HPD Gene (Protein Coding)

4-Hydroxyphenylpyruvate Dioxygenase

GC12M121839
GIFtS:
45
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] See more...

Aliases for HPD Gene

Aliases for HPD Gene

  • 4-Hydroxyphenylpyruvate Dioxygenase 2 3 4 5
  • 4HPPD 2 3 4
  • 4-Hydroxyphenylpyruvic Acid Oxidase 3 4
  • Glyoxalase Domain Containing 3 2 3
  • EC 1.13.11.27 4 51
  • 4-HPPD 2 3
  • GLOD3 2 3
  • PPD 3 4
  • HPPDASE 3
  • HPPDase 4
  • HPD 5

External Ids for HPD Gene

Previous HGNC Symbols for HPD Gene

  • PPD

Previous GeneCards Identifiers for HPD Gene

  • GC12M121132
  • GC12P121808
  • GC12M122046
  • GC12M120675
  • GC12M120740
  • GC12M122277
  • GC12M119289

Summaries for HPD Gene

Entrez Gene Summary for HPD Gene

  • The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for HPD Gene

HPD (4-Hydroxyphenylpyruvate Dioxygenase) is a Protein Coding gene. Diseases associated with HPD include Tyrosinemia, Type Iii and Hawkinsinuria. Among its related pathways are Tyrosine metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen and 4-hydroxyphenylpyruvate dioxygenase activity. An important paralog of this gene is HPDL.

UniProtKB/Swiss-Prot Summary for HPD Gene

Additional gene information for HPD Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HPD Gene

Genomics for HPD Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for HPD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HPD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HPD

Top Transcription factor binding sites by QIAGEN in the HPD gene promoter:
  • Brachyury
  • CBF(2)
  • CBF-A
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • Gfi-1
  • NF-Y
  • Pbx1a

Genomic Locations for HPD Gene

Genomic Locations for HPD Gene
chr12:121,839,527-121,888,611
(GRCh38/hg38)
Size:
49,085 bases
Orientation:
Minus strand
chr12:122,277,433-122,326,517
(GRCh37/hg19)
Size:
49,085 bases
Orientation:
Minus strand

Genomic View for HPD Gene

Genes around HPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HPD Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HPD Gene

Proteins for HPD Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32754-HPPD_HUMAN
    Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
    Protein Accession:
    P32754
    Secondary Accessions:
    • A8K461
    • B3KQ63
    • Q13234

    Protein attributes for HPD Gene

    Size:
    393 amino acids
    Molecular mass:
    44934 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HPD Gene

    Alternative splice isoforms for HPD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HPD Gene

Protein Expression for HPD Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for HPD Gene

P32754:
  • GLETGSR
  • FHRFWSVDD
  • TYGDTTHT
  • VGNAKQAA
  • DHIVGNQPD
  • GKKKSQI
  • HGDGVKD
  • KMPINEPA
  • GFGAGNF
  • VTFWVGNA
  • AYRGLETG
  • GAGVQHIAL
  • LLQIFTKP

Post-translational modifications for HPD Gene

  • Ubiquitination at Lys297
  • Modification sites at PhosphoSitePlus

Other Protein References for HPD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HPD
  • Boster Bio Antibodies for HPD

Domains & Families for HPD Gene

Gene Families for HPD Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HPD Gene

InterPro:
Blocks:
  • Glyoxalase/Bleomycin resistance protein/dioxygenase domain
ProtoNet:

Suggested Antigen Peptide Sequences for HPD Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ32948 fis, clone TESTI2008014, highly similar to 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (B3KQ63_HUMAN)
  • 4-hydroxyphenylpyruvic acid oxidase (HPPD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32754

UniProtKB/Swiss-Prot:

HPPD_HUMAN :
  • Belongs to the 4HPPD family.
Family:
  • Belongs to the 4HPPD family.
genes like me logo Genes that share domains with HPD: view

Function for HPD Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for HPD Gene

UniProtKB/Swiss-Prot Function:
Key enzyme in the degradation of tyrosine.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate; Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27;.
GENATLAS Biochemistry:
4-hydroxyphenylpyruvate dioxygenase,predominantly expressed in liver,catalyzing the second step of tyrosine catabolism

Enzyme Numbers (IUBMB) for HPD Gene

Phenotypes From GWAS Catalog for HPD Gene

Gene Ontology (GO) - Molecular Function for HPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity IBA,ISS --
GO:0016491 oxidoreductase activity IEA --
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen IEA --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with HPD: view
genes like me logo Genes that share phenotypes with HPD: view

Human Phenotype Ontology for HPD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPD

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HPD Gene

Localization for HPD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HPD gene
Compartment Confidence
cytosol 5
extracellular 4
nucleus 3
endoplasmic reticulum 3
golgi apparatus 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HPD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HPD Gene

Pathways & Interactions for HPD Gene

genes like me logo Genes that share pathways with HPD: view

Pathways by source for HPD Gene

1 BioSystems pathway for HPD Gene
1 GeneGo (Thomson Reuters) pathway for HPD Gene
  • Transcription CREB pathway

UniProtKB/Swiss-Prot P32754-HPPD_HUMAN

  • Pathway: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.

Gene Ontology (GO) - Biological Process for HPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006559 L-phenylalanine catabolic process TAS --
GO:0006572 tyrosine catabolic process TAS,ISS --
GO:0009072 aromatic amino acid family metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HPD: view

No data available for SIGNOR curated interactions for HPD Gene

Drugs & Compounds for HPD Gene

Products:

  1. Drug

(11) Drugs for HPD Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitisinone Approved, Investigational Pharma Target, inhibitor 16
Oxygen Approved, Vet_approved Pharma 0
Carbon dioxide Approved, Investigational, Vet_approved Pharma 0
Iron Approved, Experimental Pharma 1560
2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE Experimental Pharma Target 0

(11) Additional Compounds for HPD Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ortho-Hydroxyphenylacetic acid
  • (O-Hydroxyphenyl)acetic acid
  • 2'-Hydroxyphenylacetic acid
  • 2-Hydroxybenzeneacetic acid
  • 2-Hydroxyphenylacetic acid
  • O-Hydroxyphenylacetic acid
 614-75-5
genes like me logo Genes that share compounds with HPD: view

Transcripts for HPD Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HPD Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HPD

Alternative Splicing Database (ASD) splice patterns (SP) for HPD Gene

No ASD Table

Relevant External Links for HPD Gene

GeneLoc Exon Structure for
HPD

Expression for HPD Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HPD Gene

mRNA expression in normal human tissues for HPD Gene
mRNA expression by GTEx for HPD GenemRNA expression by BioGPS for HPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPD Gene

This gene is overexpressed in Liver (x41.5) and Kidney - Cortex (x8.1).

Protein differential expression in normal tissues from HIPED for HPD Gene

This gene is overexpressed in Liver, secretome (56.8) and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HPD Gene



Protein tissue co-expression partners for HPD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HPD

SOURCE GeneReport for Unigene cluster for HPD Gene:

Hs.2899

Evidence on tissue expression from TISSUES for HPD Gene

  • Liver(4.8)
  • Kidney(3.2)
  • Nervous system(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HPD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • eye
  • head
Abdomen:
  • liver
Limb:
  • ankle
  • digit
  • foot
  • hand
  • knee
  • lower limb
  • upper limb
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with HPD: view

No data available for mRNA Expression by UniProt/SwissProt for HPD Gene

Orthologs for HPD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HPD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia HPD 30 31
  • 99.49 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia HPD 30 31
  • 90.67 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia HPD 30 31
  • 90.25 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Hpd 30
  • 86.34 (n)
Mouse
(Mus musculus)
 Mammalia Hpd 30 17 31
  • 86.09 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia HPD 31
  • 76 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia HPD 31
  • 72 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves HPD 30 31
  • 75.77 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia HPD 31
  • 68 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia hpd 30
  • 68.56 (n)
Str.8493 30
African clawed frog
(Xenopus laevis)
 Amphibia MGC68535 30
Zebrafish
(Danio rerio)
 Actinopterygii hpdb 30 31
  • 68.97 (n)
 OneToOne
zgc56326 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8483 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG11796 30 31 32
  • 65.09 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004802 30
  • 63.52 (n)
Worm
(Caenorhabditis elegans)
 Secernentea T21C12.2 32
  • 61 (a)
hpd-1 30 31
  • 59.3 (n)
 OneToOne
C31H2.4 32
  • 41 (a)
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons PDS1 30
  • 48.82 (n)
Rice
(Oryza sativa)
 Liliopsida Os02g0168100 30
  • 57.12 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.7220 31
  • 61 (a)
 OneToMany
-- 31
  • 60 (a)
 OneToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU01830 30
  • 60.85 (n)
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.10805 30
Species where no ortholog for HPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for HPD Gene

ENSEMBL:
Gene Tree for HPD (if available)
TreeFam:
Gene Tree for HPD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HPD: view image

Paralogs for HPD Gene

Paralogs for HPD Gene

genes like me logo Genes that share paralogs with HPD: view

Variants for HPD Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HPD Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
638895 Uncertain Significance: Hawkinsinuria; Tyrosinemia type 3 121,839,790(-) C/T MISSENSE_VARIANT
638896 Uncertain Significance: Hawkinsinuria; Tyrosinemia type 3 121,857,422(-) A/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
642856 Pathogenic: Hawkinsinuria; Tyrosinemia type 3 121,857,367(-) A/AC FRAMESHIFT_VARIANT
712611 Likely Benign: not provided 121,843,766(-) G/T SYNONYMOUS_VARIANT
719449 Likely Benign: Hawkinsinuria; Tyrosinemia type 3 121,840,055(-) G/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for HPD Gene

Structural Variations from Database of Genomic Variants (DGV) for HPD Gene

Variant ID Type Subtype PubMed ID
dgv322e199 CNV deletion 23128226
dgv883n106 CNV deletion 24896259
esv1346224 CNV deletion 17803354
esv2164211 CNV deletion 18987734
esv2433173 CNV deletion 19546169
esv2746496 CNV deletion 23290073
esv3549898 CNV deletion 23714750
esv3549901 CNV deletion 23714750
esv3630960 CNV loss 21293372
esv3892268 CNV loss 25118596
nsv1070135 CNV deletion 25765185
nsv1127299 CNV deletion 24896259
nsv1145887 CNV deletion 26484159
nsv1160065 CNV deletion 26073780
nsv472039 CNV novel sequence insertion 20440878
nsv911 CNV deletion 18451855
nsv912 CNV insertion 18451855
nsv957277 CNV deletion 24416366

Variation tolerance for HPD Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HPD Gene

Human Gene Mutation Database (HGMD)
HPD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HPD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPD Gene

Disorders for HPD Gene

MalaCards: The human disease database

(16) MalaCards diseases for HPD Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tyrosinemia, type iii
  • tyrsn3
hawkinsinuria
  • 4-alpha-hydroxyphenylpyruvate hydroxylase deficiency
tyrosinemia
  • hereditary tyrosinemia
tyrosinemia, type i
  • tyrsn1
alkaptonuria
  • aku
- elite association - COSMIC cancer census association via MalaCards
Search HPD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HPPD_HUMAN
  • Tyrosinemia 3 (TYRSN3) [MIM:276710]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. {ECO:0000269 PubMed:10942115, ECO:0000269 PubMed:11073718}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hawkinsinuria (HAWK) [MIM:140350]: An inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. {ECO:0000269 PubMed:11073718}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for HPD Gene

tyrosinemia,type III

Additional Disease Information for HPD

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with HPD: view

Publications for HPD Gene

  1. Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III. (PMID: 10942115) Rüetschi U … Holme E (Human genetics 2000) 3 4 23
  2. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria. (PMID: 11073718) Tomoeda K … Endo F (Molecular genetics and metabolism 2000) 3 4 23
  3. Human 4-hydroxyphenylpyruvate dioxygenase gene (HPD). (PMID: 9325050) Rüetschi U … Lindstedt S (Genomics 1997) 3 4 23
  4. Regional assignment of the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) to 12q24-->qter by fluorescence in situ hybridization. (PMID: 8521727) Stenman G … Lindstedt S (Cytogenetics and cell genetics 1995) 3 4 23
  5. Structure of the human 4-hydroxyphenylpyruvic acid dioxygenase gene (HPD). (PMID: 7851880) Awata H … Matsuda I (Genomics 1994) 3 4 23

ExternalLinks

View latest publications for HPD gene in Mastermind

Products for HPD Gene

Sources for HPD Gene