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Aliases for HPSE Gene

Aliases for HPSE Gene

  • Heparanase 2 3 3 5
  • Endo-Glucoronidase 3 4
  • Heparanase-1 3 4
  • HPSE1 3 4
  • HPA1 3 4
  • HPR1 3 4
  • HSE1 3 4
  • HPA 3 4
  • EC 3.2.1.166 4
  • Hpa1 4
  • HEP 4

External Ids for HPSE Gene

Previous GeneCards Identifiers for HPSE Gene

  • GC04M084138
  • GC04M084507
  • GC04M084672
  • GC04M084570
  • GC04M084435
  • GC04M084213
  • GC04M079959

Summaries for HPSE Gene

Entrez Gene Summary for HPSE Gene

  • Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for HPSE Gene

HPSE (Heparanase) is a Protein Coding gene. Diseases associated with HPSE include Israeli Tick Typhus and Urofacial Syndrome 1. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan degradation. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and syndecan binding. An important paralog of this gene is HPSE2.

UniProtKB/Swiss-Prot for HPSE Gene

  • Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Tocris Summary for HPSE Gene

  • Antiangiogenic agents are compounds which prevent angiogenesis in vitro and/or in vivo. Angiogenesis inhibitors may be endogenous or synthetic; others are obtained from diet, for example resveratrol.

Gene Wiki entry for HPSE Gene

Additional gene information for HPSE Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPSE Gene

Genomics for HPSE Gene

GeneHancer (GH) Regulatory Elements for HPSE Gene

Promoters and enhancers for HPSE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J083334 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 655.9 +0.3 288 1.2 CLOCK SIN3A ZBTB7B GLIS2 SP3 ZNF592 ZNF610 GLIS1 WT1 SP7 HPSE HNRNPD HELQ SEC31A ABRAXAS1 LOC105377313
GH04J083320 Enhancer 0.9 FANTOM5 Ensembl ENCODE 53.9 +14.5 14452 1.4 HLF MAX HPSE THAP9 PLAC8 COQ2 HELQ LIN54 LOC105377313
GH04J083315 Enhancer 0.8 FANTOM5 Ensembl ENCODE 53.2 +18.3 18323 1.8 PRDM10 HPSE THAP9 PLAC8 COQ2 HELQ LIN54 LOC105377313
GH04J083454 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -121.0 -120992 3.8 MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A HELQ MRPS18C ABRAXAS1 SEC31A THAP9-AS1 HPSE GPAT3 SLC25A14P1
GH04J083547 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -213.4 -213363 1.8 PKNOX1 FOXA2 SMAD1 ARNT SIN3A FEZF1 IRF4 FOS DEK JUNB ABRAXAS1 HPSE GPAT3 MRPS18C PLAC8 COQ2 HELQ ENSG00000201633 GC04M083639
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPSE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HPSE gene promoter:
  • deltaCREB
  • CREB
  • NF-kappaB

Genomic Locations for HPSE Gene

Genomic Locations for HPSE Gene
chr4:83,292,461-83,335,153
(GRCh38/hg38)
Size:
42,693 bases
Orientation:
Minus strand
chr4:84,213,614-84,256,306
(GRCh37/hg19)
Size:
42,693 bases
Orientation:
Minus strand

Genomic View for HPSE Gene

Genes around HPSE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPSE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPSE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPSE Gene

Proteins for HPSE Gene

  • Protein details for HPSE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y251-HPSE_HUMAN
    Recommended name:
    Heparanase
    Protein Accession:
    Q9Y251
    Secondary Accessions:
    • A9JIG7
    • C7F7I3
    • C7F7I4
    • E9PCA9
    • E9PGR1
    • Q53GE5
    • Q9UL39

    Protein attributes for HPSE Gene

    Size:
    543 amino acids
    Molecular mass:
    61149 Da
    Quaternary structure:
    • Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity. Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1. Interacts with HPSE2.

    Three dimensional structures from OCA and Proteopedia for HPSE Gene

    Alternative splice isoforms for HPSE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPSE Gene

Post-translational modifications for HPSE Gene

  • Proteolytically processed. The cleavage of the 65 kDa form leads to the generation of a linker peptide, and 8 kDa and 50 kDa products. The active form, the 8/50 kDa heterodimer, is resistant to degradation. Complete removal of the linker peptide appears to be a prerequisite to the complete activation of the enzyme.
  • N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility.
  • Glycosylation at Asn459, isoforms=2, 3, 4238, isoforms=3, 4217, Asn200, isoforms=3, 4178, and isoforms=2, 3, 4162
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HPSE Gene

Domains & Families for HPSE Gene

Gene Families for HPSE Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for HPSE Gene

Suggested Antigen Peptide Sequences for HPSE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y251

UniProtKB/Swiss-Prot:

HPSE_HUMAN :
  • Belongs to the glycosyl hydrolase 79 family.
Family:
  • Belongs to the glycosyl hydrolase 79 family.
genes like me logo Genes that share domains with HPSE: view

Function for HPSE Gene

Molecular function for HPSE Gene

UniProtKB/Swiss-Prot Function:
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
UniProtKB/Swiss-Prot CatalyticActivity:
Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by EDTA, laminarin sulfate and, to a lower extent, by heparin and sulfamin and activated by calcium and magnesium.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.7 uM for M09 S05a, an heparin sulfate analog with a nonasaccharide with N-sulfation and a single GlcNS(6S) toward the reducing end {ECO:0000269 PubMed:28581485}; Note=Kcat is 0.53 sec(-1) for M09 S05a. {ECO:0000269 PubMed:28581485}; pH dependence: Optimum pH is 4-6. {ECO:0000269 PubMed:10446189, ECO:0000269 PubMed:10764835, ECO:0000269 PubMed:12713442, ECO:0000269 PubMed:15848168};
GENATLAS Biochemistry:
heparanase,widely expressed,noteworthy in placenta,platelet,spleen,smooth muscle cells,endoglyosidase cleaving heparan sulfate proteoglycan at a limited mumber of sites along the polysaccharide chain,essential in the disassembly of the extracellular matrix (ECM) by invading cells,involved in tumor invasion and metastasis

Enzyme Numbers (IUBMB) for HPSE Gene

Phenotypes From GWAS Catalog for HPSE Gene

Gene Ontology (GO) - Molecular Function for HPSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004566 beta-glucuronidase activity TAS 10395325
GO:0005515 protein binding IPI 15292202
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0030305 heparanase activity TAS --
genes like me logo Genes that share ontologies with HPSE: view
genes like me logo Genes that share phenotypes with HPSE: view

Animal Models for HPSE Gene

MGI Knock Outs for HPSE:
  • Hpse Hpse<tm1Jpli>
  • Hpse Hpse<tm1.2Mdh>
  • Hpse Hpse<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for HPSE

CRISPR Products

miRNA for HPSE Gene

miRTarBase miRNAs that target HPSE

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPSE

Clone Products

  • Addgene plasmids for HPSE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HPSE Gene

Localization for HPSE Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPSE Gene

Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPSE gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HPSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA,IDA 20309870
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IEA,IDA 15126626
GO:0005765 lysosomal membrane IEA --
genes like me logo Genes that share ontologies with HPSE: view

Pathways & Interactions for HPSE Gene

genes like me logo Genes that share pathways with HPSE: view

Gene Ontology (GO) - Biological Process for HPSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0006029 proteoglycan metabolic process TAS 10446189
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IDA 12773484
GO:0010575 positive regulation of vascular endothelial growth factor production IDA 16452201
genes like me logo Genes that share ontologies with HPSE: view

No data available for SIGNOR curated interactions for HPSE Gene

Drugs & Compounds for HPSE Gene

(24) Drugs for HPSE Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist, cofactor, Enzyme, substrate 905
Dalteparin Approved Pharma Enzyme, substrate 341
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0

(22) Additional Compounds for HPSE Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Linomide
84088-42-6
OGT 2115
853929-59-6

(3) Tocris Compounds for HPSE Gene

Compound Action Cas Number
Combretastatin A4 Antiangiogenic 117048-59-6
Linomide Immunomodulator with antiangiogenic properties 84088-42-6
OGT 2115 Antiangiogenic. Heparanase inhibitor 853929-59-6
genes like me logo Genes that share compounds with HPSE: view

Transcripts for HPSE Gene

Unigene Clusters for HPSE Gene

Heparanase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPSE

Clone Products

  • Addgene plasmids for HPSE

Alternative Splicing Database (ASD) splice patterns (SP) for HPSE Gene

No ASD Table

Relevant External Links for HPSE Gene

GeneLoc Exon Structure for
HPSE
ECgene alternative splicing isoforms for
HPSE

Expression for HPSE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HPSE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPSE Gene

This gene is overexpressed in Whole Blood (x19.5).

Protein differential expression in normal tissues from HIPED for HPSE Gene

This gene is overexpressed in Platelet (38.9), Peripheral blood mononuclear cells (19.1), and Serum (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HPSE Gene



Protein tissue co-expression partners for HPSE Gene

NURSA nuclear receptor signaling pathways regulating expression of HPSE Gene:

HPSE

SOURCE GeneReport for Unigene cluster for HPSE Gene:

Hs.44227

mRNA Expression by UniProt/SwissProt for HPSE Gene:

Q9Y251-HPSE_HUMAN
Tissue specificity: Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henles and Huxleys layers of inner the root sheath (IRS) at anagen phase.

Evidence on tissue expression from TISSUES for HPSE Gene

  • Blood(4.4)
  • Liver(4.4)
  • Intestine(4.3)
  • Kidney(4.3)
  • Pancreas(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with HPSE: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HPSE Gene

Orthologs for HPSE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HPSE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPSE 34 33
  • 99.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HPSE 34 33
  • 86.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HPSE 34 33
  • 86.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hpse 16 34 33
  • 80.37 (n)
rat
(Rattus norvegicus)
Mammalia Hpse 33
  • 79.91 (n)
oppossum
(Monodelphis domestica)
Mammalia HPSE 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves HPSE 34 33
  • 62.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HPSE 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hpse 33
  • 61.96 (n)
zebrafish
(Danio rerio)
Actinopterygii hpse 34 33
  • 57.03 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons GUS3 33
  • 44.35 (n)
rice
(Oryza sativa)
Liliopsida Os06g0179000 33
  • 44.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for HPSE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPSE Gene

ENSEMBL:
Gene Tree for HPSE (if available)
TreeFam:
Gene Tree for HPSE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPSE: view image

Paralogs for HPSE Gene

Paralogs for HPSE Gene

(1) SIMAP similar genes for HPSE Gene using alignment to 4 proteins:

  • HPSE_HUMAN
  • D6RAQ1_HUMAN
  • D6RHG4_HUMAN
  • E9PFG6_HUMAN
genes like me logo Genes that share paralogs with HPSE: view

Variants for HPSE Gene

Sequence variations from dbSNP and Humsavar for HPSE Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
VAR_023600 Some hepatocellular carcinoma p.Asn260Ser
rs1000020561 -- 83,328,258(-) G/A intron_variant
rs1000074379 -- 83,327,963(-) G/A intron_variant
rs1000093623 -- 83,314,751(-) G/T intron_variant
rs10001403 -- 83,298,925(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HPSE Gene

Variant ID Type Subtype PubMed ID
dgv156n6 CNV deletion 16902084
esv1009126 CNV deletion 20482838
esv1199239 CNV deletion 17803354
esv2180695 CNV deletion 18987734
esv2448972 CNV deletion 19546169
esv2600138 CNV deletion 19546169
esv2667959 CNV deletion 23128226
esv2727902 CNV deletion 23290073
esv2727903 CNV deletion 23290073
esv3564161 CNV deletion 23714750
esv3601192 CNV gain 21293372
esv3601194 CNV gain 21293372
esv3893971 CNV gain 25118596
esv4639 CNV loss 18987735
esv6001 CNV loss 19470904
nsv1139276 CNV deletion 24896259
nsv1150337 CNV deletion 26484159
nsv526041 CNV loss 19592680
nsv829992 CNV loss 17160897
nsv956348 CNV deletion 24416366

Variation tolerance for HPSE Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPSE Gene

Human Gene Mutation Database (HGMD)
HPSE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPSE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPSE Gene

Disorders for HPSE Gene

MalaCards: The human disease database

(8) MalaCards diseases for HPSE Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search HPSE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HPSE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HPSE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPSE Gene

Publications for HPSE Gene

  1. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. (PMID: 10395325) Vlodavsky I … Pecker I (Nature medicine 1999) 2 3 4 22 58
  2. Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. (PMID: 20097882) Purushothaman A … Sanderson RD (Blood 2010) 3 4 22 58
  3. Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation. (PMID: 19406828) Ostrovsky O … Nagler A (Journal of leukocyte biology 2009) 3 22 44 58
  4. Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis. (PMID: 18557927) Malgouries S … Bernard BA (Experimental dermatology 2008) 3 4 22 58
  5. Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies. (PMID: 17611567) Ostrovsky O … Nagler A (Leukemia 2007) 3 22 44 58

Products for HPSE Gene

  • Addgene plasmids for HPSE

Sources for HPSE Gene

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