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This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. ... See more...
Aliases for HPGD Gene
Aliases for HPGD Gene
- 15-Hydroxyprostaglandin Dehydrogenase 2 3 5
- SDR36C1 2 3 4
- Short Chain Dehydrogenase/Reductase Family 36C Member 1 3 4
- 15-Hydroxyprostaglandin Dehydrogenase (NAD(+)) 2 3
- 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)] 3 4
- Hydroxyprostaglandin Dehydrogenase 15-(NAD) 2 3
- Prostaglandin Dehydrogenase 1 3 4
- EC 1.1.1.141 4 51
External Ids for HPGD Gene
- HGNC: 5154
- NCBI Entrez Gene: 3248
- Ensembl: ENSG00000164120
- OMIM®: 601688
- UniProtKB/Swiss-Prot: P15428
Previous GeneCards Identifiers for HPGD Gene
- GC04M176331
- GC04M175949
- GC04M176107
- GC04M175786
- GC04M175647
- GC04M175411
- GC04M171160
Summaries for HPGD Gene
-
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for HPGD Gene
HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Prostaglandin Synthesis and Regulation and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD binding.
UniProtKB/Swiss-Prot Summary for HPGD Gene
-
Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PubMed:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113).
Additional gene information for HPGD Gene
- HGNC (5154)
- NCBI Entrez Gene (3248)
- Ensembl (ENSG00000164120)
- OMIM® (601688)
- UniProtKB/Swiss-Prot (P15428)
- Open Targets Platform(ENSG00000164120)
- Monarch Initiative
- Search for HPGD at DataMed
- Search for HPGD at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPGD Gene
Genomics for HPGD Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HPGD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HPGD on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HPGD
- Top Transcription factor binding sites by QIAGEN in the HPGD gene promoter:
-
- AREB6
- FOXO3a
- FOXO3b
- Lhx3a
- LHX3b
- POU3F1
- POU3F2
- RFX1
- RSRFC4
- STAT3
Genomic Locations for HPGD Gene
Latest Assembly
- chr4:174,490,175-174,523,154
- (GRCh38/hg38)
- Size:
- 32,980 bases
- Orientation:
- Minus strand
Previous Assembly
- chr4:175,411,326-175,444,044
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 32,719 bases
- Orientation:
- Minus strand
- chr4:175,411,328-175,444,305
- (GRCh37/hg19 by Ensembl)
- Size:
- 32,978 bases
- Orientation:
- Minus strand
Genomic View for HPGD Gene
Genes around HPGD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q34.1 by HGNC
- 4q34.1 by Entrez Gene
- 4q34.1 by Ensembl
HPGD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HPGD Gene
Proteins for HPGD Gene
-
Protein details for HPGD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15428-PGDH_HUMAN
- Recommended name:
- 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- Protein Accession:
- P15428
- B4DTA4
- B4DU74
- B4DV57
- D3DP43
- E7EV11
- O00749
- Q06F08
- Q12998
Protein attributes for HPGD Gene
- Size:
- 266 amino acids
- Molecular mass:
- 28977 Da
- Quaternary structure:
-
- Homodimer.
Protein Expression for HPGD Gene
Selected DME Specific Peptides for HPGD Gene
- P15428:
-
- SIEKEENMG
- GAKVALVDWNLE
- QLRDTFRKVVDHFG
- LMNSGVR
- QCDVADQ
- KVALVTG
- LIEDDALNGAIMKIT
Post-translational modifications for HPGD Gene
Other Protein References for HPGD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences 15-PGDH / HPGD Antibody (LS-B115) and 15-PGDH / HPGD Antibody (LS-B11719)
-
Custom Antibody ServicesOriGene Antibodies for HPGD
- Novus Biologicals Antibodies for HPGD
- Invitrogen Antibodies for HPGD (AFLGC-HPGD)
-
Boster Bio Antibodies for HPGD
-
Santa Cruz Biotechnology (SCBT) Antibodies for HPGD
- Sino Biological Antibodies for HPGD
Protein products for research
- G Biosciences Human PGDH(15-PGDH)/HPGD, Liquid
- RayBiotech Recombinant Human 15-PGDH
- Search Origene for MassSpec and Protein Over-expression Lysates for HPGD
- Origene Custom Protein Services for HPGD
- Sino Biological Recombinant Proteins for HPGD
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HPGD
-
ProSci Proteins for HPGD
-
Abcam proteins for HPGD
Domains & Families for HPGD Gene
Gene Families for HPGD Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for HPGD Gene
- InterPro:
- Blocks:
-
- Short-chain dehydrogenase/reductase SDR
- Glucose/ribitol dehydrogenase family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for HPGD Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ50680, highly similar to 15-hydroxyprostaglandin dehydrogenase (B4DU74_HUMAN)
- cDNA FLJ51962, highly similar to 15-hydroxyprostaglandin dehydrogenase (B4DV57_HUMAN)
- Prostaglandin dehydrogenase 1 (PGDH_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15428UniProtKB/Swiss-Prot:
PGDH_HUMAN :- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
- Family:
-
- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Function for HPGD Gene
Molecular function for HPGD Gene
- UniProtKB/Swiss-Prot Function:
- Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PubMed:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11876, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:606564; EC=1.1.1.141; Evidence={ECO:0000269|PubMed:15044627, ECO:0000269|PubMed:8086429};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:41572, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:67026, ChEBI:CHEBI:78311; Evidence={ECO:0000269|PubMed:10837478};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+); Xref=Rhea:RHEA:41596, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78325, ChEBI:CHEBI:78329; Evidence={ECO:0000269|PubMed:10837478};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + prostaglandin A1 = 15-keto-prostaglandin A1 + H(+) + NADH; Xref=Rhea:RHEA:41263, ChEBI:CHEBI:15378, ChEBI:CHEBI:57398, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:85072; Evidence={ECO:0000269|PubMed:8086429};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH; Xref=Rhea:RHEA:16477, ChEBI:CHEBI:15378, ChEBI:CHEBI:57397, ChEBI:CHEBI:57401, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:8086429};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:23260, ChEBI:CHEBI:15378, ChEBI:CHEBI:57409, ChEBI:CHEBI:57410, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:21916491};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:48640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78836, ChEBI:CHEBI:90697; Evidence={ECO:0000269|PubMed:21916491};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH; Xref=Rhea:RHEA:48952, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90866, ChEBI:CHEBI:90867; Evidence={ECO:0000269|PubMed:25586183};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH; Xref=Rhea:RHEA:49244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:91000, ChEBI:CHEBI:91001; Evidence={ECO:0000269|PubMed:16757471};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH; Xref=Rhea:RHEA:50124, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132079, ChEBI:CHEBI:132080; Evidence={ECO:0000269|PubMed:22844113};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH; Xref=Rhea:RHEA:50128, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132079, ChEBI:CHEBI:132081; Evidence={ECO:0000269|PubMed:22844113};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH; Xref=Rhea:RHEA:53584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:133367, ChEBI:CHEBI:137497; Evidence={ECO:0000269|PubMed:22844113};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH; Xref=Rhea:RHEA:53588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:133367, ChEBI:CHEBI:137498; Evidence={ECO:0000269|PubMed:22844113};.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269|PubMed:16828555, ECO:0000269|PubMed:8086429}; KM=5.5 uM for prostaglandin E1 {ECO:0000269|PubMed:8086429}; KM=4.5 uM for prostaglandin A1 {ECO:0000269|PubMed:8086429}; KM=22 uM for prostaglandin A2 {ECO:0000269|PubMed:8086429}; KM=3.42 uM for (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate {ECO:0000269|PubMed:21916491}; KM=1.65 uM for (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate {ECO:0000269|PubMed:21916491}; KM=22 uM for NAD {ECO:0000269|PubMed:8086429}; KM=38 uM for NAD {ECO:0000269|PubMed:16828555}; Vmax=296 nmol/min/mg enzyme toward (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate {ECO:0000269|PubMed:21916491}; Vmax=403.8 nmol/min/mg enzyme toward (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate {ECO:0000269|PubMed:21916491}; Vmax=13.1 umol/min/mg enzyme toward prostaglandin A2 {ECO:0000269|PubMed:8086429}; Vmax=21.58 umol/min/mg enzyme toward prostaglandin A1 {ECO:0000269|PubMed:8086429}; Vmax=24.98 umol/min/mg enzyme toward NAD {ECO:0000269|PubMed:8086429}; Vmax=22.8 umol/min/mg enzyme toward prostaglandin E1 {ECO:0000269|PubMed:8086429}; Vmax=24.6 umol/min/mg enzyme toward prostaglandin E2 {ECO:0000269|PubMed:8086429}; Note=kcat is 8.6 min(-1) with (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate and (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate as substrates. {ECO:0000269|PubMed:21916491};
Enzyme Numbers (IUBMB) for HPGD Gene
Phenotypes From GWAS Catalog for HPGD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004957 | prostaglandin E receptor activity | IDA | 10198228 |
| GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | IBA,NAS | 7557451 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IDA | 16757471 |
| GO:0042802 | identical protein binding | IPI | 21072165 |
Phenotypes for HPGD Gene
- MGI mutant phenotypes for HPGD:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HPGD:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Decreased viability after Maraba virus infection
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased influenza A/WSN/33 replication
- Increased mitotic index
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
Animal Models for HPGD Gene
- MGI Knock Outs for HPGD:
-
- Hpgd Hpgd<tm1Bhk>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HPGD - Starting at $85 >
- * HPGD CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HPGD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HPGD
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPGD
miRNA for HPGD Gene
- miRTarBase miRNAs that target HPGD
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HPGD
- Browse OriGene Inhibitory RNA Products For HPGD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPGD
Clone products for research
- Applied Biological Materials (abm): Clones for HPGD - Starting at $45 >
- * HPGD as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG203530
- MR203530
- MR203530L3
- MR203530L4
- RC204160
- RC204160L1
- RC204160L2
- RC204160L3
- RC204160L4
- RC226902
- RC226902L3
- RC226902L4
- RC231810
- RC233303
- RC233304
- RC233415
- RG204160
- RG226902
- RG231810
- RG233303
- RG233304
- RG233415
- RR212381
- RR212381L3
- RR212381L4
- MR203530L3V
- MR203530L4V
- RC204160L1V
- RC204160L2V
- RC204160L3V
- RC204160L4V
- RC226902L3V
- RC226902L4V
- RR212381L3V
- RR212381L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HPGD
- Addgene plasmids for HPGD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HPGD
Cell Lines for research
-
Horizon Cell Lines for HPGD
No data available for Transcription Factor Targets and HOMER Transcription for HPGD Gene
Localization for HPGD Gene
Subcellular locations from UniProtKB/Swiss-Prot for HPGD Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 3 |
| mitochondrion | 2 |
| peroxisome | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for HPGD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Arachidonic acid metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Transcriptional misregulation in cancer | ||
| 4 | Prostaglandin 2 biosynthesis and metabolism FM |
Prostaglandin 2 biosynthesis and metabolism FM
-
|
|
| 5 | Prostaglandin Synthesis and Regulation | ||
Pathways by source for HPGD Gene
1 BioSystems pathway for HPGD Gene
1 KEGG pathway for HPGD Gene
1 GeneGo (Thomson Reuters) pathway for HPGD Gene
- Prostaglandin 2 biosynthesis and metabolism FM
Interacting Proteins for HPGD Gene
GPS-Prot Interaction Network for HPGD
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001822 | kidney development | IEA | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006693 | prostaglandin metabolic process | IBA,IDA | 16828555 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15574495 |
Drugs & Compounds for HPGD Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 15-Keto-prostaglandin F2a |
|
35850-13-6 |
|
Drug products for research
- G Biosciences Human PGDH(15-PGDH)/HPGD, Liquid
- RayBiotech Recombinant Human 15-PGDH
Transcripts for HPGD Gene
mRNA/cDNA for HPGD Gene
- 7 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296521 1171 nts (view in UCSC)
- ENST00000296522 2619 nts (view in UCSC)
- ENST00000422112 805 nts (view in UCSC)
- ENST00000504433 1910 nts (view in UCSC)
- ENST00000506910 819 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for HPGD - Starting at $85 >
- * HPGD CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for HPGD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HPGD
-
Santa Cruz Biotechnology (SCBT) CRISPR for HPGD
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HPGD
- Browse OriGene Inhibitory RNA Products For HPGD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPGD
Clone products for research
- Applied Biological Materials (abm): Clones for HPGD - Starting at $45 >
- * HPGD as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG203530
- MR203530
- MR203530L3
- MR203530L4
- RC204160
- RC204160L1
- RC204160L2
- RC204160L3
- RC204160L4
- RC226902
- RC226902L3
- RC226902L4
- RC231810
- RC233303
- RC233304
- RC233415
- RG204160
- RG226902
- RG231810
- RG233303
- RG233304
- RG233415
- RR212381
- RR212381L3
- RR212381L4
- MR203530L3V
- MR203530L4V
- RC204160L1V
- RC204160L2V
- RC204160L3V
- RC204160L4V
- RC226902L3V
- RC226902L4V
- RR212381L3V
- RR212381L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HPGD
- Addgene plasmids for HPGD
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HPGD
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||
| SP6: | - |
Relevant External Links for HPGD Gene
- GeneLoc Exon Structure for
- HPGD
Expression for HPGD Gene
mRNA differential expression in normal tissues according to GTEx for HPGD Gene
This gene is overexpressed in Bladder (x5.1), Vagina (x4.9), Whole Blood (x4.8), Liver (x4.5), and Esophagus - Mucosa (x4.3).
This gene is overexpressed in Lung (14.4), Placenta (8.9), Cardia (8.3), and Stomach (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HPGD Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HPGD
SOURCE GeneReport for Unigene cluster for HPGD Gene:
Hs.596913mRNA Expression by UniProt/SwissProt for HPGD Gene:
P15428-PGDH_HUMAN
Tissue specificity:
Detected in colon epithelium (at protein level).
Evidence on tissue expression from TISSUES for HPGD Gene
- Intestine(4.8)
- Pancreas(4.5)
- Lung(3.9)
- Nervous system(3.8)
- Skin(3.4)
- Liver(3.1)
- Kidney(3)
- Stomach(3)
- Muscle(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HPGD Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- skeletal muscle
- skeleton
Regions:
Head and neck:
- ear
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- scalp
- skull
Thorax:
- chest wall
- clavicle
- heart
- rib
- rib cage
- scapula
- sternum
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- hair
- skin
- spinal column
- sweat gland
- vertebrae
Primer products for research
-
OriGene qPCR primer pairs for HPGD
-
OriGene qPCR primer pairs and template standards for HPGD
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HPGD Gene
Orthologs for HPGD Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HPGD 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HPGD 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HPGD 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Hpgd 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hpgd 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | HPGD 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HPGD 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HPGD 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hpgd 30 |
|
||
| Str.8168 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC565975 30 |
|
||
| CU928070.1 31 |
|
OneToOne | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6946 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001753 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pdh 31 32 |
|
OneToMany | |
| CG4842 31 32 |
|
OneToMany | |||
| CG18814 31 |
|
OneToMany | |||
| Fbp2 31 |
|
OneToMany | |||
| Adhr 31 |
|
OneToMany | |||
| Adh 31 |
|
OneToMany |
- Species where no ortholog for HPGD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HPGD Gene
- ENSEMBL:
- Gene Tree for HPGD (if available)
- TreeFam:
- Gene Tree for HPGD (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HPGD: view image
Paralogs for HPGD Gene
(6) SIMAP similar genes for HPGD Gene using alignment to 6 proteins:
- PGDH_HUMAN
- D6RA66_HUMAN
- D6RA83_HUMAN
- D6RHF8_HUMAN
- E9PBZ2_HUMAN
- E9PD69_HUMAN
No data available for Paralogs for HPGD Gene
Variants for HPGD Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HPGD Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 899799 | Likely Benign: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,490,313(-) |
T/C NM_000860.6(HPGD):c.*1643A>G |
THREE_PRIME_UTR | |
| 899800 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,490,362(-) |
T/C NM_000860.6(HPGD):c.*1594A>G |
THREE_PRIME_UTR | |
| 899858 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,491,137(-) |
A/G NM_000860.6(HPGD):c.*819T>C |
THREE_PRIME_UTR | |
| 899859 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,491,247(-) |
T/G NM_000860.6(HPGD):c.*709A>C |
THREE_PRIME_UTR | |
| 899919 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,491,915(-) |
T/C NM_000860.6(HPGD):c.*41A>G |
THREE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HPGD Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGD Gene
Disorders for HPGD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| digital clubbing, isolated congenital |
|
|
| hypertrophic osteoarthropathy, primary, autosomal recessive, 1 |
|
|
| primary hypertrophic osteoarthropathy |
|
|
| agenesis of corpus callosum, cardiac, ocular, and genital syndrome |
|
|
| acroosteolysis |
|
|
Search HPGD in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PGDH_HUMAN- Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by variants affecting the gene represented in this entry.
- Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by variants affecting the gene represented in this entry.
- Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269 PubMed:18805827}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for HPGD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for HPGD Gene
Publications for HPGD Gene
- Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). (PMID: 18805827) Tariq M … Ahmad W (Journal of medical genetics 2009) 3 4 23 74
- Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. (PMID: 18500342) Uppal S … Bonthron DT (Nature genetics 2008) 3 4 23 74
- Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 23 41
- Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. (PMID: 16828555) Cho H … Tai HH (Bioorganic & medicinal chemistry 2006) 3 4 23
- 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PMID: 15574495) Yan M … Markowitz SD (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23
ExternalLinks
Products for HPGD Gene
- Custom Antibody ServicesOriGene Antibodies for HPGD
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- OriGene qPCR primer pairs for HPGD
- OriGene qPCR primer pairs and template standards for HPGD
- OriGene CRISPR knockouts for HPGD
- MG203530
- MR203530
- MR203530L3
- MR203530L4
- RC204160
- RC204160L1
- RC204160L2
- RC204160L3
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- RC226902
- RC226902L3
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- RC233303
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- RC233415
- RG204160
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- RG233303
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- RR212381
- RR212381L3
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- MR203530L3V
- MR203530L4V
- RC204160L1V
- RC204160L2V
- RC204160L3V
- RC204160L4V
- RC226902L3V
- RC226902L4V
- RR212381L3V
- RR212381L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals proteins and lysates for HPGD
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- Santa Cruz Biotechnology (SCBT) Antibodies for HPGD
- Search Santa Cruz Biotechnology (SCBT) for HPGD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HPGD
- Horizon Cell Lines for HPGD
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HPGD
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- Boster Bio Antibodies for HPGD
- Browse Boster Bio ELISA Kits
Sources for HPGD Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
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- (43) HuGE
- (44) Atlas
- (45) GenBank
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- (48) IMGT
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- (50) miRBase
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- (53) PubMed
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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