Aliases for HPGD Gene
- 15-Hydroxyprostaglandin Dehydrogenase 2 3 5
- SDR36C1 2 3 4
- Short Chain Dehydrogenase/Reductase Family 36C Member 1 3 4
- 15-Hydroxyprostaglandin Dehydrogenase (NAD(+)) 2 3
- 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)] 3 4
- Hydroxyprostaglandin Dehydrogenase 15-(NAD) 2 3
- Prostaglandin Dehydrogenase 1 3 4
- EC 18.104.22.168 4 51
External Ids for HPGD Gene
Previous GeneCards Identifiers for HPGD Gene
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for HPGD Gene
HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Prostaglandin Synthesis and Regulation and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD binding.
UniProtKB/Swiss-Prot Summary for HPGD Gene
Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PubMed:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113).