Aliases for HPSE2 Gene
External Ids for HPSE2 Gene
Previous HGNC Symbols for HPSE2 Gene
Previous GeneCards Identifiers for HPSE2 Gene
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
GeneCards Summary for HPSE2 Gene
HPSE2 (Heparanase 2 (Inactive)) is a Protein Coding gene. Diseases associated with HPSE2 include Urofacial Syndrome 1 and Uterine Benign Neoplasm. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan degradation. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding and heparanase activity. An important paralog of this gene is HPSE.
UniProtKB/Swiss-Prot for HPSE2 Gene
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).