Aliases for HPGDS Gene
External Ids for HPGDS Gene
Previous GeneCards Identifiers for HPGDS Gene
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
GeneCards Summary for HPGDS Gene
HPGDS (Hematopoietic Prostaglandin D Synthase) is a Protein Coding gene. Diseases associated with HPGDS include Pseudopterygium and Intermediate Malignant Teratoma. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include calcium ion binding and magnesium ion binding. An important paralog of this gene is GSTA3.
UniProtKB/Swiss-Prot Summary for HPGDS Gene
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.