Aliases for HPDL Gene

Aliases for HPDL Gene

  • 4-Hydroxyphenylpyruvate Dioxygenase Like 2 3 5
  • 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein 3 4
  • Glyoxalase Domain-Containing Protein 1 3 4
  • GLOXD1 3 4
  • Glyoxalase Domain Containing 1 2
  • EC 1.13.-.- 4
  • 4-HPPD-L 3

External Ids for HPDL Gene

Previous HGNC Symbols for HPDL Gene

  • GLOXD1

Previous GeneCards Identifiers for HPDL Gene

  • GC01P045568
  • GC01P045792
  • GC01P043905

Summaries for HPDL Gene

GeneCards Summary for HPDL Gene

HPDL (4-Hydroxyphenylpyruvate Dioxygenase Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen and 4-hydroxyphenylpyruvate dioxygenase activity. An important paralog of this gene is HPD.

UniProtKB/Swiss-Prot Summary for HPDL Gene

Additional gene information for HPDL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPDL Gene

Genomics for HPDL Gene

GeneHancer (GH) Regulatory Elements for HPDL Gene

Promoters and enhancers for HPDL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J045325 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 750.6 +1.3 1315 4.9 LCORL POLR2A TCF7L2 HCFC1 MYC MAX ZNF121 NFIB SP1 NKRF HPDL CCDC163 MMACHC lnc-TESK2-3 MUTYH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPDL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HPDL gene promoter:
  • AML1a
  • AP-4
  • CBF(2)
  • CBF-B
  • CP1A
  • FOXO4
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for HPDL Gene

Genomic Locations for HPDL Gene
chr1:45,326,873-45,328,675
(GRCh38/hg38)
Size:
1,803 bases
Orientation:
Plus strand
chr1:45,792,545-45,794,347
(GRCh37/hg19)
Size:
1,803 bases
Orientation:
Plus strand

Genomic View for HPDL Gene

Genes around HPDL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPDL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPDL Gene

Proteins for HPDL Gene

  • Protein details for HPDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IR7-HPDL_HUMAN
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase-like protein
    Protein Accession:
    Q96IR7
    Secondary Accessions:
    • B2R9B0

    Protein attributes for HPDL Gene

    Size:
    371 amino acids
    Molecular mass:
    39386 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

neXtProt entry for HPDL Gene

Post-translational modifications for HPDL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HPDL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPDL Gene

Domains & Families for HPDL Gene

Gene Families for HPDL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HPDL Gene

GenScript: Design optimal peptide antigens:
  • Glyoxalase domain-containing protein 1 (HPDL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96IR7

UniProtKB/Swiss-Prot:

HPDL_HUMAN :
  • Belongs to the 4HPPD family.
Family:
  • Belongs to the 4HPPD family.
genes like me logo Genes that share domains with HPDL: view

Function for HPDL Gene

Molecular function for HPDL Gene

UniProtKB/Swiss-Prot Function:
May have dioxygenase activity.

Enzyme Numbers (IUBMB) for HPDL Gene

Gene Ontology (GO) - Molecular Function for HPDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen IEA --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with HPDL: view
genes like me logo Genes that share phenotypes with HPDL: view

Animal Model Products

CRISPR Products

miRNA for HPDL Gene

miRTarBase miRNAs that target HPDL

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPDL Gene

Localization for HPDL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPDL gene
Compartment Confidence
mitochondrion 2
peroxisome 1
cytosol 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HPDL Gene

Pathways & Interactions for HPDL Gene

PathCards logo

SuperPathways for HPDL Gene

No Data Available

Gene Ontology (GO) - Biological Process for HPDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009072 aromatic amino acid family metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HPDL: view

No data available for Pathways by source and SIGNOR curated interactions for HPDL Gene

Drugs & Compounds for HPDL Gene

No Compound Related Data Available

Transcripts for HPDL Gene

mRNA/cDNA for HPDL Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(96) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPDL Gene

No ASD Table

Relevant External Links for HPDL Gene

GeneLoc Exon Structure for
HPDL
ECgene alternative splicing isoforms for
HPDL

Expression for HPDL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HPDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPDL Gene

This gene is overexpressed in Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for HPDL Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HPDL Gene



Protein tissue co-expression partners for HPDL Gene

NURSA nuclear receptor signaling pathways regulating expression of HPDL Gene:

HPDL

SOURCE GeneReport for Unigene cluster for HPDL Gene:

Hs.162717

Evidence on tissue expression from TISSUES for HPDL Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with HPDL: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPDL Gene

Orthologs for HPDL Gene

This gene was present in the common ancestor of animals.

Orthologs for HPDL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HPDL 33 32
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HPDL 33 32
  • 83.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HPDL 33 32
  • 82.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hpdl 17 33 32
  • 78.17 (n)
rat
(Rattus norvegicus)
Mammalia Hpdl 32
  • 78.05 (n)
oppossum
(Monodelphis domestica)
Mammalia HPDL 33
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HPDL 33 32
  • 62.36 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hpdl 32
  • 49.34 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171978 32
  • 54.66 (n)
HPDL 33
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C31H2.4 33
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2641 33
  • 29 (a)
OneToOne
Species where no ortholog for HPDL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPDL Gene

ENSEMBL:
Gene Tree for HPDL (if available)
TreeFam:
Gene Tree for HPDL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPDL: view image

Paralogs for HPDL Gene

Paralogs for HPDL Gene

genes like me logo Genes that share paralogs with HPDL: view

Variants for HPDL Gene

Sequence variations from dbSNP and Humsavar for HPDL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001879687 -- 45,325,483(+) C/T upstream_transcript_variant
rs1002059633 -- 45,326,744(+) C/G upstream_transcript_variant
rs1002128865 -- 45,328,387(+) T/A 3_prime_UTR_variant
rs1003909326 -- 45,326,790(+) C/T upstream_transcript_variant
rs1003958739 -- 45,327,032(+) C/A/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HPDL Gene

Variant ID Type Subtype PubMed ID
nsv1133024 OTHER inversion 24896259

Variation tolerance for HPDL Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPDL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPDL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPDL Gene

Disorders for HPDL Gene

Additional Disease Information for HPDL

No disorders were found for HPDL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPDL Gene

Publications for HPDL Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  5. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 56

Products for HPDL Gene

Sources for HPDL Gene