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Aliases for HPDL Gene

Aliases for HPDL Gene

  • 4-Hydroxyphenylpyruvate Dioxygenase Like 2 3 5
  • Glyoxalase Domain-Containing Protein 1 3 4
  • Glyoxalase Domain Containing 1 2 3
  • GLOXD1 3 4
  • 4-Hydroxyphenylpyruvate Dioxygenase-Like Protein 3
  • EC 1.13.-.- 4
  • 4-HPPD-L 3

External Ids for HPDL Gene

Previous HGNC Symbols for HPDL Gene

  • GLOXD1

Previous GeneCards Identifiers for HPDL Gene

  • GC01P045568
  • GC01P045792
  • GC01P043905

Summaries for HPDL Gene

GeneCards Summary for HPDL Gene

HPDL (4-Hydroxyphenylpyruvate Dioxygenase Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen and 4-hydroxyphenylpyruvate dioxygenase activity. An important paralog of this gene is HPD.

UniProtKB/Swiss-Prot for HPDL Gene

  • May have dioxygenase activity.

Additional gene information for HPDL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPDL Gene

Genomics for HPDL Gene

GeneHancer (GH) Regulatory Elements for HPDL Gene

Promoters and enhancers for HPDL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I045325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.4 1447 4.7 HDGF PKNOX1 SMAD1 SIN3A YY1 ETS1 ZNF121 ZNF143 FOS REST HPDL TOE1 LRRC41 GPBP1L1 CCDC163 RPL7AP16 NASP MUTYH HECTD3 MMACHC
GH01I045334 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 0.4 +11.4 11400 7.9 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 TOE1 MUTYH GPBP1L1 LRRC41 RPL7AP16 HECTD3 PRDX1 MMACHC CCDC163 TESK2
GH01I045319 Enhancer 0.8 FANTOM5 ENCODE 0.4 -5.7 -5679 3.5 FOXA2 JUNB BATF ZNF316 ATF4 GLIS1 ETV6 PRDM1 EMSY PRDX1 HMGB1P48 CCDC163 C1orf228 MMACHC HPDL ZSWIM5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HPDL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HPDL gene promoter:

Genomic Locations for HPDL Gene

Genomic Locations for HPDL Gene
1,803 bases
Plus strand

Genomic View for HPDL Gene

Genes around HPDL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPDL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPDL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPDL Gene

Proteins for HPDL Gene

  • Protein details for HPDL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase-like protein
    Protein Accession:
    Secondary Accessions:
    • B2R9B0

    Protein attributes for HPDL Gene

    371 amino acids
    Molecular mass:
    39386 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    No Data Available

neXtProt entry for HPDL Gene

Post-translational modifications for HPDL Gene

No Post-translational modifications

Other Protein References for HPDL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HPDL Gene

Domains & Families for HPDL Gene

Gene Families for HPDL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HPDL Gene

Suggested Antigen Peptide Sequences for HPDL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 4HPPD family.
  • Belongs to the 4HPPD family.
genes like me logo Genes that share domains with HPDL: view

Function for HPDL Gene

Molecular function for HPDL Gene

UniProtKB/Swiss-Prot Function:
May have dioxygenase activity.

Enzyme Numbers (IUBMB) for HPDL Gene

Phenotypes From GWAS Catalog for HPDL Gene

Gene Ontology (GO) - Molecular Function for HPDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003868 NOT 4-hydroxyphenylpyruvate dioxygenase activity IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen IEA --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with HPDL: view
genes like me logo Genes that share phenotypes with HPDL: view

miRNA for HPDL Gene

miRTarBase miRNAs that target HPDL

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HPDL Gene

Localization for HPDL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPDL gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HPDL Gene

Pathways & Interactions for HPDL Gene

No Data Available

Gene Ontology (GO) - Biological Process for HPDL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006572 NOT tyrosine catabolic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HPDL: view

No data available for Pathways by source and SIGNOR curated interactions for HPDL Gene

Drugs & Compounds for HPDL Gene

No Compound Related Data Available

Transcripts for HPDL Gene

mRNA/cDNA for HPDL Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(96) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HPDL Gene

4-hydroxyphenylpyruvate dioxygenase-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPDL Gene

No ASD Table

Relevant External Links for HPDL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPDL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HPDL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPDL Gene

This gene is overexpressed in Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for HPDL Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HPDL Gene

Protein tissue co-expression partners for HPDL Gene

NURSA nuclear receptor signaling pathways regulating expression of HPDL Gene:


SOURCE GeneReport for Unigene cluster for HPDL Gene:


Evidence on tissue expression from TISSUES for HPDL Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with HPDL: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HPDL Gene

Orthologs for HPDL Gene

This gene was present in the common ancestor of animals.

Orthologs for HPDL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HPDL 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia HPDL 33 34
  • 83.83 (n)
(Bos Taurus)
Mammalia HPDL 33 34
  • 82.48 (n)
(Mus musculus)
Mammalia Hpdl 33 16 34
  • 78.17 (n)
(Rattus norvegicus)
Mammalia Hpdl 33
  • 78.05 (n)
(Monodelphis domestica)
Mammalia HPDL 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
(Gallus gallus)
Aves HPDL 33 34
  • 62.36 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hpdl 33
  • 49.34 (n)
(Danio rerio)
Actinopterygii zgc:171978 33
  • 54.66 (n)
  • 38 (a)
(Caenorhabditis elegans)
Secernentea C31H2.4 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2641 34
  • 29 (a)
Species where no ortholog for HPDL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPDL Gene

Gene Tree for HPDL (if available)
Gene Tree for HPDL (if available)

Paralogs for HPDL Gene

Paralogs for HPDL Gene

genes like me logo Genes that share paralogs with HPDL: view

Variants for HPDL Gene

Sequence variations from dbSNP and Humsavar for HPDL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001879687 -- 45,325,483(+) C/T upstream_transcript_variant
rs1002059633 -- 45,326,744(+) C/G upstream_transcript_variant
rs1002128865 -- 45,328,387(+) T/A 3_prime_UTR_variant
rs1003909326 -- 45,326,790(+) C/T upstream_transcript_variant
rs1003958739 -- 45,327,032(+) C/T 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HPDL Gene

Variant ID Type Subtype PubMed ID
nsv1133024 OTHER inversion 24896259

Variation tolerance for HPDL Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPDL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPDL Gene

Disorders for HPDL Gene

Additional Disease Information for HPDL

No disorders were found for HPDL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HPDL Gene

Publications for HPDL Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana PC … Emili A (Cell 2012) 3 58

Products for HPDL Gene

Sources for HPDL Gene

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