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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
HOXC10 (Homeobox C10) is a Protein Coding gene. Diseases associated with HOXC10 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 10835276 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 10835276 |
GO:0003677 | DNA binding | IEA | -- |
GO:0043565 | sequence-specific DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001501 | skeletal system development | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | TAS | 10835276 |
GO:0009952 | anterior/posterior pattern specification | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | HOXC10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | HOXC10 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Hoxc10 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Hoxc10 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | HOXC10 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | HOXC10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | HOXC10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | HOXC10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | hoxc10 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.21864 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | hoxc10a 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14322 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
718767 | Benign: not provided | 53,985,511(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759900 | CNV | gain+loss | 17122850 |
nsv1136151 | CNV | deletion | 24896259 |
nsv428282 | CNV | gain | 18775914 |
nsv826379 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
megalencephalic leukoencephalopathy with subcortical cysts 1 |
|
|