Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008] See more...

Aliases for HPGDS Gene

Aliases for HPGDS Gene

  • Hematopoietic Prostaglandin D Synthase 2 3 4 5
  • GSTS 2 3 4
  • PGDS 2 3 4
  • Glutathione-Requiring Prostaglandin D Synthase 3 4
  • Glutathione-Dependent PGD Synthase 3 4
  • Glutathione S-Transferase Sigma 2 3
  • Prostaglandin-H2 D-Isomerase 3 4
  • GST Class-Sigma 3 4
  • GSTS1-1 2 3
  • H-PGDS 2 4
  • GSTS1 2 3
  • PGD2 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Hematopoietic Prostaglandin D2 Synthase 3
  • Glutathione-Dependent PGD Synthetase 3
  • Glutathione S-Transferase 4
  • EC 5.3.99.2 4
  • EC 2.5.1.18 4
  • PTGDS2 4
  • HPGDS 5

External Ids for HPGDS Gene

Previous GeneCards Identifiers for HPGDS Gene

  • GC04M095439
  • GC04M095219
  • GC04M090957

Summaries for HPGDS Gene

Entrez Gene Summary for HPGDS Gene

  • Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for HPGDS Gene

HPGDS (Hematopoietic Prostaglandin D Synthase) is a Protein Coding gene. Diseases associated with HPGDS include Pseudopterygium and Intermediate Malignant Teratoma. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is GSTA3.

UniProtKB/Swiss-Prot Summary for HPGDS Gene

  • Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

Gene Wiki entry for HPGDS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPGDS Gene

Genomics for HPGDS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HPGDS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J094343 Promoter 0.9 EPDnew Ensembl 250.7 +0.1 75 0.4 PRDM10 SPI1 L3MBTL2 HPGDS lnc-HPGDS-5 ENSG00000287552 SMARCAD1
GH04J094342 Promoter 0.6 Ensembl 250.7 +0.8 775 0.6 CEBPA IRF9 CEBPG CEBPB DACH1 HPGDS lnc-HPGDS-5 ENSG00000287552 SMARCAD1
GH04J094349 Enhancer 0.7 FANTOM5 dbSUPER 42.3 -6.5 -6496 0.2 NFATC3 PRDM6 MEIS2 SMARCE1 ATF3 SMARCA4 HSALNG0035882 HPGDS PDLIM5 RPL35AP11 ENSG00000287552
GH04J094338 Enhancer 0.8 FANTOM5 ENCODE 9.3 +3.7 3693 0.8 ZNF316 NFE2 RELA BATF MAFG MAFK JUNB DPF2 SOX6 HMBOX1 HPGDS lnc-HPGDS-5 ENSG00000287552 SMARCAD1
GH04J094542 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -204.9 -204924 10 MYC NCOR1 IKZF1 JUND ZNF592 ATF2 NFIC NONO CEBPB HES1 PDLIM5 HPGDS L13714-347 MF281438-018 NONHSAG038451.2 BMPR1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPGDS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HPGDS

Genomic Locations for HPGDS Gene

Latest Assembly
chr4:94,298,535-94,342,876
(GRCh38/hg38)
Size:
44,342 bases
Orientation:
Minus strand

Previous Assembly
chr4:95,219,686-95,263,987
(GRCh37/hg19 by Entrez Gene)
Size:
44,302 bases
Orientation:
Minus strand

chr4:95,219,686-95,264,027
(GRCh37/hg19 by Ensembl)
Size:
44,342 bases
Orientation:
Minus strand

Genomic View for HPGDS Gene

Genes around HPGDS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPGDS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPGDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPGDS Gene

Proteins for HPGDS Gene

  • Protein details for HPGDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60760-HPGDS_HUMAN
    Recommended name:
    Hematopoietic prostaglandin D synthase
    Protein Accession:
    O60760
    Secondary Accessions:
    • Q6FHT9

    Protein attributes for HPGDS Gene

    Size:
    199 amino acids
    Molecular mass:
    23344 Da
    Cofactor:
    Name=glutathione; Xref=ChEBI:CHEBI:57925;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HPGDS Gene

neXtProt entry for HPGDS Gene

Post-translational modifications for HPGDS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPGDS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPGDS Gene

Domains & Families for HPGDS Gene

Gene Families for HPGDS Gene

Protein Domains for HPGDS Gene

Suggested Antigen Peptide Sequences for HPGDS Gene

GenScript: Design optimal peptide antigens:
  • Prostaglandin-H2 D-isomerase (HPGDS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60760

UniProtKB/Swiss-Prot:

HPGDS_HUMAN :
  • Belongs to the GST superfamily. Sigma family.
Family:
  • Belongs to the GST superfamily. Sigma family.
genes like me logo Genes that share domains with HPGDS: view

Function for HPGDS Gene

Molecular function for HPGDS Gene

UniProtKB/Swiss-Prot Function:
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=prostaglandin H2 = prostaglandin D2; Xref=Rhea:RHEA:10600, ChEBI:CHEBI:57405, ChEBI:CHEBI:57406; EC=5.3.99.2; Evidence={ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:15113825};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2; Xref=Rhea:RHEA:51232, ChEBI:CHEBI:85166, ChEBI:CHEBI:133979; Evidence={ECO:0000269|PubMed:12244105};.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13-acetate (TPA).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 mM for glutathione for the glutathione-conjugating activity {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; KM=0.6 mM for glutathione for the prostaglandin D synthase activity in the presence of EDTA {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; KM=0.14 mM for glutathione for the prostaglandin D synthase activity in the presence of magnesium ions {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=8.6 umol/min/mg enzyme with 1-bromo-2,4-dinitrobenzene as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=5.1 umol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=44.3 umol/min/mg enzyme with 1-fluoro-2,4-dinitrobenzene as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=10.7 umol/min/mg enzyme with 1-iodo-2,4-dinitrobenzene as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=6.8 umol/min/mg enzyme with allyl isothiocyanate as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=6.3 umol/min/mg enzyme with benzyl isothiocyanate as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825}; Vmax=0.05 umol/min/mg enzyme with cumene hydroperoxide as substrate {ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825};
UniProtKB/Swiss-Prot EnzymeRegulation:
Prostaglandin PGD2 synthesis is stimulated by calcium and magnesium ions. One calcium or magnesium ion is bound between the subunits of the homodimer. The interactions with the protein are for the most part mediated via water molecules. Magnesium increases the affinity for glutathione, while calcium has no effect on the affinity for glutathione.

Enzyme Numbers (IUBMB) for HPGDS Gene

Phenotypes From GWAS Catalog for HPGDS Gene

Gene Ontology (GO) - Molecular Function for HPGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12627223
GO:0004364 glutathione transferase activity IBA 21873635
GO:0004667 prostaglandin-D synthase activity TAS,IDA 12627223
GO:0005509 calcium ion binding IDA 12627223
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HPGDS: view
genes like me logo Genes that share phenotypes with HPGDS: view

Animal Models for HPGDS Gene

MGI Knock Outs for HPGDS:
  • Hpgds Hpgds<tm1Urad>
  • Hpgds Hpgds<tm1b(KOMP)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for HPGDS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPGDS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HPGDS Gene

Localization for HPGDS Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPGDS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPGDS gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 3
mitochondrion 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HPGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9353279
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with HPGDS: view

Pathways & Interactions for HPGDS Gene

genes like me logo Genes that share pathways with HPGDS: view

Pathways by source for HPGDS Gene

1 GeneGo (Thomson Reuters) pathway for HPGDS Gene
  • Prostaglandin 2 biosynthesis and metabolism FM

Gene Ontology (GO) - Biological Process for HPGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006693 prostaglandin metabolic process IEA,IDA 12627223
genes like me logo Genes that share ontologies with HPGDS: view

No data available for SIGNOR curated interactions for HPGDS Gene

Drugs & Compounds for HPGDS Gene

(17) Drugs for HPGDS Gene - From: DrugBank, ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Oxidized glutathione Approved, Experimental, Investigational Pharma Target, activator 0
Tretinoin Approved, Investigational Nutra Target 288
Glycerol Approved, Investigational Pharma 207
1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID Experimental Pharma Target 0

(1) Additional Compounds for HPGDS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prostaglandin H2
  • (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
  • (5Z,13E,15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
  • (5Z,9alpha,11alpha,13E,15S)-9,11-Epidioxy-15-hydroxyprosta-5,13-dien-1-Oic acid
  • 9,11-Epoxymethano-PGH2
  • PGH2
42935-17-1

(2) ApexBio Compounds for HPGDS Gene

Compound Action Cas Number
HPGDS inhibitor 1 HPGDS inhibitor 1033836-12-2
HQL 79 162641-16-9
genes like me logo Genes that share compounds with HPGDS: view

Transcripts for HPGDS Gene

mRNA/cDNA for HPGDS Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPGDS

Alternative Splicing Database (ASD) splice patterns (SP) for HPGDS Gene

No ASD Table

Relevant External Links for HPGDS Gene

GeneLoc Exon Structure for
HPGDS

Expression for HPGDS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HPGDS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HPGDS Gene

This gene is overexpressed in Oral epithelium (13.5), Pancreas (8.4), Stomach (7.6), and Lung (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HPGDS Gene



Protein tissue co-expression partners for HPGDS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HPGDS

SOURCE GeneReport for Unigene cluster for HPGDS Gene:

Hs.128433

mRNA Expression by UniProt/SwissProt for HPGDS Gene:

O60760-HPGDS_HUMAN
Tissue specificity: Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver.

Evidence on tissue expression from TISSUES for HPGDS Gene

  • Blood(4.7)
  • Nervous system(4.6)
  • Intestine(3.1)
  • Kidney(3)
  • Liver(2.8)
  • Heart(2.8)
  • Lung(2.8)
  • Muscle(2.7)
  • Skin(2.6)
  • Pancreas(2.3)
  • Stomach(2.3)
  • Urine(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with HPGDS: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPGDS Gene

Orthologs for HPGDS Gene

This gene was present in the common ancestor of animals.

Orthologs for HPGDS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HPGDS 29 30
  • 99.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HPGDS 29 30
  • 89.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HPGDS 29 30
  • 88.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hpgds 29
  • 83.25 (n)
Mouse
(Mus musculus)
Mammalia Hpgds 29 16 30
  • 82.24 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia HPGDS 30
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HPGDS 30
  • 71 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HPGDS 29 30
  • 69.35 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hpgds 29
  • 61.26 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta GstS1 29 30
  • 48.97 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GST_ANOGA 29
  • 45.9 (n)
Worm
(Caenorhabditis elegans)
Secernentea gst-5 29
  • 45.96 (n)
gst-11 30
  • 37 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 40 (a)
OneToMany
-- 30
  • 37 (a)
OneToMany
-- 30
  • 36 (a)
OneToMany
-- 30
  • 32 (a)
OneToMany
-- 30
  • 32 (a)
OneToMany
CSA.3517 30
  • 32 (a)
OneToMany
CSA.4286 30
  • 29 (a)
OneToMany
Species where no ortholog for HPGDS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for HPGDS Gene

ENSEMBL:
Gene Tree for HPGDS (if available)
TreeFam:
Gene Tree for HPGDS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPGDS: view image
Alliance of Genome Resources:
Additional Orthologs for HPGDS

Paralogs for HPGDS Gene

Paralogs for HPGDS Gene

genes like me logo Genes that share paralogs with HPGDS: view

Variants for HPGDS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HPGDS Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs144419616 Benign: not provided 94,299,483(-) G/C
NM_014485.3(HPGDS):c.597C>G (p.Leu199=)
SYNONYMOUS
rs148378201 Benign: not provided 94,334,588(-) T/C
NM_014485.3(HPGDS):c.42A>G (p.Arg14=)
SYNONYMOUS
rs34124298 Benign: not provided 94,302,198(-) A/G
NM_014485.3(HPGDS):c.383T>C (p.Met128Thr)
MISSENSE
rs61752528 Benign: not provided 94,308,699(-) T/C
NM_014485.3(HPGDS):c.271A>G (p.Ile91Val)
MISSENSE
rs76328980 Benign: not provided 94,299,521(-) C/T
NM_014485.3(HPGDS):c.559G>A (p.Val187Ile)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HPGDS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HPGDS Gene

Variant ID Type Subtype PubMed ID
esv3601448 CNV loss 21293372
nsv594901 CNV gain 21841781

Variation tolerance for HPGDS Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPGDS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPGDS
Leiden Open Variation Database (LOVD)
HPGDS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGDS Gene

Disorders for HPGDS Gene

MalaCards: The human disease database

(13) MalaCards diseases for HPGDS Gene - From: COP

Disorder Aliases PubMed IDs
pseudopterygium
intermediate malignant teratoma
  • intermediate immature teratoma
filarial elephantiasis
  • bancroftian elephantiasis
inflammatory bowel disease 16
  • ibd16
skin papilloma
  • cutaneous papilloma
- elite association - COSMIC cancer census association via MalaCards
Search HPGDS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HPGDS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HPGDS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HPGDS Gene

Publications for HPGDS Gene

  1. Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. (PMID: 11672424) Jowsey IR … Hayes JD (The Biochemical journal 2001) 2 3 4 22
  2. Novel prostaglandin D synthase inhibitors generated by fragment-based drug design. (PMID: 18341273) Hohwy M … Edman K (Journal of medicinal chemistry 2008) 3 4 22
  3. First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase. (PMID: 15113825) Inoue T … Urade Y (Journal of biochemistry 2004) 3 4 25
  4. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. (PMID: 10824118) Kanaoka Y … Hayaishi O (European journal of biochemistry 2000) 3 4 22
  5. Prostaglandin D synthase in human megakaryoblastic cells. (PMID: 9353279) Mahmud I … Hayaishi O (The Journal of biological chemistry 1997) 2 3 4

Products for HPGDS Gene

Sources for HPGDS Gene