This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. ... See more...

Aliases for HPGD Gene

Aliases for HPGD Gene

  • 15-Hydroxyprostaglandin Dehydrogenase 2 3 5
  • SDR36C1 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 36C Member 1 3 4
  • 15-Hydroxyprostaglandin Dehydrogenase (NAD(+)) 2 3
  • 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)] 3 4
  • Hydroxyprostaglandin Dehydrogenase 15-(NAD) 2 3
  • Prostaglandin Dehydrogenase 1 3 4
  • EC 1.1.1.141 4 50
  • 15-PGDH 3 4
  • PGDH1 3 4
  • Short Chain Dehydrogenase/Reductase Family 36C, Member 1 2
  • NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase 3
  • EC 1.1.1 50
  • PHOAR1 3
  • PGDH 3
  • HPGD 5

External Ids for HPGD Gene

Previous GeneCards Identifiers for HPGD Gene

  • GC04M176331
  • GC04M175949
  • GC04M176107
  • GC04M175786
  • GC04M175647
  • GC04M175411
  • GC04M171160

Summaries for HPGD Gene

Entrez Gene Summary for HPGD Gene

  • This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for HPGD Gene

HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Transcriptional misregulation in cancer and Prostaglandin Synthesis and Regulation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD binding.

UniProtKB/Swiss-Prot Summary for HPGD Gene

  • Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PubMed:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113).

Gene Wiki entry for HPGD Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPGD Gene

Genomics for HPGD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HPGD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J174521 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 281.4 +0.5 533 4.8 IKZF1 ZNF592 ZIC2 YY1 SMAD5 BHLHE40 FEZF1 RARA GABPB1 ZBTB33 HPGD ENSG00000251584 HSALNG0038653 HSALNG0038654 LOC105377548 ENSG00000250596 lnc-HPGD-1 CEP44
GH04J174580 Enhancer 0.8 FANTOM5 Ensembl 63.9 -58.1 -58147 4.2 CUX1 ATF4 HLF ATF3 EP300 SP1 NR2F1 HSALNG0038657 HPGD piR-56759-441 HSALNG0038656-001 GLRA3
GH04J174617 Enhancer 0.8 Ensembl ENCODE 39.3 -92.5 -92547 5.4 NFIC TAL1 PRDM10 SPI1 NR2F6 SMARCE1 CBFA2T2 CTBP1 ZNF24 SOX6 HPGD HSALNG0038656-002 HSALNG0038656-003 LOC105377549 LOC105377551 HSALNG0038656-001 GLRA3
GH04J174605 Enhancer 0.5 Ensembl 25.8 -83.8 -83847 2.4 YY1 JUND HNF4A CEBPB NANOG SP1 HSALNG0038656-002 HPGD piR-55627-105 HSALNG0038656-001 GLRA3
GH04J174631 Enhancer 0.6 Ensembl 20.1 -108.9 -108900 0.9 ZNF654 CTCF REST RAD21 SMC3 FOXM1 ZNF384 CHAMP1 ZNF143 PKNOX1 HPGD LOC105377551 piR-36393-400 HSALNG0038656-001 GLRA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPGD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HPGD

Top Transcription factor binding sites by QIAGEN in the HPGD gene promoter:
  • AREB6
  • FOXO3a
  • FOXO3b
  • Lhx3a
  • LHX3b
  • POU3F1
  • POU3F2
  • RFX1
  • RSRFC4
  • STAT3

Genomic Locations for HPGD Gene

Latest Assembly
chr4:174,490,175-174,523,154
(GRCh38/hg38)
Size:
32,980 bases
Orientation:
Minus strand

Previous Assembly
chr4:175,411,326-175,444,044
(GRCh37/hg19 by Entrez Gene)
Size:
32,719 bases
Orientation:
Minus strand

chr4:175,411,328-175,444,305
(GRCh37/hg19 by Ensembl)
Size:
32,978 bases
Orientation:
Minus strand

Genomic View for HPGD Gene

Genes around HPGD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPGD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPGD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPGD Gene

Proteins for HPGD Gene

  • Protein details for HPGD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15428-PGDH_HUMAN
    Recommended name:
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
    Protein Accession:
    P15428
    Secondary Accessions:
    • B4DTA4
    • B4DU74
    • B4DV57
    • D3DP43
    • E7EV11
    • O00749
    • Q06F08
    • Q12998

    Protein attributes for HPGD Gene

    Size:
    266 amino acids
    Molecular mass:
    28977 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HPGD Gene

    Alternative splice isoforms for HPGD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPGD Gene

Selected DME Specific Peptides for HPGD Gene

P15428:
  • SIEKEENMG
  • GAKVALVDWNLE
  • QLRDTFRKVVDHFG
  • LMNSGVR
  • QCDVADQ
  • KVALVTG
  • LIEDDALNGAIMKIT

Post-translational modifications for HPGD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for HPGD Gene

Gene Families for HPGD Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for HPGD Gene

InterPro:
Blocks:
  • Short-chain dehydrogenase/reductase SDR
  • Glucose/ribitol dehydrogenase family signature

Suggested Antigen Peptide Sequences for HPGD Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50680, highly similar to 15-hydroxyprostaglandin dehydrogenase (B4DU74_HUMAN)
  • cDNA FLJ51962, highly similar to 15-hydroxyprostaglandin dehydrogenase (B4DV57_HUMAN)
  • Prostaglandin dehydrogenase 1 (PGDH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15428

UniProtKB/Swiss-Prot:

PGDH_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HPGD: view

Function for HPGD Gene

Molecular function for HPGD Gene

UniProtKB/Swiss-Prot Function:
Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels (PubMed:15574495, PubMed:16828555, PubMed:8086429). Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (PubMed:10837478). Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE) (PubMed:21916491). Has hydroxylated docosahexaenoic acid metabolites as substrates (PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions (PubMed:16757471, PubMed:22844113).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADH; Xref=Rhea:RHEA:11876, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:606564; EC=1.1.1.141; Evidence={ECO:0000269|PubMed:15044627, ECO:0000269|PubMed:8086429};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:41572, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:67026, ChEBI:CHEBI:78311; Evidence={ECO:0000269|PubMed:10837478};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+); Xref=Rhea:RHEA:41596, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78325, ChEBI:CHEBI:78329; Evidence={ECO:0000269|PubMed:10837478};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + prostaglandin A1 = 15-keto-prostaglandin A1 + H(+) + NADH; Xref=Rhea:RHEA:41263, ChEBI:CHEBI:15378, ChEBI:CHEBI:57398, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:85072; Evidence={ECO:0000269|PubMed:8086429};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH; Xref=Rhea:RHEA:16477, ChEBI:CHEBI:15378, ChEBI:CHEBI:57397, ChEBI:CHEBI:57401, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:8086429};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:23260, ChEBI:CHEBI:15378, ChEBI:CHEBI:57409, ChEBI:CHEBI:57410, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:21916491};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH; Xref=Rhea:RHEA:48640, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78836, ChEBI:CHEBI:90697; Evidence={ECO:0000269|PubMed:21916491};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH; Xref=Rhea:RHEA:48952, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90866, ChEBI:CHEBI:90867; Evidence={ECO:0000269|PubMed:25586183};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + resolvin E1 = 18-oxo-resolvin E1 + H(+) + NADH; Xref=Rhea:RHEA:49244, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:91000, ChEBI:CHEBI:91001; Evidence={ECO:0000269|PubMed:16757471};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH; Xref=Rhea:RHEA:50124, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132079, ChEBI:CHEBI:132080; Evidence={ECO:0000269|PubMed:22844113};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH; Xref=Rhea:RHEA:50128, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132079, ChEBI:CHEBI:132081; Evidence={ECO:0000269|PubMed:22844113};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + resolvin D2 = 7-oxoresolvin D2 + H(+) + NADH; Xref=Rhea:RHEA:53584, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:133367, ChEBI:CHEBI:137497; Evidence={ECO:0000269|PubMed:22844113};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + resolvin D2 = 16-oxoresolvin D2 + H(+) + NADH; Xref=Rhea:RHEA:53588, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:133367, ChEBI:CHEBI:137498; Evidence={ECO:0000269|PubMed:22844113};.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cortisol, dexamethasone and betamethasone. Down-regulated in colon cancer. Up-regulated by TGFB1.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.4 uM for prostaglandin E2 {ECO:0000269|PubMed:16828555, ECO:0000269|PubMed:8086429}; KM=5.5 uM for prostaglandin E1 {ECO:0000269|PubMed:8086429}; KM=4.5 uM for prostaglandin A1 {ECO:0000269|PubMed:8086429}; KM=22 uM for prostaglandin A2 {ECO:0000269|PubMed:8086429}; KM=3.42 uM for (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate {ECO:0000269|PubMed:21916491}; KM=1.65 uM for (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate {ECO:0000269|PubMed:21916491}; KM=22 uM for NAD {ECO:0000269|PubMed:8086429}; KM=38 uM for NAD {ECO:0000269|PubMed:16828555}; Vmax=296 nmol/min/mg enzyme toward (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate {ECO:0000269|PubMed:21916491}; Vmax=403.8 nmol/min/mg enzyme toward (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate {ECO:0000269|PubMed:21916491}; Vmax=13.1 umol/min/mg enzyme toward prostaglandin A2 {ECO:0000269|PubMed:8086429}; Vmax=21.58 umol/min/mg enzyme toward prostaglandin A1 {ECO:0000269|PubMed:8086429}; Vmax=24.98 umol/min/mg enzyme toward NAD {ECO:0000269|PubMed:8086429}; Vmax=22.8 umol/min/mg enzyme toward prostaglandin E1 {ECO:0000269|PubMed:8086429}; Vmax=24.6 umol/min/mg enzyme toward prostaglandin E2 {ECO:0000269|PubMed:8086429}; Note=kcat is 8.6 min(-1) with (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate and (5Z,8Z,11Z,13E,15S)-hydroxyeicosatetraenoate as substrates. {ECO:0000269|PubMed:21916491};

Enzyme Numbers (IUBMB) for HPGD Gene

Phenotypes From GWAS Catalog for HPGD Gene

Gene Ontology (GO) - Molecular Function for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004957 prostaglandin E receptor activity IDA 10198228
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity IBA,NAS 7557451
GO:0016491 oxidoreductase activity IEA --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA 16757471
GO:0042802 identical protein binding IPI 21072165
genes like me logo Genes that share ontologies with HPGD: view
genes like me logo Genes that share phenotypes with HPGD: view

Human Phenotype Ontology for HPGD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HPGD Gene

MGI Knock Outs for HPGD:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPGD

No data available for Transcription Factor Targets and HOMER Transcription for HPGD Gene

Localization for HPGD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HPGD Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPGD gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 3
mitochondrion 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with HPGD: view

Pathways & Interactions for HPGD Gene

genes like me logo Genes that share pathways with HPGD: view

Pathways by source for HPGD Gene

1 KEGG pathway for HPGD Gene
1 GeneGo (Thomson Reuters) pathway for HPGD Gene
  • Prostaglandin 2 biosynthesis and metabolism FM

SIGNOR curated interactions for HPGD Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HPGD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006693 prostaglandin metabolic process IBA,IDA 16828555
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 15574495
genes like me logo Genes that share ontologies with HPGD: view

Drugs & Compounds for HPGD Gene

(27) Drugs for HPGD Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
Dinoprost Approved, Investigational Pharma 16
Dinoprostone Approved Pharma activates the PGE2 receptor, Major endogenous prostanoid 150
NAD Experimental Pharma 0

(16) Additional Compounds for HPGD Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15-Keto-prostaglandin F2a
  • 15-Keto-PGF2a
  • 15-Keto-PGF2alpha
  • 15-Keto-prostaglandin F2alpha
  • 15-Ketoprostaglandin F2alpha
  • 15-Keto-PGF2α
35850-13-6
genes like me logo Genes that share compounds with HPGD: view

Transcripts for HPGD Gene

mRNA/cDNA for HPGD Gene

7 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPGD

Alternative Splicing Database (ASD) splice patterns (SP) for HPGD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for HPGD Gene

GeneLoc Exon Structure for
HPGD

Expression for HPGD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HPGD Gene

mRNA differential expression in normal tissues according to GTEx for HPGD Gene

This gene is overexpressed in Bladder (x5.1), Vagina (x4.9), Whole Blood (x4.8), Liver (x4.5), and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for HPGD Gene

This gene is overexpressed in Lung (14.4), Placenta (8.9), Cardia (8.3), and Stomach (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HPGD Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HPGD

SOURCE GeneReport for Unigene cluster for HPGD Gene:

Hs.596913

mRNA Expression by UniProt/SwissProt for HPGD Gene:

P15428-PGDH_HUMAN
Tissue specificity: Detected in colon epithelium (at protein level).

Evidence on tissue expression from TISSUES for HPGD Gene

  • Intestine(4.8)
  • Pancreas(4.5)
  • Lung(3.9)
  • Nervous system(3.8)
  • Skin(3.4)
  • Liver(3.1)
  • Kidney(3)
  • Stomach(3)
  • Muscle(2.1)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HPGD Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • scalp
  • skull
Thorax:
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • hair
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with HPGD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HPGD Gene

Orthologs for HPGD Gene

This gene was present in the common ancestor of animals.

Orthologs for HPGD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HPGD 29 30
  • 99.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HPGD 29 30
  • 92.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HPGD 29 30
  • 90.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hpgd 29 16 30
  • 88.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hpgd 29
  • 87.88 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 84 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia HPGD 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HPGD 29 30
  • 75.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HPGD 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hpgd 29
  • 69.79 (n)
Str.8168 29
Zebrafish
(Danio rerio)
Actinopterygii LOC565975 29
  • 62.84 (n)
CU928070.1 30
  • 57 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6946 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001753 29
  • 49.18 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Pdh 30 31
  • 29 (a)
OneToMany
CG4842 30 31
  • 28 (a)
OneToMany
CG18814 30
  • 27 (a)
OneToMany
Fbp2 30
  • 25 (a)
OneToMany
Adhr 30
  • 24 (a)
OneToMany
Adh 30
  • 23 (a)
OneToMany
Species where no ortholog for HPGD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HPGD Gene

ENSEMBL:
Gene Tree for HPGD (if available)
TreeFam:
Gene Tree for HPGD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPGD: view image
Alliance of Genome Resources:
Additional Orthologs for HPGD

Paralogs for HPGD Gene

(6) SIMAP similar genes for HPGD Gene using alignment to 6 proteins:

  • PGDH_HUMAN
  • D6RA66_HUMAN
  • D6RA83_HUMAN
  • D6RHF8_HUMAN
  • E9PBZ2_HUMAN
  • E9PD69_HUMAN
genes like me logo Genes that share paralogs with HPGD: view

No data available for Paralogs for HPGD Gene

Variants for HPGD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HPGD Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
1032480 Pathogenic: Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 174,517,987(-) GT/G
NM_000860.6(HPGD):c.307del (p.Thr103fs)
FRAMESHIFT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON
899799 Likely Benign: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 174,490,313(-) T/C
NM_000860.6(HPGD):c.*1643A>G
THREE_PRIME_UTR
899800 Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 174,490,362(-) T/C
NM_000860.6(HPGD):c.*1594A>G
THREE_PRIME_UTR
899858 Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 174,491,137(-) A/G
NM_000860.6(HPGD):c.*819T>C
THREE_PRIME_UTR
899859 Uncertain Significance: Digital clubbing, isolated congenital; Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 174,491,247(-) T/G
NM_000860.6(HPGD):c.*709A>C
THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HPGD Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HPGD Gene

Variant ID Type Subtype PubMed ID
dgv1043e214 CNV loss 21293372
nsv509946 OTHER sequence alteration 20534489
nsv525487 CNV gain 19592680

Variation tolerance for HPGD Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPGD Gene

Human Gene Mutation Database (HGMD)
HPGD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPGD
Leiden Open Variation Database (LOVD)
HPGD

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPGD Gene

Disorders for HPGD Gene

MalaCards: The human disease database

(11) MalaCards diseases for HPGD Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search HPGD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PGDH_HUMAN
  • Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269 PubMed:18500342}. Note=The disease is caused by variants affecting the gene represented in this entry.
  • Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269 PubMed:18805827}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for HPGD

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HPGD: view

No data available for Genatlas for HPGD Gene

Publications for HPGD Gene

  1. Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). (PMID: 18805827) Tariq M … Ahmad W (Journal of medical genetics 2009) 3 4 22 72
  2. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. (PMID: 18500342) Uppal S … Bonthron DT (Nature genetics 2008) 3 4 22 72
  3. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. (PMID: 20086108) Poole EM … Ulrich CM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 22 40
  4. Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2. (PMID: 16828555) Cho H … Tai HH (Bioorganic & medicinal chemistry 2006) 3 4 22
  5. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. (PMID: 15574495) Yan M … Markowitz SD (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22

Products for HPGD Gene

Sources for HPGD Gene