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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. Thi... See more...
Aliases for HOXC10 Gene
Aliases for HOXC10 Gene
External Ids for HOXC10 Gene
- HGNC: 5122
- Entrez Gene: 3226
- Ensembl: ENSG00000180818
- OMIM: 605560
- UniProtKB: Q9NYD6
Previous HGNC Symbols for HOXC10 Gene
- HOX3I
Previous GeneCards Identifiers for HOXC10 Gene
- GC12M054414
- GC12P054491
- GC12P054095
- GC12P052665
- GC12P054378
- GC12P051416
- GC12P053987
- GC12P053989
- GC12P054054
- GC12P054071
- GC12P053988
- GC12P054165
- GC12P053993
- GC12P053996
- GC12P053999
- GC12P054003
- GC12P054004
- GC12P054005
- GC12P054014
- GC12P054044
Summaries for HOXC10 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXC10 Gene
HOXC10 (Homeobox C10) is a Protein Coding gene. Diseases associated with HOXC10 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.
UniProtKB/Swiss-Prot Summary for HOXC10 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Additional gene information for HOXC10 Gene
- HGNC(5122)
- Entrez Gene(3226)
- Ensembl(ENSG00000180818)
- OMIM(605560)
- UniProtKB(Q9NYD6)
- Open Targets Platform(ENSG00000180818)
- Search for HOXC10 at DataMed
- Search for HOXC10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXC10 Gene
Genomics for HOXC10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for HOXC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around HOXC10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXC10
- Top Transcription factor binding sites by QIAGEN in the HOXC10 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- FOXO1a
Genomic Locations for HOXC10 Gene
Genomic Locations for HOXC10 Gene
- chr12:53,985,065-53,990,279
- (GRCh38/hg38)
- Size:
- 5,215 bases
- Orientation:
- Plus strand
- chr12:54,378,849-54,384,063
- (GRCh37/hg19)
- Size:
- 5,215 bases
- Orientation:
- Plus strand
Genomic View for HOXC10 Gene
Genes around HOXC10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
HOXC10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXC10 Gene
Proteins for HOXC10 Gene
-
Protein details for HOXC10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NYD6-HXC10_HUMAN
- Recommended name:
- Homeobox protein Hox-C10
- Protein Accession:
- Q9NYD6
- O15219
- O15220
- Q9BVD5
Protein attributes for HOXC10 Gene
- Size:
- 342 amino acids
- Molecular mass:
- 38073 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXC10 Gene
Post-translational modifications for HOXC10 Gene
Other Protein References for HOXC10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ HOXC10 Antibody
- GeneTex Anti-Homeobox C10 antibody
-
Custom Antibody ServicesOriGene Antibodies for HOXC10
- Novus Biologicals Antibodies for HOXC10
-
Abcam antibodies for HOXC10
- Invitrogen Antibodies for HOXC10 (AFLGC-HOXC10)
-
Biorbyt antibodies for HOXC10
-
Boster Bio Antibodies for HOXC10
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXC10
Protein Products
-
OriGene Purified Proteins for HOXC10
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC10
- Origene Custom Protein Services for HOXC10
- antibodies-online: Show 5 available HOXC10 Proteins ranked by validation data
- Compare Top HOXC10 Proteins
-
Quality Products:
-
Signalway Proteins for HOXC10
-
Abcam proteins for HOXC10
No data available for DME Specific Peptides for HOXC10 Gene
Domains & Families for HOXC10 Gene
Gene Families for HOXC10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HOXC10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXC10 Gene
- GenScript: Design optimal peptide antigens:
-
- Homeobox protein Hox-3I (HXC10_HUMAN)
- cDNA, FLJ94360, Homo sapiens homeo box C10 (HOXC10), mRNA (Q53XI4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NYD6- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXC10 Gene
Molecular function for HOXC10 Gene
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
- GENATLAS Biochemistry:
- homeo box C10(3I),homologous to mouse Hox-3.6,involved in mouse posterior limb patterning,expressed in posterior limb
Phenotypes From GWAS Catalog for HOXC10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 10835276 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 10835276 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXC10 Gene
- MGI mutant phenotypes for HOXC10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HOXC10:
Animal Models for HOXC10 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HOXC10 - Select products 50% OFF >
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-
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-
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miRNA for HOXC10 Gene
- miRTarBase miRNAs that target HOXC10
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for HOXC10 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HOXC10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOXC10
Cell Line Products
-
Horizon Cell Lines for HOXC10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC10 Gene
Localization for HOXC10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXC10 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for HOXC10 Gene
Interacting Proteins for HOXC10 Gene
Selected Interacting proteins:
Q9NYD6-HXC10_HUMAN
ENSP00000307321
for HOXC10 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for HOXC10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | TAS | 10835276 |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXC10 Gene
Transcripts for HOXC10 Gene
mRNA/cDNA for HOXC10 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000303460 1976 nts (view in UCSC)
- ENST00000511575 887 nts (view in UCSC)
- ENST00000513413 799 nts (view in UCSC)
- ENST00000514415 550 nts (view in UCSC)
- ENST00000515593 526 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for HOXC10 - Select products 50% OFF >
- * HOXC10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for HOXC10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for HOXC10
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HOXC10
- Browse OriGene Inhibitory RNA Products For HOXC10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXC10
Clone Products
- Applied Biological Materials (abm): Clones for HOXC10 - Select products 50% OFF >
- * HOXC10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for HOXC10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for HOXC10
Relevant External Links for HOXC10 Gene
- GeneLoc Exon Structure for
- HOXC10
Expression for HOXC10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
mRNA differential expression in normal tissues according to GTEx for HOXC10 Gene
This gene is overexpressed in Muscle - Skeletal (x16.5), Kidney - Cortex (x5.4), and Artery - Tibial (x5.4).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HOXC10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXC10
SOURCE GeneReport for Unigene cluster for HOXC10 Gene:
Hs.44276Evidence on tissue expression from TISSUES for HOXC10 Gene
- Muscle(2.8)
- Kidney(2.3)
- Skin(2.2)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for HOXC10
-
OriGene qPCR primer pairs and template standards for HOXC10
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC10 Gene
Orthologs for HOXC10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | HOXC10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | HOXC10 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Hoxc10 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Hoxc10 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | HOXC10 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | HOXC10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | HOXC10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | HOXC10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hoxc10 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21864 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | hoxc10a 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14322 30 |
|
- Species where no ortholog for HOXC10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for HOXC10 Gene
- ENSEMBL:
- Gene Tree for HOXC10 (if available)
- TreeFam:
- Gene Tree for HOXC10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for HOXC10: view image
Paralogs for HOXC10 Gene
Paralogs for HOXC10 Gene
- HOXD10 5
- HOXA10 5
- HOXC9 5
- HOXD9 5
- HOXB9 5
- HOXA11 5
- HOXD11 5
- HOXC11 5
- HOXB3 5
- HOXD3 5
- HOXB8 5
- HOXA2 5
- HOXA3 5
- HOXB5 5
- HOXC12 5
- HOXC8 5
- PDX1 5
- HOXA1 5
- HOXA5 5
- HOXA13 5
- HOXD8 5
- HOXD1 5
- HOXB1 5
- HOXB2 5
- HOXB6 5
- HOXB7 5
- HOXC13 5
- HOXA6 5
- HOXA7 5
- HOXA4 5
- HOXD12 5
- GSX2 5
- HOXB4 5
- HOXB13 5
- HOXC4 5
- HOXD13 5
- HOXD4 5
- HOXC5 5
- HOXC6 5
- TLX1 5
- TLX2 5
- ENSG00000273049 5
- TLX3 5
(4) SIMAP similar genes for HOXC10 Gene using alignment to 3 proteins:
- HXC10_HUMAN
- D6RAG4_HUMAN
- Q53XI4_HUMAN
Variants for HOXC10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXC10 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 718767 | Benign: not provided | 53,985,511(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759900 | CNV | gain+loss | 17122850 |
| nsv1136151 | CNV | deletion | 24896259 |
| nsv428282 | CNV | gain | 18775914 |
| nsv826379 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.93;
35.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HOXC10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXC10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC10 Gene
Disorders for HOXC10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| megalencephalic leukoencephalopathy with subcortical cysts 1 |
|
|
Search HOXC10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HOXC10
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXC10 Gene
Publications for HOXC10 Gene
- Selection of homeotic proteins for binding to a human DNA replication origin. (PMID: 10835276) de Stanchina E … Biamonti G (Journal of molecular biology 2000) 3 4 23
- Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (PMID: 17974957) Zhai Y … Cho KR (Cancer research 2007) 3 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PMID: 9357979) Flagiello D … Malfoy B (FEBS letters 1997) 3 4
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott MP (Cell 1992) 2 3
ExternalLinks
Products for HOXC10 Gene
- Custom Antibody ServicesOriGene Antibodies for HOXC10
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- antibodies-online: Show 37 available HOXC10 Antibodies ranked by validation data
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- Signalway Proteins for HOXC10
Sources for HOXC10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
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