Aliases for HOXD13 Gene
External Ids for HOXD13 Gene
Previous HGNC Symbols for HOXD13 Gene
Previous GeneCards Identifiers for HOXD13 Gene
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXD13 Gene
HOXD13 (Homeobox D13) is a Protein Coding gene. Diseases associated with HOXD13 include Brachydactyly-Syndactyly Syndrome and Synpolydactyly 1. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is HOXA13.
UniProtKB/Swiss-Prot for HOXD13 Gene
Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).