations for HPX Gene

Latest Assembly
11,569 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
9,939 bases
Minus strand

(GRCh37/hg19 by Ensembl)
11,569 bases
Minus strand

Genomic View for HPX Gene

Genes around HPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPX Gene

Proteins for HPX Gene

  • Protein details for HPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R957

    Protein attributes for HPX Gene

    462 amino acids
    Molecular mass:
    51676 Da
    Quaternary structure:
    • Interacts with FLVCR1.
    • (Microbial infection) Interacts with hepatitis E virus/HEV protein ORF3.
    • Sequence=CAA26382.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    • The isolated N-terminal domain binds one heme. The full-length protein also binds one heme, but at a different site. The physiological significance of this is not clear (By similarity).

neXtProt entry for HPX Gene

Post-translational modifications for HPX Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylation in the 30-40 region is minor compared to glycosylation at Thr-24 and Thr-29.
  • Glycosylation at Thr24, Thr29, Thr40, Asn64, Asn187, Asn240, Asn246, and Asn453
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • HEMO_HUMAN (757)

Other Protein References for HPX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPX Gene

Domains & Families for HPX Gene

Gene Families for HPX Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for HPX Gene

GenScript: Design optimal peptide antigens:
  • Beta-1B-glycoprotein (HEMO_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the hemopexin family.
  • Belongs to the hemopexin family.
genes like me logo Genes that share domains with HPX: view

Function for HPX Gene

Molecular function for HPX Gene

UniProtKB/Swiss-Prot Function:
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
GENATLAS Biochemistry:
hemopexin,beta 1 glycoprotein of blood serum

Phenotypes From GWAS Catalog for HPX Gene

Gene Ontology (GO) - Molecular Function for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20610401
GO:0015232 heme transporter activity TAS,IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HPX: view
genes like me logo Genes that share phenotypes with HPX: view

Animal Models for HPX Gene

MGI Knock Outs for HPX:
  • Hpx Hpx<tm1Altr>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HPX Gene

Localization for HPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPX Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPX gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 19433579
GO:0062023 collagen-containing extracellular matrix HDA 28675934
GO:0070062 extracellular exosome HDA 19056867
GO:0071682 endocytic vesicle lumen TAS --
genes like me logo Genes that share ontologies with HPX: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HPX Gene

Pathways & Interactions for HPX Gene

genes like me logo Genes that share pathways with HPX: view

SIGNOR curated interactions for HPX Gene


Gene Ontology (GO) - Biological Process for HPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA --
GO:0006879 cellular iron ion homeostasis TAS,IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0015886 heme transport TAS,IEA --
genes like me logo Genes that share ontologies with HPX: view

Drugs & Compounds for HPX Gene

(23) Drugs for HPX Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daptomycin Approved, Investigational Pharma Carrier, binder 105
Zinc chloride Approved, Investigational Pharma Target, ligand 0
Zinc sulfate, unspecified form Approved, Experimental Pharma Target, ligand 0
Fe2+ Experimental Pharma 0
heme Pharma 0

(13) Additional Compounds for HPX Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HPX: view

Transcripts for HPX Gene

mRNA/cDNA for HPX Gene

7 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPX

Alternative Splicing Database (ASD) splice patterns (SP) for HPX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP8: -

Relevant External Links for HPX Gene

GeneLoc Exon Structure for

Expression for HPX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPX Gene

This gene is overexpressed in Liver (x52.1).

Protein differential expression in normal tissues from HIPED for HPX Gene

This gene is overexpressed in Synovial fluid (21.2), Plasma (10.4), and Serum (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HPX Gene

Protein tissue co-expression partners for HPX Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HPX

SOURCE GeneReport for Unigene cluster for HPX Gene:


mRNA Expression by UniProt/SwissProt for HPX Gene:

Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for HPX Gene

  • Liver(5)
  • Nervous system(4.5)
  • Bone marrow(4.3)
  • Saliva(4.3)
  • Heart(3.7)
  • Blood(2.9)
  • Kidney(2.8)
  • Intestine(2.3)
  • Lung(2.3)
  • Spleen(2.2)
  • Eye(2.1)
  • Pancreas(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with HPX: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HPX Gene

Orthologs for HPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HPX 29 30
  • 99.71 (n)
(Canis familiaris)
Mammalia HPX 29 30
  • 85.95 (n)
(Rattus norvegicus)
Mammalia Hpx 29
  • 82.57 (n)
(Mus musculus)
Mammalia Hpx 29 16 30
  • 81.84 (n)
(Bos Taurus)
Mammalia HPX 29 30
  • 81.05 (n)
(Monodelphis domestica)
Mammalia HPX 30
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia HPX 30
  • 52 (a)
(Gallus gallus)
Aves HPX 29 30
  • 57.66 (n)
(Anolis carolinensis)
Reptilia HPX 30
  • 42 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100495728 29
  • 54.95 (n)
(Danio rerio)
Actinopterygii hpx 29 30
  • 50.65 (n)
HPX (2 of 2) 30
  • 38 (a)
Species where no ortholog for HPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HPX Gene

Gene Tree for HPX (if available)
Gene Tree for HPX (if available)
Evolutionary constrained regions (ECRs) for HPX: view image
Alliance of Genome Resources:
Additional Orthologs for HPX

Paralogs for HPX Gene

genes like me logo Genes that share paralogs with HPX: view

Variants for HPX Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HPX Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs114914301 Likely Benign: not provided 6,431,468(-) G/A
NM_000613.3(HPX):c.1132C>T (p.Arg378Trp)
rs12117 Benign: not provided 6,440,254(-) G/Ap.Arg83Trp
NM_000613.3(HPX):c.247C>T (p.Arg83Trp)
rs149204852 Benign: not provided 6,437,622(-) G/A
NM_000613.3(HPX):c.521C>T (p.Thr174Met)
rs151128069 Benign: not provided 6,440,940(-) G/A
NM_000613.3(HPX):c.24C>T (p.Pro8=)
rs34273718 Benign: not provided 6,437,609(-) C/T
NM_000613.3(HPX):c.534G>A (p.Lys178=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HPX Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for HPX Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HPX Gene

Disorders for HPX Gene

MalaCards: The human disease database

(17) MalaCards diseases for HPX Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatitis e
blackwater fever
  • black water fever
testicular yolk sac tumor
  • testicular yolk sac neoplasm
porphyria cutanea tarda
  • pct
  • disorder of porphyrin and hem metabolism
- elite association - COSMIC cancer census association via MalaCards
Search HPX in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HPX

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPX Gene

Publications for HPX Gene

  1. Structure of the human hemopexin gene and evidence for intron-mediated evolution. (PMID: 2842511) Altruda F … Silengo L (Journal of molecular evolution 1988) 2 3 4
  2. The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology. (PMID: 2989777) Altruda F … Silengo L (Nucleic acids research 1985) 2 3 4
  3. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. (PMID: 20610401) Yang Z … Abkowitz JL (The Journal of biological chemistry 2010) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein. (PMID: 19433579) Watanabe J … Reddy ST (The Journal of biological chemistry 2009) 3 22

Products for HPX Gene

Sources for HPX Gene