Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Prostaglandin Synthesis and Regulation and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004957 | prostaglandin E receptor activity | IDA | 10198228 |
GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity | IBA,NAS | 7557451 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IDA | 16757471 |
GO:0042802 | identical protein binding | IPI | 21072165 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0016323 | basolateral plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Arachidonic acid metabolism | ||
2 | Metabolism |
.40
|
|
3 | Transcriptional misregulation in cancer | ||
4 | Prostaglandin 2 biosynthesis and metabolism FM |
Prostaglandin 2 biosynthesis and metabolism FM
-
|
|
5 | Prostaglandin Synthesis and Regulation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001822 | kidney development | IEA | -- |
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006693 | prostaglandin metabolic process | IBA,IDA | 16828555 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA | 15574495 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
15-Keto-prostaglandin F2a |
|
35850-13-6 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HPGD 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HPGD 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HPGD 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Hpgd 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hpgd 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | HPGD 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HPGD 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HPGD 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hpgd 30 |
|
||
Str.8168 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | LOC565975 30 |
|
||
CU928070.1 31 |
|
OneToOne | |||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6946 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001753 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pdh 31 32 |
|
OneToMany | |
CG4842 31 32 |
|
OneToMany | |||
CG18814 31 |
|
OneToMany | |||
Fbp2 31 |
|
OneToMany | |||
Adhr 31 |
|
OneToMany | |||
Adh 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
899799 | Likely Benign: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,490,313(-) |
T/C NM_000860.6(HPGD):c.*1643A>G |
THREE_PRIME_UTR | |
899800 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,490,362(-) |
T/C NM_000860.6(HPGD):c.*1594A>G |
THREE_PRIME_UTR | |
899858 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,491,137(-) |
A/G NM_000860.6(HPGD):c.*819T>C |
THREE_PRIME_UTR | |
899859 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,491,247(-) |
T/G NM_000860.6(HPGD):c.*709A>C |
THREE_PRIME_UTR | |
899919 | Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 | 174,491,915(-) |
T/C NM_000860.6(HPGD):c.*41A>G |
THREE_PRIME_UTR |
Disorder | Aliases | PubMed IDs |
---|---|---|
digital clubbing, isolated congenital |
|
|
hypertrophic osteoarthropathy, primary, autosomal recessive, 1 |
|
|
primary hypertrophic osteoarthropathy |
|
|
agenesis of corpus callosum, cardiac, ocular, and genital syndrome |
|
|
acroosteolysis |
|
|