This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the ... See more...

Aliases for HPR Gene

Aliases for HPR Gene

  • Haptoglobin-Related Protein 2 3 4 5
  • Haptoglobin-Related Locus 3
  • A-259H10.2 3
  • HP 3

External Ids for HPR Gene

Previous GeneCards Identifiers for HPR Gene

  • GC16P062990
  • GC16P072830
  • GC16P071832
  • GC16P071873
  • GC16P071883
  • GC16P070665
  • GC16P057863

Summaries for HPR Gene

Entrez Gene Summary for HPR Gene

  • This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]

GeneCards Summary for HPR Gene

HPR (Haptoglobin-Related Protein) is a Protein Coding gene. Diseases associated with HPR include Sleeping Sickness and Trypanosomiasis. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and African trypanosomiasis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and hemoglobin binding. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot Summary for HPR Gene

  • Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.

Gene Wiki entry for HPR Gene

Additional gene information for HPR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPR Gene

Genomics for HPR Gene

GeneHancer (GH) Regulatory Elements for HPR Gene

Promoters and enhancers for HPR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J072063 Promoter/Enhancer 1.1 EPDnew Ensembl 507.1 -0.5 -547 2 FOXK2 NCOR1 KDM6A ZBTB25 SKI ZSCAN9 FOXA2 CEBPB KAT7 TBP HPR DHX38 TXNL4B DHODH MF281447
GH16J072008 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 14 -54.1 -54147 2 FOXK2 ZBTB40 ZNF217 NRF1 USF1 POLR2G SP1 RBAK PHF8 ZNF639 DHODH DHX38 ENSG00000247324 HYDIN PHLPP2 ATXN1L IST1 CMTR2 HPR ZNF19
GH16J072072 Enhancer 1.1 Ensembl ENCODE 21 +10.1 10066 2 FOXK2 NCOR1 TEAD4 KDM6A ZBTB11 TCF7 ZBTB25 TOE1 TGIF2 CTBP1 HPR DHX38 TXNL4B DHODH ENSG00000260252
GH16J072012 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 14.9 -49.5 -49452 2.2 ZIC2 ZBTB11 MYC CTBP1 RBM25 NR2F2 NCOR1 ESRRA NEUROD1 NFIC PKD1L3 TXNL4B HP HPR DHODH DHX38 piR-30361
GH16J072171 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.8 +110.3 110252 4.8 ZBTB40 EP300 USF1 RFX1 TRIM22 BCL11A TCF12 ZNF316 MAFF USF2 HPR HP PMFBP1 PKD1L3 IST1 AP1G1 ATXN1L DHX38 piR-34822-122
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPR on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HPR

Top Transcription factor binding sites by QIAGEN in the HPR gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CREB
  • deltaCREB
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2
  • SRY

Genomic Locations for HPR Gene

Genomic Locations for HPR Gene
chr16:72,063,148-72,077,246
(GRCh38/hg38)
Size:
14,099 bases
Orientation:
Plus strand
chr16:72,088,522-72,111,145
(GRCh37/hg19)
Size:
22,624 bases
Orientation:
Plus strand

Genomic View for HPR Gene

Genes around HPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPR Gene

Proteins for HPR Gene

  • Protein details for HPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00739-HPTR_HUMAN
    Recommended name:
    Haptoglobin-related protein
    Protein Accession:
    P00739
    Secondary Accessions:
    • Q7LE20
    • Q92658
    • Q92659
    • Q9ULB0

    Protein attributes for HPR Gene

    Size:
    348 amino acids
    Molecular mass:
    39030 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPR Gene

Post-translational modifications for HPR Gene

  • Glycosylation at Asn126 and Asn149
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for HPR Gene

No data available for DME Specific Peptides for HPR Gene

Domains & Families for HPR Gene

Gene Families for HPR Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for HPR Gene

Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HPR Gene

GenScript: Design optimal peptide antigens:
  • Haptoglobin-related protein (HPTR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P00739

UniProtKB/Swiss-Prot:

HPTR_HUMAN :
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
  • Belongs to the peptidase S1 family.
Domain:
  • The uncleaved signal sequence interacts with HDL fluid lipids and mediates incorporation into the HDL particle.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with HPR: view

Function for HPR Gene

Molecular function for HPR Gene

UniProtKB/Swiss-Prot Function:
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
GENATLAS Biochemistry:
haptoglobin-related sequence

Phenotypes From GWAS Catalog for HPR Gene

Gene Ontology (GO) - Molecular Function for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA,IEA 21873635
GO:0030492 hemoglobin binding NAS 2987228
genes like me logo Genes that share ontologies with HPR: view
genes like me logo Genes that share phenotypes with HPR: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPR Gene

Localization for HPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPR Gene

Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269 PubMed:16778136}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPR gene
Compartment Confidence
extracellular 4
plasma membrane 2
nucleus 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0034366 spherical high-density lipoprotein particle IDA 16682745
GO:0070062 extracellular exosome HDA 23533145
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with HPR: view

Pathways & Interactions for HPR Gene

genes like me logo Genes that share pathways with HPR: view

Pathways by source for HPR Gene

Gene Ontology (GO) - Biological Process for HPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IBA 21873635
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0010033 response to organic substance IBA 21873635
GO:0010942 positive regulation of cell death IBA 21873635
genes like me logo Genes that share ontologies with HPR: view

No data available for SIGNOR curated interactions for HPR Gene

Drugs & Compounds for HPR Gene

(38) Drugs for HPR Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 2822
Copper Approved, Investigational Pharma Target 236
zinc acetate Approved, Investigational Pharma Target 0
Zinc chloride Approved, Investigational Pharma Target 0
Clopidogrel Approved Pharma P2Y12 receptor antagonist 909

(13) Additional Compounds for HPR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HPR: view

Transcripts for HPR Gene

mRNA/cDNA for HPR Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPR Gene

No ASD Table

Relevant External Links for HPR Gene

GeneLoc Exon Structure for
HPR

Expression for HPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPR Gene

This gene is overexpressed in Liver (x36.9) and Heart - Left Ventricle (x7.4).

Protein differential expression in normal tissues from HIPED for HPR Gene

This gene is overexpressed in Plasma (24.8), Serum (7.9), and Urine (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HPR Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HPR

SOURCE GeneReport for Unigene cluster for HPR Gene:

Hs.655361

mRNA Expression by UniProt/SwissProt for HPR Gene:

P00739-HPTR_HUMAN
Tissue specificity: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
genes like me logo Genes that share expression patterns with HPR: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPR Gene

Orthologs for HPR Gene

This gene was present in the common ancestor of chordates.

Orthologs for HPR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPR 31 30
  • 94.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HP 31
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hp 31
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 68 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HP 31
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hp 31
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
ManyToMany
CSA.10613 31
  • 14 (a)
ManyToMany
-- 31
  • 11 (a)
ManyToMany
-- 31
  • 10 (a)
ManyToMany
-- 31
  • 1 (a)
ManyToMany
Species where no ortholog for HPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HPR Gene

ENSEMBL:
Gene Tree for HPR (if available)
TreeFam:
Gene Tree for HPR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPR: view image

Paralogs for HPR Gene

(5) SIMAP similar genes for HPR Gene using alignment to 2 proteins:

  • HPTR_HUMAN
  • J3KTC3_HUMAN
genes like me logo Genes that share paralogs with HPR: view

Variants for HPR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HPR Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
739000 Benign: not provided 72,076,568(+) G/T SYNONYMOUS_VARIANT
768788 Benign: not provided 72,076,983(+) C/T SYNONYMOUS_VARIANT
768789 Benign: not provided 72,077,049(+) C/G MISSENSE_VARIANT
791062 Benign: not provided 72,076,424(+) G/T SYNONYMOUS_VARIANT
rs1049933 - p.Ala156Val

Additional dbSNP identifiers (rs#s) for HPR Gene

Structural Variations from Database of Genomic Variants (DGV) for HPR Gene

Variant ID Type Subtype PubMed ID
dgv1636e59 CNV duplication 20981092
dgv3017n100 CNV gain 25217958
dgv504e199 CNV deletion 23128226
dgv530e214 CNV gain 21293372
dgv531e214 CNV gain 21293372
dgv532e214 CNV gain 21293372
esv2215660 CNV deletion 18987734
esv23639 CNV gain+loss 19812545
esv2422047 CNV duplication 20811451
esv2478287 CNV deletion 19546169
esv2714683 CNV deletion 23290073
esv2714685 CNV deletion 23290073
esv2758654 CNV gain 17122850
esv3638989 CNV loss 21293372
esv3638992 CNV loss 21293372
esv3892884 CNV loss 25118596
nsv1864 CNV insertion 18451855
nsv428329 CNV gain 18775914
nsv436836 CNV insertion 17901297
nsv514814 CNV gain 21397061
nsv572951 CNV gain 21841781
nsv7285 OTHER inversion 18451855
nsv817737 CNV loss 17921354
nsv827729 CNV loss 20364138
nsv833273 CNV loss 17160897
nsv9456 CNV gain+loss 18304495
nsv978167 CNV duplication 23825009

Variation tolerance for HPR Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPR Gene

Disorders for HPR Gene

MalaCards: The human disease database

(7) MalaCards diseases for HPR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sleeping sickness
  • african sleeping sickness
trypanosomiasis
anhaptoglobinemia
  • ahp
bacterial pneumonia
  • gram-negative pneumonia
3-methylglutaconic aciduria, type iv
  • mgca4
- elite association - COSMIC cancer census association via MalaCards
Search HPR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HPR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPR Gene

Publications for HPR Gene

  1. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. (PMID: 16778136) Nielsen MJ … Moestrup SK (Blood 2006) 2 3 4 23 54
  2. Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells. (PMID: 8945641) Tabak S … Shalitin C (DNA and cell biology 1996) 3 4 23 54
  3. Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. (PMID: 2987228) Maeda N (The Journal of biological chemistry 1985) 2 3 4 54
  4. A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein. (PMID: 25037218) Harrington JM … Hajduk SL (The Journal of biological chemistry 2014) 3 4 54
  5. A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. (PMID: 22403646) Froguel P … Visvikis-Siest S (PloS one 2012) 3 41 54

Products for HPR Gene

Sources for HPR Gene