This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. Thi... See more...

Aliases for HOXC9 Gene

Aliases for HOXC9 Gene

  • Homeobox C9 2 3 5
  • Homeobox Protein Hox-3B 3 4
  • Homeobox Protein Hox-C9 3 4
  • Homeo Box C9 2 3
  • HOX3B 3 4
  • HOX3 3

External Ids for HOXC9 Gene

Previous HGNC Symbols for HOXC9 Gene

  • HOX3
  • HOX3B

Previous GeneCards Identifiers for HOXC9 Gene

  • GC12M054413
  • GC12P054506
  • GC12P054110
  • GC12P052680
  • GC12P054393
  • GC12P054388
  • GC12P051432
  • GC12P053995
  • GC12P053998
  • GC12P054109
  • GC12P054122
  • GC12P054136
  • GC12P054013
  • GC12P054042
  • GC12P054053
  • GC12P054062
  • GC12P054074
  • GC12P054086
  • GC12P054096
  • GC12P054102

Summaries for HOXC9 Gene

Entrez Gene Summary for HOXC9 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC9 Gene

HOXC9 (Homeobox C9) is a Protein Coding gene. Among its related pathways are Differentiation of white and brown adipocyte. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD9.

UniProtKB/Swiss-Prot Summary for HOXC9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXC9 Gene

Additional gene information for HOXC9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXC9 Gene

Genomics for HOXC9 Gene

GeneHancer (GH) Regulatory Elements for HOXC9 Gene

Promoters and enhancers for HOXC9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXC9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXC9

Top Transcription factor binding sites by QIAGEN in the HOXC9 gene promoter:
  • E2F-5
  • E47
  • Hand1
  • RORalpha1
  • Sp1

Genomic Locations for HOXC9 Gene

Genomic Locations for HOXC9 Gene
chr12:53,994,895-54,003,337
(GRCh38/hg38)
Size:
8,443 bases
Orientation:
Plus strand
chr12:54,388,679-54,397,121
(GRCh37/hg19)
Size:
8,443 bases
Orientation:
Plus strand

Genomic View for HOXC9 Gene

Genes around HOXC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC9 Gene

Proteins for HOXC9 Gene

  • Protein details for HOXC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31274-HXC9_HUMAN
    Recommended name:
    Homeobox protein Hox-C9
    Protein Accession:
    P31274
    Secondary Accessions:
    • B2RCN7
    • Q9H1I0

    Protein attributes for HOXC9 Gene

    Size:
    260 amino acids
    Molecular mass:
    29248 Da
    Quaternary structure:
    • Interacts with Geminin/GMNN, which inhibits transcriptional activity.

    Three dimensional structures from OCA and Proteopedia for HOXC9 Gene

neXtProt entry for HOXC9 Gene

Post-translational modifications for HOXC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC9 Gene

Domains & Families for HOXC9 Gene

Gene Families for HOXC9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXC9 Gene

Blocks:
  • Lambda and other repressor helix-turn-helix signature
  • Hox9 activation region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOXC9 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox protein Hox-3B (HXC9_HUMAN)
  • HOXC9 protein (O15222_HUMAN)
  • HOXC9 protein (Q8N561_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P31274

UniProtKB/Swiss-Prot:

HXC9_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC9: view

Function for HOXC9 Gene

Molecular function for HOXC9 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box C9(3B),homologous to mouse Hox-3.2,Drosophila abd-B,involved in mouse posterior limb patterning,expressed in posterior limb

Phenotypes From GWAS Catalog for HOXC9 Gene

Gene Ontology (GO) - Molecular Function for HOXC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18305892
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC9: view
genes like me logo Genes that share phenotypes with HOXC9: view

Animal Models for HOXC9 Gene

MGI Knock Outs for HOXC9:

Animal Model Products

CRISPR Products

miRNA for HOXC9 Gene

miRTarBase miRNAs that target HOXC9
Targeted motifs for HOXC9 Gene
HOMER Transcription Factor Regulatory Elements motif HOXC9
  • Consensus sequence: GGCCATAAATCA Submotif: canonical Cell Type: Ainv15 GEO ID: GSE21812

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HOXC9 Gene

Localization for HOXC9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXC9 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOXC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with HOXC9: view

Pathways & Interactions for HOXC9 Gene

PathCards logo

SuperPathways for HOXC9 Gene

genes like me logo Genes that share pathways with HOXC9: view

Pathways by source for HOXC9 Gene

1 BioSystems pathway for HOXC9 Gene

Gene Ontology (GO) - Biological Process for HOXC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXC9: view

No data available for SIGNOR curated interactions for HOXC9 Gene

Drugs & Compounds for HOXC9 Gene

No Compound Related Data Available

Transcripts for HOXC9 Gene

mRNA/cDNA for HOXC9 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC9 Gene

No ASD Table

Relevant External Links for HOXC9 Gene

GeneLoc Exon Structure for
HOXC9

Expression for HOXC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXC9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC9 Gene

This gene is overexpressed in Muscle - Skeletal (x9.9), Adipose - Subcutaneous (x4.5), and Fallopian Tube (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOXC9 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXC9

SOURCE GeneReport for Unigene cluster for HOXC9 Gene:

Hs.658823

Evidence on tissue expression from TISSUES for HOXC9 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with HOXC9: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC9 Gene

Orthologs for HOXC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC9 31 30
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HOXC9 31 30
  • 97.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxc9 17 31 30
  • 96.03 (n)
rat
(Rattus norvegicus)
Mammalia Hoxc9 30
  • 95.64 (n)
dog
(Canis familiaris)
Mammalia -- 31
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HOXC9 31 30
  • 75.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXC9 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733557 30
  • 74.9 (n)
zebrafish
(Danio rerio)
Actinopterygii hoxc9a 31 30 30
  • 67.05 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToMany
Species where no ortholog for HOXC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC9 Gene

ENSEMBL:
Gene Tree for HOXC9 (if available)
TreeFam:
Gene Tree for HOXC9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXC9: view image

Paralogs for HOXC9 Gene

(9) SIMAP similar genes for HOXC9 Gene using alignment to 3 proteins:

  • HXC9_HUMAN
  • O15222_HUMAN
  • Q8N561_HUMAN
genes like me logo Genes that share paralogs with HOXC9: view

Variants for HOXC9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXC9 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_036267 A colorectal cancer sample p.Gly87Ser

Additional dbSNP identifiers (rs#s) for HOXC9 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXC9 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Variation tolerance for HOXC9 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXC9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC9 Gene

Disorders for HOXC9 Gene

Additional Disease Information for HOXC9

No disorders were found for HOXC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC9 Gene

Publications for HOXC9 Gene

  1. Structural basis for homeodomain recognition by the cell-cycle regulator Geminin. (PMID: 22615398) Zhou B … Zhu G (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4 54
  5. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine PJ … Shows TB (Genomics 1990) 2 3 54

Products for HOXC9 Gene