This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with so... See more...

Aliases for HOXB9 Gene

Aliases for HOXB9 Gene

  • Homeobox B9 2 3 5
  • Homeobox Protein Hox-2.5 3 4
  • Homeobox Protein Hox-B9 3 4
  • Homeobox Protein Hox-2E 3 4
  • Homeo Box B9 2 3
  • HOX2E 3 4
  • Homeo Box 2E 3
  • HOX-2.5 3
  • HOXB9 5
  • HOX2 3

External Ids for HOXB9 Gene

Previous HGNC Symbols for HOXB9 Gene

  • HOX2E
  • HOX2

Previous GeneCards Identifiers for HOXB9 Gene

  • GC17M046409
  • GC17M049179
  • GC17M047040
  • GC17M047173
  • GC17M044053
  • GC17M046694
  • GC17M042067

Summaries for HOXB9 Gene

Entrez Gene Summary for HOXB9 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB9 Gene

HOXB9 (Homeobox B9) is a Protein Coding gene. Diseases associated with HOXB9 include Lung Cancer and Prostate Cancer. Among its related pathways are Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXC9.

UniProtKB/Swiss-Prot Summary for HOXB9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for HOXB9 Gene

Genomics for HOXB9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for HOXB9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around HOXB9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for HOXB9

Top Transcription factor binding sites by QIAGEN in the HOXB9 gene promoter:
  • AML1a
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • STAT3

Genomic Locations for HOXB9 Gene

Latest Assembly
chr17:48,621,156-48,626,358
(GRCh38/hg38)
Size:
5,203 bases
Orientation:
Minus strand

Previous Assembly
chr17:46,698,518-46,703,720
(GRCh37/hg19 by Entrez Gene)
Size:
5,203 bases
Orientation:
Minus strand

chr17:46,698,518-46,703,839
(GRCh37/hg19 by Ensembl)
Size:
5,322 bases
Orientation:
Minus strand

Genomic View for HOXB9 Gene

Genes around HOXB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB9 Gene

Proteins for HOXB9 Gene

  • Protein details for HOXB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17482-HXB9_HUMAN
    Recommended name:
    Homeobox protein Hox-B9
    Protein Accession:
    P17482
    Secondary Accessions:
    • B2RDB7
    • Q9H1I1

    Protein attributes for HOXB9 Gene

    Size:
    250 amino acids
    Molecular mass:
    28059 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB9 Gene

Post-translational modifications for HOXB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for HOXB9

No data available for DME Specific Peptides for HOXB9 Gene

Domains & Families for HOXB9 Gene

Gene Families for HOXB9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HOXB9 Gene

InterPro:
Blocks:
  • Lambda and other repressor helix-turn-helix signature
  • Hox9 activation region

Suggested Antigen Peptide Sequences for HOXB9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ31852 fis, clone NT2RP7000812, highly similar to HOMEOBOX PROTEIN HOX-B9 (B3KPJ1_HUMAN)
  • Homeobox protein Hox-2E (HXB9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17482

UniProtKB/Swiss-Prot:

HXB9_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXB9: view

Function for HOXB9 Gene

Molecular function for HOXB9 Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
GENATLAS Biochemistry:
homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B

Phenotypes From GWAS Catalog for HOXB9 Gene

Gene Ontology (GO) - Molecular Function for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
genes like me logo Genes that share ontologies with HOXB9: view
genes like me logo Genes that share phenotypes with HOXB9: view

Animal Models for HOXB9 Gene

MGI Knock Outs for HOXB9:

miRNA for HOXB9 Gene

miRTarBase miRNAs that target HOXB9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXB9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB9 Gene

Localization for HOXB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB9 gene
Compartment Confidence
mitochondrion 5
nucleus 5
extracellular 2
cytoskeleton 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0090575 RNA polymerase II transcription factor complex IEA --
genes like me logo Genes that share ontologies with HOXB9: view

Pathways & Interactions for HOXB9 Gene

PathCards logo

SuperPathways for HOXB9 Gene

SuperPathway Contained pathways
1 Cyclins and Cell Cycle Regulation
.36
genes like me logo Genes that share pathways with HOXB9: view

Pathways by source for HOXB9 Gene

1 Qiagen pathway for HOXB9 Gene
  • Cell Cycle Control by BTG Proteins

SIGNOR curated interactions for HOXB9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0009952 anterior/posterior pattern specification IEA,IBA 21873635
genes like me logo Genes that share ontologies with HOXB9: view

Drugs & Compounds for HOXB9 Gene

No Compound Related Data Available

Transcripts for HOXB9 Gene

mRNA/cDNA for HOXB9 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for HOXB9

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB9 Gene

No ASD Table

Relevant External Links for HOXB9 Gene

GeneLoc Exon Structure for
HOXB9

Expression for HOXB9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB9 Gene

This gene is overexpressed in Colon - Transverse (x26.4), Kidney - Cortex (x9.3), and Small Intestine - Terminal Ileum (x7.2).

Protein differential expression in normal tissues from HIPED for HOXB9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HOXB9 Gene



Protein tissue co-expression partners for HOXB9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for HOXB9

SOURCE GeneReport for Unigene cluster for HOXB9 Gene:

Hs.463350

Evidence on tissue expression from TISSUES for HOXB9 Gene

  • Muscle(4.4)
  • Intestine(3.5)
  • Nervous system(2.4)
  • Kidney(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with HOXB9: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB9 Gene

Orthologs for HOXB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXB9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HOXB9 29 30
  • 99.6 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia HOXB9 29 30
  • 98.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia HOXB9 29 30
  • 98.4 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Hoxb9 29 16 30
  • 95.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Hoxb9 29
  • 95.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia HOXB9 30
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia HOXB9 30
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves HOXB9 29 30
  • 78.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia HOXB9 30
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia hoxb9 29
  • 74.04 (n)
MGC75797 29
Zebrafish
(Danio rerio)
Actinopterygii hoxb9a 29 30
  • 70.45 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5766 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 19 (a)
OneToMany
Species where no ortholog for HOXB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for HOXB9 Gene

ENSEMBL:
Gene Tree for HOXB9 (if available)
TreeFam:
Gene Tree for HOXB9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for HOXB9: view image
Alliance of Genome Resources:
Additional Orthologs for HOXB9

Paralogs for HOXB9 Gene

(6) SIMAP similar genes for HOXB9 Gene using alignment to 2 proteins:

  • HXB9_HUMAN
  • F8W0V6_HUMAN
genes like me logo Genes that share paralogs with HOXB9: view

Variants for HOXB9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for HOXB9 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs150997786 Benign: not provided 48,622,990(-) G/A
NM_024017.5(HOXB9):c.663C>T (p.Leu221=)
SYNONYMOUS
rs184775794 Benign: not provided 48,626,038(-) A/G
NM_024017.5(HOXB9):c.232T>C (p.Tyr78His)
MISSENSE
rs199882905 Likely Benign: not provided 48,625,804(-) C/T
NM_024017.5(HOXB9):c.466G>A (p.Gly156Arg)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for HOXB9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for HOXB9 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Variation tolerance for HOXB9 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HOXB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB9
Leiden Open Variation Database (LOVD)
HOXB9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB9 Gene

Disorders for HOXB9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HOXB9 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search HOXB9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HOXB9

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with HOXB9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB9 Gene

Publications for HOXB9 Gene

  1. Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. (PMID: 19341834) Rouault K … Férec C (Osteoarthritis and cartilage 2009) 3 40
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4
  5. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott MP (Cell 1992) 2 3

Products for HOXB9 Gene

Sources for HOXB9 Gene