Free for academic non-profit institutions. Other users need a Commercial license
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. Thi... See more...
Aliases for HOXC4 Gene
Aliases for HOXC4 Gene
External Ids for HOXC4 Gene
- HGNC: 5126
- Entrez Gene: 3221
- Ensembl: ENSG00000198353
- OMIM: 142974
- UniProtKB: P09017
Previous HGNC Symbols for HOXC4 Gene
- HOX3
- HOX3E
Previous GeneCards Identifiers for HOXC4 Gene
- GC12M054370
- GC12P054523
- GC12P054127
- GC12P052696
- GC12P054410
- GC12P051448
Summaries for HOXC4 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXC4 Gene
HOXC4 (Homeobox C4) is a Protein Coding gene. Among its related pathways are Developmental Biology and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and HMG box domain binding. An important paralog of this gene is HOXD4.
UniProtKB/Swiss-Prot Summary for HOXC4 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXC4 Gene
Genomics for HOXC4 Gene
GeneHancer (GH) Regulatory Elements for HOXC4 Gene
Promoters and enhancers for HOXC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HOXC4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HOXC4 gene promoter:
-
- Sp1
Genomic Locations for HOXC4 Gene
Genomic Locations for HOXC4 Gene
- chr12:54,016,852-54,056,030
- (GRCh38/hg38)
- Size:
- 39,179 bases
- Orientation:
- Plus strand
- chr12:54,410,642-54,449,814
- (GRCh37/hg19)
- Size:
- 39,173 bases
- Orientation:
- Plus strand
Genomic View for HOXC4 Gene
Genes around HOXC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
HOXC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXC4 Gene
Proteins for HOXC4 Gene
-
Protein details for HOXC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09017-HXC4_HUMAN
- Recommended name:
- Homeobox protein Hox-C4
- Protein Accession:
- P09017
Protein attributes for HOXC4 Gene
- Size:
- 264 amino acids
- Molecular mass:
- 29811 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXC4 Gene
Post-translational modifications for HOXC4 Gene
Other Protein References for HOXC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-HOXC4 Antibody
- Creative Diagnostics Anti-HOXC4 (aa 1-50) polyclonal antibody and Anti-HOXC4 (aa 160-264) polyclonal antibody
-
Creative Biolabs
- Novus Biologicals Antibodies for HOXC4
-
Abcam antibodies for HOXC4
- Invitrogen Antibodies for HOXC4 (AFLGC-HOXC4)
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXC4
Protein Products
- Atlas Antibodies PrEST Antigen HOXC4
- Creative Biomart Recombinant Human HOXC4 and Recombinant Human HOXC4 293 Cell Lysate
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC4
- Origene Custom Protein Services for HOXC4
- antibodies-online: Show 6 available HOXC4 Proteins ranked by validation data
- Compare Top HOXC4 Proteins
-
Quality Products:
-
Abcam proteins for HOXC4
Assay Products
- Creative Diagnostics Human HOXC4 ELISA Matched Antibody Pair
- antibodies-online: Show 2 available HOXC4 Elisa Kits ranked by validation data
- Compare Top HOXC4 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for HOXC4 Gene
Domains & Families for HOXC4 Gene
Gene Families for HOXC4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HOXC4 Gene
Suggested Antigen Peptide Sequences for HOXC4 Gene
- GenScript: Design optimal peptide antigens:
-
- Homeobox protein Hox-3E (HXC4_HUMAN)
- Homeobox C4 (Q86TF7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P09017- Family:
-
- Belongs to the Antp homeobox family. Deformed subfamily.
Function for HOXC4 Gene
Molecular function for HOXC4 Gene
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
- GENATLAS Biochemistry:
- homeo box C4(3E),Drosophila Dfd,expressed in first trimester trophoblast,involved in mouse anterior limb patterning,expressed in anterior limb
Phenotypes From GWAS Catalog for HOXC4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IDA | 15252056 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 15252056 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for HOXC4 Gene
- MGI mutant phenotypes for HOXC4:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HOXC4:
Animal Models for HOXC4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for HOXC4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOXC4
- genomics-online: gRNA clones - Search results for available HOXC4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for HOXC4 - Select products 50% OFF >
- * HOXC4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HOXC4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC4
miRNA for HOXC4 Gene
- miRTarBase miRNAs that target HOXC4
-
- hsa-mir-331-3p (MIRT019246)
- hsa-mir-125a-5p (MIRT021293)
- hsa-mir-124-3p (MIRT022277)
- hsa-mir-26b-5p (MIRT029035)
- hsa-mir-615-3p (MIRT040437)
- hsa-let-7a-5p (MIRT052528)
- hsa-mir-1277-5p (MIRT273689)
- hsa-mir-5011-5p (MIRT273692)
- hsa-mir-6780a-5p (MIRT453090)
- hsa-mir-6779-5p (MIRT453092)
- hsa-mir-3689c (MIRT453093)
- hsa-mir-3689b-3p (MIRT453094)
- hsa-mir-3689a-3p (MIRT453095)
- hsa-mir-30b-3p (MIRT453096)
- hsa-mir-1273h-5p (MIRT453097)
- hsa-mir-6778-5p (MIRT453098)
- hsa-mir-1233-5p (MIRT453099)
- hsa-mir-6721-5p (MIRT453100)
- hsa-mir-6883-5p (MIRT453101)
- hsa-mir-6799-5p (MIRT453102)
- hsa-mir-6785-5p (MIRT453103)
- hsa-mir-4728-5p (MIRT453104)
- hsa-mir-149-3p (MIRT453105)
- hsa-mir-7106-5p (MIRT453106)
- hsa-mir-8085 (MIRT453107)
- hsa-mir-6731-5p (MIRT453108)
- hsa-mir-4763-3p (MIRT453109)
- hsa-mir-1207-5p (MIRT453110)
- hsa-mir-6797-5p (MIRT453111)
- hsa-mir-1249-5p (MIRT453112)
- hsa-mir-6722-3p (MIRT453113)
- hsa-mir-1909-3p (MIRT453114)
- hsa-mir-3616-3p (MIRT453115)
- hsa-mir-6133 (MIRT453116)
- hsa-mir-6130 (MIRT453117)
- hsa-mir-6129 (MIRT453118)
- hsa-mir-6127 (MIRT453119)
- hsa-mir-4510 (MIRT453120)
- hsa-mir-4419a (MIRT453121)
- hsa-mir-194-3p (MIRT453122)
- hsa-mir-7843-5p (MIRT453123)
- hsa-mir-6879-5p (MIRT453124)
- hsa-mir-6735-5p (MIRT453125)
- hsa-mir-4632-5p (MIRT453126)
- hsa-mir-4436b-3p (MIRT453127)
- hsa-mir-4779 (MIRT453128)
- hsa-mir-6760-5p (MIRT453129)
- hsa-mir-212-3p (MIRT453130)
- hsa-mir-132-3p (MIRT453131)
- hsa-mir-190a-3p (MIRT508616)
- hsa-mir-656-3p (MIRT508617)
- hsa-mir-10a-3p (MIRT508618)
- hsa-mir-548b-3p (MIRT550174)
- hsa-mir-3133 (MIRT707180)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HOXC4
- Browse OriGene Inhibitory RNA Products For HOXC4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC4
- genomics-online: shRNA clones - Search results for available HOXC4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for HOXC4
- Addgene plasmids for HOXC4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOXC4
- genomics-online: cdna clones - Search results for available HOXC4 gene related products
- orf clones - Search results for available HOXC4 gene related products
- Applied Biological Materials (abm): Clones for HOXC4 - Select products 50% OFF >
- * HOXC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HOXC4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for HOXC4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC4 Gene
Localization for HOXC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXC4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | -- |
Pathways & Interactions for HOXC4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXC4 Gene
Interacting Proteins for HOXC4 Gene
Selected Interacting proteins:
P09017-HXC4_HUMAN
ENSP00000399808
for HOXC4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for HOXC4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IBA | 21873635 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA | 15252056 |
No data available for SIGNOR curated interactions for HOXC4 Gene
Drugs & Compounds for HOXC4 Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen HOXC4
- Creative Biomart Recombinant Human HOXC4 and Recombinant Human HOXC4 293 Cell Lysate
Transcripts for HOXC4 Gene
mRNA/cDNA for HOXC4 Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (228) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000303406 1524 bps (ENST00000303406.4)
- ENST00000507650 575 bps (ENST00000507650.1)
- ENST00000430889 1708 bps (ENST00000430889.2)
CRISPR Products
-
OriGene CRISPR knockouts for HOXC4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOXC4
- genomics-online: gRNA clones - Search results for available HOXC4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for HOXC4 - Select products 50% OFF >
- * HOXC4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * HOXC4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HOXC4
- Browse OriGene Inhibitory RNA Products For HOXC4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC4
- genomics-online: shRNA clones - Search results for available HOXC4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for HOXC4
- Addgene plasmids for HOXC4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOXC4
- genomics-online: cdna clones - Search results for available HOXC4 gene related products
- orf clones - Search results for available HOXC4 gene related products
- Applied Biological Materials (abm): Clones for HOXC4 - Select products 50% OFF >
- * HOXC4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * HOXC4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for HOXC4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Spinal Cord (Nervous System)
- Flexor Carpi Ulnaris Muscle Motor Neurons Caudal Brachial Medial Motor Division
- Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
- Lateral Motor Neurons Rostral Brachial Lateral Motor Column
- Pectoralis Muscle Motor Neurons Caudal Brachial Medial Motor Division
- Lateral Motor Neurons Caudal Brachial Lateral Motor Column
-
Neurons
- Flexor Carpi Ulnaris Muscle Motor Neurons Caudal Brachial Medial Motor Division
- Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
- Lateral Motor Neurons Rostral Brachial Lateral Motor Column
- Pectoralis Muscle Motor Neurons Caudal Brachial Medial Motor Division
- Lateral Motor Neurons Caudal Brachial Lateral Motor Column
-
Adipose (Muscoskeletal System)
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
- Cervical Brown Adipocyte Cells Cervical Brown Adipose Depot
- Thoracic Brown Adipocyte Cells Thoracic Brown Adipose Depot
- Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HOXC4 Gene
This gene is overexpressed in Fallopian Tube (x7.0), Kidney - Cortex (x4.2), and Artery - Tibial (x4.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HOXC4 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXC4 Gene:
HOXC4SOURCE GeneReport for Unigene cluster for HOXC4 Gene:
Hs.549040Primer Products
-
OriGene qPCR primer pairs for HOXC4
-
OriGene qPCR primer pairs and template standards for HOXC4
- genomics-online: primer clones - Search results for available HOXC4 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC4 Gene
Orthologs for HOXC4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXC4 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HOXC4 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HOXC4 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hoxc4 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxc4 17 33 32 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxc4 32 |
|
||
| Str.7417 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | hoxc6-A-prov 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxc4a 33 32 32 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Scr 34 |
|
|
|
| Dfd 33 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for HOXC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for HOXC4 Gene
- ENSEMBL:
- Gene Tree for HOXC4 (if available)
- TreeFam:
- Gene Tree for HOXC4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HOXC4: view image
Paralogs for HOXC4 Gene
Paralogs for HOXC4 Gene
- HOXD4 5
- HOXB4 5
- HOXA4 5
- HOXA5 5
- HOXB5 5
- HOXA3 5
- HOXB6 5
- HOXA7 5
- HOXB3 5
- HOXC5 5
- HOXB7 5
- HOXC6 5
- HOXD3 5
- HOXC8 5
- HOXA6 5
- HOXB2 5
- HOXB8 5
- PDX1 5
- HOXA2 5
- HOXD8 5
- HOXA10 5
- HOXD10 5
- HOXB1 5
- HOXD9 5
- HOXD1 5
- GSX2 5
- HOXB9 5
- HOXC9 5
- HOXA1 5
- TLX1 5
- ENSG00000273049 5
- TLX3 5
- HOXC10 5
- TLX2 5
- HOXA13 5
- HOXD11 5
- HOXC13 5
- HOXC11 5
- HOXA11 5
- HOXC12 5
- HOXD12 5
- HOXD13 5
- HOXB13 5
(16) SIMAP similar genes for HOXC4 Gene using alignment to 2 proteins:
- HXC4_HUMAN
- Q86TF7_HUMAN
Variants for HOXC4 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000059230 | -- | 54,014,986(+) | G/A | upstream_transcript_variant | |
| rs1000137595 | -- | 54,028,295(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000191769 | -- | 54,028,030(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000269134 | -- | 54,022,527(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000358677 | -- | 54,044,367(+) | A/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2672088 | CNV | deletion | 23128226 |
| esv2759900 | CNV | gain+loss | 17122850 |
| nsv428282 | CNV | gain | 18775914 |
| nsv472156 | CNV | novel sequence insertion | 20440878 |
| nsv558998 | CNV | loss | 21841781 |
| nsv716 | CNV | insertion | 18451855 |
| nsv826379 | CNV | gain | 20364138 |
| nsv832418 | CNV | loss | 17160897 |
| nsv952182 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
33.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.62;
78.23% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HOXC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXC4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC4 Gene
Disorders for HOXC4 Gene
Additional Disease Information for HOXC4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for HOXC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC4 Gene
Publications for HOXC4 Gene
- Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. (PMID: 16215934) Gong LG … Sun KL (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2005) 3 23 43 56
- [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. (PMID: 19236766) Feng JQ … Chen SQ (Zhongguo shi yan xue ye xue za zhi 2009) 3 23 56
- Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. (PMID: 12672812) Schaffer A … Casali P (The Journal of biological chemistry 2003) 3 23 56
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4 56
- HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. (PMID: 9327740) Bijl JJ … Meijer CJ (The American journal of pathology 1997) 3 23 56
ExternalLinks
Products for HOXC4 Gene
- Custom Antibody ServicesOriGene Antibodies for HOXC4
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC4
- Origene Custom Protein Services for HOXC4
- Origene sirna, shrna, and RNAi products in human, mouse, rat for HOXC4
- Browse OriGene Inhibitory RNA Products For HOXC4
- OriGene qPCR primer pairs for HOXC4
- OriGene qPCR primer pairs and template standards for HOXC4
- OriGene CRISPR knockouts for HOXC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HOXC4
- Sino Biological Human cDNA Clone for HOXC4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for HOXC4
- Novus Biologicals proteins and lysates for HOXC4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for HOXC4
- Abcam proteins for HOXC4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for HOXC4 (AFLGC-HOXC4)
- Addgene plasmids for HOXC4
- antibodies-online: Show 23 available HOXC4 Antibodies ranked by validation data
- Compare Top HOXC4 Antibodies
- antibodies-online: Show 2 available HOXC4 Elisa Kits ranked by validation data
- Compare Top HOXC4 Elisa Kits
- Quality Products:
- antibodies-online: Show 6 available HOXC4 Proteins ranked by validation data
- Compare Top HOXC4 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for HOXC4
- Search Santa Cruz Biotechnology (SCBT) for HOXC4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HOXC4
- Horizon Cell Lines for HOXC4
- genomics-online: cdna clones - Search results for available HOXC4 gene related products
- orf clones - Search results for available HOXC4 gene related products
- genomics-online: gRNA clones - Search results for available HOXC4 gene related products
- genomics-online: primer clones - Search results for available HOXC4 gene related products
- genomics-online: shRNA clones - Search results for available HOXC4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOXC4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOXC4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for HOXC4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC4
Sources for HOXC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource