This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. Thi... See more...

Aliases for HOXC10 Gene

Aliases for HOXC10 Gene

  • Homeobox C10 2 3 5
  • Homeobox Protein Hox-C10 3 4
  • Homeobox Protein Hox-3I 3 4
  • Homeo Box C10 2 3
  • HOX3I 3 4
  • Homeoprotein C10 3
  • HOXC10 5

External Ids for HOXC10 Gene

Previous HGNC Symbols for HOXC10 Gene

  • HOX3I

Previous GeneCards Identifiers for HOXC10 Gene

  • GC12M054414
  • GC12P054491
  • GC12P054095
  • GC12P052665
  • GC12P054378
  • GC12P051416
  • GC12P053987
  • GC12P053989
  • GC12P054054
  • GC12P054071
  • GC12P053988
  • GC12P054165
  • GC12P053993
  • GC12P053996
  • GC12P053999
  • GC12P054003
  • GC12P054004
  • GC12P054005
  • GC12P054014
  • GC12P054044

Summaries for HOXC10 Gene

Entrez Gene Summary for HOXC10 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC10 Gene

HOXC10 (Homeobox C10) is a Protein Coding gene. Diseases associated with HOXC10 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot Summary for HOXC10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXC10 Gene

Additional gene information for HOXC10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXC10 Gene

Genomics for HOXC10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HOXC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXC10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXC10

Top Transcription factor binding sites by QIAGEN in the HOXC10 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • FOXO1a

Genomic Locations for HOXC10 Gene

Genomic Locations for HOXC10 Gene
chr12:53,985,065-53,990,279
(GRCh38/hg38)
Size:
5,215 bases
Orientation:
Plus strand
chr12:54,378,849-54,384,063
(GRCh37/hg19)
Size:
5,215 bases
Orientation:
Plus strand

Genomic View for HOXC10 Gene

Genes around HOXC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC10 Gene

Proteins for HOXC10 Gene

  • Protein details for HOXC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYD6-HXC10_HUMAN
    Recommended name:
    Homeobox protein Hox-C10
    Protein Accession:
    Q9NYD6
    Secondary Accessions:
    • O15219
    • O15220
    • Q9BVD5

    Protein attributes for HOXC10 Gene

    Size:
    342 amino acids
    Molecular mass:
    38073 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC10 Gene

Post-translational modifications for HOXC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC10 Gene

Domains & Families for HOXC10 Gene

Gene Families for HOXC10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXC10 Gene

Suggested Antigen Peptide Sequences for HOXC10 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox protein Hox-3I (HXC10_HUMAN)
  • cDNA, FLJ94360, Homo sapiens homeo box C10 (HOXC10), mRNA (Q53XI4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYD6

UniProtKB/Swiss-Prot:

HXC10_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC10: view

Function for HOXC10 Gene

Molecular function for HOXC10 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box C10(3I),homologous to mouse Hox-3.6,involved in mouse posterior limb patterning,expressed in posterior limb

Phenotypes From GWAS Catalog for HOXC10 Gene

Gene Ontology (GO) - Molecular Function for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10835276
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 10835276
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC10: view
genes like me logo Genes that share phenotypes with HOXC10: view

Animal Models for HOXC10 Gene

MGI Knock Outs for HOXC10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC10 Gene

Localization for HOXC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXC10 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with HOXC10: view

Pathways & Interactions for HOXC10 Gene

PathCards logo

SuperPathways for HOXC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0008284 positive regulation of cell proliferation TAS 10835276
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXC10: view

No data available for Pathways by source and SIGNOR curated interactions for HOXC10 Gene

Drugs & Compounds for HOXC10 Gene

No Compound Related Data Available

Transcripts for HOXC10 Gene

mRNA/cDNA for HOXC10 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC10

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC10 Gene

No ASD Table

Relevant External Links for HOXC10 Gene

GeneLoc Exon Structure for
HOXC10

Expression for HOXC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC10 Gene

This gene is overexpressed in Muscle - Skeletal (x16.5), Kidney - Cortex (x5.4), and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for HOXC10 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOXC10 Gene



Protein tissue co-expression partners for HOXC10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXC10

SOURCE GeneReport for Unigene cluster for HOXC10 Gene:

Hs.44276

Evidence on tissue expression from TISSUES for HOXC10 Gene

  • Muscle(2.8)
  • Kidney(2.3)
  • Skin(2.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with HOXC10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC10 Gene

Orthologs for HOXC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HOXC10 30 31
  • 99.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HOXC10 30 31
  • 96.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hoxc10 30
  • 95.32 (n)
Mouse
(Mus musculus)
Mammalia Hoxc10 30 17 31
  • 95.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HOXC10 30 31
  • 93.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HOXC10 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HOXC10 30 31
  • 73.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HOXC10 31
  • 65 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hoxc10 30
  • 71.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21864 30
Zebrafish
(Danio rerio)
Actinopterygii hoxc10a 30 31
  • 54.22 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 21 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.14322 30
Species where no ortholog for HOXC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HOXC10 Gene

ENSEMBL:
Gene Tree for HOXC10 (if available)
TreeFam:
Gene Tree for HOXC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXC10: view image

Paralogs for HOXC10 Gene

(4) SIMAP similar genes for HOXC10 Gene using alignment to 3 proteins:

  • HXC10_HUMAN
  • D6RAG4_HUMAN
  • Q53XI4_HUMAN
genes like me logo Genes that share paralogs with HOXC10: view

Variants for HOXC10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXC10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
718767 Benign: not provided 53,985,511(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for HOXC10 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXC10 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv1136151 CNV deletion 24896259
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Variation tolerance for HOXC10 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC10 Gene

Disorders for HOXC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOXC10 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with HOXC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXC10 Gene

Publications for HOXC10 Gene

  1. Selection of homeotic proteins for binding to a human DNA replication origin. (PMID: 10835276) de Stanchina E … Biamonti G (Journal of molecular biology 2000) 3 4 23
  2. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (PMID: 17974957) Zhai Y … Cho KR (Cancer research 2007) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PMID: 9357979) Flagiello D … Malfoy B (FEBS letters 1997) 3 4
  5. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott MP (Cell 1992) 2 3

Products for HOXC10 Gene

  • Signalway Proteins for HOXC10

Sources for HOXC10 Gene